专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1423701B1 CROSS-REACTIVE MONOCLONAL AND POLYCLONAL ANTIBODIES WHICH RECOGNIZE SURFACE PROTEINS FROM COAGULASE-NEGATIVE STAPHYLOCOCCI AND STAPHYLOCOCCUS AUREUS 有权
标题翻译：交叉反应的单克隆和多克隆抗体，表面蛋白的分离凝固酶葡萄球菌，金黄色葡萄球菌RECOGNIZE
公开(公告)号：EP1423701B1
公开(公告)日：2012-07-25
申请号：EP02756219.8
申请日：2002-06-17
申请人： Inhibitex, Inc. , The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin , Universita' Degli Studi Di Pavia
发明人： Foster, Timothy J. , Roche, Fiona, c/o The Provost Fellows & Scholars , Patti, Joseph M. , Hutchins, Jeff T. , Speziale, Pietro , Pallen, Mark
IPC分类号： C07K16/12 , C07K14/31 , G01N33/569 , A61K39/40
CPC分类号： C07K16/1271
摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

2. 发明公开

EP2391600A2 INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID 有权
标题翻译：在3-（氨基甲基）对映选择性合成中间体-5-甲基 - 己酸
公开(公告)号：EP2391600A2
公开(公告)日：2011-12-07
申请号：EP10701391.4
申请日：2010-01-29
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： CONNON, Stephen Joseph , PESCHIULLI, Aldo , MARKEY, Lyn
IPC分类号： C07C327/22 , C07C67/08 , C07C69/42 , C07C231/02 , C07C233/05 , C07C209/58 , C07C229/08
CPC分类号： C07C327/22 , B01J31/0237 , B01J31/0244 , B01J31/0249 , B01J2231/42 , C07B2200/07 , C07C67/08 , C07C227/32 , C07C229/08 , C07C231/02 , C07C231/18 , C07C69/34 , C07C233/05
摘要： (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.

3. 发明公开

EP2339344A1 Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus 审中-公开
标题翻译：鉴定交叉反应的单克隆和多克隆抗体，凝固酶的葡萄球菌和金黄色葡萄球菌的表面蛋白
公开(公告)号：EP2339344A1
公开(公告)日：2011-06-29
申请号：EP10182270.8
申请日：2002-06-17
申请人： Inhibitex, Inc. , The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin , Universita' Degli Studi Di Pavia
发明人： Foster, Timothy J. , Roche, Fiona , Patti, Joseph M. , Hutchins, Jeff T. , Speziale Pietro , Pallen, Mark
IPC分类号： G01N33/569 , C12N5/16 , C07K16/00 , C07K16/12 , C07K14/31 , A61K39/40
CPC分类号： C07K16/1271
摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. (hemolyticus), are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. (aureus) and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
摘要翻译：提供哪些是交叉反应性的，以两个凝固酶阳性的葡萄球菌细菌，：如对（溶血性）多克隆和单克隆抗体可以从两个凝固酶阳性和凝固酶阴性葡萄球菌细菌识别表面蛋白。从表面蛋白thathave被分离特性的基础上，可以产生的抗体做了用于产生本发明的抗体S.（金黄色葡萄球菌）和凝固酶阴性葡萄球菌，和合成的重组表面蛋白之间可能是共同的。因此，提供了疫苗和其利用合成蛋白质和抗体用于抗多种葡萄球菌感染的治疗或保护方法。

4. 发明公开

EP2334300A2 COMPOSITION AND METHOD FOR TREATMENT OF PRETERM LABOR 失效转让
标题翻译：组合物及法治疗早产
公开(公告)号：EP2334300A2
公开(公告)日：2011-06-22
申请号：EP09783381.8
申请日：2009-09-24
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin , The Coombe Lying-in Hospital
发明人： O'NEILL, Luke Anthony , O'LEARY, John , DALY, Sean , SCHARFE NUGENT, Andrea
IPC分类号： A61K31/47 , A61K38/17 , A61P29/00
CPC分类号： A61K31/47 , A61K31/00 , A61K31/7088 , A61K38/177 , A61K45/06 , C12N15/117 , C12N2310/17 , A61K2300/00
摘要： The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.

5. 发明公开

EP2321479A1 GRAVITY FLOW WASTEWATER DISTRIBUTION DEVICE 有权
标题翻译：重力流动污水分配装置
公开(公告)号：EP2321479A1
公开(公告)日：2011-05-18
申请号：EP09780283.9
申请日：2009-07-07
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： GILL, Laurence William , O'LUANAIGH, Niall David , PATEL, Titiksh
IPC分类号： E03F1/00 , E03B1/04
CPC分类号： E03F1/002 , C02F1/006 , C02F3/046 , E03F2201/30 , Y02W10/15
摘要： A fluid distribution device (1) comprising a reservoir (8); a pair of buckets (2), and a plurality of outlet pipes (6) for receiving the fluid discharged into the reservoir (8). Each bucket (2) is pivotable under gravity between a first receiving position in which it can receive fluid and a second discharge position in which it can release fluid contained therein into the reservoir (8). The buckets (2) are arranged such that when one bucket is located in the first receiving position, the other bucket is located in the second discharge position. The outlet pipes (6) are divided into two groups of equal number. located at opposite sides of the reservoir (8), and each group is arranged to receive the fluid from one of the buckets (2) when in the discharge position. Each outlet pipe (6) in a group receives an equal portion of the discharged fluid from its associated bucket. This may be achieved by fluid directing means.
摘要翻译： 1。一种流体分配装置（1），包括储存器（8）; 一对桶（2）和多个排出管（6），用于接收排出到储存器（8）中的流体。每个铲斗（2）在重力作用下可在第一接收位置和第二排出位置之间枢转，在第一接收位置中，所述铲斗可以接收流体，在第二排出位置中，所述铲斗能够将其中容纳的流体释放到储存器（8）桶（2）被布置为使得当一个桶位于第一接收位置时，另一个桶位于第二排出位置。出口管（6）被分成两组数量相等的组。位于储存器（8）的相对侧处，并且每个组布置成当处于排出位置时从其中一个桶（2）接收流体。一组中的每个出口管（6）接收来自其相关桶的排出流体的相等部分。这可以通过流体引导装置来实现。

6. 发明公开

EP2251687A1 Colorimetric anion sensor element 审中-公开
标题翻译：比色阴离子传感器元件
公开(公告)号：EP2251687A1
公开(公告)日：2010-11-17
申请号：EP09159892.0
申请日：2009-05-11
申请人： The Provost Fellows And Scholars Of The College Of The Holy and Undivided Trinity Of Queen Elizabeth Near Dublin
发明人： Gunnlaugsson, Thorfinnur , Veale, Emma
IPC分类号： G01N31/22 , G01J1/42 , G01N21/78
CPC分类号： G01N31/22
摘要： A sensor element suitable for colorimetric detection of anions in a sample, the sensor element comprising a water insoluble polymeric hydrogel having a polymer network defining a water permeable microvoid network, and an anion recognition dye (receptor) incorporated into the polymeric hydrogel. The anion recognition dye has a general formula (I),

Wherein R1, R2, R3 and R4 are each, independently, selected from H or an optionally substituted group consisting of lower alkyl, allyl, aryl, thioureas, urea, amide, ether, and X is S or O. An anion detection probe comprising a support that incorporates the sensor element and provided in the form of a dip-stick is also disclosed.
摘要翻译：适用于比色检测样品中阴离子的传感器元件，所述传感器元件包含具有限定透水微孔网络的聚合物网络的水不溶性聚合物水凝胶和并入所述聚合物水凝胶中的阴离子识别染料（受体）。阴离子识别染料具有通式（I），其中R 1，R 2，R 3和R 4各自独立地选自H或由低级烷基，烯丙基，芳基，硫脲，脲，酰胺，醚，并且X是S或O.还公开了一种阴离子检测探针，其包括并入传感器元件并以浸渍棒形式提供的支持物。

7. 发明公开

EP2021013A2 TRACHEAL CYTOTOXIN (TCT) AND RELATED COMPOUNDS FOR SUPPRESSING IMMUNE RESPONSES 审中-公开
标题翻译：气管细胞毒素（TCT）及相关化合物免疫反应的抑制
公开(公告)号：EP2021013A2
公开(公告)日：2009-02-11
申请号：EP07728271.3
申请日：2007-04-18
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： MILLS, Kingston , LAVELLE, Ed , HIGGINS, Sarah
IPC分类号： A61K38/04 , A61K38/14 , A61P37/00 , A61P37/06 , A61P37/08 , A61P11/06
CPC分类号： A61K38/164 , Y02A50/409
摘要： The present invention provides compositions and methods for the suppression of Th2-mediated immune response. Tracheal cytotoxin is shown to mediate a selective suppression of T helper cell type 2 (Th2)-mediated immune responses. The methods and compositions of the invention are useful for the treatment of Th2-mediated diseases and conditions due to their utility in suppressing Th2-mediated immune responses. The invention further extends to methods for suppressing the production of cytokines, such as IL-4 and IL-5 which contribute to the development of Th2-mediated immune responses.

8. 发明公开

EP2007830A1 MODIFIED ORGANOCLAYS 审中-公开
标题翻译：改性有机粘土
公开(公告)号：EP2007830A1
公开(公告)日：2008-12-31
申请号：EP07736105.3
申请日：2007-04-18
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： BLAU, Werner, J. , PADAMATI, Ramesh, Babu
IPC分类号： C08K13/06
CPC分类号： C09C1/42 , B82Y30/00 , C01P2002/72 , C01P2002/88 , C01P2004/03 , C01P2004/13 , C01P2004/16 , C08L25/06 , C08L63/00 , C08L67/02 , C08L69/00
摘要： A process for the preparation of modified nanoclay in one case comprises the steps of providing an organoclay, dispersing the organoclay in a solvent or mixture of solvents and/or surfactant, providing nariotubes or nanowires, dispersing the nanotubes or nanowires in a solvent or mixture of solvents and/or surfactant, and mixing the organoclay suspension with the nanotube and/or nanowire suspension. The organoclays modified with nanowires or nanotubes provide nanoadditives, which have enhanced thermal stability and electrical conductivity properties. The nanoadditive may include an inherently conducting polymer such as polyaniline. Also provided are polmyer composites including the nanoadditive.

9. 发明公开

EP1962872A2 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE 有权
标题翻译：组合物和方法调制的免疫反应
公开(公告)号：EP1962872A2
公开(公告)日：2008-09-03
申请号：EP06821545.8
申请日：2006-12-05
申请人： The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： MILLS, Kingston , BRADY, Miriam
IPC分类号： A61K35/56
CPC分类号： A61K38/164 , A61K35/62 , A61K45/06 , A61K2300/00
摘要： The present invention provides a composition for suppressing an inflammatory immune response comprising the excretory/secretory (ES) component of Fasciola hepatica or a fraction thereof. The composition has particular utility in the treatment or prophylaxis of T cell mediated inflammatory immune responses, and in particular autoimmune disease. The invention further extends to methods for modulating a T cell mediated immune response wherein a therapeutically effective amount of the excretory/secretory (ES) component from Fasciola hepatica is administered to a subject in need of such treatment in order to suppress the development of the response.

10. 发明公开

EP1889178A2 A DATA PROCESSING SYSTEM AND METHOD 审中-公开
标题翻译：数据处理系统和方法
公开(公告)号：EP1889178A2
公开(公告)日：2008-02-20
申请号：EP06728164.2
申请日：2006-05-15
申请人： Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： GERAGHTY, Dermot , MOLONEY, David
IPC分类号： G06F17/16
CPC分类号： G06F17/16 , H03M7/30
摘要： A matrix by vector multiplication processing system (1) comprises a compression engine (2) for receiving and dynamically compressing a stream of elements of a matrix; in which the matrix elements are clustered, and in which the matrix elements are in numerical floating point format, and a memory (SDRAM, 3) for storing the compressed matrix. It also comprises a decompression engine (4) for dynamically decompressing elements retrieved from the memory (3), and a processor (10) for dynamically receiving decompressed elements from the decompression engine (3), and comprising a vector cache (13, 19), and multiplication logic (12, 21) for dynamically multiplying elements of the vector cache with the matrix elements. There is a cache (13) for vector elements to be multiplied by matrix elements to one side of a diagonal, and a separate cache or register (19) for vector elements to be multiplied by matrix elements to the other side of the diagonal. A control mechanism (16, 17, 18) multiplies a single matrix element by a corresponding element in one vector cache and separately by a corresponding element in the other vector cache. The compression engine and the decompression logic are circuits within a single integrated circuit, and the compression engine (2) performs matrix element address compression by generating a relative address for a plurality of clustered elements.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式