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1. 发明公开

EP4173486A1 COMPOSITION FOR INHIBITING BINDING OF SARS-COV-2 TO ACE2 PROTEIN 审中-实审
公开(公告)号：EP4173486A1
公开(公告)日：2023-05-03
申请号：EP21829262.1
申请日：2021-03-03
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： OGATA, Norio , MIURA, Takanori
IPC分类号： A01P1/00 , A61L9/01 , A01N25/02 , A01N59/00 , A01N59/08
摘要： The present invention searches for compounds etc. that may inhibit the interaction between the spike (S) protein of SARS-CoV-2 and the ACE2 protein. The present invention provides a composition for inhibiting the binding between the spike (S) protein of SARS-CoV-2 and the angiotensin converting enzyme 2 (ACE2) protein comprising an effective amount of chlorine dioxide.

2. 发明公开

EP2955155A1 METHOD FOR TRAPPING CHLORINE DIOXIDE GAS, METHOD FOR MEASURING CONCENTRATION OF CHLORINE DIOXIDE GAS, AND TRAPPING AGENT FOR CHLORINE DIOXIDE GAS 审中-公开
标题翻译：用于捕获二氧化氯气体，METHOD FOR MEASURING二氧化氯的浓度的方法和手段，用于捕获的二氧化氯气体
公开(公告)号：EP2955155A1
公开(公告)日：2015-12-16
申请号：EP14749434.8
申请日：2014-01-21
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： ASADA Shigeo , NAKAHARA Koichi , TAGUCHI Kazuhiko
IPC分类号： C01B11/02
CPC分类号： G01N1/4044 , B01D53/1493 , B01D2252/50 , C01B11/022 , G01N1/2202 , G01N1/2273 , G01N31/223 , Y10T436/19
摘要： A method of entrapping chlorine dioxide gas, including the steps of using an aqueous solution containing an alkaline substance and an iodide and bringing air containing the chlorine dioxide gas into contact with the aqueous solution.
摘要翻译：包埋二氧化氯气体，包括使用在wässrige溶液在碱性物质和碘化物的含并且使空气包含的二氧化氯气体与wässrige溶液接触的步骤的方法。

3. 发明授权

EP2548997B1 Electrolyzer apparatus 有权
标题翻译：电解槽
公开(公告)号：EP2548997B1
公开(公告)日：2015-05-27
申请号：EP11756404.7
申请日：2011-03-17
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： ASADA Shigeo , TAGUCHI Kazuhiko , TAURA Kouichi , NAKAHARA Koichi
IPC分类号： C25B9/00 , C25B1/26
CPC分类号： C25B9/00 , C25B1/26 , C25B15/00 , C25B15/08

4. 发明公开

EP2690061A1 CHLORINE DIOXIDE GENERATOR 有权
标题翻译：二氧化氯发生器
公开(公告)号：EP2690061A1
公开(公告)日：2014-01-29
申请号：EP12761220.8
申请日：2012-03-06
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： OZAWA, Fumihiro , ASADA, Shigeo , NAKAHARA, Koichi , TAGUCHI, Kazuhiko
IPC分类号： C01B11/02
CPC分类号： C01B11/024 , B01J8/0015 , B01J2208/00752 , B01J2208/00814
摘要： A chlorine dioxide generator (10) includes a container body (12) deformable in response to application of a force from the outside. The container body (12) contains therein a solid acidic composition (18) and an aqueous chlorite solution (19) under a non-contact state from each other. The solid acidic composition (18) comprises a porous material containing an acidic substance. The aqueous chlorite solution (19) is sealed within an easily breakable enclosure (20). In operation, when the container body (12) is deformed, the enclosure (20) contained therein is broken to bring the aqueous chlorite solution (19) into contact with the solid acidic composition (18), whereby chlorine dioxide gas is generated. This generated chlorine dioxide gas is discharged via a gas discharge port (14) to the outside of the container body (12).
摘要翻译：二氧化氯发生器（10）包括响应于从外部施加力而变形的容器主体（12）。容器主体（12）在其中以非接触状态彼此包含固体酸性组合物（18）和亚氯酸盐水溶液（19）。固体酸性组合物（18）包含含有酸性物质的多孔材料。亚氯酸盐水溶液（19）密封在易破坏的外壳（20）内。在操作中，当容器主体（12）变形时，容纳在其中的外壳（20）被破坏以使亚氯酸盐水溶液（19）与固体酸性组合物（18）接触，由此产生二氧化氯气体。产生的二氧化氯气体通过气体排出口（14）排出到容器主体（12）的外部。

5. 发明公开

EP2554513A1 DEVICE FOR GENERATING CHLORINE DIOXIDE 审中-公开
标题翻译： VORRICHTUNG ZUR ERZEUGUNG VON CHLORDIOXID
公开(公告)号：EP2554513A1
公开(公告)日：2013-02-06
申请号：EP11759253.5
申请日：2011-03-15
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： TAGUCHI, Kazuhiko , ASADA, Shigeo , NAKAHARA, Koichi
IPC分类号： C01B11/02 , A61L9/01 , A61L9/015 , A61L9/20 , B01J7/00
CPC分类号： C01B11/024 , A61L9/015 , A61L9/20 , B01J7/00 , B01J19/123 , B01J19/18 , B01J2219/0869 , B01J2219/0879
摘要： Provided is a device for generating chlorine dioxide which has been miniaturized so that a chlorine dioxide source can be carried and which has no fear of liquid leakage and can be continuously used. A cartridge (28) having a chemical-holding space (29) in which a granular chlorite is held, a fan (24), and ultraviolet LED lamps (32) have been disposed within a device main body (12) which can be separated into two or more detachable portions. The cartridge (28) has light-transmitting properties and has a structure which enables air to pass through the chemical-holding space (29) and the inside of the device main body (12). When the fan (24) works, air is discharged from the inside of the device main body (12) and, simultaneously therewith, air comes in from the outside of the device main body (12). By the action of ultraviolet rays, chlorine dioxide gas is generated from the chlorite present in the cartridge (28). By the operation of the fan (24), the gas is discharged from the inside of the device main body (12) through air discharge ports (22).
摘要翻译：本发明提供了一种小型化的二氧化氯装置，能够承载二氧化氯源，不会出现液体泄漏的可能性，能够连续使用。具有保存有颗粒状亚氯酸盐的化学保持空间（29）的盒（28），风扇（24）和紫外线LED灯（32）已经设置在可分离的装置主体（12）内分成两个或更多个可拆卸部分。盒（28）具有透光性，并且具有能够使空气通过化学品保持空间（29）和装置主体（12）的内部的结构。当风扇24工作时，空气从装置主体12的内部排出，同时空气从装置主体12的外部进入。通过紫外线的作用，从筒（28）中存在的亚氯酸盐产生二氧化氯气体。通过风扇（24）的操作，气体通过排气口（22）从装置主体（12）的内部排出。

6. 发明公开

EP2548997A1 ELECTROLYZER 有权
标题翻译： Elektrolysiervorrichtung
公开(公告)号：EP2548997A1
公开(公告)日：2013-01-23
申请号：EP11756404.7
申请日：2011-03-17
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： ASADA Shigeo , TAGUCHI Kazuhiko , TAURA Kouichi , NAKAHARA Koichi
IPC分类号： C25B9/00 , C25B1/26
CPC分类号： C25B9/00 , C25B1/26 , C25B15/00 , C25B15/08
摘要： Provided is an electrolyzer apparatus capable of readily preventing acid-base properties of a cathode side from giving adverse effect on an anode side. The electrolyzer apparatus 10 is configured as follows. An anode tank 14 having an anode 12 and a cathode tank 18 having a cathode 16 are provided separately from each other. The anode tank 14 includes a feed opening 20 for feeding an amount of electrolytic solution 13 into the tank, an anode aeration device 22 for feeding aeration air to the fed electrolytic solution 13, and a gas extraction pipe 24 for guiding gas generated from the anode tank 14 to the outside of the tank. A communication pipe 28 is provided for allowing the amount of electrolytic solution 13 fed into the anode tank 14 to flow into the cathode tank 18, and via the electrolytic solution 13 in the communication pipe 28, electric conduction becomes possible between the anode 12 and the cathode 16. An amount of gas generated by an electrolysis reaction inside the anode tank 14 is discharged to the outside of the anode tank 14 via the gas extraction pipe 24 together with the aeration air. The electrolytic solution 13 introduced into the cathode tank 18 is discharged continuously.
摘要翻译：本发明提供能够容易地防止阴极侧的酸碱性质对阳极侧产生不利影响的电解装置。电解装置10如下构成。具有阳极12和具有阴极16的阴极罐18的阳极槽14彼此分开设置。阳极槽14包括用于将一定量的电解液13供给到罐中的进料口20，用于向进料的电解液13供给通风空气的阳极曝气装置22和用于引导从阳极产生的气体的气体抽出管24 坦克14到坦克的外面。提供连通管28，用于允许供给到阳极罐14中的电解液13的量流入阴极罐18，并且通过连通管28中的电解液13，可以在阳极12和阳极罐14内部的电解反应产生的气体量与曝气用空气一起经由气体抽出管24排出到阳极罐14的外部。导入阴极罐18的电解液13被连续排出。

7. 发明公开

EP2130542A4 BROAD-SPECTRUM ANTIVIRAL COMPOSITION HAVING EXCELLENT STORAGE STABILITY 审中-公开
标题翻译：具有出色保质期的抗病毒成分宽带
公开(公告)号：EP2130542A4
公开(公告)日：2010-06-02
申请号：EP08711323
申请日：2008-02-15
申请人： TAIKO PHARMACEUTICAL CO LTD
发明人： FUKUDA TOSHIAKI , ABE KOJI , SHIBATA TAKASHI
IPC分类号： A61K33/20 , A61K9/08 , A61K47/02 , A61P31/12
CPC分类号： A61K9/0014 , A61K33/00 , A61K33/20 , A61K33/42 , A61K45/06 , A61K47/02 , A61K2300/00

8. 发明公开

EP1985582A1 CHLORINE DIOXIDE GENERATING COMPOSITION 审中-公开
标题翻译： ZUSAMMENSETZUNG ZUR ERZEUGUNG VON CHLORDIOXID
公开(公告)号：EP1985582A1
公开(公告)日：2008-10-29
申请号：EP07708382.2
申请日：2007-02-14
申请人： Taiko Pharmaceutical Co. Ltd.
发明人： SHIBATA, Takashi , ABE, Koji
IPC分类号： C01B11/02 , A01N25/12 , A01N59/00 , A01N59/08 , A01P3/00 , A61L9/01 , B01J7/00
CPC分类号： A61L9/01 , A01N59/00 , C01B11/024
摘要： A chlorine dioxide generating composition capable of generating chlorine dioxide through reaction between a chlorite and an acid. The composition contains a solid form chlorite, a solid form acid, and a solid form, moisture slow-release agent capable of slowly releasing moisture retained therein.
摘要翻译：能够通过亚氯酸盐和酸之间的反应产生二氧化氯的产生二氧化氯的组合物。该组合物包含固体形式的亚氯酸盐，固体形式的酸和固体形式，能够缓慢释放保留在其中的水分的水分缓释剂。

9. 发明公开

EP0802258A3 Method of synthesizing polydeoxyribonucleotides, method of synthesizing chromosomal DNA and method of producing chromosomes 失效
标题翻译：一种制备聚脱氧核糖核苷酸的，过程用于制备染色体DNA和过程的染色体的制备方法
公开(公告)号：EP0802258A3
公开(公告)日：1998-04-01
申请号：EP97106471.2
申请日：1997-04-18
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： Miura, Takanori , Ogata, Norio
IPC分类号： C12N15/10 , C12N15/70 , C12N15/79 , C12Q1/68
CPC分类号： C12Q1/6844 , C12N15/90 , C12P19/34
摘要： The invention relates to a method of synthesizing polydeoxyribonucleotides which comprises causing a thermostable deoxyribunucleotide polymerase to act on deoxyribonucleotides without using any template and any primers, to the thus-obtained polydeoxyribonucleotides, to a method of screening cDNA libraries using the same as probes, to a method comprising joining the DNA resulting from the above method of synthesis to the 3'-OH terminus of a double-stranded DNA containing a gene derived from cells of a living organism, followed by transfection of such cells with the product of joining and culture of the cells, to thereby cause insertion of the product into chromosomal DNA and production of the protein encoded by the gene, to a method of synthesizing chromosomal DNA and to a method of synthesizing chromosomes. According to the invention, it is possible to create DNA not occurring in the nature and create novel proteins using the thus created genes, hence means for providing novel physiologically or pharmacologically active substances can be provided.

10. 发明授权

EP2690061B1 CHLORINE DIOXIDE GENERATOR 有权
公开(公告)号：EP2690061B1
公开(公告)日：2018-09-05
申请号：EP12761220.8
申请日：2012-03-06
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： OZAWA, Fumihiro , ASADA, Shigeo , NAKAHARA, Koichi , TAGUCHI, Kazuhiko
IPC分类号： C01B11/02
CPC分类号： C01B11/024 , B01J8/0015 , B01J2208/00752 , B01J2208/00814
摘要： A chlorine dioxide generator (10) includes a container body (12) deformable in response to application of a force from the outside. The container body (12) contains therein a solid acidic composition (18) and an aqueous chlorite solution (19) under a non-contact state from each other. The solid acidic composition (18) comprises a porous material containing an acidic substance. The aqueous chlorite solution (19) is sealed within an easily breakable enclosure (20). In operation, when the container body (12) is deformed, the enclosure (20) contained therein is broken to bring the aqueous chlorite solution (19) into contact with the solid acidic composition (18), whereby chlorine dioxide gas is generated. This generated chlorine dioxide gas is discharged via a gas discharge port (14) to the outside of the container body (12).

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