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1. 发明公开

EP4203896A1 ACCELERATING TOOTH REMINERALISATION AND BONE REGENERATION WITH SELF-ASSEMBLING PEPTIDES AND AMORPHOUS CALCIUM PHOSPHATE 审中-实审
公开(公告)号：EP4203896A1
公开(公告)日：2023-07-05
申请号：EP21789775.0
申请日：2021-10-19
申请人： Credentis AG
发明人： HUG, Michael , LYSEK, Dominikus Amadeus
IPC分类号： A61K8/02 , A61K8/24 , A61Q11/00 , A61K33/42 , A61K33/16 , A61K8/64 , A61K6/75 , A61K33/02 , A61P1/02

2. 发明公开

EP3284477A1 COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS 审中-公开
标题翻译：包含自组装肽的组合物用于治疗牙龈炎，牙周炎和/或周围血管炎
公开(公告)号：EP3284477A1
公开(公告)日：2018-02-21
申请号：EP16184309.9
申请日：2016-08-16
申请人： Credentis AG
发明人： Hug, Michael , Lysek, Dominikus Amadeus , Koch, Franziska , Jung, Ronald , Mathes, Stephanie , Meyer, Nina , Hämmerle, Christoph , Bröseler, Frank , Pieles, Uwe
IPC分类号： A61K38/08 , A61P31/04 , A61P29/00 , A61P1/02
CPC分类号： A61K38/08
摘要： The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., P11-4, P11-8, P11-14, P11-13, P11-12, P11-28, P11-29, P11-2, P11-5, P11-17, P11-19 or P11-20, for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.
摘要翻译：本发明提供了包含特定自组装肽的组合物，其能够在低于7.5的pH下和至少生理离子强度下自组装，例如P11-4，P11-8，P11-14，P11-13， P11-12，P11-28，P11-29，P11-2，P11-5，P11-17，P11-19或P11-20，用于治疗选自牙龈炎，牙周炎和/ 或者种植体周围炎。所述组合物可在适当的清洁程序之后用于填充所述疾病中与牙齿相邻形成的凹穴，这增强了组织再生。该组合物可适用于控制释放活性剂，例如抗微生物剂或抗生素剂。本发明还提供适用于所述处理的试剂盒，其进一步包含适合在第一组合物上形成第二层的自组装肽。

3. 发明公开

EP3248590A1 PERSONAL DENTAL CARE PRODUCT FOR CARIES TREATMENT 审中-公开
标题翻译：龋齿治疗用个人牙科护理产品
公开(公告)号：EP3248590A1
公开(公告)日：2017-11-29
申请号：EP16171015.7
申请日：2016-05-24
申请人： Credentis AG
发明人： Hug, Michael , Lysek, Dominikus Amadeus
IPC分类号： A61K8/64 , A61Q11/00 , A61K6/00 , C07K7/00 , A61K38/04 , A61P1/02
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/00
摘要： The present invention provides new dental care products comprising self-assembling peptides that are capable of undergoing self-assembly at a certain pH for use in dental care, e.g. preventing and/or treating a tooth lesion such as a caries lesion, remineralising a tooth surface or increasing smoothness or shine, or for increasing hardness of a tooth surface. The present invention provides dental care products such as chewing gum, toffees or toothpaste, in which the peptides are present in monomeric form for a prolonged period after application into the oral cavity, thereby enabling non-targeted treatment of a plurality of teeth, independent of the diagnosis of an active lesion. Products of the invention are useful for animals and humans.
摘要翻译：本发明提供了包含自组装肽的新型牙科护理产品，所述自组装肽能够在一定的pH下进行自组装，以用于牙科护理，例如牙科护理。预防和/或治疗诸如龋齿病变的牙齿病变，使牙齿表面再矿化或增加光滑度或光泽，或用于增加牙齿表面的硬度。本发明提供牙科护理产品，例如口香糖，太妃糖或牙膏，其中肽在施用于口腔后以单体形式长时间存在，从而能够对多个牙齿进行非靶向治疗，独立于活动性病变的诊断。本发明的产品可用于动物和人类。

4. 发明公开

EP3984517A1 ACCELERATING TOOTH REMINERALISATION AND BONE REGENERATION WITH SELF-ASSEMBLING PEPTIDES AND AMORPHOUS CALCIUM PHOSPHATE 审中-公开
公开(公告)号：EP3984517A1
公开(公告)日：2022-04-20
申请号：EP20202539.1
申请日：2020-10-19
申请人： Credentis AG
发明人： Hug, Michael , Lysek, Dominikus Amadeus
IPC分类号： A61K8/02 , A61K8/24 , A61Q11/00 , A61K33/42 , A61K33/16 , A61K8/64 , A61K6/75
摘要： The present invention relates to the field of medicinal tissue mineralisation, in particular, i.e. tooth remineralisation and bone regeneration with self-assembling peptides. Use of self-assembling peptides, such as P11-4, also designated Oligopeptide-104, in these processes leads to generation of hydroxyapatite, which is also present in natural enamel, dentin and bone. The inventors have discovered that both tooth remineralisation and bone regeneration can be significantly accelerated by adding amorphous calcium phosphate or calcium and phosphate ions that, when mixed in solution, can lead to immediate precipitation of calcium phosphate, preferably, amorphous, i.e., non-crystalline calcium phosphate. The presence of self-assembling peptide however changes the structure of the precipitated calcium phosphate, and advantageously induces crystallisation and a synergistic accelerated formation of crystalline calcium phosphate, in particular, hydroxyapatite (HA). The invention thus provides a kit comprising, a self-assembling peptide and either calcium and phosphate ions in separate compositions suitable for immediately forming calcium phosphate precipitates, e.g., amorphous calcium phosphate (ACP), if the compositions are mixed in the presence of water, or calcium phosphate particles, preferably, in the form of a suspension of calcium phosphate particles comprising at least 50% ACP. The invention also provides medical use of said kit, in particular, for in the tooth for remineralisation of lesions, mineralisation of pits and fissures, pulp capping, and for bone regeneration.

5. 发明授权

EP2884991B1 METHOD FOR PRODUCING A COMPOSITION FOR TREATING A TOOTH LESION 有权
标题翻译：生产治疗牙齿损伤的组合物的方法
公开(公告)号：EP2884991B1
公开(公告)日：2018-03-21
申请号：EP13748317.8
申请日：2013-08-14
申请人： Credentis AG
发明人： HUG, Michael , LYSEK, Domenikus Amadeus
IPC分类号： A61K38/17 , C07K1/00 , A61P1/02
CPC分类号： C07K7/06 , A61C5/68 , A61K6/0017 , A61K38/00 , A61K38/17 , C03C2205/06 , C07K1/00 , Y10S522/908
摘要： The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion.

6. 发明公开

EP2884991A1 METHOD FOR PRODUCING A COMPOSITION FOR TREATING A TOOTH LESION 有权
标题翻译：方法生产组合物牙齿损伤的治疗
公开(公告)号：EP2884991A1
公开(公告)日：2015-06-24
申请号：EP13748317.8
申请日：2013-08-14
申请人： Credentis AG
发明人： HUG, Michael , LYSEK, Domenikus Amadeus
IPC分类号： A61K38/17 , C07K1/00 , A61P1/02
CPC分类号： A61K38/17 , A61K6/0017
摘要： The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion.

7. 发明授权

EP3463279B1 PERSONAL DENTAL CARE PRODUCT FOR CARIES TREATMENT 有权
公开(公告)号：EP3463279B1
公开(公告)日：2020-07-29
申请号：EP17728086.4
申请日：2017-05-24
申请人： Credentis AG
发明人： HUG, Michael , LYSEK, Dominikus Amadeus
IPC分类号： A61K8/64 , A61P1/02 , A61K38/04 , A61K6/00 , A61Q11/00 , C07K7/00

8. 发明公开

EP3248591A1 METHOD AND PRODUCT FOR CARIES TREATMENT 审中-公开
标题翻译：龋病治疗方法和产品
公开(公告)号：EP3248591A1
公开(公告)日：2017-11-29
申请号：EP16171027.2
申请日：2016-05-24
申请人： Credentis AG
发明人： Hug, Michael , Lysek, Dominikus Amadeus
IPC分类号： A61K8/64 , A61Q11/00 , A61K6/00 , C07K7/00 , A61K38/04 , A61P1/02
CPC分类号： A61Q11/00 , A61C17/0205 , A61K6/0017 , A61K8/64 , A61K38/00 , A61K2800/884
摘要： The present invention provides new dental care products comprising self-assembling peptides (SAP) that are capable of undergoing self-assembly at a certain pH for use in dental care, e.g. preventing and/or treating a tooth lesion such as a caries lesion, remineralising a tooth surface, increasing smoothness or shine or increasing hardness of a tooth surface. The dental care products may be administered following a simple protocol involving multiple steps, thereby enabling non-targeted treatment of a plurality of teeth in a subject, independent of the diagnosis of active caries. The invention also relates to said method as well as kits and devices suitable therefor.
摘要翻译：本发明提供了包含自组装肽（SAP）的新型牙科护理产品，所述自组装肽能够在特定的pH下进行自组装以用于牙科护理，例如牙科护理。预防和/或治疗诸如龋齿病变的牙齿损伤，使牙齿表面再矿化，增加牙齿表面的光滑度或光泽度或增加硬度。牙科护理产品可以按照涉及多个步骤的简单方案进行施用，从而能够独立于活性龋的诊断而对受试者中的多个牙齿进行非目标治疗。本发明还涉及所述方法以及适用于其的试剂盒和装置。

9. 发明公开

EP2698162A1 Method for producing a composition for treating a tooth lesion 审中-公开
标题翻译： Verfahren zur Herstellung einer Zusammensetzung zur Behandlung einerZahnläsion
公开(公告)号：EP2698162A1
公开(公告)日：2014-02-19
申请号：EP12180578.2
申请日：2012-08-15
申请人： Credentis AG
发明人： Hug, Michael , Lysek, Dominik
IPC分类号： A61K38/17 , C07K1/00 , A61P1/02
CPC分类号： A61K38/17 , A61K6/0017
摘要： The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion.
摘要翻译：本发明涉及一种制备用于治疗牙齿损伤的组合物的方法，所述组合物包含能够在一定pH下进行自组装的肽。本发明的组合物非常适合用于医疗领域，特别是用于再矿化牙齿损伤。

10. 发明公开

EP4017466A1 PERSONAL DENTAL CARE PRODUCT FOR PREVENTING DEMINERALISATION 审中-公开
公开(公告)号：EP4017466A1
公开(公告)日：2022-06-29
申请号：EP20816490.5
申请日：2020-12-04
申请人： Credentis AG
发明人： HUG, Michael , LYSEK, Dominikus Amadeus
IPC分类号： A61K8/64 , A61Q11/00

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