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1. 发明公开

EP1658845A1 Use of statin or precursor thereof for the treatment of virusinfections 审中-公开
标题翻译： Verwendung von Statine und derenVorläuferzur Behandlung von Virusinfektionen
公开(公告)号：EP1658845A1
公开(公告)日：2006-05-24
申请号：EP04077770.8
申请日：2004-10-06
申请人： PrimaGen Holding B.V.
发明人： de Baar, Marinus Petrus , Paxton, William Anderson , Pollakis, Georgios
IPC分类号： A61K31/366 , A61P31/18
CPC分类号： A61K31/366
摘要： The invention relates to a new use of statins. It was found that statins are capable of reducing human immunodeficiency virus (HIV) infection of cells that are normally susceptible to HIV-infection. Provided are pharmaceuticals, methods and uses of a statin in the treatment of infections.
摘要翻译：本发明涉及他汀类药物的新用途。发现他汀类能够减少通常易感染艾滋病毒的细胞的人体免疫缺陷病毒（HIV）感染。提供他汀类药物治疗感染的药物，方法和用途。

2. 发明公开

EP1298221A1 Means and methods for treatment evaluation 审中-公开
标题翻译：手段和治疗的评估方法
公开(公告)号：EP1298221A1
公开(公告)日：2003-04-02
申请号：EP01203703.2
申请日：2001-09-28
申请人： PrimaGen Holding B.V.
发明人： van der Kuyl, Antoinette C. , Cornelissen, Marion
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： The invention provides a method for determining whether a treatment is effective in changing the status of a certain set of target cells, such as a tumor, in a patient. This method implies obtaining a sample from a patient after initiation of a treatment, and determining whether said sample comprises an expression product of at least one marker gene. Preferably, said sample is a blood sample. In one aspect, said expression product is expressed by a peripheral blood mononuclear cell. Said marker gene may be a gene involved in the generation, maintenance and/or breakdown of blood vessels (angiogenesis). A method of the invention is very suitable to determine within a few days if a certain treatment against Kaposi's Sarcoma is successful. Moreover, this method is suitable for determining the presence of angiogenesis and/or tumor cells in a patient.

3. 发明公开

EP1652935A1 Methods using mitochondrial nucleic acid for determining a health status of an individual 审中-公开
标题翻译：通过使用线粒体核酸确定个体的健康状态的方法
公开(公告)号：EP1652935A1
公开(公告)日：2006-05-03
申请号：EP04077978.7
申请日：2004-10-29
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： Penning, Maarten Tjerk , Maas, Henriette Catharina Gerarda Irene Martina , de Baar, Marinus Petrus , Voest, Emile Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101 , C12Q2545/10
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.
摘要翻译：本发明描述的途径与确定性采矿线粒体结合的核酸的方法和诊断其描述了使用。优选无细胞线粒体结合的核酸是确定性的开采。

4. 发明公开

EP1571225A1 Diagnosis of a disease and monitoring of therapy using the AC133 gene 审中-公开
标题翻译：诊断von Krankheiten undÜberwachungeiner Therapie unter Verwendung des AC133 Gens
公开(公告)号：EP1571225A1
公开(公告)日：2005-09-07
申请号：EP04075686.8
申请日：2004-03-02
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： Penning, Maarten Tjerk , Beerepoot, Laurens Victor , van den Broek, Sebastiaan Johannes Jacobus , Mehra, Niven , Voest, Emile Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158
摘要： The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from said individual comprises an expression product of AC133 in an amount that is indicative for said disease or for the treatment thereof. Said amount is preferably quantified and compared with a reference value. In one aspect said amount is compared with an amount of said expression product present in a sample that was obtained from said individual before said treatment. A use of a nucleic acid molecule comprising at least part of a sequence of AC133 or an analogue thereof for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule.
摘要翻译：本发明提供了一种用于分类患有或有风险患有疾病的个体的样品的方法，以及用于监测患有疾病的个体的治疗的方法，包括确定来自所述个体的样品是否包含 AC133，其量表示所述疾病或用于治疗。所述量优选地定量并与参考值进行比较。在一个方面，将所述量与在所述处理之前从所述个体获得的样品中存在的所述表达产物的量进行比较。还提供了包含至少部分AC133序列的核酸分子或其类似物用于监测患有疾病的个体的治疗的用途，以及包含该核酸分子的诊断试剂盒。

5. 发明公开

EP1493823A1 HMG coenzyme A reductase inhibitors affect the mitochondrial DNA content of cells 审中-公开
标题翻译： HMG-CoA还原酶的抑制剂影响细胞线粒体的DNA含量
公开(公告)号：EP1493823A1
公开(公告)日：2005-01-05
申请号：EP03077075.4
申请日：2003-07-02
申请人： PrimaGen Holding B.V.
发明人： van Gemen, Bob , de Baar, Marinus Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/16
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

6. 发明授权

EP1427860B1 STORING AND QUANTIFYING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 有权
标题翻译：存储并固定在载体应用NUCLEIC定量
公开(公告)号：EP1427860B1
公开(公告)日：2009-06-17
申请号：EP03738785.9
申请日：2003-07-03
申请人： PrimaGen Holding B.V.
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

7. 发明公开

EP1418242A1 Method for quantifying a ratio between at least two nucleic acid sequences 审中-公开
标题翻译： Verfahren zur Quantifizierung desVerhältnissesvon mindestens zweiNukleinsäuresequenzen
公开(公告)号：EP1418242A1
公开(公告)日：2004-05-12
申请号：EP03078547.1
申请日：2003-11-07
申请人： PrimaGen Holding B.V.
发明人： Timmermans, Eveline Catherina Anna Clasina , van Gemen, Bob
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2527/113
摘要： The invention provides a method for quantifying an initial ratio of the amounts of at least two nucleic acids of interest in a sample by means of a multiplex nucleic acid amplification reaction, comprising:

amplifying said nucleic acids of interest in said amplification reaction;
measuring the amount of at least two nucleic acids of interest at at least two different time points in said reaction;
determining from at least two of said measurements the amplification rate of said at least two nucleic acids of interest;
comparing said rates with a reference; and
determining from said comparison said initial ratio of the amounts of said at least two nucleic acids of interest in said sample.

Preferably, at least one variable factor in said nucleic acid amplification reaction is adjusted in order to allow detectable levels of all nucleic acids of interest to be reached before an amplification and/or detection limit of one or more of the nucleic acids of interest is reached.
With a method of the invention, small differences between ratios can be determined. Moreover, direct measurement of the initial nucleic acid ratio can be determined. A method of the invention is for instance suitable for determining functioning of a cellular organism, for determining the staging of a disease, and for determining therapeutic activity and/or possible side-effects of a medicament or candidate compound.
摘要翻译：本发明提供了一种通过多重核酸扩增反应定量样品中至少两种感兴趣的核酸的量的初始比例的方法，包括：在所述扩增反应中扩增所述目的核酸; 在所述反应中在至少两个不同时间点测量至少两种感兴趣的核酸的量; 从所述测量中的至少两个确定所述至少两个感兴趣的核酸的扩增速率; 将比率与参考比较; 并从所述比较中确定所述样品中所述至少两种感兴趣的核酸的量的初始比例。优选地，调节所述核酸扩增反应中的至少一个可变因子，以便在一种或多种核酸的扩增和/或检测极限之前达到所有感兴趣的核酸的可检测水平感兴趣。利用本发明的方法，可以确定比率之间的小差异。此外，可以确定初始核酸比的直接测量。本发明的方法例如适用于确定细胞生物的功能，用于确定疾病的分期，以及用于确定药物或候选化合物的治疗活性和/或可能的副作用。

8. 发明公开

EP1418241A1 Method for quantifying a ratio between at least two nucleic acid sequences 审中-公开
标题翻译： Methode zur Quantifizierung desVerhältnisseszweierNukleinsäuresequenzen
公开(公告)号：EP1418241A1
公开(公告)日：2004-05-12
申请号：EP02079673.6
申请日：2002-11-08
申请人： PrimaGen Holding B.V.
发明人： Timmermans, Eveline Catherina Anna Clasina , van Gemen, Bob
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2527/113 , C12Q2545/101 , C12Q2545/113 , C12Q2561/101
摘要： The invention provides a method for quantifying an initial ratio of the amounts of at least two nucleic acids of interest in a sample by means of a multiplex nucleic acid amplification reaction, comprising:

amplifying said nucleic acids of interest in said amplification reaction;
measuring the amount of at least two nucleic acids of interest at at least two different time points in said reaction;
determining from at least two of said measurements the amplification rate of said at least two nucleic acids of interest;
comparing said rates with a reference; and
determining from said comparison said initial ratio of the amounts of said at least two nucleic acids of interest in said sample.

Preferably, at least one variable factor in said nucleic acid amplification reaction is adjusted in order to allow detectable levels of all nucleic acids of interest to be reached before an amplification and/or detection limit of one or more of the nucleic acids of interest is reached.
With a method of the invention, small differences between ratios can be determined. Moreover, direct measurement of the initial nucleic acid ratio can be determined. A method of the invention is for instance suitable for determining functioning of a cellular organism, for determining the staging of a disease, and for determining therapeutic activity and/or possible side-effects of a medicament or candidate compound.
摘要翻译：本发明提供了一种通过多重核酸扩增反应定量样品中至少两种感兴趣的核酸的量的初始比例的方法，包括：在所述扩增反应中扩增所述目的核酸; 在所述反应中在至少两个不同时间点测量至少两种感兴趣的核酸的量; 从所述测量中的至少两个确定所述至少两个感兴趣的核酸的扩增速率; 将比率与参考比较; 并从所述比较中确定所述样品中所述至少两种感兴趣的核酸的量的初始比例。优选地，调节所述核酸扩增反应中的至少一个可变因子，以便在一种或多种核酸的扩增和/或检测极限之前达到所有感兴趣的核酸的可检测水平感兴趣。利用本发明的方法，可以确定比率之间的小差异。此外，可以确定初始核酸比的直接测量。本发明的方法例如适用于确定细胞生物的功能，用于确定疾病的分期，以及用于确定药物或候选化合物的治疗活性和/或可能的副作用。

9. 发明授权

EP1807532B1 METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 有权
标题翻译：程序对于个人从NUCLEIC线粒体的使用健康状况
公开(公告)号：EP1807532B1
公开(公告)日：2015-03-11
申请号：EP05797967.6
申请日：2005-10-28
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： PENNING, Maarten Tjerk , MAAS, Henriette Catharina Gerarda Irene Martina , DE BAAR, Marinus Petrus , VOEST, Emile Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101

10. 发明授权

EP1725679B1 Treatment monitoring of tumors using AC133 mRNA 有权
标题翻译：监视器使用的mRNA ACC133肿瘤治疗
公开(公告)号：EP1725679B1
公开(公告)日：2009-06-03
申请号：EP05710924.1
申请日：2005-03-02
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： PENNING, Maarten, Tjerk , VAN DEN BROEK, Sebastiaan, Johannes, Jacobus , VOEST, Emile, Eugene , BEEREPOOT, Laurens, Victor , MEHRA, Niven
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158
摘要： The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from said individual comprises an expression product of AC133 in an amount that is indicative for said disease or for the treatment thereof. Said amount is preferably quantified and compared with a reference value. In one aspect said amount is compared with an amount of said expression product present in a sample that was obtained from said individual before said treatment. A use of a nucleic acid molecule comprising at least part of a sequence of AC133 or an analogue thereof for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule.

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