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1. 发明公开

EP1950578A2 Superconductive quantum interference device (squid) system for measuring magnetic susceptibility of materials 有权转让
标题翻译：量子信号测量系统（SQUID）zum Messen der magnetischenSuszeptibilitätvon Materialien
公开(公告)号：EP1950578A2
公开(公告)日：2008-07-30
申请号：EP07106654.2
申请日：2007-04-20
申请人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Hung, Angelo Chen-Jong , Yang, Shieh-Yueh , Yang, Hong-Chang
发明人： Chieh, Jen-Jie , Hong, Chin-Yih Rex , Horng, Herng-Er , Hung, Angelo Chen-Jong , Yang, Shieh-Yueh , Yang, Hong-Chang
IPC分类号： G01R33/035
CPC分类号： G01R33/0354 , G01R33/16
摘要： A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf 1 + nf 2 , where f 1 and f 2 are two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.
摘要翻译：提供了一种超导量子干涉装置（SQUID）系统，用于测量单个频率的材料的交流（AC）磁化率或来自多个频率的混频，如mf 1 + nf 2，其中f 1和f 2为两个初级线圈的两个激励频率。该系统包括用于在样品上产生AC磁通量的磁通量源单元和用于经由磁通量变换器从样本读出感应磁通量的磁通量读取单元。磁通量读取单元包括用于检测感应磁通量的SQUID，以便在转换计算中获得样品的磁化率。

2. 发明公开

EP1865324A1 Diagnostic methods using magnetic nanoparticles 审中-公开
标题翻译：诊断病人
公开(公告)号：EP1865324A1
公开(公告)日：2007-12-12
申请号：EP07106904.1
申请日：2007-04-25
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Wu, Chau-Chung , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Wu, Chau-Chung , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N33/543
CPC分类号： G01N33/54326
摘要： The present invention is designed as the diagnostic methods using magnetic nanoparticles to quantitatively measure the ligands or biomolecules for assessing/evaluating the status or risks of diseases, such as atherosclerosis, infection/inflammatory diseases, and tumors. Through the use of the magnetic nanoparticles and the bio-receptors coated to the magnetic nanoparticles, the ligands conjugated with the bio-receptors can be detected or marked, and the amount of the ligands in a sample can be determined by measuring the changes in magnetic properties resulting from the existence of the ligands.
摘要翻译：本发明被设计为使用磁性纳米颗粒定量测量配体或生物分子以评估/评估疾病如动脉粥样硬化，感染/炎性疾病和肿瘤的状况或风险的诊断方法。通过使用磁性纳米颗粒和涂覆到磁性纳米颗粒的生物受体，可以检测或标记与生物受体结合的配体，并且样品中配体的量可以通过测量磁性变化来确定由配体的存在产生的性质。

3. 发明授权

EP0972289B1 MAGNETIC FLUID THIN FILM DISPLAYS 失效
标题翻译：薄膜显示器设备使用液态MAGNETISIEBARER
公开(公告)号：EP0972289B1
公开(公告)日：2004-03-24
申请号：EP98914401.9
申请日：1998-04-01
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yeung, Wai-Bong
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yeung, Wai-Bong
IPC分类号： H01F1/44 , G02F1/09
CPC分类号： H01F1/44 , G02F1/09 , G02F1/23 , G02F2201/305

4. 发明公开

EP0933800A3 Cyclotron displays 审中-公开
标题翻译： Zyklotronanzeigevorrichtung
公开(公告)号：EP0933800A3
公开(公告)日：2001-05-16
申请号：EP99102142.9
申请日：1999-02-03
申请人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
发明人： Horng, Herng-Er , Yeung, Wai-Bong , Yang, Kai
IPC分类号： H01J31/12 , H01J29/48
CPC分类号： H01J29/48 , H01J3/02 , H01J29/04 , H01J29/62
摘要： The present invention comprises cyclotron display devices similar to cathode ray tubes (CRTs) in which the CRT electron gun is replaced by one or more cyclotrons that produce electrons using lower voltages and energy costs than a CRT electron gun does. This can be done both with monochrome and color displays, as disclosed. In addition, the electrons emerge from the cyclotron with adequate velocity, thus obviating the need for accelerating electrodes. The need for electron focusing is also greatly reduced, or eliminated, since the electrons emerge from the cyclotrons as beams, rather than as diffuse clouds. The cyclotron display assembly can be made to be significantly shorter than the conventional electron gun CRT. In addition, an array of cyclotrons, rather than just a single one, can be used, so that each cyclotron maps to a fractional portion of the video screen. This further shortens the length of the cyclotron display.

5. 发明授权

EP1950578B8 Superconductive quantum interference device (squid) system for measuring magnetic susceptibility of materials 有权转让
标题翻译：超导Quanteninterferometersystem（SQUID），用于测量材料的磁化率
公开(公告)号：EP1950578B8
公开(公告)日：2012-03-14
申请号：EP07106654.2
申请日：2007-04-20
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Jen-Jie CHIEH , Chin-Yih Rex HONG , Herng-Er HORNG , Hong-Chang YANG , Shieh-Yueh YANG
IPC分类号： G01R33/035
CPC分类号： G01R33/0354 , G01R33/16

6. 发明公开

EP2385365A2 Method for tumor detection using T1 measurements and a SQUID-based tabletop NMR system 审中-公开
标题翻译：的使用的SQUID表-NMR系统由T1测量检测肿瘤的方法
公开(公告)号：EP2385365A2
公开(公告)日：2011-11-09
申请号：EP11003664.7
申请日：2011-05-04
申请人： Huang, Kai-Wen , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Huang, Kai-Wen , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N24/08 , G01R33/30 , G01R33/36 , G01R33/465 , G01R33/48 , G01R33/50
CPC分类号： G01N24/08 , A61B5/055 , G01R33/326 , G01R33/445 , G01R33/50
摘要： The present invention provides a method for rapid detecting tumor. Moreover, this invention uses only the T 1 -1 value as a parameter to distinguish tumor from normal tissue, and the accuracy of this detection is highly reliable.
摘要翻译：本发明提供用于快速检测肿瘤的方法。更过，本发明仅使用T 1 -1值作为参数来从正常组织区分肿瘤，并且该检测的精度的可靠性高。

7. 发明公开

EP2224236A1 Device for measuring ac magnetization of materials and method for detecting bio-molecules 有权转让
标题翻译：用于测量材料的交流磁化和方法用于检测生物分子的装置
公开(公告)号：EP2224236A1
公开(公告)日：2010-09-01
申请号：EP10154646.3
申请日：2010-02-25
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N27/74 , G01N33/53 , G01N33/543
CPC分类号： G01N27/745 , B82Y5/00 , B82Y15/00 , B82Y25/00 , G01N33/5302 , G01N33/54326 , G01N33/54333 , G01N33/54346 , G01N33/5438
摘要： A method to quantitatively measure an amount of bio-molecules in a sample includes providing a solution having magnetic nanoparticles; coating bioprobe molecules to surfaces of the magnetic nanoparticles in the solution; measuring a first alternating current (ac) magnetization of the solution at a mixture frequency (γf 1 + βf 2 ), wherein γ or β is independently an integer larger than zero; adding a sample containing the bio-molecules to be detected to the solution, so that the biomolecules in the sample conjugate with the bioprobe molecules coated on the nanoparticles; and measuring a second ac magnetization of the solution at the mixture frequency (γf 1 + βf 2 ) after adding the sample and incubation, so as to obtain an ac magnetization reduction at the mixture frequency (γf 1 + βf 2 ) between the first and the second magnetization to determine the amount of the bio-molecules.
摘要翻译：到的样品中的生物分子的量的定量测量的方法，包括：提供具有磁性纳米粒子的溶液; 涂层的生物样品的分子在溶液中的磁性纳米粒子的表面; 在混合物频率溶液的测量第一交流电流（AC）磁化强度（³F²f1 + 2），worin³或²是独立的整数大于零; 加入含有生物分子被检测到该溶液中的样品，所以没有与涂敷在纳米颗粒中的生物样品分子的样品共轭生物分子; 和测量在混合物频率的解决方案的第二交流磁化（³F1 +²f2）将所述样品和温育，以便获得在交流磁化量减量在第一之间的混合频率（³F1 +²f2）之后和第二磁化确定性矿生物分子的量。

8. 发明公开

EP3578653A3 METHOD OF APTAMER SELECTION AND METHOD FOR PURIFYING BIOMOLECULES WITH APTAMERS 审中-公开
公开(公告)号：EP3578653A3
公开(公告)日：2020-01-08
申请号：EP19177160.9
申请日：2019-05-29
申请人： Hong, Chin-Yih , Horng, Herng-Er
发明人： Hong, Chin-Yih , Horng, Herng-Er
IPC分类号： C12N15/10 , C12N15/115
摘要： The present invention proposes a method of using oligonucleotide aptamers binding with certain specific biomolecules associated with a disease to purify the specific biomolecules from disease patient's samples and to identify biomarkers for the particular disease. The present invention describes a method using the magnetic assisted rapid aptamer selection (MARAS) to select aptamers having high binding affinity for certain disease-related biomolecules and not for other non-disease-related biomolecules from nucleic acid libraries. Meanwhile, the present invention also proposes a method of using the aptamer obtained above as a capture ligand to purify certain specific biomolecules related to a disease from disease patients' samples. Further, the present invention describes the use of the obtained aptamer as the capture ligand to purify biomolecules with a specific binding affinity range by applying an oscillating magnetic field range as a virtual filter.

9. 发明公开

EP2138835A1 Method and system for suppressing bindings on magnetic particles 有权转让
标题翻译： Verfahren und System zurUnterdrückungvon Bindungen一个磁铁Teilchen
公开(公告)号：EP2138835A1
公开(公告)日：2009-12-30
申请号：EP09251627.7
申请日：2009-06-23
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er , Yang, Hong-Chang , Yang, Shieh-Yueh
IPC分类号： G01N27/76 , G01N33/543 , G01N35/00
CPC分类号： G01N33/54333
摘要： A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.
摘要翻译：用于抑制分子之间的非特异性结合的方法包括提供分散在液体中的磁性颗粒，其中每个磁性颗粒具有磁化强度。磁性颗粒涂覆有涂层分子。将混合有第一类型结合分子和第二类型结合分子的结合分子应用于液体，其中涂层分子与第一型结合分子特异性结合，并与第二型结合分子非特异性结合。在具有频率水平的轴上施加交流（ac）磁场，其中频率水平引起第二类结合分子与涂层分子结合的抑制。

10. 发明公开

EP1016097A1 ORDERED STRUCTURES IN HOMOGENEOUS MAGNETIC FLUID THIN FILMS AND METHOD OF PREPARATION 失效
标题翻译：磁性薄膜齐油液小构造及其制造方法
公开(公告)号：EP1016097A1
公开(公告)日：2000-07-05
申请号：EP98914444.9
申请日：1998-04-01
申请人： Hong, Chin-Yih Rex , Horng, Herng-Er
发明人： Hong, Chin-Yih Rex , Horng, Herng-Er
IPC分类号： H01F1/44
CPC分类号： B82Y25/00 , G02F1/09 , H01F1/009 , H01F1/44 , H01F1/445
摘要： Methods for preparing homogeneous magnetic fluid compositions capable of forming ordered one dimensional structures or two-dimensional lattices in response to externally applied magnetic fields are disclosed. The compositions are prepared using improved co-precipitation methods in which the steps of the procedure have been tuned to reduce sample heterogeneity. Fe3O4 particles are coated with a surfactant and dispersed in a continuous carrier phase to form these homogeneous magnetic fluid compositions. The ability of these compositions to generate ordered structures can be tested by holding a magnet near a thin film of the compositions and observing the formation of colors in the region near the magnet. Methods for controlling the characteristic spacing of the ordered structures formed by the composition also are disclosed. Relevant parameters include the thickness of the film, the strength and orientation of the externally applied magnetic field, the rate of change of field strength, the volume fraction of the magnetic particles dispersed in the continuous phase, and the temperature of the homogeneous magnetic fluid. The homogeneous magnetic fluid composition is useful for the manufacture of liquid crystal devices. The devices take advantage of the serendipitous fact that the spacings in the material are on the order of the wavelength of visible light. A variety of magnetic-optical devices can be constructed that use the ordered structures to diffract, reflect, and polarize light in a controlled and predictable manner. These devices include color displays, monochromatic light switches, and tunable wavelength filters.

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