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1. 发明授权

EP0436730B1 METHOD OF PRODUCING D-PANTOLACTONE 有权转让
标题翻译：工艺的生产D-泛酸内酯。
公开(公告)号：EP0436730B1
公开(公告)日：1995-10-11
申请号：EP90910899.5
申请日：1990-07-27
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： SAKAMOTO, Keiji , YAMADA, Hideaki , SHIMIZU, Sakayu
IPC分类号： C12P41/00 , C12R1/645 , C12R1/665 , C12R1/77 , C12R1/82 , C12R1/845 , C12P7/42
CPC分类号： C12P7/42 , C12P41/003
摘要： A method of producing D-pantolactone from DL-pantolactone, which comprises asymmetrically hydrolyzing only the D-enantiomer of DL-pantolactone selectively with a microorganism as specified in the claim to give D-pantoic acid, and converting the separated D-pantoic acid into D-pantolactone.

2. 发明授权

EP0328690B1 METHOD FOR DIAGNOSING CHRONIC ARTICULAR RHEUMATISM 失效
标题翻译：诊断方法的类风湿性关节炎。
公开(公告)号：EP0328690B1
公开(公告)日：1994-08-10
申请号：EP88907394.6
申请日：1988-08-25
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： HAYAKAWA, Taro , KODAMA, Shuji , IWATA, Kazushi , KISHI, Junichi , YAMASHITA, Kyoko , IWATA, Hisashi
IPC分类号： G01N33/573 , G01N33/577 , G01N33/564
CPC分类号： C07K16/38
摘要： A method for diagnosing chronic articular rheumatism, which comprises enzyme-immunologically determining a collagenase inhibitor existing in serum, plasma or synovia according to the sandwiching method utilizing a combination of two monoclonal antibodies specifically binding to different antigenic determinants of the collagenase inhibitor, and comparing the value with that of normal adults.

3. 发明公开

EP0550760A4 EP0550760A4 - 失效
标题翻译： EP0550760A4 - Google专利
公开(公告)号：EP0550760A4
公开(公告)日：1994-04-27
申请号：EP92914735
申请日：1992-07-14
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： HAYAKAWA, TARO, 406, MUKAIGAOKA 3-CHOME , YAMASHITA, KYOKO, 1-13-11015, CHIYODABASHI , IWATA, KAZUSHI, 190, IKARIHIGASHIMACHI
IPC分类号： C07K14/81 , C12N5/00 , C12N5/06
CPC分类号： C07K14/8146 , C12N5/0037 , C12N5/0043 , C12N2501/70

4. 发明公开

EP0504421A1 D-PANTOLACTONE HYDROLASE AND PRODUCTION THEREOF 失效转让
标题翻译： D-PANTOLACTONHYDROLASE UND IHRE HERSTELLUNG。
公开(公告)号：EP0504421A1
公开(公告)日：1992-09-23
申请号：EP91917332.8
申请日：1991-10-04
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： SAKAMOTO, Keiji , YAMADA, Hideaki , SHIMIZU, Sakayu
IPC分类号： C12N9/18
CPC分类号： C12P7/42 , C12N9/18 , C12P17/04 , C12P41/005
摘要： A novel enzyme which selectively hydrolyzes D-pantolactone in D,L-pantolactone, produced by any of the microorganisms belonging to the Genera Fusarium, Cylindrocarpon Gibberella, Aspergillus, Penicillium, Rhizopus, Bordetell a, Gliocladium, Eurotium, Nectria, Schizophyllum, Myrothecium, Neurospora, Acremonium, Tubercullna, Absidia, Sporothrix, Verticillium and Arthroderma.
摘要翻译：一种新颖的酶，其选择性地水解D，L-泛酸内酯中的D-泛酸内酯，其由属于镰刀菌属，赤霉菌，曲霉菌，青霉菌，根霉，博德特氏菌，Gliocladium，Eurotium，Nectria，Schizophyllum，Myrothecium，Neurospora ，顶孢菌属，结核菌属，茜草属，孢子虫属，轮枝菌属和关节炎。

5. 发明公开

EP0401370A4 ENZYME IMMUNOASSAY ACCORDING TO SANDWICH METHOD OF HUMAN IV-TYPE COLLAGEN 失效
标题翻译：根据人类IV型胶原的三种方法进行的酶免疫
公开(公告)号：EP0401370A4
公开(公告)日：1991-11-13
申请号：EP89902540
申请日：1989-02-17
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： OBATA, KENICHI , IWATA, KAZUSHI , OSHIMA, AKIRA , INOUE, KYOICHI
IPC分类号： C07K16/18 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18

6. 发明公开

EP0193935A3 Method for determining human prolyl 4-hydroxylase by immunoassay 失效
标题翻译：用免疫测定方法测定人类四羟基-4-羟化酶
公开(公告)号：EP0193935A3
公开(公告)日：1987-12-02
申请号：EP86102858
申请日：1986-03-05
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： Yoshida, Shinichi , Ishikawa, Eiji , Oshima, Akira , Bai, Yasuo , Muragaki, Yasuteru , Inada, Kazuyoshi , Iwata, Kazushi , Obata, Kenichi , Nagai, Yasuo
IPC分类号： G01N33/573 , G01N33/543 , G01N33/577 , G01N33/534 , G01N33/535
CPC分类号： G01N33/573
摘要： A method for determining human prolyl 4-hydroxylase by an enzyme immunoassay or a radioimmunoassay according to the sandwich technique is provided. The determination is carried out using a first anti-human prolyl 4-hydroxylase antibody which is coated onto a solid phase and a second anti-human prolyl 4-hydroxylase antibody which is labelled with an enzyme or ' 30 tope. Furthermore, a method for the in-vitro diagnosis of hepatic diseases is provided.

7. 发明公开

EP1101496A1 THERAPEUTIC AGENTS FOR ALLERGIC DISEASES 审中-公开
标题翻译：治疗过敏性疾病的药物
公开(公告)号：EP1101496A1
公开(公告)日：2001-05-23
申请号：EP99929876.3
申请日：1999-07-16
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： IGETA, Katsuhiro, Fuji Yakuhin Kogyo K.K. , TOBETTO, Kenji, Maruho R+D Laboratories , SAIKI, Ikuo , ODAKE, Shinjiro, Fuji Yakuhin Kogyo K.K. , FUJISAWA, Tetsunori, Fuji Yakuhin Kogyo K.K. , MATSUO, Tetsu, Maruho Co., Ltd. , OKU, Tohru, Fuji Yakuhin Kogyo K.K.
IPC分类号： A61K45/00
CPC分类号： C07C279/18 , A61K31/00 , C07C259/06
摘要： Disclosed are anti-inflammatory agents, antiallergic agents, particularly prophylactically and/or therapeutically effective drugs for type I and/or IV allergic conditions, and further pharmaceutical drugs for prophylactically and/or therapeutically treating bronchial asthma, atopic diseases, etc. The inventive drugs comprising a prophylactically and/or therapeutically effective amount of a metalloproteinase inhibitor are active in the prophylaxis and/or therapy of allergy, especially type I and/or IV allergy, etc. The drugs are active in prophylactically and/or therapeutically treating inflammation, rhinitis, conjunctivitis, bronchial asthma, atopic diseases (including dermatitis, enteritis, etc.), or allergic gastroenterocolitis (allergic inflammation in digestive tract). The application of such drugs leads to (A) reduction of cells (such as lymphocytes, neutrophils, mast cells, eosinophils, basophils, macrophages and monocytes) at a diseased site, and/or (B) alleviation of inflammatory symptoms caused by migration, infiltration or accumulation of cells (such as lymphocytes, neutrophils, mast cells, eosinophils, basophils, macrophages and monocytes) to (or at) the diseased site, (C) inhibition of pathophysiological functions in cells (such as lymphocytes, neutrophils, mast cells, eosinophils, basophils, macrophages, monocytes, Langerhans cell and dendritic cells), and/or (D) reducing the blood level or inhibiting the production, of antibodies, especially IgE. Accordingly, the drugs are useful in the prophylaxis and/or therapy of diseases, disorders or ill conditions at the site.
摘要翻译：公开了用于I型和/或IV型变应性病症的抗炎剂，抗过敏剂，特别是预防和/或治疗有效的药物，以及用于预防和/或治疗性治疗支气管哮喘，特应性疾病等的其它药物。本发明的药物包含预防和/或治疗有效量的金属蛋白酶抑制剂在预防和/或治疗变态反应，特别是I型和/或IV变态反应等方面具有活性。所述药物在预防和/或治疗性治疗炎症，鼻炎，结膜炎，支气管哮喘，特应性疾病（包括皮炎，肠炎等）或过敏性胃肠炎（消化道过敏性炎症）。这些药物的应用导致（A）在患病部位细胞（如淋巴细胞，嗜中性粒细胞，肥大细胞，嗜酸性粒细胞，嗜碱性粒细胞，巨噬细胞和单核细胞）减少，和/或（B）缓解由迁移引起的炎症症状，细胞（例如淋巴细胞，嗜中性粒细胞，肥大细胞，嗜酸性粒细胞，嗜碱性粒细胞，巨噬细胞和单核细胞）向病变部位（或其）的浸润或积聚，（C）细胞中的病理生理功能的抑制（例如淋巴细胞，嗜中性粒细胞，肥大细胞，嗜酸性粒细胞，嗜碱性粒细胞，巨噬细胞，单核细胞，朗格汉斯细胞和树突细胞）和/或（D）降低血液水平或抑制抗体特别是IgE的产生。因此，这些药物可用于预防和/或治疗该部位的疾病，病症或病症。

8. 发明公开

EP0870826A1 NOVEL PROTEIN AND MONOCLONAL ANTIBODY SPECIFIC THERETO 失效
标题翻译：胶原蛋白基质金属蛋白酶在GEGEN DIESE GERICHTETE MONOKLONALEANTIKÖRPER
公开(公告)号：EP0870826A1
公开(公告)日：1998-10-14
申请号：EP96923081.2
申请日：1996-07-12
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： SEIKI, Motoharu , SATO, Hiroshi Heiwashukusha C57-11 , SHINAGAWA, Akira Fuji Yakuhin Kogyo Kabushiki
IPC分类号： C12N9/64 , C12N15/00 , C12P21/08 , C12Q1/68
CPC分类号： C12N9/6491 , A61K38/00 , C07K16/40 , Y02A50/473
摘要： A novel protein which is useful as diagnostic means for the studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and in other medicinal and physiological purposes; a gene encoding the same; and an antibody, in particular, a monoclonal antibody specific to the protein. MT-MMP-3, which is a pro MMP-2 activator having the ability to activate pro MMP-2 which is under expression specifically on the surface layer of a human cancer cell and falling within the category of MMP but being different from MT-MMP-1; a DNA containing the base sequence encoding the same; host cells transformed by the DNA; a process for producing a matrix metalloproteinase protein by using the host cells; a monoclonal antibody binding specifically to the matrix metalloproteinase protein; and use of the protein and antibody.
摘要翻译：一种新的蛋白质，可用于诊断和治疗癌症（癌症细胞的检测，恶性肿瘤的估计等）和其他药物和生理学目的的诊断手段; 编码该基因的基因; 特别是抗体，特别是针对蛋白质的单克隆抗体。 MT-MMP-3是具有活化pro MMP-2的能力的亲MMP-2激活剂，其特异性地表达在人类癌细胞的表面上，并且属于MMP类别，但不同于MT- MMP-1; 含有编码其的碱基序列的DNA; 由DNA转化的宿主细胞; 通过使用宿主细胞产生基质金属蛋白酶蛋白质的方法; 与基质金属蛋白酶蛋白特异性结合的单克隆抗体; 并使用蛋白质和抗体。

9. 发明公开

EP0504421A4 EP0504421A4 - 失效转让
标题翻译： EP0504421A4 - Google专利
公开(公告)号：EP0504421A4
公开(公告)日：1994-04-06
申请号：EP91917332
申请日：1991-10-04
申请人： FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： SAKAMOTO, KEIJI , YAMADA, HIDEAKI , SHIMIZU, SAKAYU
IPC分类号： C12N9/18 , C12P7/42 , C12P17/04 , C12P41/00 , C12R1/645 , C12R1/665 , C12R1/77 , C12R1/82 , C12R1/845
CPC分类号： C12P7/42 , C12N9/18 , C12P17/04 , C12P41/005

10. 发明公开

EP0474486A2 Attractant compositions for fall webworm 失效
标题翻译： LockmittelfürweissenBärenspinner。
公开(公告)号：EP0474486A2
公开(公告)日：1992-03-11
申请号：EP91308119.6
申请日：1991-09-04
申请人： Nitto Denko Co. Ltd. , FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
发明人： Senda, Shuji, c/o Nitto Denko Co., Ltd. , Omata, Tetsuo, c/o Nitto Denko Co., Ltd. , Ninomiya, Yasuo, c/o Nitto Denko Co., Ltd. , Aburatani, Masakazu, c/o Fuji Yakuhin Kogyo K. K. , Takeuchi, Tadashi, c/o Fuji Yakuhin Kogyo K. K.
IPC分类号： A01N43/20
CPC分类号： A01N43/20 , A01N35/02 , A01N2300/00
摘要： This invention relates to attractant compositions for Fall webworm (Hyphantria cunea) comprising sex pheromone attracting Fall webworm (Hyphantria cunea) , the sex pheromone comprising at least (3Z,6Z)-cis-9,10-epoxy-3,6-henicosadiene (formula 1), (3Z,6Z)-cis-9,10-epoxy-1,3,6-henicosatriene (formula 2), and (9Z,12Z,15Z)-9,12,15-octadecatrien-1-al (formula 3) chosen from (3Z,6Z)-cis-9,10-epoxy-3,6-henicosadiene(formula 1), (3Z,6Z)-cis-9,10-epoxy-1,3,6-henicosatriene(formula 2), (9Z,12Z,15Z)-9,12,15-octadecatrien-1-al (formula 3), and (3Z,6Z)-cis-9,10-epoxy-1,3,6-icosatriene (formula 4). This inventional attractant compositions are more particularly directed to attractant composition efficiently attracting Fall webworm (Hyphantria cunea) which is manufactured in relatively high yield, and thereby effectively used for preventing the breeding of and massively exterminating Fall webworm (Hyphantria cunea) .
摘要翻译：本发明涉及包含吸引Fall虫（Hyphantria cunea）的性信息素的秋季蛔虫（Hyphantria cunea）的引诱剂组合物，所述性信息素包含至少（3Z，6Z） - 顺-9,10-环氧-3,6-硫代二烯（（3Z，6Z） - 顺式-9,10-环氧-1,3,6-己三酸（式2）和（9Z，12Z，15Z）-9,12,15-十八碳三烯-1-基（3Z，6Z） - 顺式-9,10-环氧-3,6-己氮二烯（式1），（3Z，6Z） - 顺式-9,10-环氧-1,3,6- （式2），（9Z，12Z，15Z）-9,12,15-十八碳三烯-1-基（式3）和（3Z，6Z） - 顺式-9,10-环氧-1,3,6 （四氢呋喃）。本发明的引诱剂组合物更具体地涉及引诱剂组合物有效地吸引以较高产率制造的Fall虫（Hyphantria cunea），从而有效地用于防止蚯蚓（Hyphantria cunea）的繁殖和大量灭绝。 r

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