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2. 发明公开

EP3308757A1 DEVICE FOR OCULAR ADMINISTRATION OF FLUIDS 有权
标题翻译：装置用于眼部流体的眼部施用
公开(公告)号：EP3308757A1
公开(公告)日：2018-04-18
申请号：EP17196000.8
申请日：2017-10-11
申请人： Università degli Studi di Parma
发明人： RONDA, Nicoletta , BETTINI, Ruggero , BERNINI, Franco
IPC分类号： A61F9/00
CPC分类号： A61F9/0026
摘要： Device for administering a fluid into a patient's conjunctival sac, which combines in a single product optimum characteristics in terms of stability, positioning and spacing of the fluid dispenser with respect to the surface of the eye, as well as guiding of the dispensed fluid towards the center of the eye. The device has the shape of a hollow truncated cone (1), the minor (top,2) base of which is adapted to house the dropper of a fluid dispenser and the major (bottom,3) base of which has a non-coplanar ovoid shape and is adapted to rest precisely on the periocular area. The device allows safe spacing of the tip of the dripper from the corneal surface, preventing accidental contact between dripper and cornea. The dispensed fluid is directed towards the center of the eye surface, without coming into contact with the device. The device is constructively simple, low-cost and suitable for possible disposable use.
摘要翻译：用于将流体施用到患者的结膜囊中的装置，其在流体分配器相对于眼睛表面的稳定性，定位和间隔方面结合单一产品的最佳特性，以及将分配的流体导向眼睛的中心。该装置具有中空的截头圆锥体（1）的形状，小的（顶部，2）基部适于容纳流体分配器的滴管，并且其主（底部，3）基部具有非共面的卵形并且适于精确地停留在眼周区域。该装置可使滴头与角膜表面保持安全间距，防止滴头与角膜之间意外接触。分配的流体被导向眼睛表面的中心，而不会与设备接触。该装置结构简单，成本低，适合一次性使用。

3. 发明公开

EP3281644A1 STABLE FLUORESCENT NANOVESICLES, METHOD FOR OBTAINING THEM AND USES THEREOF 审中-公开
标题翻译：稳定的荧光纳米材料，获得它们的方法及其用途
公开(公告)号：EP3281644A1
公开(公告)日：2018-02-14
申请号：EP16382392.5
申请日：2016-08-08
申请人： Consejo Superior De Investigaciones Científicas , Università degli Studi di Parma
发明人： VENTOSA RULL, Nora , VECIANA MIRO, Jaume , ARDIZZONE, Antonio , PAINELLI, Anna , KURHUZENKAU, Siarhei , SISSA, Cristina
IPC分类号： A61K49/22
CPC分类号： A61K49/0076 , A61K49/0021
摘要： The invention provides a stable fluorescent nanovesicles, and particularly a new fluorescent nanovesicle maintaining the fluorescence's property for at least two months in an aqueous media.
The invention is also directed to their uses as a fluorescent probe and to a method for preparing the stable fluorescent nanovesicles in an easy and feasibly way.
摘要翻译：本发明提供了一种稳定的荧光纳米囊泡，特别是一种新的荧光纳米囊泡，其在水性介质中保持荧光性至少两个月。本发明还涉及它们作为荧光探针的用途以及以简单且可行的方式制备稳定的荧光纳米囊泡的方法。

4. 发明公开

EP3237451A1 PRO-APOPTOTIC ANTI-NG2/CSPG4 ANTIBODIES AND THEIR USES FOR DISEASE THERAPY 有权
标题翻译： PRO-APOPTOTIC ANTI-NG2 / CSPG4抗体及其在疾病治疗中的应用
公开(公告)号：EP3237451A1
公开(公告)日：2017-11-01
申请号：EP15823810.5
申请日：2015-12-23
申请人： Università degli Studi di Parma
发明人： PERRIS, Roberto , DALLATOMASINA, Alice , NICOLOSI, Pier Andrea , TAMBURINI, Elisa , MUCIGNAT, Maria Teresa
IPC分类号： C07K16/30 , G01N33/574
CPC分类号： C07K16/3053 , A61K39/395 , A61K45/06 , C07K2317/33 , C07K2317/73 , C07K2317/76 , G01N33/574
摘要： The present invention relates to an antibody capable of binding with high-affinity and high selectivity to the ectodomain of the transmembrane proteoglycan (PG) NG2/CSPG4, preferably to discrete isoforms of said PG, preferably isoforms that may be generated by alternative splicing, and/or coding single nucleotide polymorphisms, and/or post-transcriptional and/or post-translational modifications. The invention further relates to an anti-NG2/CSPG4 antibody possessing the ability to uniquely induce programmed cell death, exhibited as both canonical caspase-dependent apoptosis and authophagy, in NG2/CSPG4-expressing cancer cells. This action being manifested irrespectively of the coaction of other exogenously added factors. Moreover, the present invention refers to a composition comprising the antibody of the invention, in its naked, encapsulated or genetically engineered form, as pharmaceutical excipient. A further aspect of the present invention refers to the anti-NG2/CSPG4 molecule, or any of its isoforms and fragments, provided as proteolytically generated peptides or produced synthetically and/or recombinantly, for the treatment of apoptosis and/or autophagy-dependent diseases, including but not restricted to cancer.
摘要翻译：本发明涉及能够以对跨膜蛋白聚糖（PG）NG2 / CSPG4的胞外域，优选地对所述PG的离散同种型，优选可通过可变剪接产生的同种型的高亲和力和高选择性结合的抗体，以及 /或编码单核苷酸多态性，和/或转录后和/或翻译后修饰。本发明进一步涉及在表达NG2 / CSPG4的癌细胞中具有独特诱导程序性细胞死亡的能力的抗NG2 / CSPG4抗体，其作为典型的半胱天冬酶依赖性凋亡和authophagy表现出来。无论其他外部因素如何共同作用，这一行为都表现出来。此外，本发明涉及包含本发明抗体的组合物，其以裸露的，包封的或基因工程形式作为药物赋形剂。本发明的另一方面涉及作为蛋白水解产生的肽或以合成方式和/或重组方式产生的抗NG2 / CSPG4分子或其任何同种型和片段，用于治疗细胞凋亡和/或自噬依赖性疾病包括但不限于癌症。

5. 发明授权

EP1973868B1 Novel elatonin ligands having antidepressant activity as well as sleep inducing properties 有权转让
标题翻译：新Elatoninliganden具有抗抑郁活性和睡眠功能
公开(公告)号：EP1973868B1
公开(公告)日：2015-09-09
申请号：EP07701686.3
申请日：2007-01-12
申请人： McGill University , Università degli Studi di Parma , UNIVERSITA' DEGLI STUDI DI MILANO , Universita Degli Studi Di Urbino
发明人： GOBBI, Gabriella , MOR, Marco , RIVARA, Silvia , FRASCHINI, Franco , TARZIA, Giorgio , BEDINI, Annalida , SPADONI, Gilberto , LUCINI, Valeria
IPC分类号： C07C237/04 , C07C233/36 , A61P25/00
CPC分类号： C07C233/43 , C07C233/36

6. 发明公开

EP2744778A2 META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS 有权
标题翻译：外设EINGESCHRÄNKTEFAAH-HEMMER AUS META-SUBSTITUIERTEM BIPHENYL
公开(公告)号：EP2744778A2
公开(公告)日：2014-06-25
申请号：EP12826376.1
申请日：2012-08-17
申请人： The Regents of the University of California , Fondazione Istituto Italiano Di Tecnologia , Università Degli Studi Di Urbino "Carlo Bo" , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , MORENO-SANZ, Guillermo , BANDIERA, Tiziano , MOR, Marco , TARZIA, Giorgio
IPC分类号： C07C233/06 , C07C233/23 , C07D309/14 , A61K31/165 , A61P29/00
CPC分类号： C07C271/56 , C07C269/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D309/14
摘要： The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.
摘要翻译：本发明提供制备和使用外周限制性脂肪酸酰胺水解酶抑制剂（FAAH）的方法。本发明提供抑制FAAH活性并增加中枢神经系统（CNS）外的氨基酰胺水平的化合物和组合物。本发明还提出了用于抑制FAAH的方法以及治疗诸如但不限于疼痛，炎症，免疫病症，皮炎，粘膜炎，周围感觉神经元，神经性皮炎和膀胱过度活动症的过度反应的病症的方法。因此，本发明还提供了用于治疗其中选择性抑制外周FAAH（与CNS FAAH相反））有益的化合物，方法和药物组合物。

7. 发明公开

EP2632997A1 USE OF A COORDINATION COMPLEX OR COMPOUND FOR THE MEASUREMENT OF TEMPERATURE 有权
标题翻译： VERWENDUNG EINES KOORDINATIONSKOMPLEXES ODER VERBUNDES ZUR TEMPERATURMESSUNG
公开(公告)号：EP2632997A1
公开(公告)日：2013-09-04
申请号：EP11805592.0
申请日：2011-10-26
申请人： Alma Mater Studiorum -Universita' di Bologna , Università degli Studi di Parma
发明人： BONACCHI, Sara , MONTALTI, Marco , PRODI, Luca , ZACCHERONI, Nelsi , ZERBETTO, Francesco , CALVARESI, Matteo , CAUZZI, Daniele, Alessandro
IPC分类号： C09K11/06 , G01K11/20 , C09K9/02
CPC分类号： G01K11/00 , C09K9/02 , G01K11/20
摘要： Use for measuring temperatures of a coordination complex presenting formula I, wherein M
1 , M
2 , M
3 , M
4 , M
5 are chosen, each independently of the others, in the group consisting of: Cu
I , Ag
I , Au
I , Pd
II ; n is equal to the sum of the oxidation states of M
1 , M
2 , M
3 , M
4 , M
5 minus 3; II represents a respective portion of each tridentate ligand having the formula III in which R
1 is chosen in the group consisting of: Ph, C
1 -C
4 alkyl, halo-alkyl C
1 -C
4 substituted phenyl; R
2 is chosen in the group consisting of: Ph,C
1 -C
4 alkyl, C
1 -C
4 halo-alkyl-, substituted phenyl; R
3 is chosen in the group consisting of: C
3 -C
18 alkyl, benzyl, substituted benzyl, C
1 - C
20 hydroxy-alkyl, C
1 -C
20 alkoxy silane.
摘要翻译：用于测量呈现式I的配位络合物的温度，其中M1，M2，M3，M4，M5各自独立地选自：CuI，AgI，AuI，PdII; n等于M1，M2，M3，M4，M5的氧化态的总和减去3; II表示具有式III的每个三齿配体的相应部分，其中R 1选自：Ph，C 1 -C 4烷基，卤代烷基C 1 -C 4取代的苯基; R 2选自：Ph，C 1 -C 4烷基，C 1 -C 4卤代烷基 - 取代的苯基; R3选自：C 1 -C 18烷基，苄基，取代的苄基，C 1 -C 20羟基 - 烷基，C 1 -C 20烷氧基硅烷。

8. 发明公开

EP4159825A1 ANTI-ICING SOLUTION FOR THE WINTER MAINTENANCE OF OPEN-GRADED OR HIGH MACRO-TEXTURED ASPHALT PAVEMENTS 审中-实审
公开(公告)号：EP4159825A1
公开(公告)日：2023-04-05
申请号：EP22198965.0
申请日：2022-09-30
申请人： Università degli Studi di Parma
发明人： GIULIANI, Felice , LONGO, Sandro Giovanni , AUTELIANO, Federico , PETROLO, Diana
IPC分类号： C09K3/18
摘要： An anti-icing solution for the winter maintenance of open-graded or high macro-textured asphalt pavements, characterized in that it comprises a mixture of water, at least one saline solute capable of reducing the freezing point of the mixture and at least one bio-based gelling agent comprising agarose and/or pectin, wherein said gelling agent is contained in the mixture in an effective amount for the thermo-reversible transition of the mixture from a liquid state to a gelatinous state in a cooling process and vice versa in a heating process.

9. 发明授权

EP3237451B1 PRO-APOPTOTIC ANTI-NG2/CSPG4 ANTIBODIES AND THEIR USES FOR DISEASE THERAPY 有权
公开(公告)号：EP3237451B1
公开(公告)日：2019-07-24
申请号：EP15823810.5
申请日：2015-12-23
申请人： Università degli Studi di Parma
发明人： PERRIS, Roberto , DALLATOMASINA, Alice , NICOLOSI, Pier Andrea , TAMBURINI, Elisa , MUCIGNAT, Maria Teresa
IPC分类号： C07K16/30 , G01N33/574

10. 发明公开

EP3193858A1 NEW MDR1 INHIBITORS FOR OVERCOMING MULTIDRUG RESISTANCE 有权
标题翻译：用于克服多重耐药性的新型MDR1抑制剂
公开(公告)号：EP3193858A1
公开(公告)日：2017-07-26
申请号：EP15756848.6
申请日：2015-08-03
申请人： Università degli Studi di Parma
发明人： BERNINI, Franco , ADORNI, Maria Pia , PETRONINI, Pier Giorgio , ALFIERI, Roberta , GALETTI, Maricla , FAVARI, Elda , INCERTI, Matteo
IPC分类号： A61K31/194 , A61P35/00
CPC分类号： A61K31/194
摘要： New inhibitors of the activity of the multidrug resistance receptor 1 (MDR1), which are highly active to the MDR1 transporter, and showing a medium/ high selectivity to such transporter, described by the structural formula (I): where R is a C1-C4 alkylene, optionally substituted with a C1-C3 alkyl. Said inhibitors are useful in the treatment or prevention of multi-drug resistance.
摘要翻译：通过结构式（I）描述的对MDR1转运蛋白高度活性且对该转运蛋白显示出中/高选择性的多药物抗性受体1（MDR1）活性的新型抑制剂：其中R为C1- C4亚烷基，其任选被C1-C3烷基取代。所述抑制剂可用于治疗或预防多药耐药性。

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