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1. 发明公开

EP3170446A1 VERFAHREN UND VORRICHTUNG ZUR NICHTINVASIVEN OPTISCHEN IN-VIVO-BESTIMMUNG DER GLUKOSEKONZENTRATION IN FLIESSENDEM BLUT 审中-公开
标题翻译：方法和装置非侵入性光学血液中的葡萄糖浓度测定体内FLOWING
公开(公告)号：EP3170446A1
公开(公告)日：2017-05-24
申请号：EP15195694.3
申请日：2015-11-20
申请人： NIRLUS Engineering AG
发明人： HERRMANN, Vera
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/0051 , A61B5/0075 , A61B5/02055 , A61B5/14532 , A61B5/1455 , A61B5/7228
摘要： Es handelt sich um ein Verfahren und eine Vorrichtung zur nichtinvasiven optischen in-vivo-Bestimmung der Glukosekonzentration in fließendem Blut in einem Blutgefäß im Innern eines Körpers, wobei der Körper zur Markierung eines Blutgefäßes mit Ultraschallstrahlung mit einer Ultraschallfrequenz bestrahlt wird,
wobei der Körper mit dem Blutgefäß mit Licht mit zumindest einer ersten Lichtwellenlänge beleuchtet wird, bei der die Intensität des rückgestreuten Lichtes von der Glukosekonzentration abhängt,
wobei der Körper mit dem Blutgefäß mit Licht einer zweiten Lichtwellenlänge beleuchtet wird, die im Bereich einer Wasserabsorptionslinie liegt, deren Lage von der Temperatur des Blutes abhängt,
wobei das jeweils rückgestreute Licht mit zumindest einem Detektor erfasst wird,
wobei mit einer Auswerteeinheit aus den an dem Detektor gemessenen Detektorsignalen jeweils die mit einer von der Ultraschallfrequenz abhängigen Modulationsfrequenz modulierten Signalanteile extrahiert werden,
wobei aus dem bei der ersten Wellenlänge ermittelten Signalanteil ein Indikatorwert für die Glukosekonzentration ermittelt wird,
wobei der Indikatorwert zur Kompensation der Temperaturabhängigkeit mit dem Signalanteil der zweiten Lichtwellenlänge korrigiert wird.

2. 发明公开

EP2235485A2 VERFAHREN ZUR NICHTINVASIVEN, OPTISCHEN BESTIMMUNG DER TEMPERATUR EINES MEDIUMS 有权
标题翻译： METHODS FOR INSIDE的主体流动的血液的温度非侵入性，光学测定
公开(公告)号：EP2235485A2
公开(公告)日：2010-10-06
申请号：EP09704736.9
申请日：2009-01-23
申请人： Nirlus Engineering AG
发明人： HERRMANN, Vera
IPC分类号： G01J5/60 , G01N21/25
CPC分类号： G01J5/602 , A61B5/0059 , A61B5/01 , A61B5/14532 , A61B5/4806 , G01J5/58
摘要： Disclosed is a method for the non-invasive optic determination of the temperature of a medium, preferably a water-containing medium, wherein the medium to be analyzed is illuminated by infrared and/or visible light in the region of an absorption line, the position of which depends on the temperature of the medium, and wherein absorption of the light in the region of the absorption line is measured and the temperature is determined from said measurement by comparison with calibration data. Said method is characterized in that the medium is illuminated with at least two discrete light wavelengths (λ
1 , λ
2 ), which are in the region of the absorption line (B) on different sides of the absorption maximum, that at least one measured value (ΔA/Δλ) dependent on temperature is determined from the relationship of these two determined absorption values to one another, and that the temperature is determined from said measured value by comparison with the previously recorded calibration data.

3. 发明授权

EP1601285B1 BLUTOPTODE 有权
公开(公告)号：EP1601285B1
公开(公告)日：2009-10-14
申请号：EP04718910.5
申请日：2004-03-10
申请人： Nirlus Engineering AG
发明人： HERRMANN Vera
IPC分类号： A61B5/00 , G01N21/47
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/7257 , G01N21/49
摘要： The invention relates to a method for the non-invasive measurement of the concentration of blood constituents in central blood vessels, especially the haemoglobin concentration or the oxygen saturation of the blood. According to said method, backscattered light is measured under the action of ultrasonic radiation; the ultrasonic radiation is focussed towards the inside of a central blood vessel; a defined pulse length and repetition time for the ultrasonic radiation is set; a light source and an adjacent detection unit are arranged in such a way as to detect the backscattered light on the skin surface above the blood vessel, such that the distance between the light source and the plurality of light receptors of the detection unit corresponds to the depth of the examined blood vessel; the target tissue is illuminated by means of at least two discrete optical wavelengths; the backscattered light intensity is measured in an integrating manner by means of the detector surface and a plurality of ultrasonic pulses; an average light intensity distribution is detected over the length of a pulse; temporally constant parts are eliminated and the distribution is Fourier transformed; the largest Fourier components and the spectral position are determined in relation to the frequency of the ultrasonic radiation; the flow speed of the blood and the backscattering power thereof for each of the at least two optical wavelengths is deduced, taking into account the determined depth of the blood vessel; the quantity of the blood constituents contributing to the signal is deduced from the determined scattering power; and concentrations in the blood vessel are calculated, taking into account the volume of the ultrasonic focus contributing to the signal and the blood flow speed.

4. 发明公开

EP2046190A1 VERFAHREN DER GLUKOSEKONZENTRATION IN PULSIERENDEM BLUT 失效转让
标题翻译：葡萄糖浓度在血液测量脉动
公开(公告)号：EP2046190A1
公开(公告)日：2009-04-15
申请号：EP07765224.6
申请日：2007-07-18
申请人： Nirlus Engineering AG
发明人： HERRMANN, Vera
IPC分类号： A61B5/00 , A61M1/36
CPC分类号： A61B5/14532 , A61B5/14557 , A61B5/1459 , A61B5/7207 , A61M1/367 , A61M2230/201
摘要： Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps: - determination of a value for the glucose concentration for a first measurement cycle, and - repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and/or scattering power of the blood for at least two incident NIR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and/or scattering power, - continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two NIR wavelengths is selected from the wavelength range 1560-1630 nm, and the second of the at least two NIR wavelengths is selected from the wavelength range 790-815 nm, and the ratio of the transmittance and/or scattering power of the at least two wavelengths is calculated, this ratio serving in relation to the blood temperature as indicator value for reading off the blood glucose concentration from the calibration table.

5. 发明公开

EP3145412A1 VERFAHREN ZUR NICHTINVASIVEN OPTISCHEN MESSUNG VON EIGENSCHAFTEN VON FLIEßENDEM BLUT 有权
标题翻译：方法的气血运行性能的非侵入式光学测量
公开(公告)号：EP3145412A1
公开(公告)日：2017-03-29
申请号：EP15723027.7
申请日：2015-05-19
申请人： NIRLUS Engineering AG
发明人： HERRMANN, Vera
IPC分类号： A61B8/06 , A61B5/1455
CPC分类号： A61B5/0048 , A61B5/0097 , A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/7228 , A61B8/085 , A61B8/4416 , A61B8/488 , A61B2562/0233 , G01N21/4795 , G01N2021/4709
摘要： The invention relates to a method for non-invasive optical in vivo measurement of properties of free-flowing blood in a blood vessel within a body, e.g. for determining the concentration of blood constituents, wherein the body is irradiated with ultrasonic radiation at an ultrasonic frequency (f
us ) in order to mark a blood vessel, wherein the body with the blood vessel is illuminated with light with at least one light wavelength and the back-scattered light is detected with a detector, wherein the light portion back-scattered out of the blood vessel from the body is modulated with a frequency (f
MG ) which corresponds to the frequency (f
us ) of the ultrasonic radiation, wherein the light portion back-scattered inside the blood vessel is modulated on account of the Doppler effect in free-flowing blood with a frequency (f
ΜΒ ) shifted by the Doppler shift (f
D ) with respect to the frequency (f
us ) of the ultrasonic radiation, and wherein, with an evaluation unit, the signal portion modulated with the shifted frequency (f
ΜΒ ) is extracted from the detector signal measured at the detector.
摘要翻译：本发明涉及一种用于在血管的自由流动的血液特性的体内光学测量非侵入性的方法的主体内，例如确定性采矿血液成分，worin身体在为了标记的血管照射紫外线以超声波频率（FU）的浓度，worin与血管所述主体的光所照明的至少一个光的波长和背向散射光用检测器检测到的，worin光部背散射出从身体血管的调制与对应于超声波辐射的频率（FU）的频率（FMG），worin光部背散射内部的血管上的帐户在自由流动的血液相对于超声波辐射的多普勒效应移与频率（fΜΒ）由多普勒（F D）移位到频率（FU），和worin的调制，与评估单元，以频率调制的信号部分移位（fΜΒ）从在检测器测量的检测器信号中提取。

6. 发明授权

EP2235485B1 VERFAHREN ZUR NICHTINVASIVEN, OPTISCHEN BESTIMMUNG DER TEMPERATUR VON FLIESSENDEM BLUT IM INNEREN EINES KÖRPERS 有权
标题翻译： METHODS FOR INSIDE的主体流动的血液的温度非侵入性，光学测定
公开(公告)号：EP2235485B1
公开(公告)日：2013-02-27
申请号：EP09704736.9
申请日：2009-01-23
申请人： Nirlus Engineering AG
发明人： HERRMANN, Vera
IPC分类号： G01J5/60 , G01N21/25
CPC分类号： G01J5/602 , A61B5/0059 , A61B5/01 , A61B5/14532 , A61B5/4806 , G01J5/58

7. 发明授权

EP1909639B1 VERFAHREN ZUR IN VIVO GEWEBEKLASSIFIZIERUNG 有权
标题翻译：方法在体内组织分类
公开(公告)号：EP1909639B1
公开(公告)日：2010-04-14
申请号：EP06761776.1
申请日：2006-07-07
申请人： Nirlus Engineering AG
发明人： HERRMANN, Vera
IPC分类号： A61B5/00 , A61B8/00
CPC分类号： A61B5/7264 , A61B5/0048 , A61B5/0059 , A61B8/00

8. 发明授权

EP2046190B1 MESSUNG DER GLUKOSEKONZENTRATION IN PULSIERENDEM BLUT 失效转让
标题翻译：葡萄糖浓度在血液测量脉动
公开(公告)号：EP2046190B1
公开(公告)日：2010-04-07
申请号：EP07765224.6
申请日：2007-07-18
申请人： Nirlus Engineering AG
发明人： HERRMANN, Vera
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14557 , A61B5/1459 , A61B5/7207 , A61M1/367 , A61M2230/201
摘要： Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps: - determination of a value for the glucose concentration for a first measurement cycle, and - repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and/or scattering power of the blood for at least two incident NIR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and/or scattering power, - continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two NIR wavelengths is selected from the wavelength range 1560-1630 nm, and the second of the at least two NIR wavelengths is selected from the wavelength range 790-815 nm, and the ratio of the transmittance and/or scattering power of the at least two wavelengths is calculated, this ratio serving in relation to the blood temperature as indicator value for reading off the blood glucose concentration from the calibration table.

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