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1. 发明授权

EP1950578B8 Superconductive quantum interference device (squid) system for measuring magnetic susceptibility of materials 有权转让
标题翻译：超导Quanteninterferometersystem（SQUID），用于测量材料的磁化率
公开(公告)号：EP1950578B8
公开(公告)日：2012-03-14
申请号：EP07106654.2
申请日：2007-04-20
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Jen-Jie CHIEH , Chin-Yih Rex HONG , Herng-Er HORNG , Hong-Chang YANG , Shieh-Yueh YANG
IPC分类号： G01R33/035
CPC分类号： G01R33/0354 , G01R33/16

2. 发明公开

EP2385365A2 Method for tumor detection using T1 measurements and a SQUID-based tabletop NMR system 审中-公开
标题翻译：的使用的SQUID表-NMR系统由T1测量检测肿瘤的方法
公开(公告)号：EP2385365A2
公开(公告)日：2011-11-09
申请号：EP11003664.7
申请日：2011-05-04
申请人： Huang, Kai-Wen , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Huang, Kai-Wen , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N24/08 , G01R33/30 , G01R33/36 , G01R33/465 , G01R33/48 , G01R33/50
CPC分类号： G01N24/08 , A61B5/055 , G01R33/326 , G01R33/445 , G01R33/50
摘要： The present invention provides a method for rapid detecting tumor. Moreover, this invention uses only the T 1 -1 value as a parameter to distinguish tumor from normal tissue, and the accuracy of this detection is highly reliable.
摘要翻译：本发明提供用于快速检测肿瘤的方法。更过，本发明仅使用T 1 -1值作为参数来从正常组织区分肿瘤，并且该检测的精度的可靠性高。

3. 发明公开

EP2224236A1 Device for measuring ac magnetization of materials and method for detecting bio-molecules 有权转让
标题翻译：用于测量材料的交流磁化和方法用于检测生物分子的装置
公开(公告)号：EP2224236A1
公开(公告)日：2010-09-01
申请号：EP10154646.3
申请日：2010-02-25
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N27/74 , G01N33/53 , G01N33/543
CPC分类号： G01N27/745 , B82Y5/00 , B82Y15/00 , B82Y25/00 , G01N33/5302 , G01N33/54326 , G01N33/54333 , G01N33/54346 , G01N33/5438
摘要： A method to quantitatively measure an amount of bio-molecules in a sample includes providing a solution having magnetic nanoparticles; coating bioprobe molecules to surfaces of the magnetic nanoparticles in the solution; measuring a first alternating current (ac) magnetization of the solution at a mixture frequency (γf 1 + βf 2 ), wherein γ or β is independently an integer larger than zero; adding a sample containing the bio-molecules to be detected to the solution, so that the biomolecules in the sample conjugate with the bioprobe molecules coated on the nanoparticles; and measuring a second ac magnetization of the solution at the mixture frequency (γf 1 + βf 2 ) after adding the sample and incubation, so as to obtain an ac magnetization reduction at the mixture frequency (γf 1 + βf 2 ) between the first and the second magnetization to determine the amount of the bio-molecules.
摘要翻译：到的样品中的生物分子的量的定量测量的方法，包括：提供具有磁性纳米粒子的溶液; 涂层的生物样品的分子在溶液中的磁性纳米粒子的表面; 在混合物频率溶液的测量第一交流电流（AC）磁化强度（³F²f1 + 2），worin³或²是独立的整数大于零; 加入含有生物分子被检测到该溶液中的样品，所以没有与涂敷在纳米颗粒中的生物样品分子的样品共轭生物分子; 和测量在混合物频率的解决方案的第二交流磁化（³F1 +²f2）将所述样品和温育，以便获得在交流磁化量减量在第一之间的混合频率（³F1 +²f2）之后和第二磁化确定性矿生物分子的量。

4. 发明公开

EP1950578A2 Superconductive quantum interference device (squid) system for measuring magnetic susceptibility of materials 有权转让
标题翻译：量子信号测量系统（SQUID）zum Messen der magnetischenSuszeptibilitätvon Materialien
公开(公告)号：EP1950578A2
公开(公告)日：2008-07-30
申请号：EP07106654.2
申请日：2007-04-20
申请人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Hung, Angelo Chen-Jong , Yang, Shieh-Yueh , Yang, Hong-Chang
发明人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Hung, Angelo Chen-Jong , Yang, Shieh-Yueh , Yang, Hong-Chang
IPC分类号： G01R33/035
CPC分类号： G01R33/0354 , G01R33/16
摘要： A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf 1 + nf 2 , where f 1 and f 2 are two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.
摘要翻译：提供了一种超导量子干涉装置（SQUID）系统，用于测量单个频率的材料的交流（AC）磁化率或来自多个频率的混频，如mf 1 + nf 2，其中f 1和f 2为两个初级线圈的两个激励频率。该系统包括用于在样品上产生AC磁通量的磁通量源单元和用于经由磁通量变换器从样本读出感应磁通量的磁通量读取单元。磁通量读取单元包括用于检测感应磁通量的SQUID，以便在转换计算中获得样品的磁化率。

5. 发明公开

EP1865324A1 Diagnostic methods using magnetic nanoparticles 审中-公开
标题翻译：诊断病人
公开(公告)号：EP1865324A1
公开(公告)日：2007-12-12
申请号：EP07106904.1
申请日：2007-04-25
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Wu, Chau-Chung , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Wu, Chau-Chung , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N33/543
CPC分类号： G01N33/54326
摘要： The present invention is designed as the diagnostic methods using magnetic nanoparticles to quantitatively measure the ligands or biomolecules for assessing/evaluating the status or risks of diseases, such as atherosclerosis, infection/inflammatory diseases, and tumors. Through the use of the magnetic nanoparticles and the bio-receptors coated to the magnetic nanoparticles, the ligands conjugated with the bio-receptors can be detected or marked, and the amount of the ligands in a sample can be determined by measuring the changes in magnetic properties resulting from the existence of the ligands.
摘要翻译：本发明被设计为使用磁性纳米颗粒定量测量配体或生物分子以评估/评估疾病如动脉粥样硬化，感染/炎性疾病和肿瘤的状况或风险的诊断方法。通过使用磁性纳米颗粒和涂覆到磁性纳米颗粒的生物受体，可以检测或标记与生物受体结合的配体，并且样品中配体的量可以通过测量磁性变化来确定由配体的存在产生的性质。

6. 发明授权

EP0972289B1 MAGNETIC FLUID THIN FILM DISPLAYS 失效
标题翻译：薄膜显示器设备使用液态MAGNETISIEBARER
公开(公告)号：EP0972289B1
公开(公告)日：2004-03-24
申请号：EP98914401.9
申请日：1998-04-01
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yeung, Wai-Bong
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yeung, Wai-Bong
IPC分类号： H01F1/44 , G02F1/09
CPC分类号： H01F1/44 , G02F1/09 , G02F1/23 , G02F2201/305

7. 发明公开

EP0933800A3 Cyclotron displays 审中-公开
标题翻译： Zyklotronanzeigevorrichtung
公开(公告)号：EP0933800A3
公开(公告)日：2001-05-16
申请号：EP99102142.9
申请日：1999-02-03
申请人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
发明人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
IPC分类号： H01J31/12 , H01J29/48
CPC分类号： H01J29/48 , H01J3/02 , H01J29/04 , H01J29/62
摘要： The present invention comprises cyclotron display devices similar to cathode ray tubes (CRTs) in which the CRT electron gun is replaced by one or more cyclotrons that produce electrons using lower voltages and energy costs than a CRT electron gun does. This can be done both with monochrome and color displays, as disclosed. In addition, the electrons emerge from the cyclotron with adequate velocity, thus obviating the need for accelerating electrodes. The need for electron focusing is also greatly reduced, or eliminated, since the electrons emerge from the cyclotrons as beams, rather than as diffuse clouds. The cyclotron display assembly can be made to be significantly shorter than the conventional electron gun CRT. In addition, an array of cyclotrons, rather than just a single one, can be used, so that each cyclotron maps to a fractional portion of the video screen. This further shortens the length of the cyclotron display.

8. 发明公开

EP1950578A3 Superconductive quantum interference device (squid) system for measuring magnetic susceptibility of materials 有权转让
标题翻译：超导Quanteninterferometersystem（SQUID），用于测量材料的磁化率
公开(公告)号：EP1950578A3
公开(公告)日：2010-03-24
申请号：EP07106654.2
申请日：2007-04-20
申请人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01R33/035
CPC分类号： G01R33/0354 , G01R33/16
摘要： A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf 1 + nf 2 , where f 1 and f 2 are two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.

9. 发明公开

EP2045599A2 Ultra-sensitive magnetoreduction measurement system and method for determining the concentration of epitope-biomolecules 审中-公开
标题翻译： Hochempfindliches Magnetreduktionsmesssystem und Methode zur Bestimmung der Konzentration von Epitop-Biomolekülen
公开(公告)号：EP2045599A2
公开(公告)日：2009-04-08
申请号：EP08075808.9
申请日：2008-10-04
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N27/74
CPC分类号： G01N27/74 , G01N27/76 , G01N33/54326
摘要： An ultra-sensitive SQUID-based magnetoreduction measurement system for performing an assay is provided, wherein the system is capable of measuring the concentration of multiple-active-epitope biomolecules, single-active-epitope biomolecules, or small biomolecules with high sensitivity. The sensitivity of the ultra-sensitive magnetoreduction measurement system is 1 ppt or below. The system includes a sample unit and a sensor unit. The sample unit includes excitation coils and a pick up coil, and a sample housed inside the pick up coil, wherein the sample contains at least magnetic nanoparticles coated with bio-receptors that are conjugated with to-be-detected biomolecules. The sensor unit includes a SQUID magnetometer and a couple coil, wherein the magnetization of the sample sensed by the pick-up coil is transferred to the magnetometer at the sensor unit via the couple coil.
摘要翻译：提供了一种用于进行测定的超灵敏SQUID磁还原测量系统，其中该系统能够测量具有高灵敏度的多活性表位生物分子，单活性表位生物分子或小生物分子的浓度。超灵敏磁化测量系统的灵敏度为1 ppt或更低。该系统包括一个采样单元和一个传感器单元。样品单元包括激发线圈和拾取线圈，以及容纳在拾取线圈内的样品，其中样品至少包含被与被检测的生物分子结合的生物受体涂覆的磁性纳米颗粒。传感器单元包括SQUID磁力计和耦合线圈，其中由拾取线圈感测的样本的磁化通过耦合线圈传递到传感器单元处的磁力计。

10. 发明公开

EP0933800A2 Cyclotron displays 审中-公开
标题翻译：回旋加速器显示器
公开(公告)号：EP0933800A2
公开(公告)日：1999-08-04
申请号：EP99102142.9
申请日：1999-02-03
申请人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
发明人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
IPC分类号： H01J31/12 , H01J29/48
CPC分类号： H01J29/48 , H01J3/02 , H01J29/04 , H01J29/62
摘要： The present invention comprises cyclotron display devices similar to cathode ray tubes (CRTs) in which the CRT electron gun is replaced by one or more cyclotrons that produce electrons using lower voltages and energy costs than a CRT electron gun does. This can be done both with monochrome and color displays, as disclosed. In addition, the electrons emerge from the cyclotron with adequate velocity, thus obviating the need for accelerating electrodes. The need for electron focusing is also greatly reduced, or eliminated, since the electrons emerge from the cyclotrons as beams, rather than as diffuse clouds. The cyclotron display assembly can be made to be significantly shorter than the conventional electron gun CRT. In addition, an array of cyclotrons, rather than just a single one, can be used, so that each cyclotron maps to a fractional portion of the video screen. This further shortens the length of the cyclotron display.
摘要翻译：本发明包括类似于阴极射线管（CRT）的回旋加速器显示装置，其中CRT电子枪被一个或多个回旋加速器代替，该回旋加速器使用比CRT电子枪更低的电压和能量成本产生电子。如所公开的，这可以通过单色和彩色显示器来完成。另外，电子以适当的速度从回旋加速器出射，因此不需要加速电极。对电子聚焦的需求也大大减少或消除，因为电子从回旋加速器射出而不是散射云。回旋加速器显示组件可以做得比传统电子枪CRT短得多。另外，可以使用一系列回旋加速器而不是单一回旋加速器，以便每个回旋加速器映射到视频屏幕的小数部分。这进一步缩短了回旋加速器显示器的长度。

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