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1. 发明公开

EP2473154A2 COSMETIC SKIN CARE METHODS AND COMPOSITIONS 审中-公开
标题翻译：美容护肤方法和组合物
公开(公告)号：EP2473154A2
公开(公告)日：2012-07-11
申请号：EP10757837.9
申请日：2010-09-06
申请人： De Villiers, Malan , Nel, Hugo Barrie
发明人： NEL, Hugo Barrie
IPC分类号： A61K8/41 , A61K8/64 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/41 , A61K8/64 , A61K8/66 , A61K2800/782
摘要： This invention relates to a topical cosmetic skin care method and composition. The method and composition is for treating facial skin to cause contraction and tightening of the facial skin, by effecting contraction of the collagen of the skin using an active agent/s that induces fibroblast contraction of the extra cellular matrix of the skin. A preferred active agent is a beta-2-adrenergic receptor (beta2AR) inhibitor.

2. 发明公开

EP2002805A2 Intervertebral prosthesis 审中-公开
标题翻译：椎间假
公开(公告)号：EP2002805A2
公开(公告)日：2008-12-17
申请号：EP08163926.2
申请日：2003-04-24
申请人： De Villiers, Malan
发明人： de Villiers, Malan , Hähnle, Ulrich
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30771 , A61F2/4611 , A61F2002/3008 , A61F2002/30311 , A61F2002/30332 , A61F2002/30364 , A61F2002/30369 , A61F2002/30528 , A61F2002/30662 , A61F2002/30785 , A61F2002/30822 , A61F2002/30841 , A61F2002/30884 , A61F2002/30899 , A61F2002/30904 , A61F2002/443 , A61F2220/0016 , A61F2220/0025 , A61F2220/0033 , A61F2230/0065 , A61F2250/0098 , A61F2310/00017 , A61F2310/00029 , A61F2310/00179 , A61F2310/0088
摘要： This invention concerns an intervertebral prosthesis for insertion between adjacent vertebrae. The prosthesis (28) includes upper and lower prosthesis plates (10) which are located against the respective vertebrae and which are formed with concavely curved recesses (20). A core (30) is located between the plates and has opposed, convexly curved surfaces (32) which are received in the recesses of the plates. This allows plates to slide in articulated manner over the core. The recesses of the plates are spherically curved and at least one of them surrounds a locating peg (22) that projects centrally from the base of the recess. The peg locates loosely in a central opening (34) in the curved surface of the core in a manner allowing the plates to slide in all directions over the core while holding the core captive relative to the plates. Other aspects with which the invention is concerned are the prosthesis plates and core.

3. 发明授权

EP1539050B1 ARTHROPLASTY IMPLANT 有权
标题翻译：关节成形植入
公开(公告)号：EP1539050B1
公开(公告)日：2007-08-01
申请号：EP03797472.2
申请日：2003-09-19
申请人： De Villiers, Malan
发明人： De Villiers, Malan
IPC分类号： A61F2/42
CPC分类号： A61F2/4241 , A61F2/4225 , A61F2/4261 , A61F2002/30364 , A61F2002/30369 , A61F2002/30604 , A61F2002/30654 , A61F2002/30662 , A61F2002/30663 , A61F2002/30881 , A61F2002/30904 , A61F2002/4228 , A61F2002/4233 , A61F2002/4243 , A61F2220/0033 , A61F2310/00023 , A61F2310/0088
摘要： The invention concerns an arthroplasty implant for providing a joint between first and second members of the body, such as a metatarsophalangeal (MTP) joint, a metacarpophalangeal (MCP) joint or a proximal interphalangeal (PIP) joint. The implant of the invention includes a first component (10) defining a concave surface (14), a second component (20) defining a convex surface (24) and an intermediate component (32) which is located between the first and second components. The intermediate component has a convex surface (36) which is slidable on the concave surface of the first component to allow articulation between the first component and the intermediate component and a concave surface slidable on the convex surface of the second component to allow articulation between the second component and the intermediate component. A means (16, 38; 50, 60) is provided to prevent the intermediate component from separating laterally from at least one of the first and second components.

4. 发明公开

EP1758524A1 DIGITAL JOINT ARTHROPLASTY 审中-公开
标题翻译：数字联合ARTHROPLASTY
公开(公告)号：EP1758524A1
公开(公告)日：2007-03-07
申请号：EP05755916.3
申请日：2005-06-23
申请人： De Villiers, Malan , Blackbeard, Graham Alan
发明人： DE VILLIERS, Malan, South. Impl. Office Park Bld10 , MENNEN, Ulrich
IPC分类号： A61F2/42
CPC分类号： A61F2/4241 , A61F2002/30754 , A61F2002/30772 , A61F2002/4243
摘要： The invention concerns a digital joint arthroplasty (10). The arthroplasty has a stemless, unitary body having opposite sides (12, 14) at least one of which is formed with a curved concavity shaped to receive, in articulated manner, a bone end in an MCP, PIP or DIP joint. In some embodiments, both of the opposite side surfaces are concavely curved while in other embodiments, only one side surface (12) is so curved, the opposite surface (40) being flat. In use the arthroplasty is installed between the shaped ends of bones which meet at the MCP, PIP or DIP joint. The absence of stems means that the installation of the arthroplasty is less surgically invasive than is the case with conventional arthroplasties having intermedullary stems.
摘要翻译：本发明涉及数字关节成形术（10）。所述关节成形术具有无茎的单一主体，所述主体具有相对的侧面（12,14），其中至少一个侧面形成有弯曲的凹面，所述弯曲的凹面被成形为以铰接的方式接收MCP，PIP或DIP接头中的骨头。在一些实施例中，两个相对侧表面是凹入弯曲的，而在其他实施例中，仅一个侧表面（12）如此弯曲，相对表面（40）是平坦的。在使用中，关节成形术安装在骨头的成形端部之间，在MCP，PIP或DIP接头处相遇。茎的缺失意味着关节成形术的安装比传统的具有髓内茎的关节成形术的手术创伤更少。

5. 发明授权

EP1587462B1 INTERVERTEBRAL PROSTHESIS PLACEMENT INSTRUMENT 有权
标题翻译：仪器用于放置INTERVERTEBRALPROTHESE的
公开(公告)号：EP1587462B1
公开(公告)日：2012-06-06
申请号：EP04705132.1
申请日：2004-01-26
申请人： De Villiers, Malan , Spinalmotion, Inc.
发明人： DE VILLIERS, Malan , HÄHNLE, Ulrich Reinhard
IPC分类号： A61F2/46
CPC分类号： A61F2/4611 , A61B2017/0256 , A61F2002/443 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628
摘要： The invention concerns an intervertebral prosthesis placement instrument which can be used to facilitate accurate positioning of a spinal disc prosthesis between adjacent spinal vertebrae. The instrument (10) has opposed jaws 12 formed with tips (24) that are shaped for insertion between the vertebrae. The jaws can be moved apart from one another to distract the vertebrae, allowing the prosthesis to enter between the vertebrae. The jaws also have opposed surfaces which are shaped to embrace the prosthesis between them and to guide the prosthesis into position.

6. 发明授权

EP1549260B1 INTERVERTEBRAL PROSTHESIS 有权转让
标题翻译：椎间盘假体
公开(公告)号：EP1549260B1
公开(公告)日：2010-01-20
申请号：EP03797389.8
申请日：2003-04-24
申请人： De Villiers, Malan
发明人： DE VILLIERS, Malan , ULRICH, Reinhard Hähnle
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30771 , A61F2/4611 , A61F2002/3008 , A61F2002/30311 , A61F2002/30332 , A61F2002/30364 , A61F2002/30369 , A61F2002/30528 , A61F2002/30662 , A61F2002/30785 , A61F2002/30822 , A61F2002/30841 , A61F2002/30884 , A61F2002/30899 , A61F2002/30904 , A61F2002/443 , A61F2220/0016 , A61F2220/0025 , A61F2220/0033 , A61F2230/0065 , A61F2250/0098 , A61F2310/00017 , A61F2310/00029 , A61F2310/00179 , A61F2310/0088
摘要： An intervertebral prosthesis for insertion between adjacent vertebrae. The prosthesis (28) includes upper and lower prosthesis plates (10) which are located against the respective vertebrae and which are formed with concavely curved recesses (20). A core (30) is located between the plates and has opposed, convexly curved surfaces (32) which are received in the recesses of the plates. This allows plates to slide in articulated manner over the core. The recesses of the plates are spherically curved and at least one of them surrounds a locating peg (22) that projects centrally from the base of the recess. The peg locates loosely in a central opening (34) in the curved surface of the core in a manner allowing the plates to slide in all directions over the core while holding the core captive relative to the plates. Each of the plates is provided with a fin and serrations to anchor the prosthesis in the adjacent vertebrae.

7. 发明公开

EP2002805A3 Intervertebral prosthesis 审中-公开
标题翻译： Zwischenwirbelprothese
公开(公告)号：EP2002805A3
公开(公告)日：2009-01-07
申请号：EP08163926.2
申请日：2003-04-24
申请人： De Villiers, Malan
发明人： de Villiers, Malan , Hähnle, Ulrich
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30771 , A61F2/4611 , A61F2002/3008 , A61F2002/30311 , A61F2002/30332 , A61F2002/30364 , A61F2002/30369 , A61F2002/30528 , A61F2002/30662 , A61F2002/30785 , A61F2002/30822 , A61F2002/30841 , A61F2002/30884 , A61F2002/30899 , A61F2002/30904 , A61F2002/443 , A61F2220/0016 , A61F2220/0025 , A61F2220/0033 , A61F2230/0065 , A61F2250/0098 , A61F2310/00017 , A61F2310/00029 , A61F2310/00179 , A61F2310/0088
摘要： An intervertebral prosthesis for insertion between adjacent vertebrae. The prosthesis (28) includes upper and lower prosthesis plates (10) which are located against the respective vertebrae and which are formed with concavely curved recesses (20). A core (30) is located between the plates and has opposed, convexly curved surfaces (32) which are received in the recesses of the plates. This allows plates to slide in articulated manner over the core. The recesses of the plates are spherically curved and at least one of them surrounds a locating peg (22) that projects centrally from the base of the recess. The peg locates loosely in a central opening (34) in the curved surface of the core in a manner allowing the plates to slide in all directions over the core while holding the core captive relative to the plates. Each of the plates is provided with a fin and serrations to anchor the prosthesis in the adjacent vertebrae.
摘要翻译：用于插入相邻椎骨之间的椎间假体。假体（28）包括上和下假体板（10），其位于相应的椎骨上并且形成有凹形弯曲的凹部（20）。芯（30）位于板之间并且具有相对的凸曲面（32），其被接收在板的凹部中。这允许板以铰接的方式在芯上滑动。板的凹槽是球形弯曲的，并且它们中的至少一个围绕从凹部的基部中心突出的定位销（22）。钉以松散地位于芯的弯曲表面的中心开口（34）中，以允许板沿着芯部在所有方向上滑动，同时相对于板保持芯部。每个板都设置有翅片和锯齿以将假体锚固在相邻的椎骨中。

8. 发明公开

EP1624906A1 PREPARATION OF AN OSTEOINDUCTIVE AGENT 审中-公开
标题翻译：骨形成蛋白的制备
公开(公告)号：EP1624906A1
公开(公告)日：2006-02-15
申请号：EP04733611.0
申请日：2004-05-18
申请人： Du Plessis, Tjaart Andries , De Villiers, Malan
发明人： DU PLESSIS, Tjaart Andries
IPC分类号： A61L31/04
CPC分类号： A61L31/047 , A61B50/33 , A61B2050/0065 , A61F2/28 , A61F2/4601 , A61F2/4644 , A61F2310/00365 , A61L2/0011 , A61L2/02 , A61L31/04 , A61L31/044 , A61M5/002 , C08L5/08
摘要： This invention relates to a method for the preparation of an osteoinductive agent, the use of such an agent, and to a kit for preparing such an agent. This invention further relates to the use of the said kit in the preparation and dispensing of such an osteoinductive agent in a method of reconstructive bone surgery. The kit includes an osteoinductive agent comprising a modified naturally occurring biocompatible biopolymer which was subjected, in the solid, or dry state, to a source of ionising radiation in the presence of a mediating gas and annealed in the absence of oxygen at a temperature of from 40° C. to 120° C. to render the product in a dry particulate form, the product being disposed in a hermetically sealed container containing oxygen-free gas.
摘要翻译：本发明涉及制备骨诱导剂的方法，这种试剂的用途，以及制备这种试剂的试剂盒。本发明进一步涉及所述试剂盒在重建骨手术方法中制备和分配这种骨诱导剂中的用途。试剂盒包括骨诱导剂，其包含经修饰的天然存在的生物相容性生物聚合物，其在固体或干燥状态下在介导气体存在下经历电离辐射源，并且在没有氧的情况下在 40℃至120℃使产品呈干燥颗粒形式，产品置于含有无氧气体的密封容器中。

9. 发明公开

EP1587462A1 INTERVERTEBRAL PROSTHESIS PLACEMENT INSTRUMENT 有权
标题翻译：仪器用于放置INTERVERTEBRALPROTHESE的
公开(公告)号：EP1587462A1
公开(公告)日：2005-10-26
申请号：EP04705132.1
申请日：2004-01-26
申请人： De Villiers, Malan , Spinalmotion, Inc.
发明人： DE VILLIERS, Malan,Southern Implants Office Park , HÄHNLE, Ulrich Reinhard
IPC分类号： A61F2/46
CPC分类号： A61F2/4611 , A61B2017/0256 , A61F2002/443 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628
摘要： The invention concerns an intervertebral prosthesis placement instrument which can be used to facilitate accurate positioning of a spinal disc prosthesis between adjacent spinal vertebrae. The instrument (10) has opposed jaws 12 formed with tips (24) that are shaped for insertion between the vertebrae. The jaws can be moved apart from one another to distract the vertebrae, allowing the prosthesis to enter between the vertebrae. The jaws also have opposed surfaces which are shaped to embrace the prosthesis between them and to guide the prosthesis into position.

10. 发明公开

EP1549260A1 INTERVERTEBRAL PROSTHESIS 有权转让
标题翻译：椎间盘假体
公开(公告)号：EP1549260A1
公开(公告)日：2005-07-06
申请号：EP03797389.8
申请日：2003-04-24
申请人： De Villiers, Malan
发明人： DE VILLIERS, Malan , ULRICH, Reinhard Hähnle
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30771 , A61F2/4611 , A61F2002/3008 , A61F2002/30311 , A61F2002/30332 , A61F2002/30364 , A61F2002/30369 , A61F2002/30528 , A61F2002/30662 , A61F2002/30785 , A61F2002/30822 , A61F2002/30841 , A61F2002/30884 , A61F2002/30899 , A61F2002/30904 , A61F2002/443 , A61F2220/0016 , A61F2220/0025 , A61F2220/0033 , A61F2230/0065 , A61F2250/0098 , A61F2310/00017 , A61F2310/00029 , A61F2310/00179 , A61F2310/0088
摘要： An intervertebral prosthesis for insertion between adjacent vertebrae. The prosthesis (28) includes upper and lower prosthesis plates (10) which are located against the respective vertebrae and which are formed with concavely curved recesses (20). A core (30) is located between the plates and has opposed, convexly curved surfaces (32) which are received in the recesses of the plates. This allows plates to slide in articulated manner over the core. The recesses of the plates are spherically curved and at least one of them surrounds a locating peg (22) that projects centrally from the base of the recess. The peg locates loosely in a central opening (34) in the curved surface of the core in a manner allowing the plates to slide in all directions over the core while holding the core captive relative to the plates. Each of the plates is provided with a fin and serrations to anchor the prosthesis in the adjacent vertebrae.
摘要翻译：本发明涉及一种用于插入相邻椎骨之间的椎间假体。假体（28）包括上部和下部假体板（10），所述上部和下部假体板抵靠相应的椎骨定位并且形成有凹形弯曲的凹部（20）。芯部（30）位于板之间并具有相对的，凸起弯曲的表面（32），所述表面容纳在板的凹部中。这允许板以铰接的方式在芯上滑动。板的凹槽是球形弯曲的，并且它们中的至少一个围绕从凹槽底部向中央突出的定位栓（22）。该销松散地位于芯的弯曲表面中的中央开口（34）中，其方式允许板在芯上沿所有方向滑动，同时相对于板保持芯夹持件。本发明涉及的其他方面是假体板和核心。

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