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1. 发明公开

EP4337090A1 APPARATUS AND METHOD FOR SURGICAL MARGIN ASSESSMENT USING BIOIMPEDANCE SENSING ARRAY 审中-实审
公开(公告)号：EP4337090A1
公开(公告)日：2024-03-20
申请号：EP22825574.1
申请日：2022-06-10
申请人： The Trustees of Dartmouth College
发明人： DOUSSAN, Allaire , MURPHY, Ethan , HALTER, Ryan
IPC分类号： A61B5/053 , A61B5/05 , A61N1/08

2. 发明公开

EP4288081A1 ENGINEERED NATURAL LIGAND-BASED CAR: DIRECTED EVOLUTION OF THE STRESS-RECEPTOR NKP30 审中-实审
公开(公告)号：EP4288081A1
公开(公告)日：2023-12-13
申请号：EP22750429.7
申请日：2022-02-04
申请人： The Trustees Of Dartmouth College
发明人： BUTLER, Savannah, E. , BROG, Rachel, A. , CHANG, Cheryl, H. , SENTMAN, Charles, L. , HUANG, Yina, H. , ACKERMAN, Margaret, E.
IPC分类号： A61K38/17 , A61K38/16 , C07K14/435

3. 发明公开

EP4028544A1 COMPOSITION AND METHOD FOR INHIBITING BORC COMPLEX TO TREAT CANCERS WITH NF1 DEFICIENCY AND DYSREGULATED RAS SIGNALING 无效
公开(公告)号：EP4028544A1
公开(公告)日：2022-07-20
申请号：EP20864091.2
申请日：2020-09-10
申请人： The Trustees Of Dartmouth College
发明人： SANCHEZ, Yolanda , BOULEY, Stephanie Joy
IPC分类号： C12Q1/68 , C12N1/18 , G01N33/50

4. 发明公开

EP3288634A1 CHERENKOV IMAGING SYSTEMS AND METHODS FOR DETERMINING RADIATION DOSE 审中-公开
标题翻译： CHERENKOV成像系统和确定辐射剂量的方法
公开(公告)号：EP3288634A1
公开(公告)日：2018-03-07
申请号：EP16787023.7
申请日：2016-04-27
申请人： The Trustees Of Dartmouth College
发明人： ZHANG, Rongxiao , POGUE, Brian, William , GLASER, Adam, K. , GLADSTONE, David, J. , JARVIS, Lesley, A. , ANDREOZZI, Jacqueline, M. , JIANG, Shudong , DAVIS, Scott, Christian , AXELSSON, Johan, Jakob
IPC分类号： A61N5/00 , A61N5/01 , A61N5/06 , A61N5/10
CPC分类号： A61N5/1071 , A61B5/0059 , A61N5/1049 , A61N5/1075 , A61N2005/1059 , A61N2005/1076
摘要： A Cherenkov imaging system for determining surface radiation dose for a subject undergoing radiation therapy includes (a) a first camera for capturing a Cherenkov image of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, (b) a second camera for capturing a reflectance image of reflectance of optical illumination off the surface region, and (c) a correction module for correcting the Cherenkov image based upon the reflectance image to form a corrected Cherenkov image that indicates radiation dose for the surface region. A Cherenkov imaging method for determining surface radiation dose for a subject, undergoing radiation therapy includes correcting a Cherenkov image, of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, using a reflectance image of visible light reflected by the surface region, to form a corrected Cherenkov image that indicates radiation dose for the surface region.

5. 发明公开

EP3008196A1 METHODS TO ENHANCE MICROBIAL CONVERSION OF CELLULOSIC BIOMASS WITH MECHANICAL AUGMENTATION 有权转让
标题翻译：方法生物质纤维素来改善微生物转化，机械特性BOOST
公开(公告)号：EP3008196A1
公开(公告)日：2016-04-20
申请号：EP14810426.8
申请日：2014-06-14
申请人： The Trustees Of Dartmouth College , Lynd, Lee R. , Paye, Julie, M.d.
发明人： LYND, Lee, R. , PAYE, Julie, M.D.
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C08H8/00 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , Y02E50/16 , Y02E50/17
摘要： A system and method for converting biomass with no substantial pretreatment is disclosed. Combination of a microbial system and the use of mechanical disruption may help achieve high conversion rate without the extra cost and undesirable by-products typically associated with the pretreatment process.

6. 发明公开

EP2220911A2 PULSE ELECTROTHERMAL AND HEAT-STORAGE ICE DETACHMENT APPARATUS AND METHODS 审中-公开
标题翻译：器件和方法对于脉冲电加热和热存储EISABLÖSUNG
公开(公告)号：EP2220911A2
公开(公告)日：2010-08-25
申请号：EP08843424.6
申请日：2008-10-31
申请人： The Trustees of Dartmouth College
发明人： PETRENKO, Victor , SULLIVAN, Charles, Roger
IPC分类号： H05B3/84 , F25C5/08 , F28F17/00 , B64D15/12
CPC分类号： H05B3/84 , F25C1/12 , F25C5/08 , F25D21/08 , F28F17/00 , H05B3/50 , H05B2203/003 , H05B2203/004 , H05B2214/02 , Y02P60/855
摘要： Systems and methods for pulse electrothermal and heat-storage ice detachment. A pulse electrothermal ice detachment apparatus includes one or more coolant tubes, and optionally, fins in thermal contact with the coolant tubes. The tubes and/or fins form a resistive heater. Apparatus applies electrical power to the resistive heater, generating heat to detach ice from the tubes and/or the fins. A freezer unit forms a heat-storage icemaking system having a compressor and a condenser for dissipating waste heat, and coolant that circulates through the compressor, the condenser and a coolant tube. The coolant tube is in thermal contact with an evaporator plate. A tank, after the compressor and before the condenser, transfers heat from the coolant to a heating liquid. The heating liquid periodically flows through a heating tube in thermal contact with the evaporator plate, detaching ice from the evaporator plate.

7. 发明公开

EP2132959A2 SYSTEMS AND METHODS FOR WINDSHIELD DEICING 审中-公开
标题翻译：系统和方法用于除霜挡风玻璃
公开(公告)号：EP2132959A2
公开(公告)日：2009-12-16
申请号：EP08731450.6
申请日：2008-03-05
申请人： The Trustees of Dartmouth College
发明人： PETRENKO, Victor , SULLIVAN, Charles, R. , NICKOLAYEV, Oleg , KOZLYUK, Valeri
IPC分类号： H05B3/84
摘要： Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage high enough to deice a windshield in less than thirty seconds.

8. 发明公开

EP2013355A2 PROCESS FOR THE HYDROLYSIS OF CELLULOSE MEDIATED BY TERNARY COMPLEXES OF CELLULOSE, CLOSTRIDIUM THERMOCELLUM CELLS, AND CELLULASE EXPRESSED BY THESE CELLS 审中-公开
标题翻译：方法三重纤维素复合体，热纤梭菌细胞和这些细胞表达的纤维素酶SWITCHED纤维素水解
公开(公告)号：EP2013355A2
公开(公告)日：2009-01-14
申请号：EP07811862.7
申请日：2007-05-01
申请人： The Trustees of Dartmouth College , Lynd, Lee R.
发明人： LYND, Lee R. , ZHANG, Yi-heng Percival , LU, Yanpin
IPC分类号： C12P19/14
CPC分类号： C12P19/14
摘要： Methods of utilizing reduced cellulase loads to hydrolyze cellulosic substrates are disclosed. The methods include determining an amount of purified cellulase necessary to substantially hydrolyze a quantity of cellulosic substrate in a period of time; reducing the amount of purified cellulase by a factor of between 2 and 5 to determine a reduced cellulase load; and introducing to the cellulosic substrate either (1 ) a microorganism expressing cell-bound cellulase in a concentration equal to the reduced cellulase load or (2) a fermentation agent that has been engineered to express cell-bound cellulase in a concentration equal to the reduced cellulase load under suitable conditions and for said period of time sufficient to allow substantial hydrolysis of the cellulosic substrate.

9. 发明公开

EP1530973A2 Methods for inducing T cell tolerance to a tissue or organ graft 失效
标题翻译： Verfahren zur Anregung von T-Zelltoleranz zu einem Gewebe- oder Organtransplantat
公开(公告)号：EP1530973A2
公开(公告)日：2005-05-18
申请号：EP05075209.6
申请日：1995-04-25
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K39/00
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植受体中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法涉及对受试者施用：1）同种异体细胞，其表达供体抗原，并且在细胞表面上具有配体，所述配体与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用; 和2）抑制配体与受体相互作用的受体拮抗剂。在优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

10. 发明公开

EP1089724A1 THERAPEUTIC COMPOSITIONS AND METHODS OF USE 有权
标题翻译：氰基取代的齐墩果酸作为抑制剂NO生产
公开(公告)号：EP1089724A1
公开(公告)日：2001-04-11
申请号：EP99928731.1
申请日：1999-06-18
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： GRIBBLE, Gordon, W. , HONDA, Tadashi , SPORN, Michael, B. , SUH, Nanjoo
IPC分类号： A61K31/19
CPC分类号： C07C255/47 , A61K31/19 , A61K31/275 , A61K31/277 , A61K31/35
摘要： Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

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