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1. 发明公开

EP4304604A1 ? ? ?TERMINALIA CHEBULA? ? ? ? ?METHODS FOR RELIEVING BACK PAIN WITHCOMPOSITIONS 审中-实审
公开(公告)号：EP4304604A1
公开(公告)日：2024-01-17
申请号：EP22767908.1
申请日：2022-03-09
申请人： Natreon, Inc.
发明人： KALIDINDI, Sanyasi R.
IPC分类号： A61K31/7048 , A61K36/185

2. 发明公开

EP3813851A1 IMPROVEMENT OF BLOOD MICROPERFUSION TO SKIN BY SHILAJIT 审中-实审
公开(公告)号：EP3813851A1
公开(公告)日：2021-05-05
申请号：EP18924484.1
申请日：2018-06-26
申请人： Natreon, Inc.
发明人： SEN, Chandan, K. , KALIDINDI, Sanyasi
IPC分类号： A61K35/02 , A61K31/352 , A61K31/538

3. 发明公开

EP2898891A3 Terminalia chebula and Terminalia bellerica extracts for inhibition of xanthine oxidase 有权
标题翻译： Terminalia chebula- und Terminalia bellerica-Extrakte zur Hemmung von Xanthinoxidase
公开(公告)号：EP2898891A3
公开(公告)日：2016-10-19
申请号：EP14180717.2
申请日：2014-08-12
申请人： Natreon Inc.
发明人： Kalidindi, Sanyasi
IPC分类号： A61K36/185 , A61P9/02
CPC分类号： A61K36/185 , A61K36/61
摘要： Compositions containing extracts of Terminalia chebula and Terminalia bellerica, or combinations thereof and methods for treatment of uricemia, hyperuricemia, and gout in a human subject are provided.
摘要翻译：提供了包含Terminalia chebula和Terminalia bellerica的提取物或其组合的组合物，以及用于治疗人类受试者的尿酸血症，高尿酸血症和痛风的方法。

4. 发明公开

EP1750739A4 OXYGENATED DIBENZO-ALPHA-PYRONE CHROMOPROTEINS 审中-公开
标题翻译：含氧丰富的二苯并ALPHA吡喃酮色素蛋白
公开(公告)号：EP1750739A4
公开(公告)日：2010-05-05
申请号：EP05779897
申请日：2005-03-14
申请人： NATREON INC
发明人： GHOSAL SHIBNATH
IPC分类号： A61K38/00 , A61K8/00 , A61K8/49 , A61K8/64 , A61K38/16 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02
CPC分类号： A61K8/64 , A61K8/498 , A61K38/16 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02

5. 发明公开

EP1796701A1 COMPOSITIONS FOR ANTI-OBESITY, HEALTH-RESTORATIVE AND HEALTH-PROMOTIONAL BENEFITS 审中-公开
标题翻译：组合物对肥胖，恢复健康和卫生
公开(公告)号：EP1796701A1
公开(公告)日：2007-06-20
申请号：EP05797467.7
申请日：2005-09-20
申请人： Natreon Inc.
发明人： GHOSAL, Shibnath
IPC分类号： A61K36/18
CPC分类号： A23F3/14 , A23F5/14 , A23F5/40 , A61K36/185 , A61K36/81 , A61K36/896 , A61K2300/00
摘要： An obesity control agent with health-restorative and health-promotional benefits to humans comprising the extract of Chlorophytum species, more particularly, Chlorophytum arundinacceum, is disclosed. The bioactive principles responsible for anti-obesity property have been determined to be mainly due to spirosta-steroidal saponins, spirosta-steroidal alkaloids and galacto-glucan oligosaccharides. Most effective as an obesity control agent is the spirosta-steroidal saponins. Pharmaceutical, nutritional and veterinary use of this inventive composition is also disclosed.

6. 发明公开

EP3033148A4 REGULATION OF BODY WEIGHT GAIN BY USING DIBENZO-ALPHA-PYRONES 无效
标题翻译：二苯并咪唑
公开(公告)号：EP3033148A4
公开(公告)日：2017-02-08
申请号：EP14841939
申请日：2014-09-09
申请人： NATREON INC
发明人： SEN CHANDAN K
IPC分类号： A61K31/37 , A61K9/00 , A61K36/09 , A61P3/04
CPC分类号： A61K35/04 , A61K31/37 , A61K35/66 , A61K36/09 , A61K2300/00
摘要： A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
摘要翻译：提供使用二苯并吡喃酮（DBPs）的方法，其中给予受试者一种或多种以上导致体重增加减少。在一个实施方案中，向个体施用3-OH-DBP，3,8-（OH）2-DBP或其组合以控制体重增加。

7. 发明公开

EP3033148A1 REGULATION OF BODY WEIGHT GAIN BY USING DIBENZO-ALPHA-PYRONES 无效
标题翻译：体重增加二苯并-α-吡喃酮调节
公开(公告)号：EP3033148A1
公开(公告)日：2016-06-22
申请号：EP14841939.3
申请日：2014-09-09
申请人： Natreon Inc.
发明人： SEN, Chandan, K.
IPC分类号： A61P3/00 , C07D311/80 , A61K31/12 , A61K31/37
CPC分类号： A61K35/04 , A61K31/37 , A61K35/66 , A61K36/09 , A61K2300/00
摘要： A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.

8. 发明公开

EP2776462A1 INDOLEALKYLAMINO-WITHASTEROID CONJUGATES AND METHOD OF USE 有权
标题翻译： INDOLALKYLAMINO-WITH ASTEROID偶联物及其使用它们的方法
公开(公告)号：EP2776462A1
公开(公告)日：2014-09-17
申请号：EP12846938.4
申请日：2012-11-06
申请人： Natreon Inc.
发明人： GHOSAL, Shibnath , VEERARAGAVAN, Muruganandam , KALIDINDI, Sanyasi, R.
IPC分类号： C07K16/00
CPC分类号： A61K31/585 , A61K36/38 , A61K47/541 , A61K47/545 , C07J71/001
摘要： A group of indolealkylamino-withasteroid conjugates, isolated and purified from
Withania somnifera, are described. A synthetic method of making an indolealkylamino- withasteroid compound is provided.
In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

9. 发明公开

EP1906980A2 METHOD OF TREATMENT OR MANAGEMENT OF STRESS 审中-公开
标题翻译：方法用于治疗或压力管理
公开(公告)号：EP1906980A2
公开(公告)日：2008-04-09
申请号：EP06788803.2
申请日：2006-07-27
申请人： Natreon Inc.
发明人： GHOSAL, Shibnath
IPC分类号： A61K36/00
CPC分类号： A61K36/81 , A61K36/16 , A61K36/258 , A61K36/45 , A61K36/47 , A61K2300/00
摘要： The present invention provides a method of treatment or management of various adaptogenic conditions, such as, stress in mammals, more particularly, humans, comprising administering Withania somnifera plant extract. A high purity extract composition comprising withanolide glycosides, oligosaccharides, withanolide aglycones and a minimum level of polysaccharides, and a pharmaceutically, veterinary or nutritionally acceptable carrier(s) is disclosed. Preferably, the composition of the present invention can be devoid of any alkaloids or contains trace levels of alkaloids. The method of treatment or management of stress administering the composition comprising Withania somnifera of the present invention does not suffer from any one of the abovementioned side effects even after prolonged use. A method of preconditioning a mammalian patient to improve the patient's resistance and reaction to subsequently encountered stress is described.

10. 发明公开

EP1765324A2 COMPOSITIONS OF STABLE BIOACTIVE METABOLITES OF DOCOSAHEXAENOIC (DHA) AND EICOSAPENTAENOIC (EPA) ACIDS 审中-公开
标题翻译：二十二碳六稳定的生物活性代谢物（DHA）和二十碳五烯酸（EPA）ACIDS组合物
公开(公告)号：EP1765324A2
公开(公告)日：2007-03-28
申请号：EP05758080.5
申请日：2005-06-08
申请人： Natreon Inc.
发明人： GHOSAL, Shibnath
IPC分类号： A61K31/366 , A61K31/665
CPC分类号： A61K31/366 , A61K31/665
摘要： An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce short-lived prostaglandins, leukotrienes and thromboxanes that bind to specific G-protein-coupled receptors and signal cellular responses, e.g., inflammation, vasodilation, blood pressure, pain etc. But never before it was suggested/shown that C20:5n-3 PUFAs, e.g., EPA (and DHA), are transformed into stable aromatic metabolites, DBPs, which elicit a large array of bioactivities in the producer organisms and also control the synthesis and metabolism of arachidonate-derived prostaglandins. The major beneficial effects attributed to EPA and DHA are now found to be largely contributed by DBPs and their aminoacyl conjugates and the dibenzo-α-pyrone-chromoproteins (DCPs). Because of the highly unstable nature of EPA and DHA, when administered, they are metabolized into a large array of uncontrolled products, several of which are systemically undesirable. By contrast, DBPs, because of their stability, perform the biological response modifier (BRM) functions in a directed and sustained way. Many of the biological effects of DBPs described in this invention, were earlier attributed to EPA and DHA, - the precursors of DBPs.

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