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1. 发明公开

EP1163006A1 METHOD TO PREVENT XENOGRAFT TRANSPLANT REJECTION 审中-公开
标题翻译：用于预防异种移植排斥反应
公开(公告)号：EP1163006A1
公开(公告)日：2001-12-19
申请号：EP99947150.1
申请日：1999-10-08
申请人： QLT PHOTOTHERAPEUTICS,INC. , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： OBOCHI, Modestus, Onuora, Kay , MARGARON, Philippe, Maria, Clotaire , HONEY, Christopher, Richard , YIP, Stephen , LEVY, Julia, G.
IPC分类号： A61K41/00
CPC分类号： A61K41/0057 , A61K41/0071
摘要： Donor material from a xenogeneic source is modified to enhance its survival time in a recipient by treating the donor material using low-dose photodynamic therapy (PDT). The donor material, such as an organ or cell suspension, is treated with a photosensitizer and irradiated in a low-dose protocol before transplantation into a xenogeneic recipient.

2. 发明公开

EP0948329A1 USE OF GREEN PORPHYRINS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF SECONDARY CATARACTS 失效
标题翻译：绿卟啉用于制备药物次生卡塔尔文件治疗
公开(公告)号：EP0948329A1
公开(公告)日：1999-10-13
申请号：EP97946989.0
申请日：1997-12-08
申请人： QLT Phototherapeutics, Inc. , THE UNIVERSITY OF BRITISH COLUMBIA , Ciba Vision Opthalmics
发明人： MEADOWS, Howard, E. , WENKSTERN, Danielle , MALLEK, David, R. , BUSSANICH, Nick , RICHTER, Anna, M. , LEVY, Julia, G. , HARITON, Claude, A., A. , HUBER, Gustav , ROOTMAN, Jack
IPC分类号： A61K47 , A61K31 , A61K41 , A61P27
CPC分类号： A61K41/0071 , Y10S514/912
摘要： Photodynamic therapy to prevent secondary cataracts is effected using photosensitizers such as green porphyrins as photoactive agents to destroy remnant lens epithelial cells.

3. 发明公开

EP0902653A1 BALLOON CATHETER FOR PHOTODYNAMIC THERAPY 失效
标题翻译：球囊导管光动力疗法
公开(公告)号：EP0902653A1
公开(公告)日：1999-03-24
申请号：EP97921555.0
申请日：1997-05-16
申请人： QLT Phototherapeutics, Inc.
发明人： BOWER, Bob , STONEFIELD, Mike , YAN, Joseph
IPC分类号： A61M25 , A61B18 , A61N5 , A61B17
CPC分类号： A61N5/062 , A61B18/24 , A61B2017/00057 , A61B2017/22058 , A61B2017/22059 , A61B2018/2261 , A61N5/0601
摘要： The present invention provides improved balloon catheter apparatuses for use in therapies requiring delivery of uniform light to a treatment area. The improved apparatus comprises a balloon having a defined treatment window where the window is delineated using a reflective material. The apparatus may further comprise a fiber optic cable that terminates in a diffusion tip where the diffusion tip is longer than the treatment window. The present invention further provides improved therapeutic methods that use the improved balloon catheters of the present invention.

4. 发明公开

EP0885228A1 MESO-SUBSTITUTED TRIPYRRANE COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING THE SAME 失效
标题翻译：细观取代tripyrranes衍生物，其制造组合物及其用途和方法
公开(公告)号：EP0885228A1
公开(公告)日：1998-12-23
申请号：EP97903180.0
申请日：1997-02-25
申请人： QLT Phototherapeutics, Inc.
发明人： BRUCKNER, Christian , BOYLE, Ross, W. , DOLPHIN, David
IPC分类号： A61K31 , A61K41 , A61K49 , A61P43 , C07D207 , C07D487 , C09B57
CPC分类号： C07D207/323
摘要： A compound of formula (I) wherein: Q represents identical alkyl groups, cycloalkyl groups having from 5 to 7 ring atoms, or aryl or heteroaryl groups having from 5 to 12 ring atoms and R represents identical hydrogen, alkyl, alcohol or carbonyl-containing groups; or a composition containing from 5 to 100 mole % by weight of the compound of formula (I). A novel method for synthesizing the compounds of formula (I) comprises the steps of: (a) reacting a compound of the formula: Q-CHO or Q-CH(OS)(OS') wherein Q is as defined above and S and S' are independently lower alkyl, an aryl group containing from 5 to 14 ring atoms, and -(CH2)n- where n=2-4, with an excess amount of a pyrrole in the presence of a catalytic amount of a strong Lewis or Bronsted acid; (b) removing any unreacted pyrrole or other solvents used by evaporation; (c) removing polymeric materials and removing the corresponding dipyrromethane by-product, leaving the compound of formula (I).

5. 发明公开

EP0983273A1 ETHYLENE GLYCOL ESTERS OF MONOHYDROBENZOPORPHYRIN DERIVATIVES AS PHOTOACTIVE AGENTS 失效
标题翻译：作为光敏剂的单偶氮芘衍生物的乙二醇酯
公开(公告)号：EP0983273A1
公开(公告)日：2000-03-08
申请号：EP98921294.9
申请日：1998-05-06
申请人： QLT Phototherapeutics, Inc. , UNIVERSITY OF BRITISH COLUMBIA
发明人： STERNBERG, Ethan , DOLPHIN, David , LEVY, Julia, G. , RICHTER, Anna, M. , HUNT, David, W., C. , JAIN, Ashok , WATERFIELD, Elizabeth M.
IPC分类号： C07D487/22 , A61K51/00 , A61K41/00 , A61K51/04 , A61K51/10
CPC分类号： C07D487/22 , A61K41/0071
摘要： New compounds useful in photodynamic therapy are of formula (1) or (2), (3) or (4) and the metallated and/or labeled and/or conjugated forms thereof wherein each R1 is independently alkyl(1-6C); each n is independently an integer of 0-6; and R2 is vinyl or a derivative form thereof.
摘要翻译：用于光动力疗法的新化合物具有式（1）或（2），（3）或（4）及其金属化和/或标记和/或缀合形式，其中每个R 1独立地为烷基（1-6C）; 每个n独立地是0-6的整数; 和R2是乙烯基或其衍生物形式。

6. 发明公开

EP0983272A1 A NEW CLASS OF BENZOPORPHYRIN DERIVATIVE PHOTOACTIVE COMPOUNDS 失效
标题翻译：苯并PHOTO的活性化合物的衍生物的一类
公开(公告)号：EP0983272A1
公开(公告)日：2000-03-08
申请号：EP98916765.5
申请日：1998-04-29
申请人： QLT Phototherapeutics, Inc. , UNIVERSITY OF BRITISH COLUMBIA
发明人： STERNBERG, Ethan , DOLPHIN, David , LEVY, Julia, G. , RICHTER, Anna, M. , TOVEY, Andrew
IPC分类号： C07D487/22 , A61K39/395
CPC分类号： C07D487/22 , A61K41/0071
摘要： New compounds expanding the repertoire of compounds useful in photodynamic therapy are described. Monohydrobenzoporphyrins can be obtained in the triacid form or as esters with heteroatom-substituted alcohols, or as amides.

7. 发明公开

EP0981371A1 GREEN PORPHYRINS AS IMMUNOMODULATORS 失效
标题翻译：绿卟啉HOW免疫调节剂
公开(公告)号：EP0981371A1
公开(公告)日：2000-03-01
申请号：EP98921309.5
申请日：1998-05-15
申请人： QLT Phototherapeutics, Inc. , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： CHAN, Agnes , HUNT, David, W., C. , SIMKIN, Guillermo, O. , LEVY, Julia, G. , OBOCHI, Modestus, O., K. , RICHTER, Anna, M.
IPC分类号： A61K41/00
CPC分类号： C08F132/08 , A61K41/0071
摘要： Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.

8. 发明公开

EP0843547A1 METHODS OF MAKING LIPOSOMES CONTAINING HYDRO-MONOBENZOPORPHYRIN PHOTOSENSITIZERS 失效
标题翻译：制备含有氢醌单卟啉光敏剂的脂质体的方法
公开(公告)号：EP0843547A1
公开(公告)日：1998-05-27
申请号：EP96925614.0
申请日：1996-07-29
申请人： QLT Phototherapeutics, Inc.
发明人： RON, Liu
IPC分类号： A61K9 , A61K31 , A61K41
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/409 , A61K41/0071
摘要： Methods for making a pharmaceutical composition containing liposomes, which liposomes comprise a therapeutically acceptable amount of a hydro-monobenzoporphyrin photosensitizer and a mixture of phospholipids comprising egg phosphatidyl glycerol ('EPG') and dimyristoyl phosphatidyl choline ('DMPC'). The method comprises the steps of: a) combining the photosensitizer and the phospholipids in a molar ratio of about 1:7.0 or more phospholipid in the presence of an organic solvent; b) removing the organic solvent to form a lipid film; c) hydrating the lipid film with an aqueous solution at a temperature below about 300 °C, to form coarse liposomes containing a photosensitizer-phospholipid complex; and d) homogenizing or reducing the particle size of the coarse liposomes to a particle size range of about 150 to 300 nm at a temperature below about 300 °C. The invention also contemplates the liposomal pharmaceutical compositions themselves.
摘要翻译：制备含有脂质体的药物组合物的方法，所述脂质体包含治疗可接受量的氢化单苯并卟啉光敏剂和包含卵磷脂酰甘油（'EPG'）和二肉豆蔻酰磷脂酰胆碱（'DMPC'）的磷脂混合物。该方法包括以下步骤：a）在有机溶剂存在下，以约1：7.0或更高的磷脂摩尔比使光敏剂和磷脂结合; b）去除有机溶剂以形成脂质膜; c）在低于约300℃的温度下用水溶液水合脂质膜以形成含有光敏剂 - 磷脂复合物的粗脂质体; 和d）在低于约300℃的温度下将粗脂质体的粒径均化或减小至约150-300nm的粒度范围。本发明还考虑了脂质体药物组合物本身。

9. 发明授权

EP0642342B1 SELECTIVE CELL INACTIVATION IN BLOOD 失效
标题翻译：血液选择性细胞失活
公开(公告)号：EP0642342B1
公开(公告)日：2000-07-12
申请号：EP93909729.1
申请日：1993-05-27
申请人： QLT PHOTOTHERAPEUTICS, INC. , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： NORTH, Janice , LEVY, Julia
IPC分类号： A61K31/40 , A61K41/00
CPC分类号： A61K31/40 , A61K31/409 , A61K41/0071 , Y10S514/885 , Y10S514/908

10. 发明公开

EP0996465A1 COMPOSITIONS AND ARTICLES FOR REDUCING THE EFFECTS OF INFLAMMATION 失效
标题翻译：组合物和制品减少炎症的影响
公开(公告)号：EP0996465A1
公开(公告)日：2000-05-03
申请号：EP98901446.9
申请日：1998-01-14
申请人： QLT Phototherapeutics, Inc. , THE UNIVERSITY OF BRITISH COLUMBIA , Ciba Vision AG, Hettlingen
发明人： STEWART, William, C. , FSADNI, Mario , RICHTER, Anna, M. , LEVY, Julia, G. , HARITON, Claude, A., A. , HUBER, Gustav , OBOCHI, Modestus
IPC分类号： A61K41/00
CPC分类号： A61K41/0071 , Y10S514/912
摘要： A method for reducing or preventing the effects of inflammation arising from injured tissue, which method comprises the steps of: a) bringing the injured tissue, or pre-injured tissue, into contact with a photosensitizing agent capable of penetrating into the tissue, resulting in the desired degree of biodistribution in less than one hour; and b) exposing the tissue thus contacted to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to reduce or prevent inflammation in the exposed tissue, but not so long as to cause necrosis or erythema of the exposed tissue, or a pharmaceutical composition or an article for reducing or preventing the effects of inflammation arising from injured tissue. The composition comprises: a) from about 1 νg/mL to about 2 mg/mL of a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution less than one hour; and b) a pharmaceutically acceptable carrier. The article comprises: a) a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution in less than one hour; and b) an absorbent applicator.

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