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1. 发明公开

EP2967880A4 CONDUITS FOR ENHANCING TISSUE REGENERATION 有权
标题翻译：用于改善组织产生的管道
公开(公告)号：EP2967880A4
公开(公告)日：2016-12-28
申请号：EP14772954
申请日：2014-03-04
申请人： OSTEOCERAMICS INC
发明人： MCGEE THOMAS D
IPC分类号： A61F2/36 , A61L27/12
CPC分类号： A61F2/28 , A61B17/56 , A61B17/74 , A61B17/8095 , A61M27/002
摘要： Apparatuses, systems, and methods for enhancing bone or soft tissue regeneration are provided. For example, a conduit, having one or more segments, can originate at a tissue regeneration site and can have a first opening to promote physiological signals to enter the conduit and transit to a second opening that penetrates a histologically rich source of multipotent mesenchymal cells, promoting the multipotent mesenchymal cells to produce tissue regeneration response products, the response products transiting through the second opening to egress at the first opening of the conduit, and promoting tissue regeneration at the tissue regeneration site. Transit of the physiological signals and the tissue regeneration response products is promoted through physical and/or chemical means, as is promotion of the anatomical functionality of the regenerated tissue. For example, a number of the segments of the conduit can be formed at least partially from an osteoceramic material.

2. 发明公开

EP2967799A1 SYSTEMS AND METHODS OF USING CHEMICALLY BOUND ANTIBIOTICS ACTIVATED BY INFECTIONS 有权
标题翻译：系统和使用方法由感染激活的化学抗生素的约束
公开(公告)号：EP2967799A1
公开(公告)日：2016-01-20
申请号：EP14769965.6
申请日：2014-03-14
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61F2/00
摘要： Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local concentrations can be achieved during the inflammatory response. The antibiotics will remain permanently bonded to the substrate material until an infection occurs which releases the antibiotic in high concentrations to help control the infection. The high local concentrations may be much higher than systemic toxic levels, and can never reach toxic levels because the local dose is much less than needed to reach systemic toxicity if completely dissolved.

3. 发明授权

EP2967880B1 CONDUITS FOR ENHANCING TISSUE REGENERATION 有权
公开(公告)号：EP2967880B1
公开(公告)日：2019-11-06
申请号：EP14772954.5
申请日：2014-03-04
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61F2/36 , A61L27/12

4. 发明授权

EP2967799B1 SYSTEMS AND METHODS OF USING CHEMICALLY BOUND ANTIBIOTICS ACTIVATED BY INFECTIONS 有权
公开(公告)号：EP2967799B1
公开(公告)日：2020-09-02
申请号：EP14769965.6
申请日：2014-03-14
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61K47/69 , A61P31/04 , A61K6/829 , A61K6/849 , A61K6/86 , A61K31/65 , A61K47/52

5. 发明公开

EP2967880A1 CONDUITS FOR ENHANCING TISSUE REGENERATION 有权
标题翻译： LEITUNGEN ZUR VERBESSERUNG EINER GEWEBEREGENERATION
公开(公告)号：EP2967880A1
公开(公告)日：2016-01-20
申请号：EP14772954.5
申请日：2014-03-04
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61F2/36 , A61L27/12
摘要： Apparatuses, systems, and methods for enhancing bone or soft tissue regeneration are provided. For example, a conduit, having one or more segments, can originate at a tissue regeneration site and can have a first opening to promote physiological signals to enter the conduit and transit to a second opening that penetrates a histologically rich source of multipotent mesenchymal cells, promoting the multipotent mesenchymal cells to produce tissue regeneration response products, the response products transiting through the second opening to egress at the first opening of the conduit, and promoting tissue regeneration at the tissue regeneration site. Transit of the physiological signals and the tissue regeneration response products is promoted through physical and/or chemical means, as is promotion of the anatomical functionality of the regenerated tissue. For example, a number of the segments of the conduit can be formed at least partially from an osteoceramic material.
摘要翻译：提供了用于增强骨或软组织再生的装置，系统和方法。例如，具有一个或多个区段的导管可以起源于组织再生部位，并且可以具有第一开口以促进生理信号进入导管并转移到渗透组织学丰富的多能间充质细胞源的第二开口，促进多能间充质细胞以产生组织再生反应产物，所述反应产物通过所述第二开口经过所述导管的第一开口处出口并促进组织再生部位的组织再生。通过物理和/或化学手段促进生理信号和组织再生应答产物的转运，促进再生组织的解剖功能。例如，管道的多个段可以至少部分地由破骨质材料形成。

6. 发明公开

EP2967875A2 DEVICES, SYSTEMS, AND METHODS FOR ELONGATING BONE 有权
标题翻译： VORRICHTUNGEN，SYSTEME UND VERFAHREN ZUMVERLÄNGERNVON KNOCHEN
公开(公告)号：EP2967875A2
公开(公告)日：2016-01-20
申请号：EP14769378.2
申请日：2014-03-12
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61F2/28 , A61F2/78
CPC分类号： A61F2/2814 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/286 , A61F2002/30772 , A61F2002/3082 , A61F2002/7887 , A61F2250/0065
摘要： The present invention comprises devices, systems, and methods for elongating bone using an extension implant having a first end and a second end. The first end of the extension implant is inserted into an opening in the live bone and the second end of the extension implant is combined with an enlarged implant. A plurality of channels extend through the components to serve as conduits for delivering fluids and physiological signals which induce bone formation. Some embodiments include a subcutaneous cage assembly for helping to support the implant as the bone heals around it.
摘要翻译：本发明包括用于使用具有第一端和第二端的延伸植入物来伸长骨的装置，系统和方法。延伸植入物的第一端插入活骨中的开口中，并且延伸植入物的第二端与扩大的植入物组合。多个通道延伸穿过组件以用作用于输送流体的导管和诱导骨形成的生理信号。一些实施方案包括皮下笼组件，用于在骨周围愈合时帮助支撑植入物。

7. 发明授权

EP2967875B1 DEVICES FOR ELONGATING BONE 有权
标题翻译：用于延长骨骼的装置
公开(公告)号：EP2967875B1
公开(公告)日：2017-12-20
申请号：EP14769378.2
申请日：2014-03-12
申请人： Osteoceramics, Inc.
发明人： MCGEE, Thomas, D.
IPC分类号： A61F2/28 , A61F2/78
CPC分类号： A61F2/2814 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/286 , A61F2002/30772 , A61F2002/3082 , A61F2002/7887 , A61F2250/0065
摘要： The present invention comprises devices, systems, and methods for elongating bone using an extension implant having a first end and a second end. The first end of the extension implant is inserted into an opening in the live bone and the second end of the extension implant is combined with an enlarged implant. A plurality of channels extend through the components to serve as conduits for delivering fluids and physiological signals which induce bone formation. Some embodiments include a subcutaneous cage assembly for helping to support the implant as the bone heals around it.

8. 发明公开

EP2967875A4 DEVICES, SYSTEMS, AND METHODS FOR ELONGATING BONE 有权
标题翻译：用于扩展骨骼的装置，系统和方法
公开(公告)号：EP2967875A4
公开(公告)日：2016-11-16
申请号：EP14769378
申请日：2014-03-12
申请人： OSTEOCERAMICS INC
发明人： MCGEE THOMAS D
IPC分类号： A61F2/28 , A61F2/78
CPC分类号： A61F2/2814 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/286 , A61F2002/30772 , A61F2002/3082 , A61F2002/7887 , A61F2250/0065
摘要： The present invention comprises devices, systems, and methods for elongating bone using an extension implant having a first end and a second end. The first end of the extension implant is inserted into an opening in the live bone and the second end of the extension implant is combined with an enlarged implant. A plurality of channels extend through the components to serve as conduits for delivering fluids and physiological signals which induce bone formation. Some embodiments include a subcutaneous cage assembly for helping to support the implant as the bone heals around it.

9. 发明公开

EP2967799A4 SYSTEMS AND METHODS OF USING CHEMICALLY BOUND ANTIBIOTICS ACTIVATED BY INFECTIONS 有权
标题翻译：使用感染活化的化学结合抗生素的系统和方法
公开(公告)号：EP2967799A4
公开(公告)日：2016-10-26
申请号：EP14769965
申请日：2014-03-14
申请人： OSTEOCERAMICS INC
发明人： MCGEE THOMAS D
IPC分类号： A61F2/00 , A61K47/48 , A61P31/04
CPC分类号： A61K47/48015 , A61K6/00 , A61K6/0265 , A61K6/06 , A61K6/0631 , A61K31/65 , A61K47/48992 , A61K47/52 , A61K47/6957
摘要： Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local concentrations can be achieved during the inflammatory response. The antibiotics will remain permanently bonded to the substrate material until an infection occurs which releases the antibiotic in high concentrations to help control the infection. The high local concentrations may be much higher than systemic toxic levels, and can never reach toxic levels because the local dose is much less than needed to reach systemic toxicity if completely dissolved.

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