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1. 发明公开

EP2801855A1 A microscope module for imaging a sample 有权转让
标题翻译： Mikroskopmodul zur Abbildung einer Probe
公开(公告)号：EP2801855A1
公开(公告)日：2014-11-12
申请号：EP13167360.0
申请日：2013-05-10
申请人： European Molecular Biology Laboratory (EMBL)
发明人： Strnad, Petr , Hufnagel, Lars , Ellenberg, Jan , Krzic, Uros
IPC分类号： G02B21/00 , G01N21/03 , G02B21/16 , G02B21/34 , G02B21/36 , G01N21/64
CPC分类号： G02B21/06 , G01N21/6458 , G02B21/0076 , G02B21/0088 , G02B21/02 , G02B21/16 , G02B21/33 , G02B21/34 , G02B21/367
摘要： A microscope module (300) for imaging a sample (270) is disclosed. The microscope module (300) comprises at least one illumination objective (210) for producing an illumination beam along an illumination beam path (215) arranged to illuminate lower surface of the sample (270) and at least one detection objective (220) having a detection path (225). The detection path (225) is at an angle to the illumination beam path (215).
摘要翻译：公开了一种用于对样品（270）进行成像的显微镜模块（300）。所述显微镜模块（300）包括至少一个照明物镜（210），用于产生沿着照明所述样品（270）的下表面的照明光束路径（215）的照明光束和至少一个检测物镜（220）检测路径（225）。检测路径（225）与照明光束路径（215）成一角度。

2. 发明公开

EP2676163A2 LIGHT-PAD MICROSCOPE 有权转让
标题翻译： LICHTPAD显微镜
公开(公告)号：EP2676163A2
公开(公告)日：2013-12-25
申请号：EP12706003.6
申请日：2012-02-14
申请人： European Molecular Biology Laboratory (EMBL)
发明人： KNOP, Michael , WACHSMUTH, Malte , CAPOULADE, Jérémie
IPC分类号： G02B21/00 , G02B21/16 , G02B21/36 , G01N21/64
摘要： The present disclosure teaches a microscope (1) having an illumination light path (20) for illuminating a sample or object (18) and a viewing light path (40,50) for viewing the sample. The microscope comprises an illumination light path focussing arrangement in the illumination light path, the illumination light path focussing arrangement defining a substantially two-dimensional sample or object illumination region (22) extending along an illumination direction of the illumination light path and transversely thereto. The microscope further comprises an illumination region-confining device (27) in the illumination light path for selectively illuminating a portion (10) of the substantially two-dimensional object illumination region, wherein the portion of the substantially two-dimensional object illumination region is confined at least in the illumination direction and/or in the direction transversely thereto.

3. 发明公开

EP2547696A2 FRAGMENTS OF THE PA SUBUNIT OF RNA DEPENDENT RNA POLYMERASE FROM PANDEMIC INFLUENZA VIRUS A 2009 H1N1, AND THEIR USE 有权
标题翻译： PA作者RNA依赖的RNA聚合酶从流行的流感病毒2009年的H1N1病毒及其用途HEIN意识FRAGMENTS
公开(公告)号：EP2547696A2
公开(公告)日：2013-01-23
申请号：EP11709643.8
申请日：2011-03-15
申请人： EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
发明人： CUSACK, Stephen , KOWALINSKI, Eva , ZUBIETA, Chloe
IPC分类号： C07K14/11 , A61K31/428 , A61K31/33
CPC分类号： C12N9/22 , A61K31/33 , A61K38/00 , C07D211/32 , C07D211/96 , C07D311/62 , C07H19/10 , C07K14/005 , C07K16/40 , C07K2299/00 , C07K2317/34 , C12N2760/16122 , G06F19/16
摘要： The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds which are able to modulate, preferably to inhibit, the endonuclease activity of the PA subunit polypeptide fragment or variant thereof of the present invention and pharmaceutical compositions comprising said compounds for the treatment of disease conditions caused by viral infections with viruses of the Orthomyxoviridae family, Bunyaviridae family and/or Arenviridae family, preferably caused by viral infections with Influenza A 2009 pandemic H1N1 virus. Preferably, said compounds are identifiable by the methods disclosed herein or said pharmaceutical compositions are producible by the methods disclosed herein.
摘要翻译：本发明涉及包括病毒RNA依赖性RNA聚合酶波塞PA亚基的氨基末端片段的唱核酸内切酶活，worin所述PA亚基多肽片段是从流感2009大流行的H1N1病毒或其变体。所以本发明涉及的多肽片段使用X-射线晶体学和（ii）使用所述多肽的结构坐标来筛选计算方法和设计的化合物并调节其适合于所述多肽片段的结构测定（I）的晶体，优选抑制多肽片段内核酸内切酶活。此外，本发明涉及识别并化合物结合到PA多肽片段波塞唱内切酶活性并优选抑制核酸内切说活性，优选以高通量设定方法。因此，这发明涉及能够调节，优选抑制，PA亚基多肽片段或本发明的变体，和药物组合物包含所述化合物的用于疾病状况通过用病毒的病毒感染引起的治疗的核酸内切酶活性的化合物正粘病毒科，布尼亚病毒科和/或沙粒家族的，优选通过用流感病毒感染2009大流行的H1N1病毒引起的。优选地，所述化合物是通过所述方法圆盘在游离缺失或所述药物组合物通过在游离缺失方法可生产的圆盘识别。

4. 发明公开

EP1124977A1 FIBRE ADENOVIRALE MODIFIEE ET UTILISATIONS 审中-公开
标题翻译：它的用途腺病毒的改性纤维蛋白及
公开(公告)号：EP1124977A1
公开(公告)日：2001-08-22
申请号：EP00958742.9
申请日：2000-08-25
申请人： TRANSGENE S.A. , EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
发明人： VAN RAAIJ, Mark, Johan , CUSACK, Stephen , LEGRAND, Valérie , LEISSNER, Philippe , MEHTALI, Majid
IPC分类号： C12N15/861 , C12N5/10 , C12N15/34 , C07K14/075 , A61K48/00
CPC分类号： C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/10 , C12N2810/40 , C12N2810/851 , C12N2810/854 , C12N2810/859
摘要： The invention concerns a modified adenoviral fibre comprising at least one mutation at the level of one or several residues included in the region of said fibre extending from layer A to layer B and including the loop AB.

5. 发明公开

EP2623590A3 Polypeptide fragments comprising endonuclease activity and their use 审中-公开
标题翻译：包含内切核酸酶活性的多肽片段及其用途
公开(公告)号：EP2623590A3
公开(公告)日：2013-11-13
申请号：EP13162372.0
申请日：2009-12-18
申请人： European Molecular Biology Laboratory (EMBL) , University Joseph Fourier Filiale , Centre National de la Recherche Scientifique, Direction de la Politique Industrielle
发明人： Bouvier, Denis , Crepin, Thibaut , Ruigrok, Rob , Dias, Alexander , Cusack, Stephen
IPC分类号： C12N9/12
CPC分类号： C12N9/22 , A61K31/192 , C07K2299/00 , C12N9/127 , C12Q1/44 , G01N2333/922 , G01N2500/02 , G06F19/12 , G06F19/16
摘要： The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by viruses of the Orthomyxoviridae family.
摘要翻译：本发明涉及包含病毒RNA依赖性RNA聚合酶的PA亚基的氨基末端片段或其具有内切核酸酶活性的变体的多肽片段，其中所述PA亚基来自属于正粘病毒科的病毒。本发明还涉及（i）适用于使用X射线晶体学对所述多肽片段进行结构测定的多肽片段的晶体，和（ii）使用所述多肽的结构坐标来筛选和设计调节，优选抑制多肽片段内的核酸内切酶活性位点。另外，本发明涉及鉴定结合具有核酸内切酶活性的PA多肽片段的化合物的方法，所述方法优选在高通量环境中优选抑制所述核酸内切酶活性。本发明还涉及包含鉴定的化合物的化合物和药物组合物，用于治疗由正粘病毒科病毒引起的病毒感染引起的疾病状况。

6. 发明公开

EP2449383A1 DIAGNOSTIC METHOD FOR PREDICTING THE RISK OF CANCER RECURRENCE BASED ON HISTONE MACROH2A ISOFORMS 有权
标题翻译：诊断步骤用于预测癌症复发的风险基于组蛋白的macroH2A同种型
公开(公告)号：EP2449383A1
公开(公告)日：2012-05-09
申请号：EP10730098.0
申请日：2010-07-02
申请人： European Molecular Biology Laboratory (EMBL) , Thoraxklinik Heidelberg GmbH
发明人： LADURNER, Andreas , SPORN, Judith , MULEY, Thomas
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N33/57415 , G01N33/57423
摘要： The present invention relates to a method for diagnosing the risk of cancer recurrence in a mammalian patient, comprising detecting the expression of macroH2A1.1 and/or macroH2A2 in a biological sample obtained from said patient, wherein a low or reduced expression of said macroH2A1.1 and/or macroH2A2 is indicative for an increased risk of cancer recurrence in said patient. The present invention is further directed at improved methods for treating cancer, in particular breast and/or lung cancer, based on said diagnostic method.
摘要翻译：本发明涉及用于诊断癌症复发的风险中的哺乳动物患者，包括检测macroH2A1.1和/或巨H2A2从所述患者获得的生物样品中的表达，worin说macroH2A1的低或降低表达的方法。 1和/或巨H2A2是在所述患者的癌症复发风险增加指示。本发明还涉及用于特别是乳腺癌和/或肺癌，基于所述诊断方法治疗癌症的改进方法。

7. 发明公开

EP2382190A1 TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS 审中-公开
标题翻译： TOLUIDINSULFONAMIDE及其作为抑制剂
公开(公告)号：EP2382190A1
公开(公告)日：2011-11-02
申请号：EP09796981.0
申请日：2009-12-30
申请人： European Molecular Biology Laboratory (EMBL) , Elara Pharmaceuticals Gmbh
发明人： ALONSO, Jorge , ENCINAS LOPEZ, Arantxa , MUELBAIER, Marcel , AMMENN, Jochen , WENDT, Bernd , LEWIS, Joe , SCHULTES, Christoph , JANSSEN, Bernd
IPC分类号： C07D207/36 , C07D213/71 , C07D239/38 , C07D241/18 , C07D307/64 , C07D333/34 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/381 , A61K31/4427 , A61P35/00
CPC分类号： C07D207/36 , C07D213/71 , C07D239/38 , C07D241/18 , C07D307/64 , C07D333/34 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds of formula (I), wherein R
1 is a monocyclic 5- or 6-membered heteroaryl; R
4 is phenyl or monocyclic 5- or 6-membered heteroaryl; and the other substituents as defined in the claims, that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)--mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders.

8. 发明授权

EP2936164B1 AUTOMATION OF INCUBATION, PROCESSING, HARVESTING AND ANALYSIS OF SAMPLES IN A MULTI-CELL PLATE WITH THIN FILM SAMPLE SUPPORT 有权
公开(公告)号：EP2936164B1
公开(公告)日：2020-01-15
申请号：EP13811205.7
申请日：2013-12-18
申请人： European Molecular Biology Laboratory (EMBL)
发明人： CIPRIANI, Florent , MARQUEZ, Jose Antonio
IPC分类号： G01N35/00 , B01L3/06 , B01L3/00 , G01N35/02 , G01N35/04

9. 发明授权

EP2864338B1 7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权
标题翻译： 7-氧代THIAZOLOPYRIDINKOHLENSÄUREDERIVATE及其用途用于治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2864338B1
公开(公告)日：2016-12-14
申请号：EP13730130.5
申请日：2013-05-23
申请人： Savira Pharmaceuticals GmbH , F.Hoffmann-La Roche AG , European Molecular Biology Laboratory (EMBL)
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： C07D513/04 , A61K31/429 , A61P31/12
CPC分类号： C07D513/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04

10. 发明公开

EP2755765A2 MICROFLUIDIC DEVICE 有权转让
公开(公告)号：EP2755765A2
公开(公告)日：2014-07-23
申请号：EP12766297.1
申请日：2012-09-14
申请人： European Molecular Biology Laboratory (EMBL)
发明人： UTHARALA, Ramesh , MERTEN, Christoph
IPC分类号： B01L3/00
摘要： The present disclosure teaches an apparatus and a method for providing one or more substance liquids to a microfluidic channel network (30). The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network (30). The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.
摘要翻译：本公开教导了用于向微流体通道网络（30）提供一种或多种物质液体的设备和方法。微流体装置包括用于将一种或多种物质液体切换到微流体通道网络（30）的阀。该设备可用于在不混溶的分离液体中产生一种或多种物质液体的序列作为单独的液滴，其中液滴序列中的各个液滴位于分离液体之间。

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