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1. 发明公开

EP3130233A4 SALT-FREE MISO PRODUCTION METHOD, SALT-FREE MISO, HEPATIC FUNCTION IMPROVEMENT AGENT, AND HYPERTENSION IMPROVEMENT AGENT 有权转让
公开(公告)号：EP3130233A4
公开(公告)日：2017-11-22
申请号：EP15770313
申请日：2015-01-06
申请人： MARUZEN PHARMACEUTICALS CO LTD , MASUYAMISO CO LTD
发明人： NAKAHARA TATSUO , KAWANO TAKASHI
IPC分类号： A61K36/48 , A23L11/20 , A23L33/10 , A61K36/062 , A61P1/16 , A61P9/12
CPC分类号： A61K36/48 , A23L11/09 , A23L33/10 , A23V2002/00 , A61K9/0056 , A61K36/062 , A61K2236/11 , A61K2236/19
摘要： Provided are: a production method for salt-free miso, in which steamed soy beans and koji are pressurized, heated, and fermented; salt-free miso obtained by said production method; and a hepatic function improvement agent and a hypertension improvement agent that contain said salt-free miso as an effective component thereof.

2. 发明公开

EP2857032A3 Tie2 activator, vascular endothelial growth factor (vegf) inhibitor, anti-angiogenic agent, agent for maturing blood vessels, agent for normalizing blood vessels, agent for stabilizing blood vessels, and pharmaceutical composition 审中-公开
标题翻译：的Tie2活化剂，血管内皮生长因子（VEGF），抗血管生成剂，抑制剂用于血管的成熟，用于血管正常化的装置，用于血管和药物组合物的稳定化
公开(公告)号：EP2857032A3
公开(公告)日：2015-07-15
申请号：EP14003460.4
申请日：2011-10-28
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： Ohto, Nobuaki , Kiso, Akinori
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00 , A61K36/48 , A61K36/67 , A61K36/734 , A61K36/725 , A61K36/16 , A61K36/185 , A61K36/287 , A61K36/53 , A61K35/618 , A61K36/61 , A61K36/62 , A61K36/815 , A61K36/88 , A61K36/9066
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect.
A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.

3. 发明公开

EP2647385A1 Tie2 ACTIVATOR, VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) INHIBITOR, ANTI-ANGIOGENIC AGENT, AGENT FOR MATURING BLOOD VESSELS, AGENT FOR NORMALIZING BLOOD VESSELS, AGENT FOR STABILIZING BLOOD VESSELS, AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： TIE2 AKTIVATOR，血管内皮生长因子（VEGF）抑制剂，抗血管生成活性，代理为老化的血管，手段正常化血管，MEDIUM用于稳定血管的药物组合物
公开(公告)号：EP2647385A1
公开(公告)日：2013-10-09
申请号：EP11845773.8
申请日：2011-10-28
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： OHTO, Nobuaki , KISO, Akinori
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect.
A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
摘要翻译：以提供的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，并且具有高安全性的药物组合物，和优异的Tie2活化作用，血管内皮生长因子（VEGF）的抑制作用，血管生成抑制作用，血管成熟作用，血管正常化的作用，和血管稳定作用。甲的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，和含有作为活性成分，山楂提取物，杨桃的药物组合物提取物，贝壳花提取物，莲花提取物，路易波士茶提取物，印度的日期提取物，中国榅桲提取物，番石榴番石榴提取物，长辣椒提取物，皂树提取物，季提取物，银杏提取物，牡蛎提取物，姜黄提取物，菊花提取物，大枣提取物，枸杞中国提取物，甘菊提取物，或布彻的扫帚提取物，或其任何组合。

4. 发明公开

EP1859774A4 HAIR COSMETIC 审中-公开
标题翻译：头发化妆品
公开(公告)号：EP1859774A4
公开(公告)日：2009-09-30
申请号：EP06713701
申请日：2006-02-14
申请人： MARUZEN PHARMACEUTICALS CO LTD
发明人： NOJIMA JUN , MIYAKE YASUO , OHTO NOBUAKI
IPC分类号： A61K8/36 , A61K31/19 , A61P17/14 , A61P43/00 , A61Q7/00
CPC分类号： A61K8/63 , A61K8/66 , A61K31/19 , A61K31/56 , A61K2800/782 , A61Q5/00 , A61Q5/02 , A61Q7/00
摘要： With an object of discovering a substance having a testosterone 5±-reductase inhibiting action, a hair papilla cell growth promoting action, a fibroblast growth factor-7 production promoting action, a vascular endothelial growth factor production promoting action or a bone morphogenetic protein-2 production promoting action, and of providing a hair care product having this substance blended therein, and a hair growth tonic, a testosterone 5±-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter each having this substance as an active ingredient thereof, a hair care product of the present invention is made to contain corosolic acid therein, and each of a hair growth tonic, a testosterone 5±-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter of the present invention is made to contain corosolic acid as an active ingredient thereof.

5. 发明公开

EP2647385A4 Tie2 ACTIVATOR, VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) INHIBITOR, ANTI-ANGIOGENIC AGENT, AGENT FOR MATURING BLOOD VESSELS, AGENT FOR NORMALIZING BLOOD VESSELS, AGENT FOR STABILIZING BLOOD VESSELS, AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： TIE2 AKTIVATOR，血管内皮生长因子（VEGF）抑制剂，抗血管生成活性，代理为老化的血管，手段正常化血管，MEDIUM用于稳定血管的药物组合物
公开(公告)号：EP2647385A4
公开(公告)日：2014-04-30
申请号：EP11845773
申请日：2011-10-28
申请人： MARUZEN PHARMACEUTICALS CO LTD
发明人： OHTO NOBUAKI , KISO AKINORI
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect. A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.

6. 发明公开

EP2335685A1 SKIN-WHITENING AGENT, ANTI-AGING AGENT, AND SKIN COSMETIC 审中-公开
标题翻译： HAUTAUFHELLUNGSMITTEL，ANT-ANGING-MITTEL UND HAUTKOSMETIKUM
公开(公告)号：EP2335685A1
公开(公告)日：2011-06-22
申请号：EP09813119.6
申请日：2009-09-10
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： TOHI, Keiko , IWAHASHI, Hiroyasu
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/08
CPC分类号： A61K8/97 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/48 , A61K36/67 , A61K36/73 , A61K36/85 , A61K36/88 , A61Q19/02 , A61Q19/08
摘要： A skin-whitening agent or anti-aging agent is provided that contains at least one of bayberry extract, blue flag extract, Japanese pepper extract, cowslip extract, lemon verbena extract, hairy agrimony extract, blueberry extract, celery extract, salt cedar extract and passion fruit extract
摘要翻译：提供了含有杨梅提取物，蓝旗提取物，日本胡椒提取物，牛刀提取物，柠檬马鞭草提取物，毛茛提取物，蓝莓提取物，芹菜提取物，盐杉树提取物中的至少一种的皮肤美白剂或抗老化剂，百香果提取物

7. 发明公开

EP2857032A2 Tie2 activator, vascular endothelial growth factor (vegf) inhibitor, anti-angiogenic agent, agent for maturing blood vessels, agent for normalizing blood vessels, agent for stabilizing blood vessels, and pharmaceutical composition 审中-公开
标题翻译：的Tie2活化剂，血管内皮生长因子（VEGF），抗血管生成剂，抑制剂用于血管的成熟，用于血管正常化的装置，用于血管和药物组合物的稳定化
公开(公告)号：EP2857032A2
公开(公告)日：2015-04-08
申请号：EP14003460.4
申请日：2011-10-28
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： Ohto, Nobuaki , Kiso, Akinori
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect.
A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
摘要翻译：以提供的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，并且具有高安全性的药物组合物，和优异的Tie2活化作用，血管内皮生长因子（VEGF）的抑制作用，血管生成抑制作用，血管成熟作用，血管正常化的作用，和血管稳定作用。甲的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，和含有作为活性成分，山楂提取物，杨桃的药物组合物提取物，贝壳花提取物，莲花提取物，路易波士茶提取物，印度的日期提取物，中国榅桲提取物，番石榴番石榴提取物，长辣椒提取物，皂树提取物，季提取物，银杏提取物，牡蛎提取物，姜黄提取物，菊花提取物，大枣提取物，枸杞中国提取物，甘菊提取物，或布彻的扫帚提取物，或其任何组合。

8. 发明公开

EP2335685A4 SKIN-WHITENING AGENT, ANTI-AGING AGENT, AND SKIN COSMETIC 审中-公开
标题翻译：皮肤美白剂，防自动量程代理皮肤美容
公开(公告)号：EP2335685A4
公开(公告)日：2013-12-04
申请号：EP09813119
申请日：2009-09-10
申请人： MARUZEN PHARMACEUTICALS CO LTD
发明人： TOHI KEIKO , IWAHASHI HIROYASU
IPC分类号： A61K8/97 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/48 , A61K36/67 , A61K36/73 , A61K36/85 , A61K36/88 , A61Q19/02 , A61Q19/08
CPC分类号： A61K8/97 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/48 , A61K36/67 , A61K36/73 , A61K36/85 , A61K36/88 , A61Q19/02 , A61Q19/08

9. 发明公开

EP1859774A1 HAIR COSMETIC 审中-公开
标题翻译：毛发化妆品
公开(公告)号：EP1859774A1
公开(公告)日：2007-11-28
申请号：EP06713701.8
申请日：2006-02-14
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： NOJIMA, Jun, c/o MARUZEN PHARMACEUTICALS CO. LTD , MIYAKE, Yasuo, c/o MARUZEN PHARMACEUTICALS CO. LTD , OHTO, Nobuaki, c/o MARUZEN PHARMACEUTICALS CO. LTD
IPC分类号： A61K6/00
CPC分类号： A61K8/63 , A61K8/66 , A61K31/19 , A61K31/56 , A61K2800/782 , A61Q5/00 , A61Q5/02 , A61Q7/00
摘要： With an object of discovering a substance having a testosterone 5α-reductase inhibiting action, a hair papilla cell growth promoting action, a fibroblast growth factor-7 production promoting action, a vascular endothelial growth factor production promoting action or a bone morphogenetic protein-2 production promoting action, and of providing a hair care product having this substance blended therein, and a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter each having this substance as an active ingredient thereof, a hair care product of the present invention is made to contain corosolic acid therein, and each of a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter of the present invention is made to contain corosolic acid as an active ingredient thereof.
摘要翻译：为了发现具有睾酮5α-还原酶抑制作用，毛乳头细胞生长促进作用，成纤维细胞生长因子-7产生促进作用，血管内皮生长因子产生促进作用或骨形态发生蛋白-2产生的物质促进作用，以及提供其中混有该物质的头发护理产品，以及毛发生长补剂，睾酮5α-还原酶抑制剂，毛乳头细胞生长促进剂，成纤维细胞生长因子-7产生促进剂，血管内皮生长因子生产促进剂和骨形态发生蛋白-2产生促进剂，各自以该物质作为其活性成分，使本发明的护发产品中含有科罗索酸，并且使毛发生长滋养剂，睾酮5α-还原酶抑制剂，毛乳头细胞生长促进剂，成纤维细胞生长因子-7产生促进剂，血管内皮细胞g 本发明的生长因子产生促进剂和骨形态发生蛋白-2产生促进剂含有科罗索酸作为其活性成分。

10. 发明公开

EP1283048A1 Therapeutic agent for improving bladder function or treating urinary disturbance and food and drink containing it 有权
标题翻译：用于改善膀胱功能或治疗Harnwegstörung治疗剂和那些含有食物或饮料
公开(公告)号：EP1283048A1
公开(公告)日：2003-02-12
申请号：EP01127056.8
申请日：2001-11-14
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： Kawashima, Yoshihito, c/o Maruzen Pharma. Co., Ltd , Mizutani, Kenji, c/o Maruzen Pharma. Co., Ltd. , Levin, Robert M.
IPC分类号： A61K35/78 , A61K31/35 , A61K31/70 , A61P13/00
CPC分类号： A61K36/52 , A61K36/185 , A61K36/45 , A61K36/90 , A61K2300/00
摘要： A safe and effective therapeutic agent for improving bladder function or treating urinary disturbance, and food and drink for improving bladder function or treating urinary disturbance are provided. A therapeutic agent for improving bladder function or treating urinary disturbance that contains, as active ingredient, an extract of Engelhardtia chrysolepis or one or more selected from the group consisting of dihydroflavonols and glycosides thereof, and therapeutic food and drink for improving bladder function or treating urinary disturbance are provided.
摘要翻译：提供了用于改善膀胱功能或治疗泌尿道疾病，以及食品和饮料对于改善膀胱功能或治疗泌尿紊乱的安全和有效的治疗剂。用于改善膀胱功能或治疗泌尿道疾病没有治疗剂含有作为活性成分，以提取黄杞或一种或多种选自二氢黄酮醇和糖苷的其选择，治疗食品和饮料对于改善膀胱功能或治疗泌尿提供了干扰。

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