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1. 发明授权

EP3143962B1 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICE 有权
标题翻译：微量进入肺减容装置
公开(公告)号：EP3143962B1
公开(公告)日：2018-05-16
申请号：EP16196370.7
申请日：2007-03-13
申请人： PneumRx, Inc.
发明人： Thompson, David , Aronson, Nathan , Wu, Patrick , Lehrberg, David , Mathis, Mark , Vasquez, Jaime
IPC分类号： A61F2/04 , A61B17/00 , A61B17/12 , A61B90/00
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

2. 发明公开

EP3188673A1 COORDINATED DELIVERY OF COPD TREATMENT 审中-公开
标题翻译：协同递送COPD治疗
公开(公告)号：EP3188673A1
公开(公告)日：2017-07-12
申请号：EP15832211.5
申请日：2015-08-17
申请人： PneumRx, Inc.
发明人： LEHRBERG, David , MATHIS, Mark L. , RODRIGUEZ, Verna , ETTER, Jeffrey , MITZ, Kevin , STEVEN, Christoph
IPC分类号： A61B17/24
CPC分类号： A61B17/12104 , A61B17/12036 , A61B17/12145 , A61B17/1285 , A61B90/96 , A61B90/98 , A61B2017/00367 , A61B2017/00809 , A61B2017/1205 , A61B2017/2923
摘要： Methods, systems and devices are disclosed for the efficient and coordinated delivery of COPD treatment to the lung(s) of a patient. A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to an airway of a patient in a constrained configuration and to change to a tissue-compressing configuration when deployed at a target zone to provide treatment to the lung airway. The invention further discloses a method of quickly and efficiently deploying the device using a single coordinated motion or signal which may be particularly useful when multiple devices are deployed at multiple target zones.
摘要翻译：公开了用于将COPD治疗有效且协调地递送至患者的肺的方法，系统和装置。公开了一种肺部容积减小系统，其包括适于以受限构型递送至患者的气道的可植入装置，并且当部署在目标区域时改变为组织压缩构造以向肺气道提供治疗。本发明还公开了一种使用单个协调的运动或信号来快速有效地部署设备的方法，当在多个目标区域部署多个设备时这可能是特别有用的。

3. 发明公开

EP2064300A4 TISSUE ADHESIVE COMPOSITIONS AND METHODS THEREOF 审中-公开
标题翻译：组织粘结及其方法组合物
公开(公告)号：EP2064300A4
公开(公告)日：2013-05-22
申请号：EP07842812
申请日：2007-09-19
申请人： PNEUMRX INC
发明人： GONG GLEN , WARTCHOW CHARLES , SCHLOSSER ALISON
IPC分类号： C09J189/00 , C09J189/02
CPC分类号： A61L24/043 , A61L24/108 , C08L5/02 , C08L2666/02 , C08L2666/26 , C09J189/00 , C08L89/00
摘要： The present invention relates to composition and method for an adhesive composition. In particular, the present invention relates to a composition of an adhesive composition containing a protein component and an aldehyde component where the aldehyde component further comprises of a thickening agent. The adhesive composition is used for adhering to a tissue in various applications. The adhesive composition can be used for marking a location within the human body, such as a tumor.

4. 发明公开

EP1781182A4 PLEURAL EFFUSION TREATMENT DEVICE, METHOD AND MATERIAL 有权
标题翻译： VORRICHTUNG，VERFAHREN UND MATERIAL ZUR BEHANDLUNG VON PLEURAERGUSS
公开(公告)号：EP1781182A4
公开(公告)日：2011-08-24
申请号：EP05770075
申请日：2005-07-08
申请人： PNEUMRX INC
发明人： MCGURK ERIN , DIECK RONALD , WARTCHOW CHARLES , GONG GLEN , BALCETA JOBERT
IPC分类号： A61B17/08 , A61K38/00
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M25/0041 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M31/00 , A61M2025/0073
摘要： The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.
摘要翻译：本发明公开了一种治疗患者胸腔积液的方法，包括将粘合剂材料经皮递送至患者的胸膜腔。用于实施本发明方法的任何实施方案的合适的粘合剂材料可以选自水凝胶，胶原，聚（乳酸），聚（乙交酯），氰基丙烯酸酯，戊二醛，PEG，蛋白质和多糖及衍生物它们。本发明还公开了一种胸腔积液治疗装置，其包括适于粘附限定胸膜腔的胸膜的粘合剂材料和适于将粘合剂材料输送到胸膜腔的胸膜空间进入构件。

5. 发明公开

EP1773225A4 INTRA-BRONCHIAL LUNG VOLUME REDUCTION SYSTEM 审中-公开
标题翻译：系统，为VERRRINGERUNG支气管肺容积
公开(公告)号：EP1773225A4
公开(公告)日：2010-05-26
申请号：EP05758569
申请日：2005-06-14
申请人： PNEUMRX INC
发明人： MCGURK ERIN , MATHIS MARK L , THOMPSON DAVE P , ARONSON NATHAN A
IPC分类号： A61B18/18 , A61B17/12 , A61B17/22 , A61F2/04 , A61M25/00 , A61M25/10 , A61M29/00
CPC分类号： A61M25/0026 , A61B17/12104 , A61B17/12136 , A61B17/12186 , A61B2017/12054 , A61B2017/12095 , A61B2017/22067 , A61M25/0069 , A61M25/007 , A61M25/0075 , A61M25/10 , A61M25/1027 , A61M2025/1052 , A61M2025/1054 , A61M2210/1039
摘要： The invention provides devices and systems for treating lungs. One aspect of the invention provides a lung device with an expandable member having an open lumen formed therethrough, the expandable (e.g., inflatable and compliant) member having an expanded diameter adapted to contact a circumferential wall portion of a lung air passageway. The device may also include a plug adapted to close the open lumen and a coupler adapted to couple the plug and the expandable member. Another aspect of the invention provides a lung device and delivery system including: an expandable member having an open lumen formed therethrough, the expandable member having an expanded diameter adapted to fit within a lung air passageway; and a delivery catheter adapted to deliver the expandable member to a lung air passageway, the delivery catheter having a coupler adapted to couple the catheter to the expandable member.

6. 发明公开

EP1998713A2 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICES, METHODS, AND SYSTEMS 有权
标题翻译：系统FÜR最小的入侵灭火剂
公开(公告)号：EP1998713A2
公开(公告)日：2008-12-10
申请号：EP07752999.8
申请日：2007-03-13
申请人： Pneumrx, Inc.
发明人： THOMPSON, David , ARONSON, Nathan , WU, Patrick , LEHRBERG, David , MATHIS, Mark , VASQUEZ, Jaime
IPC分类号： A61F2/04
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
摘要翻译：公开了一种肺容积减小系统，其包括可植入装置，其适于在输送构型中输送到患者的肺气道并改变为展开的构型以弯曲肺气道。本发明还公开了一种弯曲患者的肺气道的方法，包括将装置以输送构造插入气道并将装置弯曲成展开构型，从而弯曲气道。

7. 发明公开

EP3632375A1 TORQUE ALLEVIATING INTRA-AIRWAY LUNG VOLUME REDUCTION COMPRESSIVE IMPLANT STRUCTURES 审中-公开
公开(公告)号：EP3632375A1
公开(公告)日：2020-04-08
申请号：EP19208967.0
申请日：2014-03-13
申请人： PneumRx Inc.
发明人： VASQUEZ, Jaime , MATHIS, Mark , MACHOLD, Timothy , STEIN, Andrew
IPC分类号： A61F2/04 , A61B17/12 , A61B90/00 , A61B17/00 , A61B1/267
摘要： A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.

8. 发明公开

EP3305234A1 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICES AND PLANNING OF THEIR DELIVERY 审中-公开
标题翻译：微量进入肺容量减少装置和他们的交付计划
公开(公告)号：EP3305234A1
公开(公告)日：2018-04-11
申请号：EP17197829.9
申请日：2009-09-14
申请人： PneumRx, Inc.
发明人： Thompson, David , Aronson, Nathan , Wu, Patrick , Lehrberg, David , Mathis, Mark , Vasquez, Jaime , Boutillette, Michael
IPC分类号： A61B34/10 , A61B17/128 , A61B17/122 , A61B17/24
CPC分类号： A61B17/12104 , A61B5/087 , A61B5/091 , A61B5/14542 , A61B5/4848 , A61B6/032 , A61B17/12022 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/12172 , A61B17/1285 , A61B17/24 , A61B90/00 , A61B2017/00477 , A61B2017/00809 , A61B2017/12054 , A61B2034/108 , A61B2090/061 , A61B2090/3966 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M2205/0266
摘要： A method of planning a lung volume reduction treatment for a lung of a patient, the lung including an airway system having a plurality of branching airways, the method comprising identifying a target axial region of the airway system, the target axial region having a proximal end toward the esophagus and a distal end away from the esophagus with a length therebetween; selecting an implant in response to the length of the target axial region such that the implant has an elongate body with a body length greater than the length of the target axial region; such that a distal end of the selected implant can be advanced through the airway system toward the distal end of the target axial region; and such that the implant can be deployed within the target axial region so that the elongate body laterally compresses a portion of the lung. A system for use in a lung volume reduction treatment plan resulting from the method, comprises a catheter having a proximal end and a distal end with a lumen therebetween, the distal end of the catheter being advanceable through the airway system; and an implant receivable by the lumen, the implant comprising an elongate body having a distal portion and a proximal portion adjacent a proximal end of the implant, and a body length greater than the length of the target axial region, the distal portion being biased so that retraction of the distal end of the catheter from the distal portion of the implant can release the distal portion to engage the airway, the proximal end of the implant being advanceable distally relative to the airway while the catheter is withdrawn proximally from the proximal portion of the implant.
摘要翻译：一种规划患者肺的肺减容治疗的方法，所述肺包括具有多个分支气道的气道系统，所述方法包括识别气道系统的目标轴向区域，所述目标轴向区域具有近端朝向食管和远离食道的远端，其间具有长度; 响应于目标轴向区域的长度选择植入物，使得植入物具有主体长度大于目标轴向区域的长度的细长主体; 使得所选择的植入物的远端可以通过气道系统朝目标轴向区域的远端前进; 并且使得植入物可以部署在目标轴向区域内，使得细长主体侧向压缩肺的一部分。用于由该方法产生的肺减容治疗计划中的系统包括具有近端和远端的导管，所述近端和远端之间具有内腔，导管的远端可通过气道系统推进; 所述植入物包括细长主体，所述细长主体具有远侧部分和邻近所述植入物的近侧端部的近侧部分以及大于所述目标轴向区域的长度的主体长度，所述远侧部分被偏置成从植入物可以释放所述远端部分的所述远端部分中的导管的远端的缩回以接合所述气道，所述植入物被朝远侧行进相对于气道的近端，而导管从近端部分向近侧撤回植入物。

9. 发明授权

EP2848208B1 Minimally invasive lung volume reduction devices 有权
标题翻译：微创肺减容装置
公开(公告)号：EP2848208B1
公开(公告)日：2017-10-25
申请号：EP14188364.5
申请日：2009-09-14
申请人： PneumRx, Inc.
发明人： Thompson, David , Wu, Patrick , Lehrberg, David , Mathis, Mark , L. , Boutillette, Michael , Aronson, Nathan , Vasquez, Jaime
IPC分类号： A61B17/128 , A61B17/122 , A61B17/24
CPC分类号： A61B17/12104 , A61B5/087 , A61B5/091 , A61B5/14542 , A61B5/4848 , A61B6/032 , A61B17/12022 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/12172 , A61B17/1285 , A61B17/24 , A61B90/00 , A61B2017/00477 , A61B2017/00809 , A61B2017/12054 , A61B2034/108 , A61B2090/061 , A61B2090/3966 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M2205/0266
摘要： A method of planning a lung volume reduction treatment for a lung of a patient, the lung including an airway system having a plurality of branching airways, the method comprising identifying a target axial region of the airway system, the target axial region having a proximal end toward the esophagus and a distal end away from the esophagus with a length therebetween; selecting an implant in response to the length of the target axial region such that the implant has an elongate body with a body length greater than the length of the target axial region; such that a distal end of the selected implant can be advanced through the airway system toward the distal end of the target axial region; and such that the implant can be deployed within the target axial region so that the elongate body laterally compresses a portion of the lung. A system for use in a lung volume reduction treatment plan resulting from the method, comprises a catheter having a proximal end and a distal end with a lumen therebetween, the distal end of the catheter being advanceable through the airway system; and an implant receivable by the lumen, the implant comprising an elongate body having a distal portion and a proximal portion adjacent a proximal end of the implant, and a body length greater than the length of the target axial region, the distal portion being biased so that retraction of the distal end of the catheter from the distal portion of the implant can release the distal portion to engage the airway, the proximal end of the implant being advanceable distally relative to the airway while the catheter is withdrawn proximally from the proximal portion of the implant.

10. 发明公开

EP3143962A1 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICES, METHODS, AND SYSTEMS 有权
标题翻译：设备，方法和系统微创肺减容
公开(公告)号：EP3143962A1
公开(公告)日：2017-03-22
申请号：EP16196370.7
申请日：2007-03-13
申请人： Pneumrx, Inc.
发明人： Thompson, David , Aronson, Nathan , Wu, Patrick , Lehrberg, David , Mathis, Mark , Vasquez, Jaime
IPC分类号： A61F2/04 , A61B17/00 , A61B17/12 , A61B90/00
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

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