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1. 发明公开

EP2765557A2 Coregistering images of needle biopsies using multiple weighted landmarks 有权转让
标题翻译： Koregistrierung von Bildern von Nadelbiopsien mittels mehrerer gewichteter Landmarken
公开(公告)号：EP2765557A2
公开(公告)日：2014-08-13
申请号：EP14153796.9
申请日：2014-02-04
申请人： Definiens AG
发明人： Brieu, Nicolas , Görner, Melanie , Schmidt, Günter , Binnig, Gerd
IPC分类号： G06T7/00
CPC分类号： A61B5/00 , A61B10/0233 , G02B21/367 , G06K9/0014 , G06T7/344 , G06T2200/24 , G06T2207/10056 , G06T2207/20072 , G06T2207/20101 , G06T2207/30024 , G06T2207/30172
摘要： A method for coregistering images involves defining middle paths through image objects depicting tissue slices of needle biopsies. First landmarks are defined on a first middle path through a first image object in a first digital image of a first tissue slice, and second landmarks are defined on a second middle path through a second image object of a second digital image of a second tissue slice. Individual first landmarks are associated with individual second landmarks. A first pixel in the first object is coregistered with a second pixel in the second object using multiple first and second landmarks. The first image is displayed in a first frame on a graphical user interface, and the second image is displayed in a second frame such that the first pixel is centered in the first frame, the second pixel is centered in the second frame, and the images have the same orientations.
摘要翻译：用于核心图像的方法涉及通过描绘针活组织切片的图像对象来定义中间路径。第一标记被定义在通过第一组织切片的第一数字图像中的第一图像对象的第一中间路径上，并且第二界标被定义在通过第二组织切片的第二数字图像的第二图像对象的第二中间路径上。个别第一地标与个别第二地标有关。使用多个第一和第二标记，第一对象中的第一个像素与第二个对象中的第二个像素核心对齐。第一图像被显示在图形用户界面上的第一帧中，并且第二图像被显示在第二帧中，使得第一像素在第一帧中居中，第二像素居中在第二帧中，并且图像具有相同的方向。

2. 发明公开

EP2610813A3 Biomarker evaluation through image analysis 失效转让
标题翻译：贝尔蒂龙冯Biomarkern手套Bildanalyse
公开(公告)号：EP2610813A3
公开(公告)日：2014-01-15
申请号：EP12189735.9
申请日：2012-10-24
申请人： Definiens AG
发明人： Binnig, Gerd , Athelogou, Maria , Schmidt, Günter
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06K9/34 , G06K9/4652 , G06K9/6215 , G06T7/11 , G06T7/155 , G06T7/187 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024
摘要： A method for determining whether a test biomarker is a stain for a type of cell component, such as membrane or nucleus, involves performing various segmentation processes on an image of tissue stained with the test biomarker. One segmentation process searches for a first cell component type, and another segmentation process searches for a second cell component type by segmenting only stained pixels. The test biomarker is identified as a stain for each component type if the process identifies the component based only on stained pixels. Whether the test biomarker is a membrane stain or nucleus stain is displayed on a graphical user interface. In addition, the method identifies stained pixels corresponding to a second cell component using pixels determined to correspond to a first cell component. An expression profile for the test biomarker is then displayed that indicates the proportion of stained pixels in each type of cell component.
摘要翻译：用于确定测试生物标志物是否是细胞组分类型（例如膜或细胞核）的染色的方法包括对用测试生物标志物染色的组织的图像执行各种分割过程。一个分割过程搜索第一个单元分量类型，另一个分割过程通过仅分割染色的像素来搜索第二单元分量类型。如果过程仅基于染色的像素识别组分，则将测试生物标志物鉴定为每种组分类型的污点。测试生物标志物是膜污染还是核染色体显示在图形用户界面上。此外，该方法使用被确定为对应于第一单元组件的像素来识别与第二单元组件对应的染色像素。然后显示用于测试生物标志物的表达谱，其指示每种类型细胞组分中染色像素的比例。

3. 发明公开

EP2546802A3 Generating artificial hyperspectral images using correlated analysis of co-registered images 有权转让
标题翻译：人工生成高光谱图像与图像coregistrierten的相关分析
公开(公告)号：EP2546802A3
公开(公告)日：2013-05-01
申请号：EP12176077.1
申请日：2012-07-12
申请人： Definiens AG
发明人： Schönmeyer, Ralf , Ellenberg, Peter , Binnig, Gerd , Athelogou, Maria , Schmidt, Günter
IPC分类号： G06T7/00 , G06T11/20
CPC分类号： G06T7/0012 , G06T11/206 , G06T2207/10061 , G06T2207/20016 , G06T2207/20021 , G06T2207/20221
摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.

4. 发明公开

EP2336972A1 Generating an anatomical model using a rule-based segmentation and classification process 审中-公开
标题翻译：通过基于规则的分割和分类方法产生的解剖模型
公开(公告)号：EP2336972A1
公开(公告)日：2011-06-22
申请号：EP11151560.7
申请日：2007-09-13
申请人： Definiens AG
发明人： Binnig, Gerd , Schmidt, Günter
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06K9/6268 , G06T2200/24 , G06T2207/20108 , G06T2207/30004
摘要： A system for computer-aided detection uses a computer-implemented network structure to analyze patterns present in digital image slices of a human body and to generate a three-dimensional anatomical model of a patient. The anatomical model is generated by detecting easily identifiable organs first and then using those organs as context objects to detect other organs. A user specifies membership functions that define which objects of the network structure belong to the various classes of human organs specified in a class hierarchy. A membership function of a potentially matching class determines whether a candidate object of the network structure belongs to the potential class based on the relation between a property of the voxels linked to the candidate object and a property of the context object. Some voxel properties used to classify an object are location, brightness and volume. The human organs are then measured to assist in the patient's diagnosis.

5. 发明公开

EP2320358A2 Computerimplementiertes Verfahren zum automatischen wissensbasierten Erzeugen von anwenderrelevanten Daten 审中-公开
标题翻译：用于自动生成用户相关的数据的知识的计算机实现的方法
公开(公告)号：EP2320358A2
公开(公告)日：2011-05-11
申请号：EP10185208.5
申请日：2006-04-10
申请人： Definiens AG
发明人： Schmidt, Günter , Schäpe, Arno , Binnig, Gerd
IPC分类号： G06N5/02
CPC分类号： G06N5/02
摘要： Das beschriebene computerimplementierte Verfahren zur automatischen wissensbasierten Erzeugung von Daten aus einer Tabelle weist gemäß einem oder mehreren Ausführungsbeispielen die Schritte auf:
Definieren einer ersten Klasse der Klassenhierarchie, die eine Gruppe von Daten-Objekten einer Tabelle mit Hilfe einer ersten Klassenbeschreibung beschreibt,
Generieren eines hierarchisch übergeordneten Daten-Objektes, das eine Gruppe von Daten-Objekten aus der Tabelle repräsentiert, wobei für die Gruppe die erste Klassenbeschreibung zutrifft, und
Berechnen einer Eigenschaft des übergeordneten Objektes anhand der Eigenschaften der Daten-Objekte.
摘要翻译：该方法包括选择异构互连对象做互联对象E.G. 数据对象，类对象，处理对象同质或异质组内。联动对象从一组对象物体的其他组的领导。被重复选择的互连对象，直到预先设置的最终标准被满足。算法被选择为处理对象的组。

6. 发明公开

EP1995690A3 Generating an anatomical model using a rule-based segmentation and classification process 有权转让
标题翻译：通过基于规则的分割和分类方法产生的解剖模型
公开(公告)号：EP1995690A3
公开(公告)日：2010-06-02
申请号：EP07018005.4
申请日：2007-09-13
申请人： Definiens AG
发明人： Binnig, Gerd , Schmidt, Günter
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06K9/6268 , G06T2200/24 , G06T2207/20108 , G06T2207/30004
摘要： A system for computer-aided detection uses a computer-implemented network structure to analyze patterns present in digital image slices of a human body and to generate a three-dimensional anatomical model of a patient. The anatomical model is generated by detecting easily identifiable organs first and then using those organs as context objects to detect other organs. A user specifies membership functions that define which objects of the network structure belong to the various classes of human organs specified in a class hierarchy. A membership function of a potentially matching class determines whether a candidate object of the network structure belongs to the potential class based on the relation between a property of the voxels linked to the candidate object and a property of the context object. Some voxel properties used to classify an object are location, brightness and volume. The human organs are then measured to assist in the patient's diagnosis.

7. 发明公开

EP1866849A2 COMPUTERIMPLEMENTIERTES VERFAHREN ZUM AUTOMATISCHEN WISSENSBASIERTEN ERZEUGEN VON ANWENDERRELEVANTEN DATEN 审中-公开
标题翻译：计算机实现的方法知识的自动生成用户相关的数据
公开(公告)号：EP1866849A2
公开(公告)日：2007-12-19
申请号：EP06725693.3
申请日：2006-04-10
申请人： Definiens AG
发明人： BINNIG, Gerd c/o DEFINIENS AG , SCHÄPE, Arno c/o DEFINIENS AG , SCHMIDT, Günter c/o DEFINIENS AG
IPC分类号： G06N5/02
CPC分类号： G06N5/02
摘要： Disclosed is a computer-implemented method for the automatic knowledge-based generation of user-relevant data. Said method comprises the following steps: objects are selected among a group encompassing data objects, class objects, processing objects, and heterogeneous linking objects in order to generate a first group of objects; heterogeneous linking objects are selected that interlink objects within homogeneous or heterogeneous groups and lead from the first group of objects to one or several second groups of objects; the heterogeneous linking objects are repeatedly selected until a predetermined final criterion has been met; one or several algorithms is/are selected to process the first and second groups of objects. All steps are repeated several times and are used in a hierarchically nested fashion, thereby defining a sequential control.

8. 发明授权

EP0858051B1 Verfahren zum Segmentieren eines digitalen Bildes 失效
公开(公告)号：EP0858051B1
公开(公告)日：2003-09-17
申请号：EP98102285.8
申请日：1998-02-10
申请人： Definiens AG.
发明人： Baatz, Martin, Dr. , Binnig, Gerd, Dr. , Eschenbacher, Peter, Dr. , Melchinger, Andreas, Dr. , Sögtrop, Michael
IPC分类号： G06T5/00
CPC分类号： G06T7/11 , G06T7/187

9. 发明授权

EP1238364B1 VERFAHREN ZUR VERARBEITUNG VON DATENSTRUKTUREN 有权
公开(公告)号：EP1238364B1
公开(公告)日：2003-08-06
申请号：EP00988795.1
申请日：2000-12-13
申请人： Definiens AG
发明人： BAATZ, Martin , SCHÄPE, Arno , SCHMIDT, Günter
IPC分类号： G06K9/00
CPC分类号： G06K9/0063 , G06K9/468 , G06T7/11 , G06T7/174 , G06T2207/10032 , G06T2207/30181 , Y10S707/99931
摘要： The invention relates to a method for processing data structures using interlinked semantic units. Said method involves the following steps: capturing a data structure; generating, analyzing, modifying, deleting and/or storing semantic structural units and/or the interlinks thereof on the basis of the data structure that has been captured by using a knowledge base consisting of a network of semantic knowledge units. Semantic structural units and/or the interlinks thereof are classified in iterative steps. A specific type of processing can be activated on the basis of said classification, which modifies a corresponding semantic structural unit and/or a given partial link.
摘要翻译：借助于网络语义单元来处理数据结构的方法。该方法包括获取数据结构，并且基于所获取的数据结构生成，修改，删除和/存储语义结构单元和/或组网它们。该方法使用由语义知识单元网络组成的知识库。语义结构单元和/或其网络分为迭代步骤。基于该分类，激活了修改相应的语义结构单元和/或特定部分网络的特定处理。

10. 发明授权

EP1032928B1 VERFAHREN UND VORRICHTUNG ZUM SIGNALISIEREN VON LOKALEN VERKEHRSSTÖRUNGEN 有权
标题翻译：方法和设备的信令当地的交通问题
公开(公告)号：EP1032928B1
公开(公告)日：2002-03-20
申请号：EP98963454.8
申请日：1998-11-13
申请人： Definiens AG.
发明人： BINNIG, Gerd
IPC分类号： G08G1/09
CPC分类号： G08G1/163 , G08G1/096716 , G08G1/096725 , G08G1/096758 , G08G1/096775 , G08G1/096791

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