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    • 3. 发明公开
    • APTAMER BIOCONJUGATE DRUG DELIVERY DEVICE
    • ARZNEIMITTELABGABEVORRICHTUNGFÜREIN APTAMER-BIOKONJUGAT
    • EP2645991A2
    • 2013-10-09
    • EP11845209.3
    • 2011-12-02
    • EcoSynthetix Ltd.
    • BLOEMBERGEN, StevenMCLENNAN, Ian, J.JONES, NathanWAGNER, RyanGANESH SHERMON, Aareet, KrsnaELSAYED, Abdel, RahmanLIU, Juewen
    • A61K9/00B82B1/00
    • A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
    • 用于活性剂的递送装置包括基于诸如淀粉的生物聚合物的纳米颗粒。 递送装置还可以是适体 - 生物聚合物 - 活性剂缀合物的形式,其中适体靶向用于治疗特定病症的装置。 可以通过在交联剂的存在下施加高剪切力来制备纳米颗粒。 颗粒可以主要在50-150nm的范围内,并且形成交联的水凝胶颗粒在水中的胶态分散体。 生物聚合物可以官能化。 适体可以直接与交联的生物聚合物缀合。 活性剂可以是用于治疗癌症的药物。 递送装置在体内存活足够长的时间以允许药物的持续释放以及将缀合物输送和摄取到靶细胞中。 然而,生物聚合物是生物相容性和可再吸收的。