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1. 发明公开

EP3194365A1 PYRROLIDONE DERIVATIVES, OLIGOMERS AND POLYMERS 无效
标题翻译：吡咯里酮衍生物，低聚物和聚合物
公开(公告)号：EP3194365A1
公开(公告)日：2017-07-26
申请号：EP15839322.3
申请日：2015-09-14
申请人： Nanosynthons LLC
发明人： TOMALIA, Donald A. , HEDSTRAND, David M. , NIXON, Linda S.
IPC分类号： C07D207/28 , C07D207/277
CPC分类号： A61K49/0021 , C07D207/277 , C07D207/28 , C07D403/14 , C09B13/00
摘要： Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.
摘要翻译：已经制备了简单的有机结构，有机/无机聚合物和其他底物，其全部具有至少一种吡咯烷酮部分，并且发现其具有低毒性，低补体活化特征并且可以用于减少与药物缀合物的蛋白质相互作用，同时当用作可注射组合物时增强这些缀合物的体内驻留时间; 因此这些化合物可以用作PEG化中的PEG的替代物。令人惊讶的是，这些化合物还表现出独特的内在荧光（IF）或非传统荧光（NTF）性质，目前无法用传统的光化学来解释，并描述了荧光范式。这些化合物在细胞成像，基因转染，生物诊断，生物传感，荧光定向手术切除，药物递送，法医学，环境诊断，矿物/宝石表征，假冒商品检测，与液体/ 水流量，油田增强和诊断，防止光漂白和LED显示增强等。

2. 发明公开

EP4164658A1 EXCIPIENTS PROVIDING STABILIZATION AND ENHANCED WATER SOLUBILIZATION AND THEIR USES 审中-实审
公开(公告)号：EP4164658A1
公开(公告)日：2023-04-19
申请号：EP21825641.0
申请日：2021-06-15
申请人： Nanosynthons LLC
发明人： TOMALIA, Donald, A. , HEDSTRAND, David, M. , SINGH, Mayank, K. , NIXON, Linda, S.
IPC分类号： A61K31/724 , A61K47/40 , C08B37/16

3. 发明公开

EP3194365A4 PYRROLIDONE DERIVATIVES, OLIGOMERS AND POLYMERS 无效
公开(公告)号：EP3194365A4
公开(公告)日：2018-04-25
申请号：EP15839322
申请日：2015-09-14
申请人： NANOSYNTHONS LLC
发明人： TOMALIA DONALD A , HEDSTRAND DAVID M , NIXON LINDA S
IPC分类号： C07D207/28 , C07D207/277
CPC分类号： A61K49/0021 , C07D207/277 , C07D207/28 , C07D403/14 , C09B13/00
摘要： Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

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