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1. 发明授权

EP2583979B1 Methods to prepare antibodies directed against p19 subunit of human IL-23 无效
标题翻译：一种用于人IL-23抗体的针对P19的制备方法
公开(公告)号：EP2583979B1
公开(公告)日：2015-12-16
申请号：EP11306352.3
申请日：2011-10-19
申请人： Effimune , Institut National de la Santé et de la Recherche Médicale , Universite D'Angers
发明人： CHEVALIER, Sylvie , DANGER, Yannick , FROGER, Josy-Anne , GASCAN, Hugues , MARY, Caroline , POIRIER, Nicolas , VANHOVE, Bernard
IPC分类号： C07K16/00 , C07K16/24
CPC分类号： C07K16/244 , C07K16/00 , C07K2317/76 , C07K2317/92

2. 发明公开

EP2891657A1 Ionic liquid supported organotin reagents for the manufacturing of radiopharmaceuticals compounds 审中-公开
标题翻译：由离子液体Organozinnreagenzien支持放射性药物化合物的制备
公开(公告)号：EP2891657A1
公开(公告)日：2015-07-08
申请号：EP14150296.3
申请日：2014-01-07
申请人： Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE DE NANTES , UNIVERSITE D'ANGERS , Université du Maine , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre Hospitalier Universitaire De Nantes
发明人： Legoupy, Stéphanie , Faye, Djibril , Gestin, Jean-François , Rajerison, Holisoa , Faivre-Chauvet, Alain , Boeda, Fabien
IPC分类号： C07F7/22 , C07B59/00
CPC分类号： C07F7/2212 , B01J19/0006 , B01J19/24 , B01J2219/24 , C07B59/001 , C07B59/002 , C07B59/008 , C07B2200/05 , C07C67/307 , C07C69/78 , C07D207/46 , C07K14/765 , C07K16/40 , C07C69/76
摘要： The present invention relates to a compound of formula (I)

The invention further relates to a process for manufacturing the compound of formula (I) and to a process for manufacturing an halogenated or radio-halogenated compound using compound of formula (I). The invention also relates to a device for implementing the halogenating process of the invention and to a kit comprising the compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物本发明还涉及到一种用于制造式（I）的化合物以及一种用于制造使用式（I）的化合物卤化或无线电卤代化合物的方法。因此本发明涉及一种设备，用于实现本发明的卤化过程，并一个试剂盒，其包含式（I）的化合物。

3. 发明公开

EP2850089A1 RADIOACTIVE RHODIUM COMPLEXES, PREPARATION METHODS AND USES THEREOF 审中-公开
标题翻译：放射性铑，方法和应用
公开(公告)号：EP2850089A1
公开(公告)日：2015-03-25
申请号：EP13724552.8
申请日：2013-05-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , CHU Nantes , Universite de Nantes , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE D'ANGERS
发明人： FAIVRE-CHAUVET, Alain , RAJERISON, Holisoa , GESTIN, Jean-François
IPC分类号： C07F15/00 , A61K31/24 , A61P35/00
CPC分类号： C07F15/0073 , A61K47/48092 , A61K47/549
摘要： The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.

4. 发明公开

EP2498195A1 Non-invasive method for assessing the presence or severity of liver fibrosis based on a new detailed classification 审中-公开
标题翻译：基于新的详细分类评估肝纤维化的存在或严重性的无创性方法
公开(公告)号：EP2498195A1
公开(公告)日：2012-09-12
申请号：EP11157978.5
申请日：2011-03-11
申请人： Centre Hospitalier Universitaire d'Angers , UNIVERSITE D'ANGERS
发明人： Calès, Paul , Boursier, Jérôme
IPC分类号： G06F19/00
CPC分类号： A61B5/4244 , A61B5/4842
摘要： The present invention relates to a non-invasive method for assessing the presence and/or severity of a lesion in an organ of an animal, including a human, said method comprising carrying out at least one non-invasive test resulting in a score/value, and positioning the at least one score/value in a class of a detailed classification based on population percentiles, or in a reliable diagnostic interval (RDI), to be crossed with another RDI for a final positioning of both RDI in a class. The present invention also relates to a device, preferably a meter, carrying out the non-invasive method of the invention.
摘要翻译：本发明涉及一种非侵入性的方法，用于assesing病变的存在和/或严重程度的动物的器官，包括人，所述方法包括进行至少一种非侵入性的试验中的得分/值所得和定位的一类基于群体百分位数的详细分类的至少一个分数/值，或在一个可靠的诊断时间间隔（RDI），以与另一RDI被越过为两个RDI的一个类中的最终定位。因此，本发明涉及一种装置，优选为米，实施发明的非侵入性方法。

5. 发明公开

EP2377093A1 METHOD AND AN APPARATUS FOR DECONVOLUTING A NOISY MEASURED SIGNAL OBTAINED FROM A SENSOR DEVICE 审中-公开
标题翻译：用于建立一个从传感器设备电路的方法和设备获得的嘈杂测量信号
公开(公告)号：EP2377093A1
公开(公告)日：2011-10-19
申请号：EP09785958.1
申请日：2009-01-09
申请人： Universite D'Angers
发明人： JEANGUILLAUME, Christian
IPC分类号： G06T5/00
CPC分类号： G06T5/003
摘要： The present invention relates to a method and apparatus for deconvolving a noisy measured signal obtained from a sensor device (100), said noisy measured signal (
y(t) ) being the sum of the convolution product (
x(t ) ⊗
N (
t ) ) of an input signal (x
(t) ) of the sensor device, representative of a feature of physical quantity, by a convolution kernel (N(t)) defined by the response function of the sensor device (100) and a noise which interfere with the measure. The method is characterised in that said method comprises an estimate computation step (400) in the course of which a minimal estimate (x
min (t) ⊗
N (t) ) of the convolution product of the input signal by the convolution kernel of the sensor device is computed in order that said minimal estimate stays below the noisy measured signal (y(t)) and has at least one point in common with the noisy measured signal (
y(t) ).
摘要翻译：本发明涉及一种用于去卷积从传感器设备（100）获得的嘈杂测量的信号的方法和装置，所述噪声的测量的信号（Y（t））的是所述卷积乘积的总和（X（t）N（t）的）的输入信号的传感器装置的（X（t））的，代表物理量的特征的，由传感器装置（100的响应函数定义的卷积核（N（t））的）和噪声哪干扰的措施。在于，所述方法的特征在于所述方法包括通过所述传感器装置的卷积核在输入信号的卷积的哪一个最小估计（（X分钟（吨）N t））的过程中的估计值计算步骤（400）被计算，以使所述最小估算保持低于嘈杂测量的信号（Y（t））和具有至少一个共同的点与所述测量噪声的信号（Y（t））的。

6. 发明公开

EP2376218A1 PROCEDE DE PREPARATION DE NANOPARTICULES LIPIDIQUES 有权
标题翻译：用于生产脂质纳米粒
公开(公告)号：EP2376218A1
公开(公告)日：2011-10-19
申请号：EP09803843.3
申请日：2009-12-11
申请人： UNIVERSITE D'ANGERS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BENOIT, Jean-Pierre , THOMAS, Olivier , RAMADAN, Alyaa, Adel , SAULNIER, Patrick
IPC分类号： B01J13/04
CPC分类号： B01J13/04
摘要： The present invention relates to a useful method for preparing nanocapsules with a liquid lipid core and a hard shell and loaded with at least one hydrophilic active agent, said method including at least the steps of: i) using at least one first water-in-oil microemulsion containing, in the hydrophilic phase thereof, at least one hydrophilic active agent; ii) using at least one second microemulsion that is formulated by the phase inversion of an emulsion; iii) adding said first microemulsion into said second microemulsion under conditions that are conducive to the formation of a novel microemulsion architecture wherein said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) quenching the mixture that is formed in the preceding step so as to obtain microcapsules containing said hydrophilic active agent and being made of a lipid core that is liquid at room temperature and coated in a hard film at room temperature. The invention also relates to nanocapsules obtainable by said method.

7. 发明公开

EP2167054A2 PROCEDE DE PREPARATION DE NANOPARTICULES LIPIDIQUES 审中-公开
标题翻译：用于生产脂质纳米粒
公开(公告)号：EP2167054A2
公开(公告)日：2010-03-31
申请号：EP08805978.7
申请日：2008-06-11
申请人： UNIVERSITE D'ANGERS
发明人： SAULNIER, Patrick , BENOIT, Jean-Pierre , ANTON, Nicolas
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K9/1075 , A61K31/192 , A61K31/70
摘要： The present invention relates to a method for use in the preparation of nanocapsules which have a liquid lipid core and a solid lipid shell and which are loaded with at least one active agent, wherein said method comprises at least the steps consisting in providing a microemulsion formulated by phase inversion of an emulsion, providing a second composition, distinct from said microemulsion and completely or partly formed from at least one active agent, placing said microemulsion in the presence of said second composition under conditions suitable for the interaction of said active agent with said microemulsion and annealing said microemulsion having interacted with said active agent in such a way as to obtain said nanocapsules. The invention also relates to a corresponding kit.

8. 发明公开

EP1979745A1 MÉTHODE DE DIAGNOSTIC IN VITRO DE RÉPONSE IMMUNITAIRE AUTOIMMUNE PAR DÉTECTION D'ANTICORPS DIRIGÉS CONTRE L'ANTIGÈNE PENTRAXINE 3 有权
标题翻译：用于自身免疫免疫应答体外诊断方法BY PROOF AGAINST THE五聚环蛋白-3抗原的抗体DIRECTED装置
公开(公告)号：EP1979745A1
公开(公告)日：2008-10-15
申请号：EP07704031.9
申请日：2007-01-19
申请人： UNIVERSITE D'ANGERS
发明人： JEANNIN, Pascale , DELNESTE, Yves , MANTOVANI, Alberto
IPC分类号： G01N33/564
CPC分类号： G01N33/564
摘要： The invention relates to a method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and also to the kits for implementing the method.

9. 发明公开

EP1265698A1 NANOCAPSULES LIPIDIQUES, PROCEDE DE PREPARATION ET UTILISATION COMME MEDICAMENT 有权
标题翻译：脂质纳米胶囊，其制造方法和用途医药
公开(公告)号：EP1265698A1
公开(公告)日：2002-12-18
申请号：EP01911828.0
申请日：2001-03-02
申请人： MAINELAB , UNIVERSITE D'ANGERS
发明人： HEURTAULT, Béatrice , SAULNIER, Patrick , BENOIT, Jean-Pierre , PROUST, Jacques-Emile , PECH, Brigitte , RICHARD, Joel
IPC分类号： B01J13/00 , B01F17/00 , A61K9/51 , B01J13/06
CPC分类号： A61K9/5123 , A61K9/5146 , B01F17/0028 , B01F17/0064 , B01F17/0085 , B01J13/0026 , B01J13/06
摘要： The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2 - 10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.

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