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1. 发明授权

EP2904629B1 NON-THERMAL PLASMA JET DEVICE AS SOURCE OF SPATIAL IONIZATION FOR AMBIENT MASS SPECTROMETRY AND METHOD OF APPLICATION 有权
公开(公告)号：EP2904629B1
公开(公告)日：2018-12-12
申请号：EP13814219.5
申请日：2013-10-07
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav)
发明人： MARTÍNEZ JARQUÍN, Sandra , WINKLER, Robert
IPC分类号： H01J49/10 , H01J49/14 , H05H1/24
CPC分类号： H01J49/105 , H01J49/142 , H05H1/2406 , H05H2001/2437 , H05H2001/2443
摘要： The present invention relates to a non-thermal plasma jet device as spatial ionization source for ambient mass spectrometry of the type which allows a free adjustment of the geometry of the plasma beam, wherein the device comprises a double dielectric barrier probe of non-thermal plasma or NTP probe, which generates a non-thermal plasma jet; a high voltage and high frequency transformer circuit that connects an outer electrode through which it is possible to perform a discharge for the ionization of a gas which produces plasma, and wherein said plasma generator circuit is in turn connected to a source of AC power; an inner electrode which is grounded and allows to perform the discharge for the production of plasma; a storage tank of a gas serving as discharge gas; a test sample on which the non-thermal plasma jet is applied; and a ion transfer adapter to direct the ions produced by the device from the vacuum-free sample into a mass analyzer. The device described allows to directly analyzing live samples (plants, for example) without causing any damage to them.

2. 发明公开

EP2904629A2 NON-THERMAL PLASMA JET DEVICE AS SOURCE OF SPATIAL IONIZATION FOR AMBIENT MASS SPECTROMETRY AND METHOD OF APPLICATION 有权
标题翻译：不热等离子体喷射器作为应用程序空间电离质谱环境的来源，方法
公开(公告)号：EP2904629A2
公开(公告)日：2015-08-12
申请号：EP13814219.5
申请日：2013-10-07
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav)
发明人： MARTÍNEZ JARQUÍN, Sandra , WINKLER, Robert
IPC分类号： H01J49/10 , H05H1/24
CPC分类号： H01J49/105 , H01J49/142 , H05H1/2406 , H05H2001/2437 , H05H2001/2443
摘要： The present invention relates to a non-thermal plasma jet device as spatial ionization source for ambient mass spectrometry of the type which allows a free adjustment of the geometry of the plasma beam, wherein the device comprises a double dielectric barrier probe of non-thermal plasma or NTP probe, which generates a non-thermal plasma jet; a high voltage and high frequency transformer circuit that connects an outer electrode through which it is possible to perform a discharge for the ionization of a gas which produces plasma, and wherein said plasma generator circuit is in turn connected to a source of AC power; an inner electrode which is grounded and allows to perform the discharge for the production of plasma; a storage tank of a gas serving as discharge gas; a test sample on which the non-thermal plasma jet is applied; and a ion transfer adapter to direct the ions produced by the device from the vacuum-free sample into a mass analyzer. The device described allows to directly analyzing live samples (plants, for example) without causing any damage to them.

3. 发明公开

EP2648501A2 PLANT CULTIVATION SYSTEM UTILIZING PHOSPHITE AS A NUTRIENT AND AS A CONTROL AGENT FOR WEEDS AND ALGAE 审中-公开
标题翻译：植物生长系统与磷酸肥料和一个手段打击杂草和藻类
公开(公告)号：EP2648501A2
公开(公告)日：2013-10-16
申请号：EP11846668.9
申请日：2011-12-07
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav)
发明人： HERRERA-ESTRELLA, Luis, R. , LOPEZ-ARREDONDO, Damar, L.
IPC分类号： A01H5/00
CPC分类号： A01G1/001 , A01G22/00 , A01N59/26 , A01N63/02 , C12N9/0004 , C12N15/821 , C12N15/8274 , C12Y120/01001
摘要： A plant cultivation system, including methods, apparatus, plants, and compositions, for utilizing phosphite as a nutrient to support growth of a transgenic plant and as a control agent for unwanted organisms, such as weeds and/or algae, among others. In an exemplary method, an effective amount of phosphite is applied to a substrate, and/or to foliage above the substrate, to enhance growth of a transgenic plant and/or to act as a weed-control agent that kills weeds and/or directly suppresses growth of weeds near the transgenic plant. In another exemplary method, soil is tested for a content of phosphate, and an effective amount of phosphite for supporting growth of a transgenic plant and controlling weeds is selected and applied based on the content of phosphate. In yet another exemplary method, phosphite is used to control algae in a hydroponic system.

5. 发明公开

EP2988590A2 PLANTS RESISTANT TO PATHOGENIC MICROORGANISMS GROWING IN VASCULAR TISSUES 有权转让
标题翻译：抗植物病原微生物在血管组织中生长的植物
公开(公告)号：EP2988590A2
公开(公告)日：2016-03-02
申请号：EP14788964.6
申请日：2014-04-24
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav) , Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y Alimentacion
发明人： XOCONOSTLE CÁZARES, Beatriz , CHAVARIN PALACIO, Claudio , LÓPEZ BUENFIL, José Abel , GUERRA LUPIÁN, Miguel Ángel , MORALES GALVÁN, Oscar , ZECUA NÁJERA, Rebeca , RUÍZ MEDRANO, Roberto , GÓMEZ FELIPE, Andrea , TRUJILLO ARRIAGA, Francisco Javier
IPC分类号： A01H5/00 , C12N15/82
摘要： The present invention relates to the generation of transgenic plants resistant to infections caused by microorganisms restricted to the phloem, and it comprises the induction of the expression of a chimeric or fusion protein, which comprises a phloem protein of Citrus aurantifolia (CsPP16), a linker protein and a protein with antimicrobial activity; for example, with antibacterial activity or antibacterial hydrolytic enzyme. The portion of the fusion protein corresponding to the CsPP16 protein can exert its function of simplasmic movement, which occurs via the plasmodesmata of the plant to reach the phloem sieve tubes, while the antimicrobial portion can act to eliminate the microorganism, which settles in the phloem. The invention allows controlling the disease that causes the citrus yellowing or Huanglongbing (HLB), also applying to the treatment of other diseases caused by bacteria and other microorganisms that settle in the vascular tissue of higher plants. The invention includes the designed molecular vectors carrying and expressing a fusion protein and the transgenic plants obtained with a stable expression of said fusion protein and the transformation method of adult plants, healthy or diseased, to express the chimeric proteins and controlling, e.g., HLB disease. The transformation of diseased plants with the fusion protein is a method to produce healthy shoots free from the microorganism causing the disease; e.g., free from HLB bacteria.
摘要翻译：本发明涉及抗由限于韧皮部的微生物引起的感染的转基因植物的产生，并且其包含诱导嵌合或融合蛋白的表达，所述嵌合或融合蛋白包含柑橘（Citrus aurantifolia）的韧皮部蛋白（CsPP16），接头蛋白质和具有抗微生物活性的蛋白质; 例如具有抗菌活性或抗菌水解酶。对应于CsPP16蛋白质的融合蛋白质部分可以发挥其通过植物的胞间连丝发生以达到韧皮部筛管的质体运动的功能，而抗微生物部分可以起作用以消除定居在韧皮部中的微生物。本发明允许控制引起柑橘黄化或黄龙病（HLB）的疾病，还用于治疗由高等植物的维管组织中沉积的细菌和其他微生物引起的其他疾病。本发明包括携带并表达融合蛋白的设计分子载体和获得的转基因植物，所述转基因植物具有所述融合蛋白的稳定表达和健康或患病的成年植物的表达嵌合蛋白和控制例如HLB疾病的转化方法。用融合蛋白转化病株是一种产生健康枝条的方法，该枝条不含引起疾病的微生物; 例如不含HLB细菌。

6. 发明公开

EP2655391A2 NEW AMPHOTERICIN ANALOGOUS COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
标题翻译：食品安全食品加工厂ZUSAMMENSETZUNGEN
公开(公告)号：EP2655391A2
公开(公告)日：2013-10-30
申请号：EP11810890.1
申请日：2011-12-16
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav) , Universidad Autónoma del Estado de Morelos , Universidad Nacional Autónoma de México
发明人： ANTILLÓN DÍAZ, Armando , CARRILLO TRIPP, Mauricio , FERNÁNDEZ ZERTUCHE, Mario , FLORES ROMERO, José David , JIMÉNEZ MONTEJO, Fabiola Eloisa , LEÓN BUITIMEA, Ángel , MORALES NAVA, Rosmarbel , OCAMPO MARTÍNEZ, Lilia , ORTEGA BLAKE, Iván , REYES ESPARZA, Jorge Alberto , RODRÍGUEZ FRAGOSO, María de Lourdes , SANTIAGO ANGELINO, Tania Minerva , VARGAS GONZÁLEZ, María Cristina
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , A01N43/90 , A61K31/7048 , A61K45/06
摘要： The present invention relates to polyene macrolide derivatives according to the formula: wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.
摘要翻译：本发明涉及下式的多烯大环内酯衍生物：其中M是大环内酯环; N是取代或未取代的多烯糖; X独立地选自O，S，N或NH; R独立地选自烷基，环烷基，杂环烷基芳基，杂芳基，芳烷基和杂芳烷基; 并且i是从1到3的整数，条件是它具有负电荷或两性离子字符被恢复; 或其药学上可接受的盐作为抗生素使用。

7. 发明公开

EP2673001A2 NTS-POLYPLEX NANOPARTICLES SYSTEM FOR GENE THERAPY OF CANCER 有权转让
标题翻译： NTS-POLYPLEX NANOPARTIKELSYSTEM ZUR GENTHERAPIE VON KREBSERKRANKUNGEN
公开(公告)号：EP2673001A2
公开(公告)日：2013-12-18
申请号：EP12737597.0
申请日：2012-02-10
申请人： Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav)
发明人： CASTILLO RODRÍGUEZ, Rosa Angélica , ESCOBEDO SÁNCHEZ, María de Lourdes , MARTÍNEZ FONG, Daniel
IPC分类号： A61K48/00 , C07K7/08 , C12N9/12 , A61K47/48
CPC分类号： C07K7/083 , A61K38/10 , A61K47/62 , A61K47/645 , A61K47/6929 , A61K48/00 , A61K48/0025 , A61K48/0091 , C07K2319/035 , C12N9/1211 , C12N15/87 , C12Y207/01021
摘要： The present invention describes a system of gene carrier nanoparticles capable of specifically internalize into cancer cells, eg, cancer cells involved in breast cancer, in vitro and in vivo. The system described allows the introduction of therapeutic genes specifically into target cells through NSTR1 receptor-mediated endocytosis of said system, making it possible to provide treatment for this type of conditions, for example by systemic, intravenous, or in situ administration.
摘要翻译：本发明描述了能够在体外和体内特异性内切入癌细胞例如乳腺癌的癌细胞的基因载体纳米颗粒系统。所描述的系统允许通过所述系统的NSTR1受体介导的胞吞作用将治疗基因特异性地引入靶细胞，使得可以例如通过全身，静脉内或原位施用来提供对这种类型的病症的治疗。

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