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1. 发明公开

EP1476572A2 DIGITAL AMPLIFICATION FOR DETECTION OF MISMATCH REPAIR DEFICIENT TUMOR CELLS 审中-公开
标题翻译：数字增益错配修复缺陷的肿瘤细胞的检测
公开(公告)号：EP1476572A2
公开(公告)日：2004-11-17
申请号：EP03707380.6
申请日：2003-01-29
申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： VOGELSTEIN, Bert , TRAVERSO, Giovanni, C. , KINZLER, Kenneth, W.
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q1/686 , C12Q2600/156 , C12Q2549/119 , C12Q2527/143
摘要： The detection of mutations in fecal DNA represents a promising, non-invasive approach for detecting colorectal cancers in average risk populations. One of the first practical applications of this technology involves the examination of microsatellite markers to sporadic cancers with mismatch repair deficiencies. As such cancers nearly always occur in the proximal colon, this test is useful as an adjunct to sigmoidoscopy, which detects only distal colorectal lesions.

2. 发明公开

EP1501523A1 CARBON MONOXIDE AS A BIOMARKER AND THERAPEUTIC AGENT 审中-公开
标题翻译：一氧化碳使用本地化的肾脏炎症的治疗
公开(公告)号：EP1501523A1
公开(公告)日：2005-02-02
申请号：EP02807413.6
申请日：2002-05-09
申请人： Yale University , The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： CHOI, Augustine, M., K. , OTTERBEIN, Leo, E.
IPC分类号： A61K33/00
CPC分类号： A61K33/00
摘要： The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including primary pulmonary hypertension, secondary pulmonary hypertension, cancers, including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, Alzheimer's disease, peripheral vascular disease and pulmonary vascular thrombotic diseases such as pulmonary embolism. CO may be used to provide anti-inflammatory relief in patients suffering from oxidative stress and other conditions especially including sepsis and septic shock. In addition, carbon monoxide may be used as a biomarker or therapeutic agent for reducing respiratory distress in lung transplant patients and to reduce or inhibit oxidative stress and inflammation in transplant patients.

3. 发明公开

EP1067939A1 USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS 有权
标题翻译： STEROIDALKALOIDDERIVATEN作为hedgehog蛋白信号通路抑制剂的用途
公开(公告)号：EP1067939A1
公开(公告)日：2001-01-17
申请号：EP99916563.2
申请日：1999-04-09
申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： BEACHY, Philip, A. , COOPER, Michael, K. , PORTER, Jeffrey, A.
IPC分类号： A61K31/585 , A61K31/58
CPC分类号： A61K31/58 , A61K31/00 , A61K31/4355
摘要： The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

4. 发明公开

EP1227875A1 METHOD AND APPARATUS OF MASS-CORRELATED PULSED EXTRACTION FOR A TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：用于飞行时间质谱仪的质量相关脉冲提取的方法和设备
公开(公告)号：EP1227875A1
公开(公告)日：2002-08-07
申请号：EP00948499.9
申请日：2000-06-07
申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： KOVTOUN, Viatcheslav, V. , COTTER, Robert, J.
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/40
摘要： A time-of-flight mass spectrometer includes a sample holder (116-118) for a sample and an ionizer (135-139) for ionizing the sample to form ions. A first element (122) is spaced downstream from the sample holder, a second element (123) is spaced downstream from the first element, and a drift region (104) is downstream of the second element. An electric field is established between the sample holder and the first element at a time subsequent to ionizing the sample in order to extract the ions. A time-dependent and mass-correlated electric field is established between at least one of: (a) the first element and the second element, and (b) the sample holder and the first element. In turn, a detector (132) detects the ions.
摘要翻译：飞行时间质谱仪包括用于样品的样品保持器（116-118）和用于离子化样品以形成离子的离子发生器（135-139）。第一元件（122）在样品架下游间隔开，第二元件（123）在第一元件下游间隔开，漂移区（104）在第二元件下游。在离子化样品以提取离子之后，在样品架和第一元件之间建立电场。在（a）第一元素和第二元素，以及（b）样品架和第一元件中的至少一个之间建立时间依赖和质量相关的电场。进而，检测器（132）检测离子。

5. 发明公开

EP1126783A1 TRANSESOPHAGEAL MAGNETIC RESONANCE ANALYSIS METHOD AND APPARATUS 审中-公开
标题翻译：方法和装置磁共振食道分析
公开(公告)号：EP1126783A1
公开(公告)日：2001-08-29
申请号：EP99956899.1
申请日：1999-11-03
申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： LIMA, Joao, A., C. , SHUNK, Kendrick, A. , ATALAR, Ergin
IPC分类号： A61B5/055
CPC分类号： G01R33/34084 , G01R33/34053 , G01R33/3657
摘要： A method of trans-esophageal magnetic resonance analysis of a patient, such as an animal or human, includes providing a non-loop antenna (84), such as a coil or solenoid coil. The non-loop antenna is received within a Levin-type gastric tube (62). The gastric tube which receives the non-loop antenna is inserted in the esophagus of the patient. A tuning, matching and de-coupling circuit (12) is electrically connected to a magnetic resonance imaging scanner (18). The magnetic resonance imaging scanner (18) is employed to provide magnetic resonance imaging or spectroscopic analysis of an intra-Thoracic structure, such as the aorta, of the patient.

6. 发明公开

EP1104492A1 SUBTLE MITOCHONDRIAL MUTATIONS AS TUMOR MARKERS 有权
标题翻译：线粒体肿瘤标志物合适的突变，只有少数基地CONCERN
公开(公告)号：EP1104492A1
公开(公告)日：2001-06-06
申请号：EP99943742.9
申请日：1999-08-20
申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing
发明人： VOGELSTEIN, Bert , KINZLER, Kenneth, W. , POLYAK, Kornelia
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/156
摘要： The accumulation of homoplasmic somatic mutations has been observed in the mitochondrial DNA of certain tumor cells. The presence or a recurrence of a tumor can be detected by determining the presence of single basepair mutations in the mitochondrial genome from a cell sample of a patient.

7. 发明授权

EP1169749B1 MAGNETIC RESONANCE IMAGING GUIDEWIRE PROBE 有权
标题翻译：与导丝成像探头使用磁共振
公开(公告)号：EP1169749B1
公开(公告)日：2010-05-26
申请号：EP00922135.9
申请日：2000-04-13
申请人： Surgi-Vision , The Johns Hopkins University, School of Medicine, Office of Technology Licencing
发明人： LARDO, Albert, C. , YANG, Xiaoming , ATALAR, Ergin , KARMARKAR, Parag , McVEIGH, Elliott, R. , HALPERIN, Henry, R. , McNAMARA, Christine, Enger , BOTTOMLEY, Paul, A.
IPC分类号： G01R33/28
CPC分类号： G01R33/287 , G01R33/34084

8. 发明公开

EP1728510A2 Treating cancer by increasing intracellular malonyl coA levels 审中-公开
标题翻译： Behandlung von Krebs durchErhöhungdes Malonyl-coA-Spiegels
公开(公告)号：EP1728510A2
公开(公告)日：2006-12-06
申请号：EP06012623.2
申请日：2000-11-13
申请人： The Johns Hopkins University, School of Medicine, Office of Technology Licencing
发明人： Pizer, Ellen S. , Townsend, Craig A. , Kuhajda, Francis P.
IPC分类号： A61K31/365 , A61K31/341 , A61K45/06 , G01N33/50 , A61K31/00
CPC分类号： G01N33/5011 , A61K31/00 , A61K31/34 , A61K31/365 , A61K45/06 , G01N2510/00 , A61K2300/00
摘要： This invention describes a method to kill cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism tht does not involve inhibition of FAS. Alternatively, growth of tumor cells may be induced by a combination of effects including FAS inhibition in conjunction with other interventions which affect fatty acid metabolism, including inhibition of camitine palmitoyltransferase-1 (CPT-1). Any combination of drugs which produces an analogous physiologic effect(s) may be expected to lead to the same effect on susceptible tumor cells. For example, combination therapy with drug(s) that inhibit the fatty acid synthesis by inhibiting acetyl CoA carboxylase (the first enzyme in the fatty acid synthesis pathway) and drug(s) that inhibit CPT-1 may be expected to induce apoptosis in tumor cells. Therefore, this invention encompasses any method to systemically modify fatty acid metabolism in cancer cells including but not limited to direct inhibition of CPT-1 through small molecule inhibitors such as etomoxir, as well as inhibition of CPT-1 incidental to increasing the level of malonyl CoA in cancer cells.
摘要翻译：本发明描述了通过促进细胞凋亡的细胞丙二酰辅酶A（丙二酰辅酶A）的急性升高来杀死癌细胞的方法。丙二酰辅酶A的升高可以通过抑制脂肪酸合成酶（FAS）或通过脂肪酸代谢的其它操作来诱导，不涉及FAS的抑制。或者，肿瘤细胞的生长可以通过包括FAS抑制与影响脂肪酸代谢的其它干预措施（包括抑制camitine palmitoyltransferase-1（CPT-1））的作用的组合来诱导。产生类似生理作用的药物的任何组合可能预期对易感的肿瘤细胞产生相同的作用。例如，通过抑制乙酰辅酶A羧化酶（脂肪酸合成途径中的第一个酶）抑制脂肪酸合成的药物和抑制CPT-1的药物的组合疗法可以预期诱导肿瘤细胞凋亡细胞。因此，本发明包括用于系统地修饰癌细胞中的脂肪酸代谢的任何方法，包括但不限于通过小分子抑制剂如依托莫司直接抑制CPT-1，以及抑制CPT-1附带增加丙二酰的水平 CoA在癌细胞中。

9. 发明公开

EP1585955A2 USE OF ISOGENIC HUMAN CANCER CELLS FOR HIGH-THROUGHPUT SCREENING AND DRUG DISCOVERY 审中-公开
标题翻译：使用方法等基因人类癌细胞有和药物发现高通量筛选
公开(公告)号：EP1585955A2
公开(公告)日：2005-10-19
申请号：EP02768559.3
申请日：2002-08-28
申请人： The Johns Hopkins University, School of Medicine, Office of Technology Licencing
发明人： TORRANCE, Christopher, J. , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
IPC分类号： G01N1/00
CPC分类号： C07D257/04 , C07H19/16 , G01N33/5011 , G01N33/5023
摘要： A strategy for drug-screening is based on cells that are isogenic except for a gene of interest. Each cell can be tranfected with a vector that encodes a different fluorescent protein that can be differentially detected to monitor cell growth. Co-culture of both cells allows facile screening for compounds with selective toxicity towards a gene of interest. The drug screening is broadly applicable for mining therapeutic agents targeted to specific genetic alterations responsible for cancer development.

10. 发明公开

EP1169749A2 MAGNETIC RESONANCE IMAGING GUIDEWIRE PROBE 有权
标题翻译：与导丝成像探头使用磁共振
公开(公告)号：EP1169749A2
公开(公告)日：2002-01-09
申请号：EP00922135.9
申请日：2000-04-13
申请人： Surgi-Vision , The Johns Hopkins University, School of Medicine, Office of Technology Licencing
发明人： LARDO, Albert, C. , YANG, Xiaoming , ATALAR, Ergin , KARMARKAR, Parag , McVEIGH, Elliott, R. , HALPERIN, Henry, R. , McNAMARA, Christine, Enger , BOTTOMLEY, Paul, A.
IPC分类号： H01Q1/00
CPC分类号： G01R33/287 , G01R33/34084
摘要： The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI; can act as an antenna, and receive MRI signals from surrounding subject matter; and can allow the use of multiple interventional tools without removal of the guide wire from a subject. The antenna (106) extends beyond probe shaft (105) at distal end (109). The probe shaft (105) has a core (101), first electric (102), shield (103), and second dielectric (104).

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