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1. 发明公开

EP2774914A4 N-BENZYLANILINE DERIVATIVE AND USES THEREOF 有权转让
标题翻译： N-苯并苯胺衍生物及其用途
公开(公告)号：EP2774914A4
公开(公告)日：2015-07-01
申请号：EP12846586
申请日：2012-10-24
申请人： UNIV NANJING MEDICAL
发明人： ZHU DONGYA , LI FEI , LUO CHUNXIA
IPC分类号： A61K31/196 , A61K31/245 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , C07C229/54 , C07C229/60 , C07C233/54
CPC分类号： C07C229/60 , A61K31/196 , A61K31/245 , C07C229/54 , C07C233/54 , C07C2603/64
摘要： Disclosed are an N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has an action of protecting against cerebral ischemia/reperfusion injury and an analgesic action for chronic pathologic pains, and may be used to prepare drugs for cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to prepare drugs for epilepsy, affective disorder, and neurodegenerative diseases.
摘要翻译：公开了N-苄基苯胺衍生物及其用途。该衍生物是由式I表示的化合物或其药学上可接受的盐。该化合物具有防止脑缺血/再灌注损伤和慢性病理性疼痛的镇痛作用，可用于制备脑中风，神经性疼痛和炎性疼痛的药物。此外，由于化合物的独特作用机理，该化合物可用于制备癫痫，情感障碍和神经退行性疾病的药物。

2. 发明公开

EP2502916A4 ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF 有权
标题翻译：有机二羧酸，它们的盐及其制造方法
公开(公告)号：EP2502916A4
公开(公告)日：2013-05-01
申请号：EP10829544
申请日：2010-11-12
申请人： UNIV SOUTHEAST , UNIV NANJING MEDICAL , ZHEJIANG SHAPUAISI PHARMACY LTD
发明人： GOU SHAOHUA , SHEN HONG , ZHANG YINDI , SHEN JIANPING , ZHU YANQIN , FENG LUZHONG , WU JIANWEI , CHEN DEKANG
IPC分类号： C07D231/56 , A61K31/416 , A61P27/12
CPC分类号： C07D231/56

3. 发明公开

EP2998312A4 POLYPEPTIDE HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF 有权转让
标题翻译：多维多利特麻醉大肠杆菌
公开(公告)号：EP2998312A4
公开(公告)日：2016-08-31
申请号：EP14798053
申请日：2014-02-24
申请人： UNIV NANJING MEDICAL
发明人： ZHOU JIANWEI , XU JIN , LI XUAN , LI AIPING
IPC分类号： C07K14/47 , A61K38/17 , A61P35/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/4703
摘要： Provided is a polypeptide having anti-tumor activity. The amino acid sequence of the polypeptide is FPGSDRF, X-FPGSDRF, FPGSDRF-Z, or X-FPGSDRF-Z, S being a phosphorylated serine residue, X and Z each being an amino acid residue or an amino acid sequence, X being selected from one of F, (R)9, (R)9-F, 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)9, and 6-aminocaproic acid-(R)9-F, and Z being selected from one of A, (G) n-RGD, and A-(G)n-RGD. The polypeptide has no toxicity for normal histocytes. However, when being used with chemicals (such as arsenic trioxide), the polypeptide can increase toxicity for tumor cells. Also provided are uses of the polypeptide for preparing anti-tumor drugs.
摘要翻译：提供了具有抗肿瘤活性的多肽。多肽的氨基酸序列是FPGSDRF，X-FPGSDRF，FPGSDRF-Z或X-FPGSDRF-Z，S是磷酸化丝氨酸残基，X和Z各自是氨基酸残基或氨基酸序列，X被选择来自F，（R）9，（R）9-F，6-氨基己酸，6-氨基己酸-F，6-氨基己酸 - （R）9和6-氨基己酸 - （R） F和Z选自A，（G）n-RGD和A-（G）n-RGD中的一个。该多肽对正常组织细胞无毒性。然而，当与化学品（例如三氧化二砷）一起使用时，多肽可以增加肿瘤细胞的毒性。还提供多肽用于制备抗肿瘤药物的用途。

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