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1. 发明授权

EP1706106B9 USE OF HIGHLY CONCENTRATED COMPOSITIONS OF SELECTED N-3 FATTY ACIDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISTURBANCES 无效
标题翻译：中选择N-3脂肪酸高浓缩的组合物为中央神经系统疾病的治疗中
公开(公告)号：EP1706106B9
公开(公告)日：2009-09-16
申请号：EP05701068.8
申请日：2005-01-20
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/202 , A61P25/28 , A61P25/08 , A61P25/18
CPC分类号： A61K31/202
摘要： The use is described of a composition comprising either a) alpha-linolenic acid (ALA, C18:3 n-3) or b) docosahexaenoic acid (DHA, C22:6 n-3) or c) DHA in admixture with eicosapentaenoic acid (EPA, C20:5 n-3), in a ratio of 1:0.5 to 1:1.7, respectively, and/or the pharmaceutically acceptable derivatives and/or precursors thereof; either a) or b) or c) being in a concentration not lower than 70% by weight of the total fatty acids weight in the composition, for the preparation of a drug for the prevention and/or treatment of the disturbances of the central nervous system (CNS) such as epilepsy, schizophrenia, bipolar (manic- depressive illness) and unipolar (major depression) psychiatric disorders, and by degenerative Alzheimer's disease and related forms of dementia.

2. 发明授权

EP2668952B1 Aqueous formulations of bisphosphonates, vitamin D and benzyl alcohol suitable for subcutaneous or intramuscular use 有权转让
标题翻译：二膦酸盐，维生素D，和苄醇的水性制剂，其适合于皮下或肌肉内使用
公开(公告)号：EP2668952B1
公开(公告)日：2017-02-08
申请号：EP13159132.3
申请日：2013-03-14
申请人： Romano, Paolo , Bruzzese, Tiberio
发明人： Romano, Paolo , Bruzzese, Tiberio
IPC分类号： A61K31/592 , A61K31/593 , A61K31/663 , A61K47/10 , A61K9/00
CPC分类号： A61K9/0019 , A61K31/592 , A61K31/593 , A61K31/663 , A61K47/10 , A61K2300/00

3. 发明公开

EP1912638A2 COMPOSITION OF N-3 FATTY ACIDS HAVING HIGH CONCENTRATION OF EPA AND/OR DHA AND CONTAINING N-6 FATTY ACIDS 有权
标题翻译： N-3脂肪酸与EPA和/或DHA和n-6脂肪酸，高浓度组合物
公开(公告)号：EP1912638A2
公开(公告)日：2008-04-23
申请号：EP06776665.9
申请日：2006-08-08
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/20 , A61K31/202 , A61P3/06 , A61P9/10 , A61P25/00
CPC分类号： A61K31/20 , A61K31/202
摘要： A composition of long- chain polyunsaturated fatty acids containing at least 80% by weight of eicosapentaenoic acid (EPA, C20:5 n-3) and/or docosahexaenoic acid (DHA, C22:6 n-3) and at least 3% by weight of n-6 fatty acids, particularly C20:4 n-6 and C22:5 n-6, is reported. For a better chemical and biological characterization of the composition, the content of other C20, C21 and C22 n-3 acids different from EPA and DHA is preferably reduced to less than 3% by weight. In the composition all said acids are present in the form of free acids, or their salts, or C1-C3 alkyl esters. The described composition is useful for the production of a dietetic or pharmaceutical preparation useful for treatment of conditions sensitive to the action of EPA and DHA, particularly in subjects potentially exposed to bleeding problems or to problems caused by coagulation defects.

4. 发明公开

EP3378926A1 A METHOD FOR PURIFYING FATTY ACID GLYCERIDES, COMPOSITIONS DERIVED THEREFROM, AND USE THEREOF 审中-公开
公开(公告)号：EP3378926A1
公开(公告)日：2018-09-26
申请号：EP18162570.8
申请日：2018-03-19
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： C11B3/00 , C11B3/02 , C11B3/12
CPC分类号： C11B3/006 , C11B3/02 , C11B3/12
摘要： The present invention relates to a new method of purification of fatty acid mono- and/or di-glycerides, of any origin, and in particular those characterized by an at least partial esterification with long chain polyunsaturated fatty acids (PUFAs).
This purification method consists in the treatment of said mono- and/or di-glycerides with an amount of urea suitable for their total complexation, and in the subsequent separation by filtration or centrifugation of the urea inclusion complex from the solvent phase containing the other products that are structurally unrelated to the mono- and/or di-glycerides, followed by the isolation from the complex of the glycerides, which are purified and therefore free from the many "Persistent" Organic Pollutants (POPs) of the environment, such as polychlorinated dibenzodioxins and polychlorinated dibenzo-furans, polychlorinated biphenyls, polybrominated- diphenyl ethers, polycyclic aromatic hydrocarbons, and other pollutants that are usually present and extremely toxic too.
The invention also relates to the purified compositions of mono- and/or di-glycerides thus obtained, as well as those derivable from the same with processes of hydrolysis or transesterification, by either chemical or enzymatic route, as well as the use of such compositions as a food, food for special medical use, food and dietary supplement, and as a drug.

5. 发明授权

EP2503992B1 FORMULATIONS OF BISPHOSPHONATES AND VITAMIN D SUITABLE FOR INTERMITTENT INTRAMUSCULAR AND SUBCUTANEOUS ADMINISTRATION 有权
标题翻译：维生素D和二膦酸盐间歇肌内和皮下给药的制剂
公开(公告)号：EP2503992B1
公开(公告)日：2016-04-20
申请号：EP10794865.5
申请日：2010-11-25
申请人： Romano, Paolo , Bruzzese, Tiberio
发明人： BRUZZESE, Tiberio
IPC分类号： A61K9/107 , A61K47/14 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/107 , A61K47/46

6. 发明公开

EP2503992A1 FORMULATIONS OF BISPHOSPHONATES AND VITAMIN D SUITABLE FOR INTERMITTENT INTRAMUSCULAR AND SUBCUTANEOUS ADMINISTRATION 有权
标题翻译：维生素D和二膦酸盐间歇肌内和皮下给药的制剂
公开(公告)号：EP2503992A1
公开(公告)日：2012-10-03
申请号：EP10794865.5
申请日：2010-11-25
申请人： Romano, Paolo , Bruzzese, Tiberio
发明人： BRUZZESE, Tiberio
IPC分类号： A61K9/107 , A61K47/14 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/107 , A61K47/46
摘要： Compositions for pharmaceutical use are described, comprising bisphosphonates and vitamin D in high concentration, destined to the intramuscular and subcutaneous intermittent administration for treatment of bone and skeletal system diseases, particularly osteoporosis, and sensitive cancers. These formulations are characterized by the use of a lipid and phospholipid emulsion at high concentration, having optimal carrier and solvent power for both the pharmacologically active components.

7. 发明公开

EP3273954A1 PURIFIED COMPOSITIONS OF POLYUNSATURATED FATTY ACIDS, THEIR PREPARATION METHOD AND THEIR USE 有权
标题翻译：多不饱和脂肪酸的纯化组合物，其制备方法及其用途
公开(公告)号：EP3273954A1
公开(公告)日：2018-01-31
申请号：EP16717102.4
申请日：2016-03-22
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/201 , A61K31/202 , C07B63/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00 , A61P37/00 , A61P43/00
摘要： The present invention refers to new purified compositions of long chain polyunsaturated fatty acids, or their salts or esters, characterized by being essentially free from other usually present—but structurally different—components, such as furan fatty acids, phytanic and pristanic acids, squalene, and some oligomers, as well as several “persistent” environmental pollutants, such as polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans, polychlorinated biphenyls, polybrominated diphenyl-ethers, polycyclic aromatic hydrocarbons, and others, which are also usually present and extremely toxic. The invention also refers to the purification method to obtain said compositions and the use thereof as food, food for special medical use, food and diet supplement, and drug.

8. 发明授权

EP1706106B1 USE OF HIGHLY CONCENTRATED COMPOSITIONS OF SELECTED N-3 FATTY ACIDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISTURBANCES 无效
标题翻译：选用N-3脂肪酸的高浓缩组合物用于治疗中枢神经系统紊乱
公开(公告)号：EP1706106B1
公开(公告)日：2009-07-15
申请号：EP05701068.8
申请日：2005-01-20
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/202 , A61P25/28 , A61P25/08 , A61P25/18
CPC分类号： A61K31/202
摘要： The use is described of a composition comprising either a) alpha-linolenic acid (ALA, C18:3 n-3) or b) docosahexaenoic acid (DHA, C22:6 n-3) or c) DHA in admixture with eicosapentaenoic acid (EPA, C20:5 n-3), in a ratio of 1:0.5 to 1:1.7, respectively, and/or the pharmaceutically acceptable derivatives and/or precursors thereof; either a) or b) or c) being in a concentration not lower than 70% by weight of the total fatty acids weight in the composition, for the preparation of a drug for the prevention and/or treatment of the disturbances of the central nervous system (CNS) such as epilepsy, schizophrenia, bipolar (manic- depressive illness) and unipolar (major depression) psychiatric disorders, and by degenerative Alzheimer's disease and related forms of dementia.
摘要翻译：使用被描述，其包括或者a）α-亚麻酸（ALA，C18的组合物：3的n-3）或b）二十二碳六烯酸（DHA，C22：6 n-3系）或c）的DHA与二十碳五烯酸的混合物（ EPA，C20：5n-3），和/或其药学上可接受的衍生物和/或前体分别以1：0.5至1：1.7的比例混合; a）或b）或c）浓度不低于组合物中总脂肪酸重量的70％，用于制备用于预防和/或治疗中枢神经系统紊乱的药物（CNS），如癫痫，精神分裂症，双极（躁郁症）和单极（重度抑郁症）精神障碍，以及退行性阿尔茨海默病和相关形式的痴呆。

9. 发明公开

EP1706106A1 USE OF HIGHLY CONCENTRATED COMPOSITIONS OF SELECTED N-3 FATTY ACIDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISTURBANCES 无效
标题翻译：中选择N-3脂肪酸高浓缩的组合物为中央神经系统疾病的治疗中
公开(公告)号：EP1706106A1
公开(公告)日：2006-10-04
申请号：EP05701068.8
申请日：2005-01-20
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/202 , A61P25/28 , A61P25/08 , A61P25/18
CPC分类号： A61K31/202
摘要： The use is described of a composition comprising either a) alpha-linolenic acid (ALA, C18:3 n-3) or b) docosahexaenoic acid (DHA, C22:6 n-3) or c) DHA in admixture with eicosapentaenoic acid (EPA, C20:5 n-3), in a ratio of 1:0.5 to 1:1.7, respectively, and/or the pharmaceutically acceptable derivatives and/or precursors thereof; either a) or b) or c) being in a concentration not lower than 70% by weight of the total fatty acids weight in the composition, for the preparation of a drug for the prevention and/or treatment of the disturbances of the central nervous system (CNS) such as epilepsy, schizophrenia, bipolar (manic- depressive illness) and unipolar (major depression) psychiatric disorders, and by degenerative Alzheimer's disease and related forms of dementia.

10. 发明授权

EP3273954B1 PURIFIED COMPOSITIONS OF POLYUNSATURATED FATTY ACIDS, THEIR PREPARATION METHOD AND THEIR USE 有权
公开(公告)号：EP3273954B1
公开(公告)日：2020-10-28
申请号：EP16717102.4
申请日：2016-03-22
申请人： Bruzzese, Tiberio
发明人： Bruzzese, Tiberio
IPC分类号： A61K31/201 , A61K31/202 , A61K31/232 , C07B31/00 , A61P1/00 , A61P3/00 , A61P7/02 , A61P9/00 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P35/00 , A61P37/00 , A61P43/00

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