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1. 发明公开

EP3069135A4 PORTABLE COAGULATION MONITORING DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译： TRAGBAREKOAGULATIONSÜBERWACHUNGSVORRICHTUNGEN，-SYSTEME UND -VERFAHREN
公开(公告)号：EP3069135A4
公开(公告)日：2017-08-30
申请号：EP14861634
申请日：2014-11-17
申请人： ENTEGRION INC
发明人： PEARCE MATTHEW , HALL RICHARD , DACORTA JOSEPH A
IPC分类号： G01N33/49
CPC分类号： G01N33/4905 , G01N33/49

2. 发明公开

EP2416790A4 SPRAY-DRIED BLOOD PRODUCTS AND METHODS OF MAKING SAME 有权转让
标题翻译： VERFAHREN ZU IHRER HERSTELLUNGSPRÜHGETROCKNETEBLUTPRODUKTE
公开(公告)号：EP2416790A4
公开(公告)日：2013-01-16
申请号：EP10762281
申请日：2010-04-06
申请人： ENTEGRION INC
发明人： FISCHER THOMAS H , DACORTA JOSEPH A , GALIGER MICHAEL LAWRENCE
IPC分类号： A61K35/16 , A61L26/00 , A61P7/00
CPC分类号： A61K9/1688 , A61F13/00063 , A61F2013/00306 , A61F2013/00472 , A61F2013/00927 , A61K9/0026 , A61K35/16 , A61K35/19 , A61L26/0047 , A61L26/0057 , A61L26/0076
摘要： The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.
摘要翻译：本发明涉及一种制备脱水血液制品的方法，包括以下步骤：（a）提供水合血液制品; （b）喷雾干燥水合血液制品以产生脱水血液制品，以及通过该方法制备的脱水血液制品。本发明涉及一种治疗患有血液相关病症的患者的方法，包括以下步骤：（a）将治疗量的脱水血液制品再水化以产生再水合的治疗组合物; 和（b）将所述再水合治疗组合物给予所述患者。本发明涉及包含上述脱水血液制品的绷带或外科辅助助剂。

3. 发明公开

EP3132808A1 HEMOSTATIC TEXTILE 有权
标题翻译： HAMOSTATISCHER TEXTILSTOFF
公开(公告)号：EP3132808A1
公开(公告)日：2017-02-22
申请号：EP16190587.2
申请日：2007-01-10
申请人： Entegrion, Inc. , The University of North Caroline at Chapel Hill
发明人： FISCHER, Thomas , ESKRIDGE, Stan , MALLOY, William , EVANS, Malloy
IPC分类号： A61L15/18 , A61L15/42
摘要： The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding. (Drawing Figure 1)
摘要翻译：本发明涉及止血织物，其包括：包含玻璃纤维和一种或多种选自丝纤维组的二次纤维的组合的材料; 陶瓷纤维; 原生或再生竹纤维; 棉纤维; 人造丝纤维; 亚麻纤维; 苎麻纤维; 黄麻纤维; 剑麻纤维; 亚麻纤维; 大豆纤维; 玉米纤维; 大麻纤维; 莱索纤维; 羊毛; 丙交酯和/或乙交酯聚合物; 丙交酯/乙交酯共聚物; 硅酸盐纤维; 聚酰胺纤维; 长石纤维; 沸石纤维，含沸石的纤维，醋酸纤维; 及其组合; 当应用于伤口时能够激活身体中的止血系统的止血织物。另外的辅因子如凝血酶和止血剂如RL血小板，RL血细胞; 纤维蛋白，纤维蛋白原及其组合也可以并入纺织品中。本发明还涉及生产纺织品的方法，以及使用纺织品止血的方法。（图1）

4. 发明授权

EP2513647B1 PORTABLE COAGULATION MONITORING DEVICE AND METHOD OF ASSESSING COAGULATION RESPONSE 有权
标题翻译：便携式KOAGULATIONSMONITOR和方法评估凝血
公开(公告)号：EP2513647B1
公开(公告)日：2015-04-22
申请号：EP10838275.5
申请日：2010-12-17
申请人： Entegrion, Inc.
发明人： DENNIS, Robert Glenn , FISCHER, Thomas H. , DACORTA, Joseph A.
IPC分类号： G01N33/49 , G01N21/17 , G01N33/86 , G01N11/00
CPC分类号： G01N33/86 , G01N21/17 , G01N33/4905 , G01N2011/008

5. 发明公开

EP2170357A4 DELIVERY OF MICRO-AND NANOPARTICLES WITH BLOOD PLATELETS 审中-公开
标题翻译：微型和纳米颗粒与血小板分布
公开(公告)号：EP2170357A4
公开(公告)日：2012-01-04
申请号：EP08767487
申请日：2008-05-02
申请人： ENTEGRION INC
发明人： FISCHER THOMAS H , ESKRIDGE STAN E JR
IPC分类号： A61K35/14 , B82B1/00 , C12N5/078 , C12N5/08
CPC分类号： C12N5/0644 , A61K31/7088 , A61K33/26 , A61K35/12 , A61K35/19 , A61K38/16 , A61K38/36 , A61K47/6901 , A61K49/1887 , A61K49/1896 , A61K49/222 , B82Y5/00
摘要： The invention is directed to platelets containing micron or nanometer size particles wherein the micron or nanometer sized particles comprises an active agent. The invention is also directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the above platelets. The invention is further directed to methods of delivering the micron or nanometer size particles containing an active agent to a site of interest in a patient.

6. 发明授权

EP3132808B1 HEMOSTATIC TEXTILE 有权
公开(公告)号：EP3132808B1
公开(公告)日：2020-08-05
申请号：EP16190587.2
申请日：2007-01-10
申请人： Entegrion, Inc. , The University of North Caroline at Chapel Hill
发明人： FISCHER, Thomas , ESKRIDGE, Stan , MALLOY, William , EVANS, Malloy
IPC分类号： A61L15/18 , A61L15/42

7. 发明授权

EP2416790B1 SPRAY-DRIED BLOOD PRODUCTS AND METHODS OF MAKING SAME 有权转让
公开(公告)号：EP2416790B1
公开(公告)日：2018-05-23
申请号：EP10762281.3
申请日：2010-04-06
申请人： Entegrion, Inc.
发明人： FISCHER, Thomas, H. , DACORTA, Joseph, A. , GALIGER, Michael Lawrence.
IPC分类号： A61K35/16 , A61L26/00 , A61P7/00
CPC分类号： A61K9/1688 , A61F13/00063 , A61F2013/00306 , A61F2013/00472 , A61F2013/00927 , A61K9/0026 , A61K35/16 , A61K35/19 , A61L26/0047 , A61L26/0057 , A61L26/0076
摘要： The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.

8. 发明公开

EP2170357A1 DELIVERY OF MICRO-AND NANOPARTICLES WITH BLOOD PLATELETS 审中-公开
标题翻译：微型和纳米颗粒与血小板分布
公开(公告)号：EP2170357A1
公开(公告)日：2010-04-07
申请号：EP08767487.5
申请日：2008-05-02
申请人： Entegrion, Inc.
发明人： FISCHER, Thomas, H. , ESKRIDGE, Stan, E., Jr.
IPC分类号： A61K35/14 , C12N5/08 , B82B1/00
CPC分类号： C12N5/0644 , A61K31/7088 , A61K33/26 , A61K35/12 , A61K35/19 , A61K38/16 , A61K38/36 , A61K47/6901 , A61K49/1887 , A61K49/1896 , A61K49/222 , B82Y5/00
摘要： The invention is directed to platelets containing micron or nanometer size particles wherein the micron or nanometer sized particles comprises an active agent. The invention is also directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the above platelets. The invention is further directed to methods of delivering the micron or nanometer size particles containing an active agent to a site of interest in a patient.

9. 发明公开

EP3811981A1 HEMOSTATIC TEXTILE 审中-公开
公开(公告)号：EP3811981A1
公开(公告)日：2021-04-28
申请号：EP20189485.4
申请日：2007-01-10
申请人： Entegrion, Inc. , The University of North Carolina at Chapel Hill
发明人： Fischer, Thomas , Eskridge, Stan , Malloy, William , Evans, Malloy
IPC分类号： A61L15/18 , A61L15/42 , A61L15/28
摘要： The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding. (Drawing Figure 1)

10. 发明公开

EP3069135A1 PORTABLE COAGULATION MONITORING DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：便携式凝血监测装置，系统和方法
公开(公告)号：EP3069135A1
公开(公告)日：2016-09-21
申请号：EP14861634.5
申请日：2014-11-17
申请人： Entegrion, Inc.
发明人： PEARCE, Matthew , HALL, Richard , DACORTA, Joseph A.
IPC分类号： G01N33/49
CPC分类号： G01N33/4905 , G01N33/49
摘要： Portable coagulation monitoring devices, systems, and methods are disclosed. Namely, a test cartridge is provided for use in a portable coagulation monitor (PCM) device. Further, the test cartridge comprises two glass-filled thermoplastic polymer plates and a disposable blood introduction device. The two glass-filled thermoplastic polymer plates are arranged substantially in parallel with a small gap therebetween for receiving a sample of blood to be tested. Using the PCM device, the two glass-filled thermoplastic polymer plates can be moved linearly relative to each other. Methods of measuring coagulation response in a blood sample using the test cartridge and the PCM device are provided. A method of introducing blood into the test cartridge using the disposable blood introduction device is provided.
摘要翻译：公开了便携式凝血监测装置，系统和方法。即，提供用于便携式凝血监测（PCM）装置的测试盒。此外，测试盒包括两个玻璃填充热塑性聚合物板和一次性血液引入装置。两个玻璃填充的热塑性聚合物板基本上平行排列，其间具有小间隙用于接收待测试的血液样本。使用PCM设备，两个玻璃填充的热塑性聚合物板可以相对于彼此线性移动。提供了使用测试盒和PCM装置测量血液样品中的凝血反应的方法。提供了一种使用一次性血液引入装置将血液引入测试盒的方法。

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