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1. 发明公开

EP1781972A2 A VALVE 有权
标题翻译：阀门
公开(公告)号：EP1781972A2
公开(公告)日：2007-05-09
申请号：EP05712371.3
申请日：2005-02-01
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： F16K1/12
CPC分类号： F16K1/12
摘要： A re-closable valve (1, 100, 700, 800) for use in sterile fluid transfer has a body (5) with open entry and exit sides (2, 3) and a passageway (4) for fluid therebetween. The entry side is connectable to an opening of a separate vessel and the exit side is connectable to downstream processing. The entry side includes a first rupturable seal (5b, 500) blocking the opening of the entry side. A piston (9) is connected to an actuator (7) via a cam mechanism (8, 85, 10) which moves the piston (9) axially in the passageway (4) and to the first seal (5b, 500). On movement of the piston (9) during a first actuation, the first seal (5b, 500) is torn free from the entry side to open the valve for fluid transfer. A sharp rim (15) surrounds the opening of the entry side and a curved surface area (193) encircles the piston exterior proximal the entry side. The valve (1, 100, 700, 800) can be re-closed by moving the piston (9) during a subsequent actuation thus engaging the sharp rim (15) with the curved surface area (193) which plastically deform to from a second seal. Arrangements are included to enable the valve (1, 100, 700, 800) to be multiply re-opened and re-closed, if desired.
摘要翻译：用于无菌流体转移的可重新关闭的阀（1,100,700,800）具有带开放入口侧和出口侧（2,3）的主体（5）以及用于其间的流体的通道（4）。入口侧可连接到单独的容器的开口，并且出口侧可连接到下游处理。入口侧包括阻塞入口侧的开口的第一可破裂密封件（5b，500）。活塞（9）经由凸轮机构（8,85,10）连接到致动器（7），所述凸轮机构在通道（4）中轴向移动活塞（9）并且移动到第一密封件（5b，500）。在第一次致动期间活塞（9）移动时，第一密封件（5b，500）从入口侧撕开以打开用于流体传递的阀。尖锐边缘（15）围绕入口侧的开口并且弯曲表面区域（193）围绕入口侧近侧的活塞外部。在随后的致动过程中，通过移动活塞（9）可以重新关闭阀门（1,100,700,800），从而使尖锐边缘（15）与从第二个位置塑性变形的弯曲表面区域（193）密封。如果需要的话，可以安排阀门（1,100,700,800）多次重新打开和重新关闭。

2. 发明公开

EP1751456A1 A BULKHEAD CONNECTOR 审中-公开
标题翻译： TRENNWANDVERBINDER
公开(公告)号：EP1751456A1
公开(公告)日：2007-02-14
申请号：EP05750329.4
申请日：2005-06-02
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： F16L5/08 , F16L5/06 , H02G3/22
CPC分类号： F16L5/08 , F16L2201/10 , H02G9/06 , H02G15/013
摘要： The present invention relates to a bulkhead connector assembly (1) for sealingly feeding a conduit (9) between two environments. The assembly provides first (2) and second (3) coupling components having first and second surfaces respectively. A gap (212) is formed between the first and second surfaces. The first coupling component (2) has an aperture (213) which extends between the first surface and a first environment and the second coupling component (3) has an aperture (32) which extends between the second surface and a second environment. Each aperture is adapted for receiving a conduit (9) therethrough. A resiliently deformable gasket (4) is provided to be placed into the gap (212) and the gasket is provided with at least one bore (41) for a conduit (9) to pass through the gasket. Means for compressing the gasket (4) in the gap (212) are provided to deform the gasket on compression so as to collapse the gasket bore (41) against any conduit (9) occupying the bore so as to form a leak-proof seal between the apertures (231, 32) of the coupling components (2, 3) and the gasket (4) or against the bore (41) itself, as the case may be.
摘要翻译：本发明涉及一种隔板连接器组件，其提供用于在两个环境之间密封地供给导管的密封装置。组件提供分别具有第一和第二表面的第一和第二联接部件。在第一和第二表面之间形成间隙。第一联接部件具有在第一表面和第一环境之间延伸的孔，并且第二联接部件具有在第二表面和第二环境之间延伸的孔。每个孔适于接收穿过其中的导管。提供可弹性变形的垫片以放置在间隙中，并且垫圈还设置有用于导管穿过垫圈的孔。提供用于压缩间隙中的垫圈的装置，以使压缩件上的垫片变形，从而使衬垫孔抵靠其自身或与占据该孔的任何导管相接合，以便在耦合部件的孔之间形成防漏密封，垫圈。

3. 发明授权

EP1499382B1 A valve 有权
标题翻译：一个阀门
公开(公告)号：EP1499382B1
公开(公告)日：2006-12-27
申请号：EP03719944.5
申请日：2003-04-25
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： A61M39/22 , F16K13/00
CPC分类号： F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , A61M2039/1027 , A61M2039/222 , F16K3/265 , F16K13/04 , F16K15/18 , F16L37/107
摘要： A valve apparatus (100) for use in sterile fluid transfer or isolator systems has open entry (10) and exit (11) sides and a passageway (9) for fluid between the entry (10) and the exit (11) sides. The entry side (10) is connectable to an opening (4c) of a vessel or pipe (4) and the exit side (11) is connectable to downstream processing by means such as tubing, a vessel or a pipe. The entry side (10) includes a rupturable seal (2a) blocking the open entry side (10). Valve (100) also includes an actuator (5) attached to a piston (1) which moves within the valve (100), the piston being connected to the seal so that on movement of the piston, the seal is torn free from the entry side thereby allowing fluid gain entry to the valve (100) and to pass along the passageway (9) between the open entry (10) and exit (11) sides to downstream processing.
摘要翻译：用于无菌流体转移或隔离系统的阀装置（100）具有开口入口（10）和出口（11）侧以及用于入口（10）和出口（11）侧之间的流体的通道（9）。入口侧（10）可连接到容器或管道（4）的开口（4c），并且出口侧（11）可通过诸如管道，容器或管道的装置连接到下游处理。入口侧（10）包括阻塞开放入口侧（10）的可破裂密封件（2a）。阀100还包括连接到在阀100内移动的活塞1的致动器5，活塞连接到密封件，从而在活塞移动时密封件从入口处被撕开从而允许流体增益进入阀（100）并且沿着开放入口（10）和出口（11）侧之间的通道（9）传递到下游处理。

4. 发明公开

EP1660799A1 A VALVE 有权
标题翻译：阀门
公开(公告)号：EP1660799A1
公开(公告)日：2006-05-31
申请号：EP04779705.5
申请日：2004-07-30
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： F16K1/12
CPC分类号： F16K1/425 , A61M39/22 , F16K1/12 , F16K31/528
摘要： The invention provides a valve (1) for sterile transfer of fluids. The valve (1) comprises a housing (5) having first and second open ends (2, 3) and a passageway (4) extending between the ends (2, 3). The first end (2) has a flange (54) for coupling the housing (5) about an opening (205) of an external conduit (201) and a seal blocking an open area of the first end (2). The seal is placed in register with the opening (205) of the external conduit (201). The valve (1) has a piston (9) movably disposed within the housing (5) so as to interrupt the seal and to permit fluid to pass along the passageway (4). A mating surface (215) of the flange (54) and the seal form a sterilizable surface. The seal is formed between a plastic plug (18) movable by the piston (9) and a sharp plastics rim (15) which encompasses the open area of a first end (16) of the housing (5).
摘要翻译：本发明提供了一种用于流体消毒传输的阀（1）。阀（1）包括具有第一和第二开口端（2,3）和在端部（2,3）之间延伸的通道（4）的壳体（5）。第一端部（2）具有用于围绕外部导管（201）的开口（205）联接壳体（5）的凸缘（54）和阻挡第一端部（2）的开放区域的密封件。密封件与外部导管（201）的开口（205）对齐。阀（1）具有可移动地设置在壳体（5）内的活塞（9），以便中断密封并允许流体沿通道（4）流动。凸缘（54）的配合表面（215）和密封件形成可灭菌表面。密封件形成在可由活塞（9）移动的塑料塞（18）和包围壳体（5）的第一端（16）的开口区域的尖锐塑料轮圈（15）之间。

5. 发明授权

EP1781972B1 A VALVE 有权
标题翻译：阀门
公开(公告)号：EP1781972B1
公开(公告)日：2010-09-15
申请号：EP05712371.3
申请日：2005-02-01
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： F16K1/12
CPC分类号： F16K1/12

6. 发明授权

EP1660799B1 A VALVE 有权
公开(公告)号：EP1660799B1
公开(公告)日：2008-12-17
申请号：EP04779705.5
申请日：2004-07-30
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： F16K1/12
CPC分类号： F16K1/425 , A61M39/22 , F16K1/12 , F16K31/528
摘要： The invention provides a valve (1) for sterile transfer of fluids. The valve (1) comprises a housing (5) having first and second open ends (2, 3) and a passageway (4) extending between the ends (2, 3). The first end (2) has a flange (54) for coupling the housing (5) about an opening (205) of an external conduit (201) and a seal blocking an open area of the first end (2). The seal is placed in register with the opening (205) of the external conduit (201). The valve (1) has a piston (9) movably disposed within the housing (5) so as to interrupt the seal and to permit fluid to pass along the passageway (4). A mating surface (215) of the flange (54) and the seal form a sterilizable surface. The seal is formed between a plastic plug (18) movable by the piston (9) and a sharp plastics rim (15) which encompasses the open area of a first end (16) of the housing (5).

7. 发明公开

EP1499382A1 A VALVE 有权
标题翻译：阀门
公开(公告)号：EP1499382A1
公开(公告)日：2005-01-26
申请号：EP03719944.5
申请日：2003-04-25
申请人： GL Tool and Manufacturing Co. Inc.
发明人： LIEPOLD, Gerhard , BIZER, Dietrich
IPC分类号： A61M39/22 , F16K13/00
CPC分类号： F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , A61M2039/1027 , A61M2039/222 , F16K3/265 , F16K13/04 , F16K15/18 , F16L37/107
摘要： A valve apparatus (100) for use in sterile fluid transfer or isolator systems has open entry (10) and exit (11) sides and a passageway (9) for fluid between the entry (10) and the exit (11) sides. The entry side (10) is connectable to an opening (4c) of a vessel or pipe (4) and the exit side (11) is connectable to downstream processing by means such as tubing, a vessel or a pipe. The entry side (10) includes a rupturable seal (2a) blocking the open entry side (10). Valve (100) also includes an actuator (5) attached to a piston (1) which moves within the valve (100), the piston being connected to the seal so that on movement of the piston, the seal is torn free from the entry side thereby allowing fluid gain entry to the valve (100) and to pass along the passageway (9) between the open entry (10) and exit (11) sides to downstream processing.
摘要翻译：用于无菌流体转移或隔离系统的阀装置（100）具有开口入口（10）和出口（11）侧以及用于入口（10）和出口（11）侧之间的流体的通道（9）。入口侧（10）可连接到容器或管道（4）的开口（4c），并且出口侧（11）可通过诸如管道，容器或管道的装置连接到下游处理。入口侧（10）包括阻塞开放入口侧（10）的可破裂密封件（2a）。阀100还包括连接到在阀100内移动的活塞1的致动器5，活塞连接到密封件，从而在活塞移动时密封件从入口处被撕开从而允许流体增益进入阀（100）并且沿着开放入口（10）和出口（11）侧之间的通道（9）传递到下游处理。

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