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1. 发明授权

EP2275566B1 Method for cellular tissue multiplication from Jatropha curcas 有权
标题翻译：一种用于麻疯树的细胞组织增强方法
公开(公告)号：EP2275566B1
公开(公告)日：2015-03-25
申请号：EP09275110.6
申请日：2009-11-19
申请人： Empresas Públicas De Medellín E.S.P. , Universidad De Antioquia
发明人： Atehortua Garces, Lucia , Correa Cordoba, Sandra Marcela
IPC分类号： C12P7/00 , C12P7/64 , C12N5/00
CPC分类号： A01H4/00 , C12P7/6463 , C12P7/649 , Y02E50/13 , Y02P30/20

2. 发明公开

EP3954365A1 METHOD FOR COATING INSOLUBLE SOLIDS 审中-实审转让
公开(公告)号：EP3954365A1
公开(公告)日：2022-02-16
申请号：EP20774095.2
申请日：2020-03-17
申请人： Universidad De Antioquia , Nexentia S.A.S.
发明人： CASANOVA YEPES, Herley , DELGADO OSPINA, Felipe , JAIMES JAIMES, Jorge Osvaldo , SÁNCHEZ RENDÓN, Julián Andrés , TORRES OQUENDO, Juan Diego
IPC分类号： A61K9/50 , B01J13/00 , B01J13/02 , B01J13/20
摘要： The invention relates to a method for coating insoluble solids in water by ionic gelation employing negatively-charged macromolecules and a source of polyvalent cations as film- forming materials. In said method the coating material represents not more than 10% (w/w) with regard to the total weight of the coated solid. The coated insoluble solids can be subsequently dried to produce surface-modified dry particles for use as active substances and/or excipients in the manufacture of pharmaceutical compositions or food products.

3. 发明公开

EP3015478A1 PRODUCTION OF A NOVEL MULTI-PURPOSE CELLULOSIC EXCIPIENT 有权
标题翻译： HERSTELLUNG EINES NEUARTIGEN CELLULOSISCHEN MEHRZWECKHILFSSTOFFS
公开(公告)号：EP3015478A1
公开(公告)日：2016-05-04
申请号：EP14818010.2
申请日：2014-02-13
申请人： Universidad De Antioquia
发明人： ROJAS CAMARGO, John, Jairo , LÓPEZ LÓPEZ, Alvin de Jesús
IPC分类号： C08B15/02
CPC分类号： A61K47/38 , A61K9/2095 , C08B15/02 , C08B16/00
摘要： The invention relates to a process for producing a novel multi-purpose agglomerated cellulosic excipient. This excipient replaces many ingredients in the production of tablets due to the fact that it functions as a diluent, a disintegrating agent and an agglutinant, all in the same material. This material is therefore ideal for producing tablets in a dry process such as direct compression and dry granulation, saving production times and costs, especially in humidity-and heat-sensitive drugs. The tablets produced using said excipient disintegrate rapidly by explosion when they come into contact with water. In addition, said excipient can be used to produce loose and compact make-up powders due to its self-agglutinating and sensory properties on the skin, and also functions as a dispersant agent that can be used in the production of semisolid products. It can further be used to produce granules and beads or as a diluent in formulations of hard gelatin capsules, and since it is a source of high fiber, it is a good replacement for insoluble dietary fiber.
摘要翻译：本发明涉及一种生产新型多用途聚集纤维素赋形剂的方法。这种赋形剂取代了片剂生产中的许多成分，因为其作为稀释剂，崩解剂和凝集剂起同样的作用。因此，该材料是干燥方法如直接压片和干法制粒生产片剂的理想选择，节省生产时间和成本，特别是在湿度和热敏感药物中。使用所述赋形剂制成的片剂在与水接触时通过爆炸快速崩解。此外，所述赋形剂由于其在皮肤上的自凝和感觉特性而可用于制备松散紧凑的补充粉末，并且还用作可用于半固体产品生产的分散剂。它可以进一步用于在硬明胶胶囊的制剂中产生颗粒和珠粒或稀释剂，并且由于它是高纤维的来源，因此它是不溶性膳食纤维的良好替代品。

4. 发明公开

EP2698341A2 CONTINUOUS METHOD FOR PRODUCING NANOPARTICLES AND NANOPARTICLES OBTAINED BY MEANS OF SAID METHOD 失效
标题翻译：连续法生产纳米颗粒并在此过程中产生的纳米粒子
公开(公告)号：EP2698341A2
公开(公告)日：2014-02-19
申请号：EP12770963.2
申请日：2012-04-13
申请人： Universidad De Antioquia
发明人： YEPES CASANOVA, Herley , HIGUITA GONZALES, Lina Paola
IPC分类号： B82Y40/00 , B82Y5/00 , A61K9/52
CPC分类号： A61K9/4816 , A23P10/30 , A61K9/5115 , A61K9/5169 , A61K9/5192 , A61K31/353 , B82Y30/00 , B82Y40/00
摘要： The invention relates to a continuous method for producing inorganic or organic nanoparticles having multiple nuclei functionalised with proteins, using a T-type reactor that operates at high pressure, the primary particles that form the nuclei of the nanoparticles being smaller than 10 nm and said primary particles being immersed in a proteinaceous matrix that forms the nanoparticle in sizes of between 30 nm and 500 nm. The invention also relates to the nanoparticles produced by means of said method.

5. 发明公开

EP4375350A1 SOLVOTHERMAL LIQUEFACTION PROCESS FOR PRODUCING BIO-CRUDE FROM BIOMASS 失效
公开(公告)号：EP4375350A1
公开(公告)日：2024-05-29
申请号：EP22845547.3
申请日：2022-07-22
申请人： Cementos Argos S.A. , Universidad De Antioquia
发明人： OCAMPO ECHEVERRI, David , RIOS, Luis Alberto , GÓMEZ MEJÍA, Elkin Andrés , VARGAS BETANCUR, Gabriel Jaime
IPC分类号： C10G1/00 , C10G1/06 , C10G3/00
CPC分类号： Y02P30/20 , Y02E50/10 , C10G1/04 , C10G1/047
摘要： The present disclosure refers to a process of obtaining a biocrude from biomass, where said process comprises the solvothermal liquefaction of the biomass in the presence of a mixture of solvents, until obtaining a gaseous phase, a solid phase, an aqueous liquid phase and an organic liquid phase comprising the biocrude. Wherein the mixture of solvents comprises between 0.5% w/w to 99.5% w/w of water and at least one solvent; and wherein the solvent is selected from alcohols, ketones, aldehydes, or precursors thereof under the processing conditions. The process described herein allows the use of biomass for the production of renewable fuels, as well as obtaining a biocrude with a yield greater than or equal to 30%, with a calorific value between 20 and 35 MJ/Kg and with a sulfur percentage lower than 1% w/w.

6. 发明公开

EP4084008A1 A MEDICAL VENTILATOR SYSTEM AND A METHOD FOR PREDICTING TRANSIENT STATES OF A VENTILATED PATIENT UPON CHANGES IN MECHANICAL VENTILATOR SETTINGS 无效
公开(公告)号：EP4084008A1
公开(公告)日：2022-11-02
申请号：EP21382381.8
申请日：2021-04-30
申请人： Universitat Politècnica de Catalunya , Universidad de Antioquia
发明人： SERNA HIGUITA, Leidy Yanet , MAÑANAS VILLANUEVA, Miguel Ángel , HERNÁNDEZ VALDIVIESO, Alher Mauricio
IPC分类号： G16H20/40 , G16H40/63 , G16H50/50 , A61B5/08 , A61M16/00
摘要： A medical ventilator system and a method for predicting transient states of a ventilated patient upon changes in mechanical ventilator settings are provided. The system includes a mechanical ventilator connected to a ventilated patient; and a modeling component to receive clinical and/or physiological variables of the ventilated patient and ventilator settings. The modeling component predicts a cardiorespiratory transient state of the ventilated patient by tunning the clinical and/or physiological variables and the ventilator settings throughout the adjustment of parameters' values of several physiological submodels, generating as a result a personalized ventilated patient model. The generated personalized ventilated patient model is simulated based on new ventilator settings, a result of the simulation providing: traces of simulated output respiratory and cardiovascular signals; indexes related to features of transient and stationary phases of each simulated output physiological signal; indexes related to ventilation, respiratory rhythm, respiratory pressures, ventilatory mechanics, work of breathing, cardiac function, arterial gases.

7. 发明授权

EP2698341B1 CONTINUOUS METHOD FOR PRODUCING NANOPARTICLES AND NANOPARTICLES OBTAINED BY MEANS OF SAID METHOD 失效
公开(公告)号：EP2698341B1
公开(公告)日：2019-01-02
申请号：EP12770963.2
申请日：2012-04-13
申请人： Universidad De Antioquia
发明人： YEPES CASANOVA, Herley , HIGUITA GONZALES, Lina Paola
IPC分类号： A61K9/51 , A23J1/20 , B82Y40/00 , A61K31/353 , B82Y5/00 , B82Y30/00 , A61K9/52 , A23P10/30

8. 发明公开

EP3311804A1 METHOD FOR PRODUCING COLLOIDOSOME MICROCAPSULES 有权转让
标题翻译：生产胶体囊肿微胶囊的方法
公开(公告)号：EP3311804A1
公开(公告)日：2018-04-25
申请号：EP16811127.6
申请日：2016-06-18
申请人： Universidad de Antioquia (UDEA) , Nexentia S.A.S.
发明人： CASANOVA, Herley , PÉREZ ZAPATA, César Augusto
IPC分类号： A61K9/50 , A61K9/51 , B01J13/02 , B01J13/20
CPC分类号： A61K9/50 , A61K9/51 , B01J13/02 , B01J13/20
摘要： This invention relates to a process for colloidosome-type microcapsules elaboration from solid particles microcapsules obtained by ionic gelation. In the process, an (O/W) type emulsion is initially generated stabilized with the solid particles microcapsules, and then the particles are fixed to the interface by adsorption of polyelectrolytes, cross-linking, heat treatment or fatty coating, generating the colloidosome with the water-insoluble phase encapsulated in the core and covered by the shell particles.
摘要翻译：本发明涉及由离子胶凝得到的固体颗粒微胶囊制备胶体体型微胶囊的方法。在此过程中，首先生成（O / W）型乳液，用固体颗粒微胶囊稳定化，然后通过聚电解质的吸附，交联，热处理或脂肪涂层将颗粒固定到界面上，包封在芯中并被壳粒子覆盖的不溶于水的相。

9. 发明授权

EP3015478B1 PRODUCTION OF A NOVEL MULTI-PURPOSE CELLULOSIC EXCIPIENT 有权
公开(公告)号：EP3015478B1
公开(公告)日：2019-09-11
申请号：EP14818010.2
申请日：2014-02-13
申请人： Universidad De Antioquia
发明人： ROJAS CAMARGO, John, Jairo , LÓPEZ LÓPEZ, Alvin de Jesús
IPC分类号： C08B15/02 , C08B16/00

10. 发明公开

EP3040373A1 IONIC GELATION ON SOLIDS 有权转让
标题翻译： IONISCHE VERGELUNG AUF FESTSTOFFEN
公开(公告)号：EP3040373A1
公开(公告)日：2016-07-06
申请号：EP14839385.3
申请日：2014-08-21
申请人： Universidad de Antioquia (Udea)
发明人： CASANOVA, Herley Fernando , PÉREZ ZAPATA, César , RESTREPO, César , DIOSA ARANGO, Johnatan
IPC分类号： C08K9/10 , C08L89/00 , A61K9/50 , A61K47/02 , A61K47/42
CPC分类号： A61K9/5089 , A61K8/11 , A61K8/19 , A61K8/64 , A61K9/2095 , A61K9/485 , A61K9/5052 , A61K9/5073 , A61K2800/10 , A61Q19/00 , C08K9/10 , C08L5/00 , C08L89/00
摘要： The invention relates to a method for ionic gelation on solids for encapsulating water-insoluble solids. The method uses negatively charged macromolecules and soluble salts of polyvalent cations as shell-forming materials having a high adsorption on the surface of the solid when subjected to thermal treatment. The shell-forming material represents at least 10% of the weight of the dry microcapsule obtained. The obtained microcapsule can be redispersed in water and treated by altering the environment thereof in order to be used as an encapsulating medium for water-soluble compounds and they can also be used as active ingredients and/or excipients in the production of pharmaceutical or nutraceutical compositions.
摘要翻译：本发明涉及用于封装水不溶性固体的固体上的离子凝胶化方法。该方法使用带负电荷的大分子和多价阳离子的可溶性盐作为在进行热处理时在固体表面上具有高吸附性的成壳材料。成壳材料占所得干燥微胶囊重量的至少10％。所获得的微胶囊可以再分散在水中并通过改变其环境进行处理，以便用作水溶性化合物的包封介质，并且它们也可以用作生产药物或营养组合物中的活性成分和/或赋形剂。

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