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1. 发明公开

EP3915984A1 SYNTHESIS OF 3-BROMO-5-(2-ETHYLIMIDAZO[1,2-alpha]PYRIDINE-3-CARBONYL)-2-HYDROXYBENZONITRILE 审中-公开
公开(公告)号：EP3915984A1
公开(公告)日：2021-12-01
申请号：EP20740931.9
申请日：2020-01-17
申请人： Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd.
发明人： SHI, Dongfang , FU, Changjin , GU, Jie , ZHANG, Min , GONG, Weiwei , LI, Pengfei
IPC分类号： C07D471/04
摘要： Disclosed in the present invention is a synthesis method for 3-bromo-5-(2-ethylimidazo[1,2-a] pyridine-3-carbonyl)-2-hydroxybenzonitrile, relating in particular to a synthesis method for a compound represented by formula (III), which specifically involves step A or step B; step A comprises: a compound represented by formula (I) and a compound represented by formula (II) first reacting by means of heating in an organic solvent, and a resulting reaction product and a bases are further being heated in the presence of water to continue reacting so as to obtain a compound represented by formula (III); step B comprises: the compound represented by formula (I), the compound represented by formula (II), and a base first reacting by means of heating in an organic solvent, and a resulting reaction product then being heated in the presence of water to continue reacting so as to obtain the compound represented by formula (III).

2. 发明公开

EP3632904A1 URAT1 INHIBITOR FOR PROMOTING URIC ACID EXCRETION 有权转让
公开(公告)号：EP3632904A1
公开(公告)日：2020-04-08
申请号：EP18806684.9
申请日：2018-05-25
申请人： Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd.
发明人： SHI, Dongfang , ZHU, Jianghua , GU, Jie , CHENG, Xi , YANG, Yan , ZHOU, He , LI, Pengfei , WU, Fan
IPC分类号： C07D307/80 , C07D471/04 , A61K31/343 , A61K31/437 , A61P13/12 , A61P19/06
摘要： The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout.

3. 发明授权

EP3296294B1 COMPOUND FOR TREATING OR PREVENTING BREAST CANCER 有权
公开(公告)号：EP3296294B1
公开(公告)日：2020-02-12
申请号：EP16792124.6
申请日：2016-05-06
申请人： Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd
发明人： SHI, Dongfang , FU, Changjin , CHENG, Xi , ZHU, jianghua
IPC分类号： C07D293/12 , A61K31/41 , A61P35/00

4. 发明公开

EP3348557A1 COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT 有权
公开(公告)号：EP3348557A1
公开(公告)日：2018-07-18
申请号：EP16843670.7
申请日：2016-09-08
申请人： Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd
发明人： SHI, Dongfang , FU, Changjin , CHENG, Xi , ZHU, Jianghua , WEN, Jie , GU, Jie
IPC分类号： C07D471/04 , A61K31/437 , A61P19/06
CPC分类号： C07D471/04 , A61K31/437 , A61P19/06
摘要： Provided are a compound as represented in formula (I), a pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and uses thereof. The compound as represented in formula (I) and the pharmaceutically acceptable salts thereof are used in the preparation of medicines for the treatment or prevention of hyperuricemia or gout by means of uric acid excretion.

5. 发明公开

EP3296294A1 COMPOUND FOR TREATING OR PREVENTING BREAST CANCER 有权
标题翻译：治疗或预防乳腺癌的化合物
公开(公告)号：EP3296294A1
公开(公告)日：2018-03-21
申请号：EP16792124.6
申请日：2016-05-06
申请人： Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd
发明人： SHI, Dongfang , FU, Changjin , CHENG, Xi , ZHU, jianghua
IPC分类号： C07D293/12 , A61K31/41 , A61P35/00
摘要： Disclosed are a class of compounds for treating or preventing breast cancer, in particular 2-phenyl benzoselenazole compounds, and a pharmaceutically acceptable salt thereof and an easily hydrolysable prodrug thereof. Further disclosed are a pharmaceutical composition containing these compounds and the use of such compounds for for treating or preventing breast cancer in mammals. The compounds of the present invention can effectively inhibit or reduce the growth or proliferation of mammalian breast cancer cells, and at the same time, such compounds do not inhibit the growth of partial test cells, apart from breast cancer cells in mammals, and have a good selectivity. Such compounds show a more obvious medicinal effect, and have high selectivivity, low toxicity and few side effects.
摘要翻译：公开了一类用于治疗或预防乳腺癌的化合物，特别是2-苯基苯并硒唑化合物及其药学上可接受的盐和其易水解的前药。还公开了含有这些化合物的药物组合物以及这些化合物用于治疗或预防哺乳动物乳腺癌的用途。本发明的化合物可以有效地抑制或减少哺乳动物乳腺癌细胞的生长或增殖，同时除了哺乳动物的乳腺癌细胞外，这些化合物不抑制部分测试细胞的生长，并且具有选择性好。这类化合物具有更明显的药效，选择性高，毒性小，副作用少。

6. 发明公开

EP4335844A1 CLASS OF XANTHINE OXIDASE INHIBITORS 审中-实审
公开(公告)号：EP4335844A1
公开(公告)日：2024-03-13
申请号：EP22798605.6
申请日：2022-04-28
申请人： Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd.
发明人： SHI, Dongfang , FU, Changjin , YANG, Yan
IPC分类号： C07D403/04 , C07D401/04 , C07D409/04 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/4439 , A61P19/06
摘要： The present invention relates to a class of xanthine oxidase inhibitors, which are compounds as represented by general formula (I) or pharmaceutically acceptable salts thereof. The xanthine oxidase inhibitors have an excellent xanthine oxidase inhibitory activity, and have potential application value in anti-gout drugs, anti-hyperuricemia drugs, etc.

7. 发明公开

EP3805216A1 COMPOUNDS FOR TREATMENT OR PREVENTION OF LIVER DISEASES 审中-实审
公开(公告)号：EP3805216A1
公开(公告)日：2021-04-14
申请号：EP19814910.6
申请日：2019-06-05
申请人： Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd.
发明人： SHI, Dongfang , FU, Changjin , CHENG, Xi , GONG, Weiwei , GU, Jie , LI, Pengfei , ZHANG, Min , YANG, Yan , JIN, Wenqing
IPC分类号： C07D407/04 , A61K31/357 , A61P1/16 , A61P37/02 , A61P37/08
摘要： The invention discloses compounds for treatment or prevention of liver diseases. The compounds are compounds represented by a formula (I) or (II), optical isomers or pharmaceutically acceptable salts of the compounds. The compounds and optical isomers or pharmaceutically acceptable salts of the compounds can be applied to preparation of drugs for treatment or prevention of liver diseases.

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