专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3222611A4 THICKENING AND STABILIZING AGENT, AND THICKENING AND STABILIZING COMPOSITION USING SAME 审中-公开
公开(公告)号：EP3222611A4
公开(公告)日：2018-05-23
申请号：EP15861230
申请日：2015-11-10
申请人： DAICEL CORP , UNIV YAMAGUCHI
发明人： SAKANISHI YUICHI , SAEKI TAKASHI , ITOH MAMI
IPC分类号： C07C235/74 , A23L29/20 , A61K8/42 , A61K47/18 , C09K3/00
CPC分类号： C07C235/74 , A23L29/20 , A23V2002/00 , A61K8/42 , A61K47/18 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C09D7/002 , C09D7/43 , C09K3/00
摘要： Provided are: a compound, a thickening/stabilizing agent including the compound, a thickened/stabilized composition including the thickening/stabilizing agent and a fluid organic substance, and a method for producing the thickened/stabilized composition, where the compound effectively thickens the fluid organic substance to a desired viscosity and effectively uniformly stabilizes the formulation of the composition containing the fluid organic substance via thickening of the fluid organic substance. The thickening/stabilizing agent according to the present invention includes a compound represented by Formula (1): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ(R 2 -HNOC) 4-n -R 1 -(CONH-R 3 ) n €ƒ€ƒ€ƒ€ƒ€ƒ(1) where R 1 is a group resulting from removing four hydrogen atoms from the structural formula of butane; R 2 and R 3 are different from each other and are aliphatic hydrocarbon groups each containing 4 or more carbon atoms; and n is an integer of 1 to 3.

2. 发明公开

EP3000466A4 INHIBITOR FOR RETINOCHOROIDAL DISORDERS 有权
标题翻译：抑制剂FÜRRETINOCHOROIDALE ERKRANKUNGEN
公开(公告)号：EP3000466A4
公开(公告)日：2017-01-25
申请号：EP14800477
申请日：2014-05-21
申请人： UNIV YAMAGUCHI
发明人： KIMURA KAZUHIRO
IPC分类号： A61K31/4155 , A61K9/06 , A61K9/08 , A61K9/20 , A61K47/26 , A61K47/44 , A61P27/02 , A61P43/00
CPC分类号： A61K31/415 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K9/2018 , A61K9/205 , A61K47/26 , A61K47/44
摘要： The present invention addresses the problem of providing an inhibitor for retinochoroidal disorders, in particular, an inhibitor for retinochoroidal scar formation and retinochoroidal atrophy in an epiretinal, intraretinal or subretinal tissue. This problem can be solved by preparing an inhibitor for retinochoroidal disorders which comprises, as an active ingredient, (E)-4-(2-{3-[(1H-pyrazol-1-yl)methyl]-5,5,8,8-tetramethyl-5 ,6,7,8-tetrahydronaphthalene-2-yl}vinyl)benzoic acid, an ester thereof or a salt of the same. The inhibitor for retinochoroidal disorders can inhibit collagen atrophy of retinal pigment epithelium cells, fibroblasts, glial cells and the like and thus inhibit retinochoroidal disorders.
摘要翻译：本发明涉及提供视网膜细胞病变抑制剂，特别是视网膜内瘢痕形成抑制剂和视网膜内视网膜或视网膜下视网膜组织中的视网膜下萎缩的问题。通过制备视黄酸失调抑制剂可以解决这个问题，该抑制剂包含作为活性成分的（E）-4-（2- {3 - [（1H-吡唑-1-基）甲基] -5,5,8 ，8-四甲基-5,6,7,8-四氢萘-2-基}乙烯基）苯甲酸，其酯或其盐。视网膜细胞因子障碍抑制剂可以抑制视网膜色素上皮细胞，成纤维细胞，神经胶质细胞等的胶原萎缩，从而抑制视网膜细胞的紊乱。

3. 发明公开

EP2907839A4 CATION EXCHANGE MEMBRANE AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：阳离子交换膜和过程及其制造
公开(公告)号：EP2907839A4
公开(公告)日：2016-06-08
申请号：EP13844805
申请日：2013-09-27
申请人： KURARAY CO , UNIV YAMAGUCHI
发明人： NAKASHIMA TAKAHIRO , JIKIHARA ATSUSHI , WAKUI TAKASHI , HIGA MITSURU
IPC分类号： C08J5/22 , B01D39/02 , B01D61/42 , B01D69/02 , B01D71/38 , B01D71/80 , B01D71/82 , B01J39/18 , C02F1/469 , C08F293/00 , C08F297/00
CPC分类号： B01D61/422 , B01D69/02 , B01D71/38 , B01D71/80 , B01D71/82 , B01D2325/42 , B01J39/19 , C02F1/4693 , C08F293/00 , C08F297/00 , C08J5/2231 , C08J2329/04 , C08J2353/00

4. 发明公开

EP2463264A4 METHOD FOR PRODUCING HYDROXYCARBOXYLIC ACID DERIVATIVE 审中-公开
标题翻译：制备羟基羧酸衍生物的方法
公开(公告)号：EP2463264A4
公开(公告)日：2014-07-02
申请号：EP10806313
申请日：2010-07-12
申请人： UNIV YAMAGUCHI , UBE INDUSTRIES
发明人： KAMIMURA AKIO , KAISO KOUJI , SUGIMOTO TSUNEMI
IPC分类号： C07C67/20 , C07C69/675
CPC分类号： C07C67/20 , Y02P20/544 , C07C69/675

5. 发明公开

EP2548958A4 AGENT FOR IMPROVING GENE TRANSFER EFFICIENCY TO MAMMALIAN CELLS 有权
标题翻译：培养基可提高哺乳动物细胞转基因效率
公开(公告)号：EP2548958A4
公开(公告)日：2013-10-02
申请号：EP11755871
申请日：2011-03-13
申请人： UNIV YAMAGUCHI
发明人： AKADA RINJI , NAKAMURA MIKIKO
IPC分类号： C12N15/09 , C12N15/88
CPC分类号： C12N15/88
摘要： Provided is an efficiency improving agent for gene transfer to mammalian cells, a method for improving efficiency of gene transfer to mammalian cells, and a method for transforming mammalian cells. The method is characterized in that tRNA is used in combination with a lipofection reagent. Preferably, the agent may be used so that the tRNA concentration in a lipofection solution falls within the range of 3 to 50 µg/mL, and the concentration in a culture is approximately 1/10. More preferably, tRNA and PEG may be used in combination with a lipofection reagent. According to the present invention, gene transfer to mammalian cells with high efficiency can be achieved.

6. 发明公开

EP2420310A4 ION-EXCHANGE MEMBRANE AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：离子交换膜及其制造方法
公开(公告)号：EP2420310A4
公开(公告)日：2013-04-17
申请号：EP10764442
申请日：2010-04-13
申请人： UNIV YAMAGUCHI , KURARAY CO
发明人： HIGA MITSURU , JIKIHARA ATSUSHI , KOBAYASHI KENICHI , FUJIWARA NAOKI
IPC分类号： B01D61/00 , B01D61/44 , B01D67/00 , B01D69/00 , B01D69/10 , B01D71/38 , B01D71/82 , C08J5/22
CPC分类号： B01D69/10 , B01D61/44 , B01D67/0013 , B01D2323/30 , C08J5/2206 , C08J2329/04 , Y02A20/134
摘要： There is provided an ion-exchange membrane comprising an ion-exchange layer made of a cationic polymer and/or an anionic polymer and a supporting layer, wherein the ion-exchange layer is formed on the supporting layer by printing. Such an ion-exchange membrane exhibits excellent anti-organic fouling and low membrane resistance, thereby high efficient and long-time stable electrodialysis can be achieved. Formation of the ion-exchange layer as a charge-mosaic layer consisting of the cationic polymer domains and the anionic polymer domains provides a charge-mosaic membrane exhibiting excellent electrolyte permselectivity and mechanical strength.

7. 发明公开

EP2256194A4 FLOCCULENT YEAST AND METHOD FOR PRODUCTION THEREOF 审中-公开
标题翻译：模糊酵母及其制造方法
公开(公告)号：EP2256194A4
公开(公告)日：2012-02-22
申请号：EP09721406
申请日：2009-03-18
申请人： UNIV YAMAGUCHI
发明人： AKADA RINJI , NONKLANG SANOM , HOSHIDA HISASHI , ABDEL-BANAT BABIKER MOHAMED AHMED
IPC分类号： C12N15/09 , C12N1/19 , C12N15/81
CPC分类号： C07K14/395 , C12N15/81 , C12N15/815 , C12P7/06 , Y02E50/17

8. 发明公开

EP1797899A4 PREVENTIVE AND REMEDY FOR COLLAGEN OR ELASTIN METABOLIC DISORDER 审中-公开
标题翻译：手段预防和治疗胶原蛋白或弹性蛋白代谢紊乱
公开(公告)号：EP1797899A4
公开(公告)日：2009-06-24
申请号：EP05780895
申请日：2005-08-24
申请人： UNIV YAMAGUCHI
发明人： YOSHIMURA KOICHI , AOKI HIROKI , MATSUZAKI MASUNORI
IPC分类号： A61K45/00 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/4985 , A61K31/505
CPC分类号： A61K31/404 , A61K31/00 , A61K31/416 , A61K31/4439 , A61K31/4985 , A61K31/505
摘要： A preventive and a remedy for a disease with collagen or elastin metabolic disorder which contain a substance having a JNK inhibitory activity as the active ingredient.

9. 发明公开

EP3205720A4 CAR EXPRESSION VECTOR AND CAR-EXPRESSING T CELLS 有权
公开(公告)号：EP3205720A4
公开(公告)日：2018-07-04
申请号：EP15849416
申请日：2015-10-06
申请人： UNIV YAMAGUCHI
发明人： TAMADA KOJI , SAKODA YUKIMI , ADACHI KEISHI
IPC分类号： C12N15/00 , A61K35/26 , A61K35/76 , A61P35/00 , C07K14/47 , C07K14/54 , C07K19/00 , C12N5/10 , C12N15/09
CPC分类号： C07K16/2887 , A61K35/17 , A61K35/26 , A61K35/76 , C07K14/47 , C07K14/521 , C07K14/54 , C07K14/5418 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/44 , C07K19/00 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0636 , C12N5/10 , C12N15/00 , C12N15/09 , C12N2510/00
摘要： An object of the present invention is to provide CAR-expressing T cells that coexpress a chimeric antigen receptor (CAR) and a T cell immune function-enhancing factor and have a high immunity-inducing effect and antitumor activity, and to provide a CAR expression vector for the preparation of the CAR-expressing T cells. A CAR expression vector comprises a nucleic acid encoding a chimeric antigen receptor (CAR) and a nucleic acid encoding a T cell immune function-enhancing factor, wherein the nucleic acid encoding an immune function-enhancing factor is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19, a nucleic acid encoding a dominant negative mutant of SHP-1, or a nucleic acid encoding a dominant negative mutant of SHP-2, or a CAR-expressing T cell introduced with the CAR expression vector are prepared.

10. 发明公开

EP2990043A4 THERAPEUTIC AGENT FOR NEUROLOGICAL DISORDER 有权
标题翻译：治疗者WIRKSTOFFFÜR神经病学ERKRANKUNGEN
公开(公告)号：EP2990043A4
公开(公告)日：2017-01-25
申请号：EP14789010
申请日：2014-04-22
申请人： UNIV YAMAGUCHI
发明人： IKEDA EIJI , CUI DAN
IPC分类号： A61K31/7105 , A61K31/713 , A61P7/10 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , C12N15/09
CPC分类号： A61K39/3955 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K2039/505 , C07K16/40
摘要： Provided is a therapeutic agent for a neurological disorder directly acting on oxygen concentration-dependent vascular barrier breakdown. The therapeutic agent for a neurological disorder contains any one of (a) a functional nucleic acid against ADAM (a disintegrin and metalloproteinase)12 or ADAM17, (b) a functional nucleic acid expression vector containing a DNA encoding the functional nucleic acid (a) and (c) a neutralizing antibody against ADAM12 or ADAM17, as an active ingredient. The functional nucleic acid is preferably siRNA. It is preferable that the functional nucleic acid against ADAM12 is siRNA consisting of a sense strand sequence of nucleotides represented by SEQ ID NO: 1 or 3 and an antisense strand sequence complementary thereto or that the functional nucleic acid against ADAM17 is siRNA consisting of a sense strand sequence of nucleotides represented by SEQ ID NO: 5 or 7 and an antisense strand sequence complementary thereto.
摘要翻译：提供了直接作用于氧浓度依赖性血管屏障分解的神经障碍的治疗剂。用于神经障碍的治疗剂包含（a）抗ADAM（去整合素和金属蛋白酶）12或ADAM17的功能性核酸中的任一种，（b）含有编码功能性核酸的DNA的功能性核酸表达载体（a）和（c）作为活性成分的针对ADAM12或ADAM17的中和抗体。功能性核酸优选为siRNA。优选针对ADAM12的功能性核酸是由SEQ ID NO：1或3所示的核苷酸有义链序列和与其互补的反义链序列构成的siRNA，或者针对ADAM17的功能性核酸是由感觉由SEQ ID NO：5或7表示的核苷酸序列和与其互补的反义链序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式