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1. 发明公开

EP3265429A1 NANOPARTICLES FOR THE USE AS PINNING CENTERS IN SUPERCONDUCTORS 审中-公开
标题翻译：用作超导体钉扎中心的纳米颗粒
公开(公告)号：EP3265429A1
公开(公告)日：2018-01-10
申请号：EP16707058.0
申请日：2016-02-24
申请人： BASF SE , Ghent University
发明人： HEMGESBERG, Maximilian , SCHWALL, Denis , STAUDT, Thorsten , DRIESSCHE, Isabel van , DE KEUKELEERE, Katrien , DE ROO, Jonathan , GRUENDLING, Till , MAIER, Matthias , BAECKER, Michael , BENNEWITZ, Jan , FEENSTRA, Ron
IPC分类号： C01G25/02 , C01G27/02 , C01G35/00 , C09C1/00 , C09C3/08 , C09D5/24 , H01L39/00
CPC分类号： C01G1/02 , C01G23/047 , C01G25/02 , C01G27/02 , C01G35/00 , C01P2002/60 , C01P2002/72 , C01P2002/74 , C01P2004/52 , C01P2004/64 , C09C1/00 , C09C1/3669 , C09C3/08 , C09D5/24 , C09D11/033 , C09D11/38 , H01L39/2425 , H01L39/2483
摘要： The present invention is in the field of nanoparticles, their preparation and their use as pinning centers in superconductors. In particular the present invention relates to nanoparticles comprising an oxide of Sr, Ba, Y, La, Ti, Zr, Hf, Nb, or Ta, wherein the nanoparticles have a weight average diameter of 1 to 30 nm and wherein an organic compound of general formula (I), (II) or (III) or an organic compound containing at least two carboxylic acid groups on the surface of the nanoparticles (I) (II) (III) wherein a is 0 to 5, b and c are independent of each other 1 to 14, n is 1 to 5, f is 0 to 5, p and q are independent of each other 1 to 14, and e and f are independent of each other 0 to 12.

2. 发明授权

EP2539357B1 METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS 有权
标题翻译：有关检测和治疗癌症的方法和组合物使用的miRNA和miRNA抑制剂和目标
公开(公告)号：EP2539357B1
公开(公告)日：2017-06-14
申请号：EP11747825.5
申请日：2011-02-28
申请人： Memorial Sloan-Kettering Cancer Center , Ghent University , Columbia University
发明人： DE KEERSMAECKER, Kim , FERRANDO, Adolfo, A. , MAVRAKIS, Konstantinos, John , ORICCHIO, Elisa , PALOMERO, Teresa , SPELEMAN, Franki , VAN VLIERBERGHE, Peter , WENDEL, Hans-guido , WOLFE, Andrew, L.
IPC分类号： C12N15/113 , C12Q1/68 , A61K31/7088 , A61P35/00 , A61P35/02
CPC分类号： C12N15/113 , C12N2310/113 , C12Q1/6809 , C12Q2525/207
摘要： The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagonists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
摘要翻译：本发明涉及与癌症相关的微RNA（miRNA），特别是血液恶性肿瘤包括，尤其T细胞急性成淋巴细胞性白血病（T-ALL），并在治疗和控制癌症其评估和调制。本发明涉及用于诊断和治疗癌症的方法和组合物特别是T-ALL，通过调节的miRNA，以及使用的miRNA和拮抗剂及其，特别是RNA拮抗剂，用于分离和选择预测和assesing对治疗的反应，在测定拮抗剂，并作为组合物治疗癌症和管理。提供了用于治疗或减轻癌症，特别是T-ALL，用miRNA的，特别是一个或多个miR-19b中，的miR-20a和miR26，miR92，miR148和miR223的拮抗剂/ RNA拮抗剂的方法和组合物。

3. 发明公开

EP2528685A1 PROCESS FOR PREPARATION OF RUTHENIUM-BASED CARBENE CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON RUTHENIUMBASIERTEN CARBENKATALYSATOREN MIT CHELATBILDENDEN ALKYLIDEN-LIGANDEN
公开(公告)号：EP2528685A1
公开(公告)日：2012-12-05
申请号：EP11701940.6
申请日：2011-01-25
申请人： Umicore AG & Co. KG , Ghent University
发明人： MONSAERT, Stijn Frans , VERPOORT, Francis Walter Cornelius
IPC分类号： B01J31/22 , B01J31/24 , C07F15/00
CPC分类号： B01J31/2204 , B01J31/2265 , B01J31/24 , B01J2231/543 , B01J2531/821 , C07F15/0046
摘要： The invention relates to a method for preparation of ruthenium-based carbene catalysts with chelating alkylidene ligands (so-called "Hoveyda-type catalysts") in a cross metathesis reaction by reacting a ruthenium-alkylidene complex with an olefin derivate in the presence of a polymer-supported cation-exchange resin (PSR) acting as a ligand (i.e. phosphine or amine) scavenger. Preferably, penta-coordinated ruthenium benzylidene or indenylidene carbene complexes are employed. The polymer-supported cation-exchange resin (PSR) may be an acidic resin (comprising sulfonic acid or carboxylic groups) or a resin containing carboxylic acid chloride (-COC1) groups or sulfonyl chloride (-SO 2 C1) groups. The process is versatile and environmentally friendly; high yields are obtained.
摘要翻译：本发明涉及一种在交叉复分解反应中用螯合亚烷基配体（所谓的“Hoveyda型催化剂”）制备钌基卡宾催化剂的方法，其中钌亚烷基配合物与烯烃衍生物在用作配体（即膦或胺）清除剂的聚合物负载的阳离子交换树脂（PSR）。优选使用五配位钌亚苄基或亚茚基碳烯配合物。聚合物负载的阳离子交换树脂（PSR）可以是酸性树脂（包含磺酸或羧基）或含羧酰氯（-COC1）或磺酰氯（-SO 2 C 1）基团的树脂。该过程是多功能和环保的; 获得高产率。

4. 发明公开

EP2361683A1 Process for preparation of ruthenium-based carbene catalysts with chelating alkylidene ligands 审中-公开
标题翻译：维他命Zur Herstellung von rutheniumbasierten Carbenkatalysatoren mit chelatbildenden Alkyliden-Liganden
公开(公告)号：EP2361683A1
公开(公告)日：2011-08-31
申请号：EP10000928.1
申请日：2010-01-29
申请人： Umicore AG & Co. KG , Ghent University
发明人： Monsaert, Stijn Frans , Verpoort, Francis Walter Cornelius
IPC分类号： B01J31/22 , B01J31/24 , C07F15/00
CPC分类号： B01J31/2204 , B01J31/2265 , B01J31/24 , B01J2231/543 , B01J2531/821 , C07F15/0046
摘要： The invention relates to a method for preparation of ruthenium-based carbene catalysts with chelating alkylidene ligands (so-called "Hoveyda-type catalysts") in a cross metathesis reaction by reacting a ruthenium-alkylidene complex with an olefin derivate in the presence of a polymer-supported cation-exchange resin (PSR) acting as a ligand (i.e. phosphine or amine) scavenger. Preferably, penta-coordinated ruthenium benzylidene or indenylidene carbene complexes are employed. The polymer-supported cation-exchange resin (PSR) may be an acidic resin (comprising sulfonic acid or carboxylic groups) or a resin containing carboxylic acid chloride (-COC1) groups or sulfonyl chloride (-SO 2 C1) groups. The process is versatile and environmentally friendly; high yields are obtained.
摘要翻译：本发明涉及一种在交叉复分解反应中用螯合亚烷基配体（所谓的“Hoveyda型催化剂”）制备钌基卡宾催化剂的方法，其中钌亚烷基配合物与烯烃衍生物在用作配体（即膦或胺）清除剂的聚合物负载的阳离子交换树脂（PSR）。优选使用五配位钌亚苄基或亚茚基碳烯配合物。聚合物负载的阳离子交换树脂（PSR）可以是酸性树脂（包含磺酸或羧基）或含羧酰氯（-COC1）或磺酰氯（-SO 2 C 1）基团的树脂。该过程是多功能和环保的; 获得高产率。

5. 发明公开

EP2203856A1 METHOD AND DEVICE FOR GENERATING A MODEL OF A MULTIPARAMETER SYSTEM 审中-公开
标题翻译：方法和设备，用于生成一个多参数系统的模型
公开(公告)号：EP2203856A1
公开(公告)日：2010-07-07
申请号：EP08801518.5
申请日：2008-08-11
申请人： IBBT vzw , Ghent University
发明人： DESCHRIJVER, Dirk , DHAENE, Tom , DE ZUTTER, Daniël
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： The present invention relates to a method (200) for generating a multivariate system model of a multivariate system which has a plurality of parameters and the multivariate system model is representative for the system response to changes in the parameters. The method (200) involves performing a plurality of measurements and/or simulations on the multivariate system to obtain reference data (201). The method further involves the selection of rational base functions (202) and combining these base functions (203) into a model of the multivariate system. The multivariate system model is obtained (208) by minimizing a cost function (205) between the model and the reference data. Explicit weight factors which are related to the reference data are used. The respective values for the explicit weight factors in the cost function are iteratively determined (205) in order to approximate the reference data with the model and the cost function is updated accordingly in each iteration.

6. 发明公开

EP2170381A1 METHODS AND COMPOSITIONS IN THE TREATMENT OF PORCINE CIRCOVIRAL INFECTION 审中-公开
标题翻译：方法和组合物猪圆环病毒感染的治疗
公开(公告)号：EP2170381A1
公开(公告)日：2010-04-07
申请号：EP08773527.0
申请日：2008-06-19
申请人： Ghent University
发明人： LEFEBVRE, David, Jacques, Gerard , NAUWYNCK, Hans
IPC分类号： A61K39/12 , G01N33/50
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K16/10 , C07K2317/34 , C07K2317/76 , C12N2750/10022 , C12N2750/10034
摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to methods of diagnosing, prognosis, treatment and prevention of porcine circoviral infection in mammals, in particular of porcine circovirus type 2 (PCV2). Methods of using a nucleic acid(s) and/or a protein(s), which are immunogenic in said mammal, and antibodies immunospecific for said protein (s), to treat, diagnose and/or prevent said porcine circoviral infection, are provided for by the present invention.

7. 发明授权

EP2528685B1 PROCESS FOR PREPARATION OF RUTHENIUM-BASED CARBENE CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS 有权
标题翻译：制备CH基碳烯催化剂与螯合亚烷基配体的方法
公开(公告)号：EP2528685B1
公开(公告)日：2017-10-18
申请号：EP11701940.6
申请日：2011-01-25
申请人： Umicore AG & Co. KG , Ghent University
发明人： MONSAERT, Stijn Frans , VERPOORT, Francis Walter Cornelius
IPC分类号： B01J31/22 , B01J31/24 , C07F15/00
CPC分类号： B01J31/2204 , B01J31/2265 , B01J31/24 , B01J2231/543 , B01J2531/821 , C07F15/0046

8. 发明公开

EP2897340A1 Routing proxy for adaptive streaming 有权转让
标题翻译：流媒体
公开(公告)号：EP2897340A1
公开(公告)日：2015-07-22
申请号：EP15151373.6
申请日：2015-01-16
申请人： Koninklijke KPN N.V. , iMinds , Ghent University
发明人： Famaey, Jeroen , Latré, Steven
IPC分类号： H04L29/06 , H04L29/08
CPC分类号： H04L67/02 , H04L65/4084 , H04L65/605 , H04L65/80 , H04L67/18 , H04L67/2814
摘要： A method for providing chunked content to a device comprising a streaming client, preferably an HTTP adaptive streaming client, is described, wherein said chunked content is defined on the basis of a manifest file comprising one or more chunk identifiers and one or more associated chunk locators for locating one or more delivery nodes configured to deliver one or more chunks identified by said chunk identifiers, and wherein said method comprises: determining whether a chunk identified by a chunk identifier in a chunk request message originating from said client can be delivered by a first delivery node, said chunk request message comprising a first network address associated with said first delivery node, preferably said first network address comprising at least part of an IP address, an URL, or an equivalent thereof; if said first delivery node cannot deliver said chunk to said client, rewriting said first network address in said chunk request message into a second network address associated with a delivery node that is capable of delivering said chunk before sending said chunk request message to said second delivery node; and, before sending a chunk response message associated with said chunk request message to said streaming client, rewriting the second network address in said response message into said first network address.
摘要翻译：描述了一种用于向包括流客户端，优选地HTTP自适应流客户端的设备提供分块内容的方法，其中基于包含一个或多个块标识符和一个或多个关联块定位符的清单文件来定义所述分块内容用于定位被配置为递送由所述块标识符标识的一个或多个块的一个或多个传送节点，并且其中所述方法包括：确定由来自所述客户端的块请求消息中的块标识符识别的块是否可以由第一所述块请求消息包括与所述第一传送节点相关联的第一网络地址，优选地，所述第一网络地址包括IP地址，URL或其等同物的至少一部分; 如果所述第一传送节点不能将所述块传送到所述客户端，则将所述块请求消息中的所述第一网络地址重写为与发送节点相关联的第二网络地址，所述传送节点能够在将所述块请求消息发送到所述第二传送之前传送所述块节点; 并且在将与所述块请求消息相关联的块响应消息发送到所述流客户端之前，将所述响应消息中的第二网络地址重写为所述第一网络地址。

9. 发明公开

EP2170175A1 SUTURELESS VESSEL ANASTOMOSIS METHOD AND APPARATUS 审中-公开
标题翻译：方法和设备进行无缝血管吻合
公开(公告)号：EP2170175A1
公开(公告)日：2010-04-07
申请号：EP08762939.0
申请日：2008-06-20
申请人： Ghent University
发明人： BLONDEEL, Phillip Nicolas
IPC分类号： A61B17/11 , A61B17/00
CPC分类号： A61B17/11 , A61B17/1114 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132
摘要： A method for performing end-to-end vessel anastomosis includes providing a vessel support including a vessel receiving portion and a handle portion extending therefrom. The vessel receiving portion is an annulus. The vessel receiving portion is positioned around the end of a first vessel and the end of the first vessel is everted about the outer diameter of the vessel receiving portion such that the inner surface of the vessel is directed outwardly. The end of the second vessel is positioned over the everted end of the first vessel such that the inner surface of the second vessel is disposed against the inner surface of the first vessel. The ends of the vessel are secured either with a suture or a surgical adhesive. The handle portion of the vessel support may be removed.

10. 发明公开

EP4293034A1 A NOVEL ACYLATED DERIVATE OF PHLORETIN AND ITS USE AS ANTIOXIDANT 审中-公开转让
公开(公告)号：EP4293034A1
公开(公告)日：2023-12-20
申请号：EP22382582.9
申请日：2022-06-17
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE , Ghent University
发明人： PLOU GASCA, Francisco José , GONZÁLEZ ALFONSO, José Luis , BALLESTEROS OLMO, Antonio , ALONSO MERINO, Cristina , CODERCH, Luisa , POVEDA CABANES, Ana , JIMÉNEZ BARBERO, Jesús , DESMET, Tom , UBIPARIP, Zorica
IPC分类号： C07H15/26 , A61P17/18 , C12P7/6454 , C12P19/02
摘要： The present invention relates to a method for producing acylated derivate of polyphenols comprising α-glucosylation of the phloretin with a sucrose phosphorylase mutant from T. thermosaccharolyticum and acylation with the lipase from Thermomyces lanuginosus, obtaining a novel acylated derivate of phloretin, particularly the phloretin 4'-O-(6-O-lauryl)-α-D-glucopyranoside. Further, the present invention relates the use of phloretin 4'-O-(6-O-lauryl)-α-D-glucopyranoside as antioxidant.

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