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1. 发明授权

EP3295950B1 USE OF GINSENG EXTRACT, GINSENOSIDE AND GINSENOSIDE DERIVATIVE IN THE PREPARATION OF MEDICINE OR HEALTH CARE PRODUCT FOR TREATING CYTOMEGALOVIRUS INFECTION DISORDERS 有权
公开(公告)号：EP3295950B1
公开(公告)日：2020-11-18
申请号：EP16795777.8
申请日：2016-04-21
申请人： Fu, Li
发明人： WANG, Kaiqian , HUI, Min , LI, Fan , FAN, Hongyu , WANG, Shuo
IPC分类号： A61K36/9068 , A61P31/12 , A61K31/704 , A61K36/258 , A61P31/20

3. 发明授权

EP3178822B1 PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF 有权
公开(公告)号：EP3178822B1
公开(公告)日：2019-03-13
申请号：EP14899456.9
申请日：2014-12-23
申请人： Fu, Li
发明人： FAN, Hongyu , WANG, Shuo , FU, Li
IPC分类号： C07D493/04 , A61K31/34 , A61P29/00 , A61P31/12

4. 发明公开

EP3178482A4 APPLICATIONS OF PHILLYRIN/PHILLYGENIN COMPOSITION IN PREPARING DRUGS OR HEALTH CARE PRODUCTS FOR RELIEVING AND/OR TREATING VIRAL DISEASES 有权
公开(公告)号：EP3178482A4
公开(公告)日：2018-04-11
申请号：EP14899145
申请日：2014-12-23
申请人： FU LI
发明人： LU MINGMING , FU QIANG , WANG KAIQIAN , HUI MIN , LIU ZHENGXIAN , LIU YANG , WANG SHUO , QU HONGYING , YU XIAOJING , WANG HAILING , GAI XIN
IPC分类号： A61K31/7048 , A61K31/34 , A61K47/40 , A61P31/16 , A61P31/22
CPC分类号： A61K31/7048 , A61K31/34 , A61K47/40
摘要： The present invention discloses a new application of a composition of phillyrin and phillygeninin in the preparation of drugs for alleviating or/and treating viral diseases. Experiments prove that the composition of phillyrin and phillygeninin has significant treatment effects on viral influenza and pneumonia, as well as on respiratory syncytial viruses, enteroviruses, herpes zoster simplex viruses, Coxsackie viruses, and the like. This composition is characterized by quick action and less toxic and side effects, and thus is an antiviral drug and health product with safety, high efficiency, stability and simple preparation process, and is suitable for industrial production and easy to promote. The present invention provides a new drug, health product and raw material for preventing and treating various viral diseases.

5. 发明公开

EP3072895A4 PHILLYGENOL SULPHATE AND DERIVATIVE THEREOF, AND PREPARATION METHOD AND APPLICATION THEREOF 有权
标题翻译： PHILLYGENOLSULFAT UND DERIVAT DAVON，HERSTELLUNGSVERFAHREN UND ANWENDUNG DAVON
公开(公告)号：EP3072895A4
公开(公告)日：2017-05-31
申请号：EP14861789
申请日：2014-11-06
申请人： FU LI
发明人： FAN HONGYU , WANG SHUO
IPC分类号： C07D493/04 , A61K31/34 , A61P31/14 , A61P31/16 , A61P31/22
CPC分类号： C07D493/04
摘要： The present invention provides a forsythiaside sulfate derivatives as represented by the following formula, the preparation method and antiviral application thereof:
摘要翻译：本发明提供了由下式表示的连翘脂素衍生物及其制备方法和抗病毒应用：

6. 发明公开

EP3072895A1 PHILLYGENOL SULPHATE AND DERIVATIVE THEREOF, AND PREPARATION METHOD AND APPLICATION THEREOF 有权
标题翻译： PHILLYGENOLSULFAT及其衍生物，方法及其应用
公开(公告)号：EP3072895A1
公开(公告)日：2016-09-28
申请号：EP14861789.7
申请日：2014-11-06
申请人： Fu, Li
发明人： FAN, Hongyu , WANG, Shuo
IPC分类号： C07D493/04 , A61K31/34 , A61P31/16 , A61P31/14 , A61P31/22
CPC分类号： C07D493/04
摘要： The present invention provides a forsythiaside sulfate derivatives as represented by the following formula, the preparation method and antiviral application thereof:

7. 发明公开

EP3295950A1 USE OF GINSENG EXTRACT, GINSENOSIDE AND GINSENOSIDE DERIVATIVE IN THE PREPARATION OF MEDICINE OR HEALTH CARE PRODUCT FOR TREATING CYTOMEGALOVIRUS INFECTION DISORDERS 有权
标题翻译：人参提取物，人参皂苷和人参皂苷衍生物在制备用于治疗巨细胞病毒感染疾病的医药或保健品中的用途
公开(公告)号：EP3295950A1
公开(公告)日：2018-03-21
申请号：EP16795777.8
申请日：2016-04-21
申请人： Fu, Li
发明人： WANG, Kaiqian , HUI, Min , LI, Fan , FAN, Hongyu , WANG, Shuo
IPC分类号： A61K36/9068 , A61P31/12
摘要： The invention discloses new application of a ginseng extract, ginsenoside and a ginsenoside derivative in the preparation of a medicine for treating HCMV infection related diseases. The related diseases comprise HCMV infection caused in the process of treating cardiovascular and cerebrovascular diseases, organ transplantation, perinatal periods, tumors, burn, AIDS and other diseases of patients. Tests prove that the ginseng extract, the ginsenoside and the ginsenoside derivative have a remarkable curative effect, quick response and a small toxic or side effect during treatment of HCMV infected diseases, are a medicine or a health product for treating the HCMV infection, which is safe, efficient and stable and has a simple preparation process, and are suitable for industrial production and easy to popularize. In the invention, a new medicine source is provided for the treatment of the HCMV infection.
摘要翻译：本发明公开了人参提取物，人参皂苷和人参皂苷衍生物在制备治疗HCMV感染相关疾病的药物中的新用途。相关疾病包括在治疗心血管和脑血管疾病，器官移植，围产期，肿瘤，烧伤，艾滋病等患者疾病过程中引起的HCMV感染。试验证明，人参提取物，人参皂苷和人参皂苷衍生物在治疗HCMV感染的疾病中疗效显着，反应快，毒副作用小，是治疗HCMV感染的药物或保健品，安全，高效，稳定，制备工艺简单，适合工业化生产，易于普及。在本发明中，提供了用于治疗HCMV感染的新药物来源。

8. 发明公开

EP3178822A4 PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF 有权
公开(公告)号：EP3178822A4
公开(公告)日：2018-01-24
申请号：EP14899456
申请日：2014-12-23
申请人： FU LI
发明人： FAN HONGYU , WANG SHUO , FU LI
IPC分类号： C07D493/04 , A61K31/34 , A61P29/00 , A61P31/12
CPC分类号： C07D493/04 , A61K31/34
摘要： The present invention provides a pharmaceutical compound of phillygenin ibuprofen ester as represented by formula (I), preparation method thereof, and applications thereof in anti-virus, antipyresis, anti-inflammation, analgesia and the like:

9. 发明公开

EP3235826A1 20(R)-GINSENOSIDE RG3 MULTIACYLATED DERIVATIVE, PREPARATION, AND APPLICATION THEREOF 有权
标题翻译： 20（R） - 人参皂苷RG3多酰化衍生物及其制备和应用
公开(公告)号：EP3235826A1
公开(公告)日：2017-10-25
申请号：EP14908284.4
申请日：2014-12-23
申请人： Fu, Li
发明人： FAN, Hongyu
IPC分类号： C07J17/00 , A61K31/704 , A61P35/00
摘要： The present invention provides 20(R)-ginsenoside Rg3 polyacylated derivatives of the formula (I) and preparation method and anti-tumor application thereof:

wherein, R= CH 3 (CH 2 )nCO, n=0∼5.
摘要翻译：本发明提供了式（I）的20（R） - 人参皂苷Rg3多酰化衍生物及其制备方法和抗肿瘤应用：其中R = CH3（CH2）nCO，n = 0-5。

10. 发明公开

EP3178834A1 CHEMICAL SYNTHESIS METHOD FOR PHILLYRIN 有权
标题翻译： PHILLYRIN的化学合成方法
公开(公告)号：EP3178834A1
公开(公告)日：2017-06-14
申请号：EP14899256.3
申请日：2014-12-23
申请人： Fu, Li
发明人： FAN, Hongyu
IPC分类号： C07H17/04 , C07H1/00 , A61K31/7048 , A61P31/14 , A61P31/16 , A61P31/22
摘要： The present invention relates to a chemical synthesis method for phillyrin. The method of the present invention comprises: first dissolving a glycosyl receptor phillygenin and a glycosyl donor in an organic solvent for glycosylation to obtain tetraacyl phillyrin; then dissolving the tetraacyl phillyrin in a second organic solvent, and adding sodium methoxide for deacylation, adding an acidic pH regulator to regulate the pH value of the reaction mixture to neutral; and finally carrying out purification treatment to obtain phillyrin. The advantages and practical values of the chemical synthesis method for phillyrin of the present invention lie in: the raw material is easy to get, the catalysts used for glycosylation are cheap and easy to get, the production cost is greatly reduced, and it can be used for industrial production.
摘要翻译：苯连二糖的化学合成方法本发明涉及苯连二糖的化学合成方法。本发明的方法包括：首先将糖基受体phillygenin和糖基供体溶解在有机溶剂中进行糖基化以获得四酰基芘基; 然后将四酰基芘基甘油酯溶解于第二有机溶剂中，并加入甲醇钠进行脱酰基反应，加入酸性pH调节剂以调节反应混合物的pH值至中性; 最后进行纯化处理得到phil rin素。本发明的酞菁类化学合成方法的优点和实用价值在于：原料易得，用于糖基化的催化剂价格便宜，易得，生产成本大大降低，可以是用于工业生产。

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