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1. 发明公开

EP3608397A1 STRAIN BELONGING TO GENUS MITSUARIA AND MICROBIAL PESTICIDE USING SAID STRAIN 审中-公开
公开(公告)号：EP3608397A1
公开(公告)日：2020-02-12
申请号：EP18781102.1
申请日：2018-03-30
申请人： Gifu University , Kumiai Chemical Industry Co., Ltd.
发明人： SHIMIZU, Masafumi , MAREK Caled Malianne , SUZUKI, Satomi , OZAKI, Koichi
IPC分类号： C12N1/20 , A01C1/00 , A01G7/00 , A01N63/00 , A01P3/00 , A01P21/00
摘要： Provided herein is a non plant-pathogenic strain that can stably exhibit a bacterial plant disease control effect at the actual site of crop production, and that can be safely used as a biopesticide against plant. A bacterial plant disease control agent using such a strain is also provided, among others. In the present invention, viable bacteria of a strain belonging to genus Mitsuaria, which was not known to have a control effect against bacterial plant disease, or a culture containing the viable bacteria of such a strain are used as an active component, and the invention provides bacterial plant disease control agents such as a vegetable wilt disease control agent, and a canker control agent.

2. 发明公开

EP3106458A1 MALEATE OF ANTI-PRION COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：抗朊病毒化合物的马来酸盐，方法及其制造和药物组合物
公开(公告)号：EP3106458A1
公开(公告)日：2016-12-21
申请号：EP15745871.2
申请日：2015-02-03
申请人： Gifu University
发明人： KUWATA, Kazuo
IPC分类号： C07D295/14 , A61K31/4025 , A61P25/00 , A61P25/28
CPC分类号： C07D295/15 , C07C57/145
摘要： An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide a medicament for preventing, ameliorating or treating a prion disease. The present invention provides a maleic acid salt of a compound represented by formula (1):
摘要翻译：本发明的一个目的是提供抗朊病毒化合物确实具有高结晶性和在结晶形式高度稳定，并提供用于预防，改善或治疗朊病毒病的药物。本发明提供了由下式表示的化合物的马来酸盐（1）：

3. 发明公开

EP2886123A1 PLURIPOTENT STEM CELL THAT INDUCES REPAIR AND REGENERATION AFTER MYOCARDIAL INFARCTION 有权转让
标题翻译： PLUIPOTENTE STAMMZELLEN ZUR INDUZIERUNG DER REPARATUR UND RECENERATION NACH EINEM MYOKARDINFARKT
公开(公告)号：EP2886123A1
公开(公告)日：2015-06-24
申请号：EP13879518.2
申请日：2013-08-15
申请人： Clio, Inc. , Gifu University , Tohoku University
发明人： YOSHIDA, Masanori , MINATOGUCHI, Shinya , DEZAWA, Mari
IPC分类号： A61K35/28 , A61P9/10 , C12N5/0775
CPC分类号： A61K35/28 , C12N5/0607
摘要： An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.
摘要翻译：本发明的目的是提供一种使用多能干细胞（Muse cells）的再生医学中使用的新型医疗应用。本发明提供了一种用于治疗心肌梗死的细胞制剂，特别是严重的大规模心肌梗塞和与其相关的心力衰竭，其包含从生物间充质组织或培养的间充质细胞分离的SSEA-3阳性的多能干细胞。本发明的细胞制备基于心脏组织再生机制，通过该心脏组织再生机制，使Muse细胞选择性地累积在损伤的心肌组织中，并由于静脉内施用Muse细胞而导致在该组织中分化为心肌，上述疾病。

4. 发明授权

EP2305658B1 NOVEL IMINO DERIVATIVE, PROCESS FOR PRODUCTION OF THE SAME, AND PESTICIDE COMPRISING THE SAME 有权
标题翻译：新亚，生产过程及农药，以
公开(公告)号：EP2305658B1
公开(公告)日：2014-12-17
申请号：EP09773500.5
申请日：2009-07-01
申请人： Meiji Seika Pharma Co., Ltd. , Gifu University
发明人： KAGABU, Shinzo , MORI, Masaru , KUMAZAWA, Satoru
IPC分类号： C07D277/20 , A01N43/40 , A01N43/50 , A01N43/60 , A01N43/78 , A01P7/04 , C07D277/32 , C07D401/06 , C07D401/14 , C07D417/06 , C07D417/14
CPC分类号： C07D277/20 , A01N43/36 , A01N43/40 , A01N43/78 , A01N47/18 , A01N47/24 , A01N47/36 , C07D277/32 , C07D401/06 , C07D401/14 , C07D417/06 , C07D417/14

5. 发明公开

EP2716750A1 URACIL-REQUIRING MOORELLA BACTERIA AND TRANSFORMING-GENE-INTRODUCED MOORELLA BACTERIA 审中-公开
标题翻译： URACILABHÄNGIGEMOORELLA-BAKTERIEN IN TRANSFORMATIONSGENEEINGEFÜHRTEMOORELLA-BAKTERIEN
公开(公告)号：EP2716750A1
公开(公告)日：2014-04-09
申请号：EP12792630.1
申请日：2012-06-01
申请人： Mitsui Engineering and Shipbuilding Co, Ltd. , Hiroshima University , Gifu University
发明人： NAKASHIMADA, Yutaka , KITA, Akihisa , SUZUKI, Tohru , SAKAI, Shinsuke , TAKAOKA, Kazue
IPC分类号： C12N1/21 , C12N15/09
CPC分类号： C12N15/74 , C12N9/88 , C12N2510/00 , C12N2510/02 , C12P7/065 , C12Y401/01023 , Y02E50/17
摘要： The present invention provides: uracil-requiring Moorella bacteria obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase; and transforming-gene-introduced Moorella bacteria obtained by introducing a gene coding for orotidine-5-phosphate decarboxylase and a transforming-gene to a chromosome of the uracil-requiring Moorella bacteria.
The present invention was accomplished by uracil-requiring Moorella bacteria, comprising an MTA-D-pF strain that is obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase on a chromosome of Moorella bacteria.
摘要翻译：本发明提供：通过破坏编码乳清苷-5-磷酸脱羧酶的基因而获得的尿嘧啶需要的毛细菌; 以及通过将编码乳清苷-5-磷酸脱羧酶的基因和转化基因引入到需要尿嘧啶的Moorella细菌的染色体而获得的转化基因导入的Moorella细菌。本发明通过需要尿嘧啶的Moorella细菌实现，其包含通过在Moorella细菌的染色体上破坏编码乳清苷-5-磷酸脱羧酶的基因获得的MTA-D-pF株。

6. 发明授权

EP2226012B1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING PROGRAM, STORAGE MEDIUM, AND ULTRASONIC DIAGNOSTIC APPARATUS 有权
标题翻译：图像处理设备，图像处理程序存储设备和超声诊断工具
公开(公告)号：EP2226012B1
公开(公告)日：2012-06-20
申请号：EP08722676.7
申请日：2008-03-24
申请人： Gifu University
发明人： YOKOTA, Yasunari , TANIGUCHI, Rie , KAWAMURA, Yoko , NOGATA, Fumio
IPC分类号： A61B8/08 , A61B5/02
CPC分类号： A61B8/0858 , A61B5/02007 , A61B8/463 , A61B8/485 , G01S7/52042
摘要： A computer (12) of an image processing apparatus (11) acquires a moving image including a cross section of a carotid artery taken along the minor axis thereof and a cross section of peripheral tissue in the periphery of the carotid artery to estimate an optical flow of points included in an area corresponding to a carotid artery wall and points included in an area corresponding to the peripheral tissue from two time-different frame images of the acquired moving image. The computer (12) calculates a displacement of the carotid artery and the peripheral tissue in the radial direction of the carotid artery depending on a change in internal pressure of the carotid artery on the basis of the estimated optical flow of the points. In addition, the computer (12) calculates a displacement of the carotid artery and the peripheral tissue in the radial direction of the carotid artery depending on a change in internal pressure of the carotid artery on the basis of a theoretical expression obtained by modeling the carotid artery and the peripheral tissue as a two-layer cylinder. The computer (12) calculates the elastic modulus of the carotid artery wall and that of the peripheral tissue so that the squared difference between the two displacements is minimized.

7. 发明公开

EP2388253A1 THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME 有权
标题翻译： THERSZOLDERIVAT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2388253A1
公开(公告)日：2011-11-23
申请号：EP10750780.8
申请日：2010-03-08
申请人： Gifu University
发明人： MURAI Toshiaki
IPC分类号： C07D277/18 , C07D417/04 , C07D417/14
CPC分类号： C07D277/18 , C07D277/42 , C07D417/04 , C07D417/14
摘要： An object is to provide a thiazole derivative produced from easily available raw materials by a simplified production process. Provided are a process for producing a novel thiazole derivative represented by the general formula (I), which is characterized by adding a strong base to a thioamide represented by the general formula (II) and reacting the mixture with a thioformamide represented by the general formula (III), and a novel thiazole derivative.
摘要翻译：目的是通过简化的生产工艺提供由容易获得的原料制备的噻唑衍生物。提供一种制备由通式（I）表示的新型噻唑衍生物的方法，其特征在于将强碱加入由通式（II）表示的硫代酰胺，并将该混合物与通式（III）和一种新的噻唑衍生物。

8. 发明公开

EP2226012A1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING PROGRAM, STORAGE MEDIUM, AND ULTRASONIC DIAGNOSTIC APPARATUS 有权
标题翻译： BILDBEARBEITUNGSGERÄT，BILDBEARBEITUNGSPROGRAMM，SPEICHERMEDIUM UNDULTRASCHALLDIAGNOSEGERÄT
公开(公告)号：EP2226012A1
公开(公告)日：2010-09-08
申请号：EP08722676.7
申请日：2008-03-24
申请人： Gifu University
发明人： YOKOTA, Yasunari , TANIGUCHI, Rie , KAWAMURA, Yoko , NOGATA, Fumio
IPC分类号： A61B8/08
CPC分类号： A61B8/0858 , A61B5/02007 , A61B8/463 , A61B8/485 , G01S7/52042
摘要： A computer 12 of an image processing apparatus 11 acquires a moving image including a minor axis cross section of a carotid artery and a cross section of surrounding tissues around the carotid artery and estimates, from images of two temporally different frames of the acquired moving image, an optical flow of each point included in an area corresponding to a carotid artery wall and an optical flow of each point included in an area corresponding to the surrounding tissues. Based on the estimated optical flow of each point, the computer 12 calculates an amount of displacement of the carotid artery and the surrounding tissues with respect to a radial direction of the carotid artery depending on a change in internal pressure of the carotid artery. The computer 12 also calculates an amount of displacement of the carotid artery and the surrounding tissues with respect to the radial direction of the carotid artery depending on a change in the internal pressure of the carotid artery based on a theoretical expression obtained by modeling the carotid artery and the surrounding tissues with a two-layer cylinder. The computer 12 calculates the elastic modulus of the carotid artery wall and the elastic modulus of the surrounding tissues so as to minimize a square error between the two calculated amounts of displacement.
摘要翻译：图像处理装置11的计算机12获取包括颈动脉的短轴截面和颈动脉周围组织的横截面的运动图像，并从所获取的运动图像的两个时间上不同的帧的图像中估计出运动图像，包括在对应于颈动脉壁的区域中的每个点的光流和包括在对应于周围组织的区域中的每个点的光流。基于每个点的估计光流量，计算机12根据颈动脉内压的变化计算颈动脉和周围组织相对于颈动脉径向的位移量。计算机12还基于颈动脉模型获得的理论表达，根据颈动脉内压的变化计算颈动脉和周围组织相对于颈动脉径向的位移量和周围组织用双层圆筒。计算机12计算颈动脉壁的弹性模量和周围组织的弹性模量，以便最小化两个计算的位移量之间的平方误差。

9. 发明公开

EP2196152A1 IMAGE PROCESSING DEVICE, IMAGE PROCESSING PROGRAM, RECORDING MEDIUM, AND ULTRASONIC DIAGNOSTIC EQUIPMENT 审中-公开
标题翻译：图像处理装置，图像处理程序，记录介质和超声诊断设备
公开(公告)号：EP2196152A1
公开(公告)日：2010-06-16
申请号：EP08722307.9
申请日：2008-03-17
申请人： Gifu University
发明人： YOKOTA, Yasunari , NOGATA, Fumio , KAWAMURA, Yoko
IPC分类号： A61B8/08
CPC分类号： G06T7/62 , G06T2207/10132 , G06T2207/30101
摘要： An image processing device acquires an ultrasound B-mode image sequence and creates an evaluation function of a mode of the longitudinal sectional shape of the carotid artery rendered in a frame following the frame that has already been modeled, thereby optimizing the evaluation function. The image processing device estimates and models the position and shape of the longitudinal sectional shape of the carotid artery for the following frame based on the optimization result, and performs the same for the subsequent frames. The image processing device outputs a variation of the carotid artery diameter in response to heartbeats based on the modeling result.

10. 发明授权

EP1385175B1 Probe tip design for optical near-field microscope 有权
标题翻译：用于光学近场显微镜的探针尖端的设计
公开(公告)号：EP1385175B1
公开(公告)日：2007-04-25
申请号：EP03254624.4
申请日：2003-07-24
申请人： President of Gifu University
发明人： Tanaka Kazuo , Tanaka Masahiro
IPC分类号： G12B21/06
CPC分类号： G01Q60/22 , G02B6/10 , G02B6/1226 , G02B6/241

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