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1. 发明公开

EP1959888A4 DRUG ELUTING VASCULAR CLOSURE DEVICES AND METHODS 有权转让
标题翻译： ACTIVE分泌血管闭合装置及相关方法
公开(公告)号：EP1959888A4
公开(公告)日：2013-05-01
申请号：EP06850411
申请日：2006-11-20
申请人： CARDIVA MEDICAL INC
发明人： YASSINZADEH ZIA
IPC分类号： A61F13/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00893 , A61B2017/3484 , A61B2090/032

2. 发明公开

EP1748733A4 SELF-TENSIONING VASCULAR OCCLUSION DEVICE AND METHOD FOR ITS USE 有权转让
标题翻译：具有自电压及使用方法血管闭合装置
公开(公告)号：EP1748733A4
公开(公告)日：2012-10-31
申请号：EP05759503
申请日：2005-05-18
申请人： CARDIVA MEDICAL INC
发明人： YASSINZADEH ZIA , PELAYO DELFIN
IPC分类号： A61B17/00 , A61B17/08 , A61F2/958
CPC分类号： A61B17/0057 , A61B2017/00659 , A61B2017/00986 , A61B2090/0807

3. 发明授权

EP2162071B1 VASCULAR CLOSURE DEVICES FOR PROVIDING HEMOSTATIC ENHANCEMENT 有权转让
标题翻译：用于提供静脉内增强的血管闭合装置
公开(公告)号：EP2162071B1
公开(公告)日：2017-05-03
申请号：EP08772314.4
申请日：2008-07-01
申请人： Cardiva Medical, Inc
发明人： YASSINZADEH, Zia , WEITZ, Jeffrey I. , STAFFORD, Alan
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和关闭布置在组织管道远端的血管穿刺部位的方法。该装置和方法依靠人体自身机制的组合来实现止血与化学和/或生物制剂以加速止血过程。一种方法包括通过组织管道引入闭合装置并在血管内的装置的远端部署可膨胀构件以闭塞穿刺部位的步骤。然后置于可膨胀构件附近的化学和/或生物密封构件移位，以暴露装置的化学和/或生物学区域或释放区域。此后，至少一种化学和/或生物制剂从装置释放并进入组织道以加速道内的阻塞过程。

4. 发明公开

EP2162071A1 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 有权转让
标题翻译： GEFÄSSVERSCHLUSSVORRICHTUNGENFÜRVERSTÄRKTEHÄMOSTATISCHEWIRKUNG
公开(公告)号：EP2162071A1
公开(公告)日：2010-03-17
申请号：EP08772314.4
申请日：2008-07-01
申请人： Cardiva Medical, Inc
发明人： YASSINZADEH, Zia , WEITZ, Jeffrey I. , STAFFORD, Alan
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的组合，以通过化学和/或生物剂来止血以加速止血过程。一种方法包括以下步骤：通过组织道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以阻塞穿刺部位。设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

5. 发明公开

EP1732450A2 DEVICE AND METHOD FOR SEALING BLOOD VESSELS 审中-公开
标题翻译：用于密封血管的装置和方法
公开(公告)号：EP1732450A2
公开(公告)日：2006-12-20
申请号：EP05735344.3
申请日：2005-04-06
申请人： Cardiva Medical, Inc
发明人： YASSINZADEH, Zia
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00672 , A61B2017/22065
摘要： The present invention provides devices, systems, and methods for percutaneously sealing a puncture site in tissue tracts and vessels in human or animal bodies. One system includes a locating assembly that is used to locate the puncture site and can also provide temporary hemostasis when the system is used for closing a vessel puncture. The system also includes a compression assembly comprising a tubular member with a balloon on a distal end thereof. This balloon is at a fixed distance from the locator tip which locates the balloon outside the vessel wall at a predetermined distance. Inflation of this balloon causes forward elongation of the balloon which compresses subcutaneous tissue between the distal tip of the balloon and the vessel wall. This tissue compression against the puncture site is the mechanism that provides hemostasis.
摘要翻译：本发明提供了用于经皮密封人或动物体内组织束和血管中的穿刺部位的装置，系统和方法。一个系统包括定位组件，该定位组件用于定位穿刺部位，并且还可以在系统用于关闭血管穿刺时提供临时止血。该系统还包括压缩组件，该压缩组件包括在其远端上具有球囊的管状构件。该气囊与定位器尖端相距固定的距离，该定位器尖端将气囊定位在血管壁外预定距离处。该气囊的膨胀引起气囊向前伸长，气囊压缩气囊远端尖端和血管壁之间的皮下组织。针对穿刺部位的这种组织压缩是提供止血的机制。

6. 发明授权

EP2293724B8 APPARATUS FOR DELIVERING HEMOSTATIC MATERIALS FOR BLOOD VESSEL CLOSURE 有权转让
公开(公告)号：EP2293724B8
公开(公告)日：2018-01-03
申请号：EP09774368.6
申请日：2009-06-30
申请人： Cardiva Medical, Inc
发明人： YASSINZADEH, Zia , PELAYO, Delfin
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00623 , A61B2017/00654 , A61B2017/00893 , A61B2017/00898 , A61B2017/22067 , A61B2090/3966
摘要： Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.

7. 发明公开

EP2162071A4 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 有权转让
标题翻译： GEFÄSSVERSCHLUSSVORRICHTUNGENUND VERFAHRENFÜRVERSTÄRKTEHÄMOSTATISCHEWIRKUNG
公开(公告)号：EP2162071A4
公开(公告)日：2013-08-07
申请号：EP08772314
申请日：2008-07-01
申请人： CARDIVA MEDICAL INC
发明人： YASSINZADEH ZIA , WEITZ JEFFREY I , STAFFORD ALAN
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的组合，以通过化学和/或生物剂来止血以加速止血过程。一种方法包括以下步骤：通过组织道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以阻塞穿刺部位。设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

8. 发明公开

EP1686922A2 EXPANSILE DEVICE FOR USE IN BLOOD VESSELS AND TRACTS IN THE BODY AND METHOD 审中-公开
标题翻译：膨胀设备中使用的血管和齿轮在身体和方法
公开(公告)号：EP1686922A2
公开(公告)日：2006-08-09
申请号：EP04810826.0
申请日：2004-11-12
申请人： Cardiva Medical, Inc
发明人： EPSTEIN, Gordon, H. , LEMPERT, Todd, E. , MARTIN, Brian, B. , TAYLOR, David, M. , ROMLEY, Richard, M. , YASSINZADEH, Zia , FOY, Glenn
IPC分类号： A61F2/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12136 , A61B2017/00495 , A61B2017/00641
摘要： A device (21) for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member (22) having proximal (23) and distal extremities (24) and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member (32) in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to the deployment members.

9. 发明授权

EP1156744B1 EXPANSILE DEVICE FOR USE IN BLOOD VESSELS AND TRACTS IN THE BODY 有权
标题翻译：可扩展的机器上使用的血管和身体洞穴
公开(公告)号：EP1156744B1
公开(公告)日：2004-11-03
申请号：EP00905795.1
申请日：2000-01-25
申请人： Cardiva Medical, Inc
发明人： EPSTEIN, Gordon , LEMPERT, Todd, E. , MARTIN, Brian, B. , TAYLOR, David, M.
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B2017/00495 , A61B2017/00867
摘要： A device (21) for expansion within a blood vessel having a wall defining a lumen in the body. The device (21) includes an elongated tubular member (22), an expansile member (32), a deformable membrane (33) covering the expansile member, a handle (122), and a deployment means (80).

10. 发明授权

EP2293724B1 APPARATUS FOR DELIVERING HEMOSTATIC MATERIALS FOR BLOOD VESSEL CLOSURE 有权转让
标题翻译：用于输送用于血管闭合的静脉内材料的装置
公开(公告)号：EP2293724B1
公开(公告)日：2017-11-22
申请号：EP09774368.6
申请日：2009-06-30
申请人： Cardiva Medical, Inc
发明人： YASSINZADEH, Zia , PELAYO, Delfin
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00623 , A61B2017/00654 , A61B2017/00893 , A61B2017/00898 , A61B2017/22067 , A61B2090/3966
摘要： Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.

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