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1. 发明授权

EP1458705B1 THIOPHENE DERIVATIVES AND THEIR USE AS FRAGRANTS 有权
标题翻译：噻吩衍生物及其作为增香剂使用
公开(公告)号：EP1458705B1
公开(公告)日：2009-07-22
申请号：EP02805589.5
申请日：2002-12-13
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07D333/22 , C07D333/46
CPC分类号： C07D333/22
摘要： Derivatives having one of the following formulas (1) and (2), wherein R 1 and R 2 are, independently, H, C 1-5 alkyl or C 1-5 substituted alkyl, X is selected from the group consisting of -C(=O)H, -OCH 3 , -C(OR) 2 H, -CN, -C(=O)CH 3 and -C(=O)OR 7 (where R 7 is a C 1-15 alkyl), are useful as fragrants.

2. 发明公开

EP1687261A1 NOVEL OXY-NITRILES 审中-公开
标题翻译：新型的氧化氮
公开(公告)号：EP1687261A1
公开(公告)日：2006-08-09
申请号：EP04818703.3
申请日：2004-11-12
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07C255/16 , C07C255/33 , C07D333/24
CPC分类号： A23G4/06 , A23L27/202 , A23L27/2022 , C07C255/16 , C07D333/16 , C11B9/0023 , C11B9/0076
摘要： A compound or a mixture of compounds comprising an aromachemical compound of I the formula: NC-CH2-O-R wherein: R is straight or branched chain alkyl, alkenyl having 1-16 carbon atoms, aryl, aralkyl, alkaryl, thiophenyl or substituted derivatives thereof as well as compositions, products, preparations or articles having improved aroma, fragrance or odor characteristics containing as active ingredient such compound or mixture of compounds.
摘要翻译：包含下式Ⅰ的芳香化合物的化合物或化合物的混合物：NC-CH2-OR其中：R是直链或支链烷基，具有1-16个碳原子的链烯基，芳基，芳烷基，烷芳基，噻吩基或其取代衍生物以及具有改善的芳香，香味或气味特征的组合物，产品，制剂或制品，其包含作为活性成分的这种化合物或化合物的混合物。

3. 发明公开

EP2142012A1 AROMACHEMICALS 审中-公开
标题翻译： AROMACHEMIKALIEN
公开(公告)号：EP2142012A1
公开(公告)日：2010-01-13
申请号：EP08730924.1
申请日：2008-02-28
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： A23L1/22 , A61K8/40
CPC分类号： A61K8/4973 , A61K8/4986 , A61Q13/00 , A61Q15/00 , C11D3/50
摘要： A compound of formula (I) : wherein each R independently represents H, methanol or ethanol, and Z represents O or S.

4. 发明授权

EP1601752B1 MACROCYCLIC MUSKS 有权
标题翻译：大环清真寺
公开(公告)号：EP1601752B1
公开(公告)日：2010-01-13
申请号：EP04757493.4
申请日：2004-03-12
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C11D3/50 , A61K8/49 , C07C49/00 , C07C49/105
CPC分类号： C11B9/0049 , C11B9/0073 , C11D3/0068 , C11D3/2072 , C11D3/2093 , C11D3/50
摘要： A compound comprising a macrocyclic ketone having at least one double bond and 15-20 carbon atoms, wherein at least one double bond has been converted to oxirane or thiirane or a macrocyclic lactone or dilactone having at least one double bond and 14-19 carbon atoms, wherein at least one double bond has been converted to oxirane or thiirane; or one of said oxiranes or thiiranes containing a methyl substituent on the ring and/or an ether oxygen or thioether sulfur substituting for a CH2 somewhere in the ring and compositions, products, preparations or articles having improved aroma, fragrance, odor, flavor and/or taste characteristics containing as active ingredient a compound or mixture of the compounds.

5. 发明公开

EP1858871A1 MACROCYCLIC THIIRANES 审中-公开
标题翻译： MAKROCYCLISCHE环硫
公开(公告)号：EP1858871A1
公开(公告)日：2007-11-28
申请号：EP06709960.6
申请日：2006-03-01
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07D331/02 , C07D495/04 , C07D495/14 , A23L1/226 , C11B9/00
CPC分类号： A61L9/01 , A23L27/2052 , C07D331/02 , C07D495/04 , C07D495/14 , C11D3/50
摘要： The present invention provides a compound having the formulae: (I) wherein Z is CH2, CH=CH or CHSCH (thiirane), provided that if two or more Z are CH=CH they are not conjugated and wherein n is selected so that the total number of carbon atoms is from 8 to 20. Mixtures of these compounds, methods for their preparation, their use as perfume materials for application to a variety of substrates and their use in flavoring and in articles of manufacture is also provided.

6. 发明公开

EP1851211A2 MICHAEL ADDITION PRODUCT AND SCHIFF'S BASE AROMACHEMICALS 审中-公开
标题翻译： MICHAELADDITIONSPRODUKT- UND SCHIFFSCHE-BASE-AROMACHEMIKALIEN
公开(公告)号：EP1851211A2
公开(公告)日：2007-11-07
申请号：EP06704135.0
申请日：2006-01-20
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07D307/32 , C07C225/06 , C11D3/00 , C11B9/00 , A23L1/226
CPC分类号： A61K8/41 , A23L27/203 , A23L27/2052 , A61K2800/57 , A61Q5/00 , A61Q5/02 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C225/06 , C07C225/20 , C07C251/12 , C07C251/20 , C07C251/24 , C07C2601/08 , C07C2602/10 , C07D307/33 , C07D307/34 , C07D309/30 , C11D3/50 , C11D3/507
摘要： A pro-odorant or pro-flavorant having the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R3, R4 and R6 are each independently hydrogen or organic moieties which together with C(O)R5 render a compound of formula R5C(O)R6C=CR3R4 a material having odorant or flavourant characteristics and R5 is hydrogen or an organic moiety; or having the formula (II): R8R9C=NR10 wherein R10 is an aliphatic group or an aromatic group having at least 10 carbon atoms; R8 and R9 are each independently hydrogen or organic moieties which together with C=O render a compound of formula R8R9C=O a material having odorant or flavourant characteristics, provided that only one of R8 and R9 is hydrogen; or having the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; Z is CH2 or O, n is 0 or 1, such that the ring is a 5 or 6 membered ring, R11 is alkyl or alkenyl having up to 10 carbon atoms so as to render a compound of formula (IV): a material having odorant or flavorant characteristics is described. Methods for producing these compounds and their use as flavours and fragrances is also described.
摘要翻译：一种具有下列结构式的前味或前味：取代物使得该化合物是气味剂或食用香料; 或公式：<？in-line-formula description =“In-line Formulas”end =“lead”？> R＆lt; 9＆lt; 10＆lt; C-NR＆ 11 线内公式描述=“在线公式”end =“tail”→取代基使得式R 9的化合物10 CO是加臭剂或调味剂; 所述取代基使得具有下式的化合物：气味剂或调味剂; 或式（IV）：

7. 发明公开

EP1848702A2 PRO-FRAGRANCE AND PRO-FLAVORANT COMPOSITIONS 审中-公开
标题翻译： PRO-DUFTSTOFF-UND PRO-GESCHMACKSTOFF-ZUSAMMENSETZUNGEN
公开(公告)号：EP1848702A2
公开(公告)日：2007-10-31
申请号：EP06701704.6
申请日：2006-01-20
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07D307/32 , C07C225/06 , C07C249/02 , C07C251/24 , C11D3/00 , C11B9/00 , A23L1/226
CPC分类号： A61K8/41 , A23L27/203 , A23L27/2052 , A61K2800/57 , A61Q5/00 , A61Q5/02 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C225/06 , C07C225/20 , C07C251/12 , C07C251/20 , C07C251/24 , C07C2601/08 , C07C2602/10 , C07D307/33 , C07D307/34 , C07D309/30 , C11D3/50 , C11D3/507
摘要： A pro-odorant or pro-flavorant that is liquid at room temperature and has a relatively low viscosity and has the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R5 is CN, COOH, COOR7, CHO or C(O)R8; R3, R4 and R6 are each independently hydrogen or organic moieties which together with R5 render a compound of formula R5R6C=CR3R4 a material having odorant or flavourant characteristics and R7 and R8 are each independently an organic moiety; or the formula (II): R9R10C=NR11 wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; R9 and R10 are each independently H or organic moieties which together with C=O render a compound of formula : R9R10C=O a material having odorant or flavourant characteristics, provided that only one of R9 and R10 is hydrogen; or the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; Z is CH2 or O, n is 0 or 1, such that the ring is a 5 or 6 membered ring, R12 is H, alkyl or alkenyl or alkoxy having up to 10 carbon atoms so as to render a compound of formula (V): a material having odorant or flavorant characteristics; or formula (IV): wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; the or each R13 is independently a straight or branched chain, saturated or unsaturated hydrocarbyl group or alkoxy group having from 1 to 8 carbon atoms or two groups R13 together with the carbon atoms to which they are attached form a five or six membered ring which may be saturated or unsaturated (including aromatic) and which may be optionally substituted with from 1 to 3 alkyl groups having from 1 to 6 carbon atoms; and x is from 1 to 5 so as to render a compound of formula (VI): a material having odorant or flavorant characteristics. Methods for producing these compounds and their use as flavours and fragrances is also described.
摘要翻译：一种具有下列结构式的前味或前味：取代物使得该化合物是气味剂或食用香料; 或公式：<？in-line-formula description =“In-line Formulas”end =“lead”？> R＆lt; 9＆lt; 10＆lt; C-NR＆ 11 线内公式描述=“在线公式”end =“tail”→取代基使得式R 9的化合物10 CO是加臭剂或调味剂; 所述取代基使得具有下式的化合物：气味剂或调味剂; 或式（IV）：

8. 发明公开

EP1771540A1 NOVEL ALDEHYDIC MUSKS AND DERIVATIVES THEREOF 审中-公开
标题翻译：新型的醛萜麝香及其衍生物
公开(公告)号：EP1771540A1
公开(公告)日：2007-04-11
申请号：EP05762498.3
申请日：2005-06-24
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C11D7/22 , C11D7/26 , C11D7/32 , C11D7/40 , C11B9/00
CPC分类号： C11B9/0061 , A23L27/204 , A23L27/205 , C11B9/0049 , C11B9/0053 , C11B9/025 , C11B9/027 , C11D3/50
摘要： A compound comprising a Schiff s base of an aldehydic musk aromachemical with a substantially nonvolatile, odorless amine, wherein the imine moiety of said Schiffs base compound is stable against oxidation to a carboxyl group or a mixture of said compounds; said Schiffs base compound being biodegradable over time to said aldehydic musk and said nonvolatile, odorless amine; as well as compositions, products, preparations or articles having improved aroma, fragrance or odor characteristics containing as active ingredient such compound or mixture of compounds; the aldehydic musks themselves, and methods for the preparation of the Schiff bases and methods of imparting fragrance characteristics to substrates.
摘要翻译：一种化合物，其包含醛基麝香芳香化合物的席夫碱与基本上不挥发的无嗅胺，其中所述席夫碱化合物的亚胺部分对于氧化为羧基或所述化合物的混合物是稳定的; 所述席夫碱化合物随时间推移可生物降解为所述醛麝香和所述非挥发性无嗅胺; 以及具有改善的芳香，香味或气味特征的组合物，产品，制剂或制品，其包含作为活性成分的这种化合物或化合物的混合物; 醛类麝香本身，以及制备席夫碱的方法和赋予底物芳香特性的方法。

9. 发明公开

EP1625106A4 NOVEL FRAGRANCE DERIVATIVES 审中-公开
标题翻译：新款香水衍生物
公开(公告)号：EP1625106A4
公开(公告)日：2010-09-08
申请号：EP04760941
申请日：2004-05-07
申请人： FLEXITRAL INC
发明人： TURIN LUCA
IPC分类号： C11B9/00 , A23L2/56 , C07D331/02 , C11D3/50
CPC分类号： C07D331/02 , C11B9/0076 , C11D3/50

10. 发明公开

EP2181085A1 CYCLOPROPANATED AROMACHEMICALS 审中-公开
标题翻译： CYCLOPROPANIERTE AROMACHEMIKALIEN
公开(公告)号：EP2181085A1
公开(公告)日：2010-05-05
申请号：EP07754769.3
申请日：2007-04-02
申请人： Flexitral, Inc.
发明人： TURIN, Luca
IPC分类号： C07C47/36 , C07C251/18 , C07C43/315 , C07C43/317 , C07D317/20 , C11B9/00 , A23L1/226
CPC分类号： C11B9/0076 , A23L27/203 , A23L27/2052 , A61K8/33 , A61K8/34 , A61K8/4973 , A61Q13/00 , C07C33/05 , C07C43/305 , C07C43/317 , C07C45/292 , C07C45/69 , C07C47/36 , C07C47/45 , C07C251/18 , C07C2601/02 , C07D317/20 , C11B9/003
摘要： A compound of formula (I): wherein R is -CH2OH, -C(O)H5 -C(OR3)2H, -C(OR4)(OH)H, -CH=NC6H4C(O)OR5 or -CH=NR6; R1 and R2 are each independently H or CH3; R3 and R4 are each independently H or a straight or branched aliphatic group having from 1 to 12 carbon atoms, or each R3 is covalently linked to the other R3 to form a cyclic acetal having from 1 to 4 carbon atoms; R5 is H or a straight or branched aliphatic group, or a cyclic, heterocyclic or aromatic group having from 1 to 12 carbon atoms; and R6 has at least 10 carbon atoms and is an aliphatic group or an aromatic group. Mixtures of these compounds, methods for their preparation, their use as perfume materials for application to a variety of substrates and their use in flavouring and in articles of manufacture is also provided.
摘要翻译：式（I）的化合物：其中R是-CH 2 OH，-C（O）H，-C（OR 3）2） H，-C（OR 4）（OH）H，-CH-NC 6 H 4 C（O）或O 5或-CH-NR 6; R 1和R 2各自独立地为H或CH 3; R 3和R 4各自独立地为H或具有1至12个碳原子的直链或支链脂族基团，或每个R 3为与另一个R 3共价连接以形成具有1至4个碳原子的环状缩醛; R 5是H或具有1至12个碳原子的直链或支链脂族基团或环状，杂环或芳族基团; 和R 6具有至少10个碳原子，并且是脂族基团或芳族基团。还提供了这些化合物的混合物，其制备方法，它们作为用于各种底物的香料的用途以及它们在调味剂和制品中的应用。

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