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1. 发明授权

EP2653186B1 METHOD FOR MANUFACTURING MICROSTRUCTURE BODY 有权转让
公开(公告)号：EP2653186B1
公开(公告)日：2020-08-12
申请号：EP11847959.1
申请日：2011-12-16
申请人： Raphas Co., Ltd.
发明人： JUNG, Hyungil , JEONG, Do Hyeon , KIM, Jung Dong , KIM, Miroo
IPC分类号： A61M37/00 , B81C1/00 , A61K9/00

2. 发明公开

EP3988016A1 BIOCOMPATIBLE AND ELECTROCONDUCTIVE POLYMERIC MICRONEEDLE BIOSENSOR FOR MINIMALLY INVASIVE BIOSENSING 有权
公开(公告)号：EP3988016A1
公开(公告)日：2022-04-27
申请号：EP20826621.3
申请日：2020-06-08
申请人： Raphas Co., Ltd.
发明人： LEE, Keun Ho , AN, Eun Jin , BAE, Jung Hyun , KIM, Jung Dong , JEONG, Do Hyeon
IPC分类号： A61B5/04 , A61B5/00 , A61B5/15 , A61B5/155
摘要： The present disclosure relates to a microneedle array for bio-sensing or a biosensor using the microneedle array. The microneedle array for bio-sensing does not include an additional electrode or an additional conductive coating, have a solid structure, and is homogeneous throughout the solid structure. The microneedle array for bio-sensing is composed of a material including poly (3,4-ethylendeddioxythiophene):poly (styrenesulfonate) (PEDOT:PSS).

3. 发明公开

EP3918977A1 MINIMALLY INVASIVE SKIN BIOPSY METHOD USING MICRONEEDLE PATCH 审中-公开
公开(公告)号：EP3918977A1
公开(公告)日：2021-12-08
申请号：EP19912866.1
申请日：2019-06-19
申请人： Raphas Co., Ltd.
发明人： LEE, Keun Ho , AN, Eun Jin , KIM, Seong Jin , SUNG, Chang Yub , KIM, Jung Dong , JEONG, Do Hyeon , LEE, Kwang Hoon
IPC分类号： A61B5/00 , A61B5/15
摘要： The present disclosure relates to a minimally-invasive skin biopsy method. The minimally-invasive skin biopsy method according to the present disclosure includes: preparing a microneedle patch; attaching the microneedle patch to a skin of an object; maintaining a state in which the microneedle patch is attached to the skin of the object for a predetermined period of time; and detaching the microneedle patch from the skin of the object after the predetermined period of time, and analyzing a protein component of the object, which adheres to a microneedle of the microneedle patch. The microneedle is made of a biocompatible polymer substance.

4. 发明公开

EP2653186A4 METHOD FOR MANUFACTURING MICROSTRUCTURE BODY 有权转让
标题翻译：用于生产的细微构造体
公开(公告)号：EP2653186A4
公开(公告)日：2014-08-13
申请号：EP11847959
申请日：2011-12-16
申请人： RAPHAS CO LTD
发明人： JUNG HYUNGIL , JEONG DO HYEON , KIM JUNG DONG , KIM MIROO
IPC分类号： A61M37/00 , A61K9/00 , B81C1/00
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B81C1/00111
摘要： A method of manufacturing a microstructure which includes a functional material sensitive to heat, has sufficient hardness, and can minimize the loss of the functional material is provided. The method of manufacturing a microstructure includes coating a first viscous material on a first planar substrate and drying the material to form a bottom layer, spotting a viscous composition in a plurality of spots spaced apart from each other on the bottom layer, contacting a second planar substrate with the spotted viscous composition, relatively moving the second substrate with respect to the first substrate, elongating the viscous composition, solidifying the elongated viscous composition, and cutting the solidified viscous composition.

5. 发明授权

EP3178475B1 MANUFACTURING METHOD OF A MICROSTRUCTURE 有权转让
公开(公告)号：EP3178475B1
公开(公告)日：2020-05-27
申请号：EP16185914.5
申请日：2016-08-26
申请人： Raphas Co., Ltd.
发明人： KIM, Hong Kee , KIM, Jung Dong , BAE, Jung Hyun , LEE, Yang Gi , PARK, So Hyun , JEONG, Do Hyeon
IPC分类号： A61K9/70
摘要： A manufacturing method of a microstructure such as a microneedle using an air blowing method which improves a process of forming a bottom layer.

6. 发明公开

EP3626234A1 MICRONEEDLE PERCUTANEOUS PATCH CONTAINING DONEPEZIL 有权转让
公开(公告)号：EP3626234A1
公开(公告)日：2020-03-25
申请号：EP18801678.6
申请日：2018-05-16
申请人： Boryung Pharmaceutical Co., Ltd. , Raphas Co., Ltd.
发明人： KIM, Tae Hyung , LEE, Booyong , KIM, Jung Dong , JEONG, Do Hyeon , SHIN, Dongchul , HWANG, Yongyoun , NAM, Yun-Sun , LEE, Joo Han , AN, Eun Jin , AN, Eun Jin
IPC分类号： A61K9/70 , A61K9/00 , A61K31/445 , A61K47/36
摘要： The present invention relates to a composition for preparing a microneedle, a soluble microneedle, and a microneedle percutaneous patch comprising the soluble microneedle. A soluble microneedle contained in a microneedle percutaneous patch of the present invention has a high drug loading capacity and excellent strength and thus may contain an effective amount of donepezil or a pharmaceutically acceptable salt thereof even with a small area of the microneedle. Accordingly, the present invention is economical and produces a lower level of skin irritation.

7. 发明公开

EP3189873A1 MANUFACTURING DEVICE FOR MICRONEEDLE 有权转让
标题翻译： MICRONEEDLE的制造装置
公开(公告)号：EP3189873A1
公开(公告)日：2017-07-12
申请号：EP16185915.2
申请日：2016-08-26
申请人： Raphas Co., Ltd.
发明人： KIM, Hong Kee , KIM, Jung Dong , BAE, Jung Hyun , LEE, Yang Gi , PARK, So Hyun , JEONG, Do Hyeon
IPC分类号： A61M37/00
CPC分类号： B29C55/00 , A61M37/0015 , A61M2037/0053 , B29C33/30 , B29C37/00 , B29C2037/90 , B29K2105/0058 , B29L2031/7544
摘要： A manufacturing device for a microneedle includes an upper plate stage (100), a lower plate stage (200) disposed in horizontally parallel with the upper plate stage, a rotating device (300) configured to rotate and move the upper plate stage over the lower plate stage, and a first cylindrical type actuator(400) configured to vertically move the lower plate stage in a state in which the upper plate stage has been rotated and moved over the lower plate stage by means of the rotating device. The first cylindrical type actuator may upwardly and downwardly move so as to be able to stretch a viscous composition in a vertical direction in a state in which a contacting to the viscous composition is performed, wherein the viscous composition is applied on both of a patch sheet (30) seated on the upper plate stage and a patch sheet seated on the lower plate stage, or is applied on one of both of them.
摘要翻译：微针制造装置包括上板台（100），与上板台水平平行配置的下平台（200），旋转装置（300）以及第一圆筒型致动器（400），该第一圆筒型致动器构造成在所述上平台通过所述旋转装置在所述下平台上旋转和移动的状态下垂直移动所述下平台。第一圆柱型致动器可以向上和向下移动，从而能够在与粘性组合物接触的状态下在垂直方向上拉伸粘性组合物，其中粘性组合物被施加到补片（30）安放在上平台上，并且安装在下平台上的贴片板，或者应用在它们中的一个上。

8. 发明公开

EP3178475A1 MANUFACTURING METHOD OF MICROSTRUCTURE 有权转让
标题翻译：显微组织的制造方法
公开(公告)号：EP3178475A1
公开(公告)日：2017-06-14
申请号：EP16185914.5
申请日：2016-08-26
申请人： Raphas Co., Ltd.
发明人： KIM, Hong Kee , KIM, Jung Dong , BAE, Jung Hyun , LEE, Yang Gi , PARK, So Hyun , JEONG, Do Hyeon
IPC分类号： A61K9/70
摘要： A manufacturing method of a microstructure such as a microneedle using an air blowing method which improves a process of forming a bottom layer.
摘要翻译：微细结构体的微细结构体的制造方法，该微细结构体使用改善了形成底层的工序的吹气法。

9. 发明授权

EP2737923B1 Electrode with integrated microneedles for introducing genetic material and a method for its preparation 有权转让
标题翻译：电极与集成微针用于引入遗传物质的和用于它们的制备方法
公开(公告)号：EP2737923B1
公开(公告)日：2016-09-14
申请号：EP12818195.5
申请日：2012-07-19
申请人： Raphas Co., Ltd. , Industry-Academic Cooperation Foundation, Yonsei University
发明人： JUNG, Hyungil , LEE, Kwang , JEONG, Do Hyeon , KIM, Jung Dong
IPC分类号： A61K9/00 , A61K48/00 , A61M5/158 , A61M37/00 , A61N1/04 , A61N1/05 , A61N1/32 , B05D5/00
CPC分类号： A61N1/327 , A61K9/0009 , A61K9/0021 , A61K48/0075 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61N1/042 , A61N1/0424 , A61N1/0476 , A61N1/0502 , B05D5/00

10. 发明公开

EP4133994A1 MIMINALLY-INVASIVE ATOPIC DERMATITIS TEST METHOD USING MICRONEEDLE PATCH AND MINIMALLY-INVASIVE ATOPIC DERMATITIS TEST KIT COMPRISING MICRONEEDLE PATCH 审中-实审
公开(公告)号：EP4133994A1
公开(公告)日：2023-02-15
申请号：EP20930116.7
申请日：2020-06-11
申请人： Raphas Co., Ltd.
发明人： JEONG, Do Hyeon , KIM, Jung Dong , LEE, Keun Ho , LEE, Kwang Hoon
IPC分类号： A61B5/00 , A61B10/02 , A61B5/15 , G01N33/68 , G01N33/53
摘要： The present invention relates to a minimally-invasive atopic dermatitis test method. The minimally-invasive atopic dermatitis test method according to one embodiment of the present invention comprises the steps of: applying, to the skin of a subject, a microneedle patch including a plurality of microneedles made of a biodegradable hyaluronic acid polymer and having a solid core structure and a bottom layer which is a base on which the plurality of microneedles are formed; maintaining the microneedle patch attached to the skin of the subject for a predetermined time; separating the microneedle patch from the skin of the subject after a predetermined time has passed to input the microneedle patch to a quantitative test; reading the amount of interleukin-4 and interleukin-13 adsorbed onto the surface of the microneedles of the microneedle patch in the quantitative test step; and evaluating atopic dermatitis activity on the basis of the reading of the amount of interleukin-4 and interleukin-13.

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