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1. 发明授权

EP2683691B1 PROCESS FOR THE PREPARATION OF (S)-(+)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE AND ESTERS THEREOF BY ENANTIOSELECTIVE REDUCTION OF 10,11-DIHYDRO-10-OXO-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE 有权转让
公开(公告)号：EP2683691B1
公开(公告)日：2018-06-06
申请号：EP12715425.0
申请日：2012-03-06
申请人： Jubilant Life Sciences Limited
发明人： BISWAS, Sujay , DUBEY, Shailendra Kumar , BANSAL, Vikas , MASAND, Mukesh , VIR, Dharam
IPC分类号： C07D223/22
CPC分类号： C07D223/28 , C07D223/22 , Y10T428/2982
摘要： The present invention provides a novel process for the preparation of substituted optically pure (S)-(+)- or (R)-(−)-10-hydroxy-dihydrodibenz[b,f]azepines or derivatives thereof, starting from 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepines using boronate esters or their derivatives. The present invention also provides use of thus prepared (S)-(+)- or (R)-(−)-10-hydroxy-dihydrodibenz[b,f]azepines for the preparation of their ester such as (S)-(−)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide or (R)-(+)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. The present invention also provides novel solid state crystalline forms J1, J2, J3, J4 and amorphous form of eslicarbazepine and the process for the preparation thereof. Also, the present invention provides novel solid state crystalline form and amorphous form of eslicarbazepine acetate and the process for the preparation thereof. The novel solid state forms of eslicarbazepine are useful for the preparation of derivatives of eslicarbazepine such as eslicarbazepine acetate.

2. 发明授权

EP2699548B1 IMPROVED CATALYTIC PROCESS FOR PRODUCTION OF PYRIDINE CARBOXYLIC ACID AMIDES 有权转让
标题翻译：改进的催化工艺用于生产吡啶甲
公开(公告)号：EP2699548B1
公开(公告)日：2017-02-08
申请号：EP12774123.9
申请日：2012-04-14
申请人： Jubilant Life Sciences Limited
发明人： KUMAR, Mahendra , SINGH, Shailendra, Kumar , AGARWAL, Ashutosh
IPC分类号： C07D213/81 , C07D213/82
CPC分类号： C07D213/82 , B01J23/34 , B01J23/864 , B01J23/866 , C07D213/81 , Y02P20/582

3. 发明公开

EP2683691A2 PROCESS FOR THE PREPARATION OF (S)-(+)-OR (R)-(-)-10 HYDROXY DIHYDRODIBENZ[B,F]AZEPINES BY ENANTIOSELECTIVE REDUCTION OF 10, 11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINES AND POLYMORPHS THEREOF 有权转让
标题翻译：工艺用于制备（S） - （+） - 或（R） - （ - ）-10- HYDROXYDIHYDRODIBENZ并[b，F]由对映选择性还原的10氮杂，11二氢-10-氧-5H-二苯并[b， F]氮杂和多晶型物
公开(公告)号：EP2683691A2
公开(公告)日：2014-01-15
申请号：EP12715425.0
申请日：2012-03-06
申请人： Jubilant Life Sciences Limited
发明人： BISWAS,. Sujay , DUBEY, Shailendra Kumar , BANSAL, Vikas , MASAND, Mukesh , VIR, Dharam
IPC分类号： C07D223/22
CPC分类号： C07D223/28 , C07D223/22 , Y10T428/2982
摘要： The present invention provides a novel process for the preparation of substituted optically pure (S)-(+)- or (R)-(−)-10-hydroxy-dihydrodibenz[b,f]azepines or derivatives thereof, starting from 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepines using boronate esters or their derivatives. The present invention also provides use of thus prepared (S)-(+)- or (R)-(−)-10-hydroxy-dihydrodibenz[b,f]azepines for the preparation of their ester such as (S)-(−)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide or (R)-(+)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. The present invention also provides novel solid state crystalline forms J1, J2, J3, J4 and amorphous form of eslicarbazepine and the process for the preparation thereof. Also, the present invention provides novel solid state crystalline form and amorphous form of eslicarbazepine acetate and the process for the preparation thereof. The novel solid state forms of eslicarbazepine are useful for the preparation of derivatives of eslicarbazepine such as eslicarbazepine acetate.
摘要翻译：本发明提供的新方法用于制备substituiertem的旋光纯的（S） - （+） - 或（R） - （ - ） - 10-羟基二氢苯并[b，f]氮杂或其衍生物，从10开始， 11二氢-10-氧-5H-二苯并[b，F]使用硼酸酯或它们的衍生物氮杂。本发明因此提供了使用如此制备（S） - （+） - 或（R） - （ - ） - 10-羟基二氢苯并[b，f]氮杂为它们的酯的制备：如（S） - （ - ） - 10-乙酰氧基-10,11-二氢-5H-二苯并[b，f]氮杂-5-甲酰胺或（R） - （+） - 10-乙酰氧基-10,11-二氢-5H-二苯并[b ，f]氮杂-5-甲酰胺。本发明因此提供新颖的固态晶体形式J1，J2，J3，J4和艾司利卡西平的无定形形式和其制备的过程。所以，本发明提供了新颖的固态晶体形式和乙酸艾司利卡西平的无定形形式和其制备的过程。艾司利卡西平的新的固态形式可用于艾司利卡西平的衍生物的制备有用：如乙酸艾司利卡西平。

4. 发明授权

EP2428505B1 Process for producing pyridine carboxylic acids 有权
标题翻译：一种制备吡啶过程
公开(公告)号：EP2428505B1
公开(公告)日：2016-08-10
申请号：EP11180328.4
申请日：2011-09-07
申请人： Jubilant Life Sciences Limited
发明人： Singh, Shailendra Kumar , Tiwari, Neeraj , Agarwal, Ashutosh
IPC分类号： C07D213/803 , C07D213/807
CPC分类号： C07D213/803 , C07D213/807

5. 发明授权

EP2349976B1 A PROCESS FOR PRODUCING (S)-3-[(1-DIMETHYLAMINO)ETHYL]PHENYL-N-ETHYL-N-METHYL-CARBAMATE VIA NOVEL INTERMEDIATES 有权
标题翻译：用于生产（S）-3 - [（1-二甲基氨基）乙基]苯基-N-乙基-N-甲基氨基甲酸叔丁酯ON的新的中间体
公开(公告)号：EP2349976B1
公开(公告)日：2012-12-26
申请号：EP09740735.7
申请日：2009-08-25
申请人： Jubilant Life Sciences Limited
发明人： DUBEY, Shailendra, Kumar , BANSAL, Vikas , PANNU, Kamaljeet , DUBEY, Sushil, Kumar
IPC分类号： C07C213/00 , C07C269/00 , C07C309/73 , C07C215/50 , C07C271/44
CPC分类号： C07C309/73 , C07B2200/07 , C07C213/00 , C07C269/00 , C07C215/50 , C07C271/44

6. 发明公开

EP2428505A2 Process For Producing Pyridine Carbocyxlic Acids 有权
标题翻译：生产吡啶碳酸羧酸的方法
公开(公告)号：EP2428505A2
公开(公告)日：2012-03-14
申请号：EP11180328.4
申请日：2011-09-07
申请人： Jubilant Life Sciences Limited
发明人： Singh, Shailendra Kumar , Tiwari, Neeraj , Agarwal, Ashutosh
IPC分类号： C07D213/803 , C07D213/807
CPC分类号： C07D213/803 , C07D213/807
摘要： Disclosed is a cost effective and ecofriendly large scale process for producing pyridine carboxylic acid with high purity and yield at industrial scale.
摘要翻译：公开了一种用于以工业规模生产高纯度和产率的吡啶羧酸的成本有效且环保的大规模工艺。

7. 发明公开

EP3534708A1 SYNERGISTIC ANTIMICROBIAL COMPOSITIONS 审中-公开
公开(公告)号：EP3534708A1
公开(公告)日：2019-09-11
申请号：EP17808164.2
申请日：2017-11-06
申请人： Jubilant Life Sciences Limited
发明人： SHARMA, Vineet , DE, Rwittika , VERMA, Pradeep Kumar , AGARWAL, Ashutosh
IPC分类号： A01N33/12 , A01N43/40 , A01N43/50 , A61K31/14 , A61K31/4164 , A61K31/4412 , A61K31/60 , A61K8/41 , A01P1/00

8. 发明公开

EP2699548A1 IMPROVED CATALYTIC PROCESS FOR PRODUCTION OF PYRIDINE CARBOXYLIC ACID AMIDES 有权转让
标题翻译：改进的催化工艺用于生产吡啶甲
公开(公告)号：EP2699548A1
公开(公告)日：2014-02-26
申请号：EP12774123.9
申请日：2012-04-14
申请人： Jubilant Life Sciences Limited
发明人： KUMAR, Mahendra , SINGH, Shailendra, Kumar , AGARWAL, Ashutosh
IPC分类号： C07D213/81
CPC分类号： C07D213/82 , B01J23/34 , B01J23/864 , B01J23/866 , C07D213/81 , Y02P20/582
摘要： An improved catalytic process for the production of pyridine carboxylic acid amides, by catalytic hydration reaction of pyridine nitriles with solid heterogeneous catalyst wherein the process involve effective utilization and recycling of the catalytic components, and reactants.

9. 发明授权

EP3160228B1 SYNERGISTIC ANTIMICROBIAL COMPOSITION OF ZINC PYRITHIONE 失效转让
公开(公告)号：EP3160228B1
公开(公告)日：2018-10-31
申请号：EP14824128.4
申请日：2014-11-07
申请人： Jubilant Life Sciences Limited
发明人： SHARMA, Vineet , AGARWAL, Ashutosh
IPC分类号： A01N43/40 , A01P3/00 , A61K8/27 , A61K8/49 , A61Q5/00 , C09D5/16 , A01N59/16
CPC分类号： A01N59/16 , A01N43/40 , A61K8/27 , A61K8/4926 , A61K8/4933 , A61K2800/58 , A61Q5/006 , A61Q17/005 , C09D5/14 , C09D5/1612 , C09D5/1625 , C09D131/02
摘要： The present invention discloses synergistic antimicrobial composition comprises zinc pyrithione and a zinc salt of pyridine carboxylic acid.

10. 发明公开

EP3041356A1 ANTI-DANDRUFF COMPOSITIONS AND HAIR CARE FORMULATIONS CONTAINING ZINC PYRITHIONE AND QUATERNARY AMMONIUM SALT 有权
标题翻译：抗肿瘤药物联合化疗联合麻醉药物联合治疗
公开(公告)号：EP3041356A1
公开(公告)日：2016-07-13
申请号：EP14786728.7
申请日：2014-09-02
申请人： Jubilant Life Sciences Limited
发明人： SHARMA, Vineet , AGARWAL, Ashutosh
IPC分类号： A01N43/40 , A01N59/16 , A01N33/12 , A01N33/08 , A01N25/02 , A01N25/30 , A61K8/41 , A61K8/49 , A61Q5/00
CPC分类号： A61K8/58 , A01N33/08 , A01N33/12 , A01N43/40 , A01N59/16 , A61K8/345 , A61K8/41 , A61K8/416 , A61K8/4926 , A61K8/4933 , A61K2800/262 , A61K2800/524 , A61K2800/591 , A61Q5/006 , A01N25/02 , A01N25/30
摘要： The present invention discloses a stable biocidal composition with enhanced antifungal activity at low concentration of active (s) and a process for preparing the same. The composition comprises: zinc pyrithione, C8-C18 quaternary ammonium salt (preferably cetylpyridinium chloride), water miscible glycol/polyol/glycol ether/lactam, organic amine and/or alkanol amine. The composition can be formulated into: hair care formulations, antidandruff hair care formulations, water based paints, coatings, adhesives, hard surface cleaners, fabric care compositions, wood products, plastic products and medical products. The biocidal compositions and the resulting formulations are transparent or opaque and are stable at varying pH and humidity conditions.
摘要翻译：本发明公开了一种在低浓度活性物质下具有增强的抗真菌活性的稳定的杀生物组合物及其制备方法。组合物包括：吡啶硫酮锌，C 8 -C 18季铵盐（优选氯化十六烷基吡啶鎓），水混溶性二醇/多元醇/二醇醚/内酰胺，有机胺和/或链烷醇胺。组合物可以配制成：护发配方，头皮护发配方，水基涂料，涂料，粘合剂，硬表面清洁剂，织物护理组合物，木制品，塑料制品和医疗产品。杀生物组合物和所得制剂是透明的或不透明的，并且在不同的pH和湿度条件下是稳定的。

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