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    • 4. 发明公开
    • COMPOSITION
    • EP4230223A1
    • 2023-08-23
    • EP21880033.2
    • 2021-10-11
    • Josho Gakuen Educational FoundationADEKA CORPORATION
    • SAKUMA ShinjiTOMONO TakumiMIYATA KoheiSHIGENO Koichi
    • A61K47/34A61K39/395A61K47/32C07K7/00C07K14/00C07K16/00
    • The object of the present invention is to provide an absorption enhancer capable of introducing high-molecular weight compounds into cells.
      The object can be solved by a composition of the present invention comprising a polymer compound having a group represented by the following general formula (1) or the following general formula (2) at a side chain, and a compound to be administered with a molecular weight of 1,000 to 1,200,000.

      wherein X 1 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X 2 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X 3 is a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms or a benzyloxy group, a is an integer of 0 to 50, and * denotes a bonding site.
      wherein X 4 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X 5 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X 6 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group or an oxycarbonyl group, b is an integer of 0 to 50, and * denotes a bonding site.