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1. 发明授权

EP3068872B1 NON-EXPANDED POST-NATAL MULTILINEAGE-INDUCIBLE CELLS 有权
公开(公告)号：EP3068872B1
公开(公告)日：2020-04-01
申请号：EP14861952.1
申请日：2014-11-13
申请人： The University of Miami , The Government of the United States of America as Represented by the Department of Veterans Affairs
发明人： SCHILLER, Paul C , D'IPPOLITO, Gianluca
IPC分类号： C12N5/071

3. 发明公开

EP3348277A1 EPITHELIAL MEMBRANE PROTEIN-2 (EMP2) AND PROLIFERATIVE VITREORETINOPATHY (PVR) 无效
公开(公告)号：EP3348277A1
公开(公告)日：2018-07-18
申请号：EP17188324.2
申请日：2010-11-18
申请人： The Regents of the University of California , The Government of the United States of America, as represented by The Department of Veterans Affairs
发明人： GORDON, Lynn K. , MORALES, Shawn A. , TELANDER, David , BRAUN, Jonathan
IPC分类号： A61K39/395 , A61K38/16 , A61P27/02 , A61P27/00
CPC分类号： C07K16/28 , A61K9/0048 , A61K9/0051 , A61K2039/505
摘要： Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.

4. 发明公开

EP3131953A1 NOVEL HYDROGEL TISSUE EXPANDERS 审中-公开
标题翻译：新型水凝胶组织扩张器
公开(公告)号：EP3131953A1
公开(公告)日：2017-02-22
申请号：EP15780119.2
申请日：2015-04-13
申请人： Akina Inc. (an Indiana (US) Corp.) , The Government of the United States of America as Represented by the Department of Veterans Affairs
发明人： BARCO, Clark Tobias , PARK, Kinam , PARK, Haesun , FU, Yourong , GARNER, John Solomon
IPC分类号： C08G81/00
CPC分类号： C08J3/075 , A61B17/8858 , A61B90/02 , A61B2017/00004 , A61B2017/00898 , A61B2017/681 , A61C8/0006 , A61F2/2803 , A61F2310/00383 , A61K47/34 , A61L31/06 , A61L31/145 , A61L31/16 , A61L33/0011 , C08F287/00 , C08F290/062 , C08F299/024 , C08G63/664 , C08G63/912 , C08G81/00 , C08J2353/00 , C08L67/04 , C08L71/02 , C08F2222/1013 , C08F222/1006
摘要： The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.
摘要翻译：本发明提供了包含在干燥状态下具有弹性的可生物降解的化学交联水凝胶的组织扩张剂。这些生物相容性组织扩张器是自膨胀和无膜的。它们缓慢地膨胀并引起极小的组织反应，同时允许外科医生在放置时快速和容易地操纵。

5. 发明公开

EP2928303A2 FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION 无效
标题翻译：第八因子突变维修和耐受诱导
公开(公告)号：EP2928303A2
公开(公告)日：2015-10-14
申请号：EP13860153.9
申请日：2013-12-06
申请人： Haplomics, Inc. , The Regents of the University of California , The Government of the United States of America, as represented by The Department of Veterans Affairs
发明人： LATERZA, Vincent , HOWARD, Tommy, E.
IPC分类号： A01N63/00 , C12N5/00 , C12N1/00 , C12N5/071
CPC分类号： A61K48/0066 , A61K38/00 , C07K14/755 , C12N9/22 , C12N15/90 , C12N2830/42
摘要： Methods of treating hemophilia A in a subject with an F8 gene mutation, wherein the F8 gene is repaired and the resultant repaired gene, upon expression, confers improved coagulation functionality to the encoded FVIII protein of the subject compared to the non-repaired F8 gene. The invention also includes methods of inducing immune tolerance to a FVIII replacement product ((r)FVIII) in a subject having a FVIII deficiency, wherein the F8 gene mutation is repaired and the repaired gene, upon expression, provides for the induction of immune tolerance to an administered replacement FVIII protein product. The invention also includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to repair the F8 gene.

6. 发明公开

EP2457539A1 Hydrogel arthroplasty device 有权转让
标题翻译：水凝胶关节成形术装置
公开(公告)号：EP2457539A1
公开(公告)日：2012-05-30
申请号：EP12156562.6
申请日：2008-04-17
申请人： The Board of Trustees of the Leland Stanford Junior University , The Government of The United States of America as, Represented by the Department of Veterans Affairs
发明人： Myung, David , Kourtis, Lampros , Hartmann, Laura , Frank, Curtis, W. , Goodman, Stuart, B. , Carter, Dennis, R
IPC分类号： A61F2/30 , A61L27/52
摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
摘要翻译：提供具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，所述互穿聚合物网络（IPN）水凝胶通过膨胀进行应变硬化并且适合于通过符合骨几何形状而保持在关节中的适当位置。应变硬化的IPN水凝胶基于两种不同的网络：（1）通过其端基聚合而化学交联的预先形成的亲水性非离子遥爪大分子单体的非有机硅网络，以及（2）非有机硅网络可电离的单体。第二个网络在第一个网络的存在下聚合并化学交联，并与第一个网络形成物理交联。在IPN内，第二网络中的化学交联程度比第一网络中的化学交联程度要低。使用盐水溶液（中性pH）使第二网络电离和溶胀。第二网络的膨胀受到第一网络的限制，导致IPN内的有效物理交联增加。

7. 发明公开

EP3607205A2 MICROFLUIDIC DIFFUSION DEVICES AND SYSTEMS, AND METHODS OF MANUFACTURING AND USING SAME 审中-实审
公开(公告)号：EP3607205A2
公开(公告)日：2020-02-12
申请号：EP18781692.1
申请日：2018-04-03
申请人： The Government of the United States of America as represented by the Department of Veterans Affairs
发明人： POTKAY, Joseph A.
IPC分类号： F04D5/00

8. 发明公开

EP2914292A2 STIMULATING BONE FORMATION BY INHIBITION OF CD28 CO-STIMULATION 审中-公开
标题翻译：刺激骨形成通过抑制CD28-CO-刺激
公开(公告)号：EP2914292A2
公开(公告)日：2015-09-09
申请号：EP13851821.2
申请日：2013-10-30
申请人： Emory University , The Government of the United States of America as Represented by the Department of Veterans Affairs
发明人： WEITZMANN, M. Neale
IPC分类号： A61K39/395 , A61K31/573 , A61P19/02 , A61P19/00
CPC分类号： C07K14/70532 , C07K14/70521 , C07K16/2809 , C07K16/2818 , C07K2317/74 , C07K2319/30

9. 发明公开

EP2158326A1 BIOMARKERS FOR THE DIAGNOSIS OF AUTOIMMUNE DISEASE 有权
标题翻译：生物标志物用于类风湿性关节炎
公开(公告)号：EP2158326A1
公开(公告)日：2010-03-03
申请号：EP08768697.8
申请日：2008-06-20
申请人： The Board of Trustees of The Leland Stanford Junior University , The Government of the United States of America, as represented by The Department of Veterans Affairs , The Regents of the University of Colorado
发明人： ROBINSON, William H. , HOLERS, Michael , DEANE, Kevin
IPC分类号： C12Q1/00
CPC分类号： G01N33/564 , G01N33/6803 , G01N33/6863 , G01N2333/5412 , G01N2800/102 , G01N2800/50
摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's probability of developing clinical symptoms or severe disease. The patterns of circulating blood levels of serum cytokines provides for a signature pattern that can discriminate patients that have a high probability of developing disease from those that have a low probability of developing disease. Assessment of this signature pattern in a patient thus allows improved methods of care and intervention. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.

10. 发明公开

EP2005184A2 METHODS FOR DETECTING A MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开
标题翻译：检测方法的结核分枝杆菌感染
公开(公告)号：EP2005184A2
公开(公告)日：2008-12-24
申请号：EP07753181.2
申请日：2007-03-14
申请人： Oregon Health and Science University , The Government of The United States of America as, Represented by the Department of Veterans Affairs
发明人： LEWINSOHN, David , LEWINSOHN, Deborah
IPC分类号： G01N33/569
CPC分类号： G01N33/5695 , A61K38/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N33/505 , G01N33/6893 , G01N2333/35 , G01N2469/10 , G01N2800/26 , Y02A50/466
摘要： Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the prevention and/or treatment of tuberculosis are also disclosed.

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