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1. 发明授权

EP2075245B1 Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe 有权
标题翻译：对于细胞内钙离子的实时监控双光子探测器，处理用于使用探针制备探针和方法，用于细胞内钙离子的实时监控
公开(公告)号：EP2075245B1
公开(公告)日：2014-12-31
申请号：EP08163077.4
申请日：2008-08-27
申请人： Korea University Industry and Academy Cooperation Foundation
发明人： Cho, Bong-Rae
IPC分类号： C07C225/22 , C07C237/04 , G01N21/64 , G01N33/58
CPC分类号： C07C237/04 , C07C225/22 , G01N33/582

2. 发明授权

EP1913301B1 SAFETY UNIT 有权
标题翻译：安全单元
公开(公告)号：EP1913301B1
公开(公告)日：2012-01-04
申请号：EP06769334.1
申请日：2006-08-11
申请人： Korea University Industry and Academy Cooperation
发明人： SONG, Jae-Bok , PARK, Jung-Jun , KIM, Byeong-Sang
IPC分类号： F16P7/02
CPC分类号： F16P5/005 , B25J19/063 , B62D1/195 , E05F15/40 , E05F15/608 , E05Y2900/132 , Y10T74/18176 , Y10T74/18184 , Y10T74/20006
摘要： The present invention provides a safety unit comprising: a case; a rotary linkage disposed at one end thereof at the outside of the case and rotatably mounted at the other end thereof to the case; a force transfer shaft mounted to one side of the rotary linkage in such a fashion as to be oriented perpendicular to the rotating plane of the rotary linkage; a crank linkage rotatably mounted at one end thereof to the inner side of the case and adapted to abut against the force transfer shaft at the outer circumferential edge thereof so as to be transferred with an external force to be rotatably moved; and a support means rotatably connected to the other end of the crank linkage and adapted to allow for the rotation of the crank linkage when an external force having a value larger than a predetermined threshold value is exerted to the rotary linkage.

3. 发明授权

EP1763510B1 METHOD FOR SEQUENCING AND QUANTIFYING AMINO ACIDS IN POLYPEPTIDES 有权转让
标题翻译：方法第多肽氨基酸测序和定量
公开(公告)号：EP1763510B1
公开(公告)日：2014-06-18
申请号：EP05756740.6
申请日：2005-06-29
申请人： Korea University Industry and Academy Cooperation Foundation
发明人： LEE, Sang Won , LEE, Yong Ho
IPC分类号： C07B59/00 , C07C331/28 , G01N33/68
CPC分类号： C07C331/28 , C07B59/001 , C07B2200/05 , G01N33/6848 , G01N33/6851 , G01N2458/15

4. 发明公开

EP2075245A3 Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe 有权
标题翻译：对于细胞内钙离子的实时监控双光子探测器，处理用于使用探针制备探针和方法，用于细胞内钙离子的实时监控
公开(公告)号：EP2075245A3
公开(公告)日：2009-12-23
申请号：EP08163077.4
申请日：2008-08-27
申请人： Korea University Industry and Academy Cooperation Foundation
发明人： Cho, Bong-Rae
IPC分类号： C07C225/22 , C07C237/04 , G01N21/64 , G01N33/84
CPC分类号： C07C237/04 , C07C225/22 , G01N33/582
摘要： A two-photon probe for real-time monitoring of intracellular calcium ions is provided. The two-photon probe is very suitable for real-time imaging of intracellular calcium ions, shows 20-50-fold TPEF enhancement in response to Ca 2+ , has a dissociation constant ( Kd TP ) of 0.14 ± 0.02 to 0.25 ± 0.03 µ M, and emits 5-fold stronger TPEF than currently available one-photon fluorescent Ca 2+ probes. Unlike the previously available probes, the two-photon probe can selectively detect dynamic levels of intracellular free Ca 2+ in live cells and living tissues without interference from other metal ions and from the membrane-bound probes. Moreover, the two-photon probe is capable of monitoring the calcium waves at a depth of 100-300 µm in live tissues for 1,100-4,000 s using two-photon microscopy (TPM) with no artifacts of photo-bleaching. Further provided are a method for preparing the two-photon probe and a method for real-time monitoring of intracellular calcium ions using the two-photon probe.

5. 发明授权

EP1871872B1 METHOD FOR ACTIVATING CD8 T CELLS 有权
标题翻译：方法激活CD8 + T细胞
公开(公告)号：EP1871872B1
公开(公告)日：2013-09-04
申请号：EP06702937.1
申请日：2006-01-20
申请人： Korea University Industry and Academy Cooperation
发明人： PARK, Yong, Keun , YOON, Won Suck
IPC分类号： C12N5/0783
CPC分类号： C12N5/0636 , A61K2035/124 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C12N2501/25 , C12N2501/59

6. 发明公开

EP2075245A2 Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe 有权
标题翻译：对于细胞内钙离子的实时监控双光子探测器，处理用于使用探针制备探针和方法，用于细胞内钙离子的实时监控
公开(公告)号：EP2075245A2
公开(公告)日：2009-07-01
申请号：EP08163077.4
申请日：2008-08-27
申请人： Korea University Industry and Academy Cooperation Foundation
发明人： Cho, Bong-Rae
IPC分类号： C07C225/22 , C07C237/04 , G01N21/64 , G01N33/84
CPC分类号： C07C237/04 , C07C225/22 , G01N33/582
摘要： A two-photon probe for real-time monitoring of intracellular calcium ions is provided. The two-photon probe is very suitable for real-time imaging of intracellular calcium ions, shows 20-50-fold TPEF enhancement in response to Ca 2+ , has a dissociation constant ( Kd TP ) of 0.14 ± 0.02 to 0.25 ± 0.03 µ M, and emits 5-fold stronger TPEF than currently available one-photon fluorescent Ca 2+ probes. Unlike the previously available probes, the two-photon probe can selectively detect dynamic levels of intracellular free Ca 2+ in live cells and living tissues without interference from other metal ions and from the membrane-bound probes. Moreover, the two-photon probe is capable of monitoring the calcium waves at a depth of 100-300 µm in live tissues for 1,100-4,000 s using two-photon microscopy (TPM) with no artifacts of photo-bleaching. Further provided are a method for preparing the two-photon probe and a method for real-time monitoring of intracellular calcium ions using the two-photon probe.
摘要翻译：提供了一种用于细胞内钙离子的实时监测的双光子探测器。双光子探针非常适合于细胞内钙离子的实时成像，示出了响应于钙20-50倍TPEF增强，具有0:14±0时02分至0点25±0.03μ的解离常数（Kd TP）比现有的单光子荧光的Ca 2+探针M和发射5倍强TPEF。不同于先前可用探针，双光子探测器可以选择性地检测胞内游离钙的动态水平2+在活细胞和活组织不受其他金属离子的干扰并从膜结合的探针。更完了，双光子探针能够使用双光子显微镜（TPM），没有光致漂白的伪像监测钙波以在1.100至4.000小号活组织100至300微米的深度的。进一步提供的是一种用于制备双光子探针和探针用于使用双光子细胞内钙离子的实时监测的方法。

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