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2. 发明公开

EP4101868A1 ANTIBODIES AGAINST CD40 审中-实审
公开(公告)号：EP4101868A1
公开(公告)日：2022-12-14
申请号：EP21194678.5
申请日：2010-03-04
申请人： Baylor Research Institute
发明人： ZURAWSKI, Gerald , BANCHEREAU, Jacques, F. , FLAMAR, Anne-Laure , MONTES, Monica , KLUCAR, Peter , AKAGAWA, Keiko
IPC分类号： C07K19/00 , C07K16/30 , C12N15/63 , C12N15/62 , A61K39/395 , A61P35/00 , C07K16/28 , A61K39/00 , C07K14/005
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

4. 发明授权

EP3489260B1 ACTIVATION OF HUMAN ANTIGEN-PRESENTING CELLS THROUGH DENDRITIC CELL LECTIN-LIKE OXIDIZED LDL RECEPTOR-1 (LOX-1) 有权
公开(公告)号：EP3489260B1
公开(公告)日：2020-12-02
申请号：EP19150601.3
申请日：2008-02-22
申请人： Baylor Research Institute
发明人： BANCHEREAU, Jacques F. , OH, SangKon , ZURAWSKI, Gerard , ZURAWSKI, Sandra , LI, Dapeng
IPC分类号： C07K16/28 , A61K39/00 , A61P37/00

5. 发明授权

EP2971132B1 TISSUE AND BLOOD-BASED MIRNA BIOMARKERS FOR THE DIAGNOSIS, PROGNOSIS AND METASTASIS-PREDICTIVE POTENTIAL IN COLORECTAL CANCER 有权转让
公开(公告)号：EP2971132B1
公开(公告)日：2020-05-06
申请号：EP14764952.9
申请日：2014-03-17
申请人： Baylor Research Institute
发明人： GOEL, Ajay , HUR, Keun , TOIYAMA, Yuji , BOLAND, Richard C.
IPC分类号： C12Q1/68 , C12P19/34 , C40B40/06

6. 发明授权

EP3148575B1 COMPOSITIONS FOR TREATING ALLERGY AND INFLAMMATORY DISEASES 无效转让
公开(公告)号：EP3148575B1
公开(公告)日：2019-08-21
申请号：EP15803012.2
申请日：2015-06-02
申请人： Baylor Research Institute
发明人： OH, Sangkon , KANE, Bob , ZURAWSKI, Gerard
IPC分类号： A61K47/68 , A61K47/54 , A61P37/08 , C07K16/28 , C07K5/10

7. 发明授权

EP2971149B1 ULCERATIVE COLITIS (UC)-ASSOCIATED COLORECTAL NEOPLASIA MARKERS 有权转让
标题翻译：溃疡性结肠炎（UC） - 同种异体大肠肿瘤标记物
公开(公告)号：EP2971149B1
公开(公告)日：2018-05-09
申请号：EP14768369.2
申请日：2014-03-13
申请人： Baylor Research Institute
发明人： GOEL, Ajay , TOIYAMA, Yuji , BOLAND, C., Richard , OKUGAWA, Yoshinaga
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61B1/31 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B10/04 , C12Q2600/154
摘要： Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

8. 发明授权

EP2966091B1 AGONISTIC ANTI-CD40 ANTIBODIES 有权
标题翻译：激动性抗CD40抗体
公开(公告)号：EP2966091B1
公开(公告)日：2018-04-25
申请号：EP15182056.0
申请日：2009-07-16
申请人： Baylor Research Institute
发明人： BANCHEREAU, Jacques F. , ZURAWSKI, Gerard , FLAMAR, Anne-laure , COBB, Amanda , MEAD, Holly , MONTES, Monica
IPC分类号： A61K39/12 , A61K39/21 , A61K39/395 , C07K14/16 , C07K16/28 , C07K19/00 , A61K47/68
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K47/646 , A61K47/6843 , A61K47/6849 , C07K16/2878 , C07K2319/01 , C07K2319/035 , C07K2319/30 , C07K2319/33 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： The present invention relates to an agonistic anti-CD40 antibody which is shown to bind and activate CD40. In particular secretion of high levels of IL-12p40 by dendritic cells (DC) is demonstrated.

9. 发明公开

EP3270924A1 METHODS AND COMPOSITIONS INVOLVING TRANSMEMBRANE AND COILED-COIL DOMAINS 3 (TMCO3) IN CANCER 审中-公开
标题翻译：涉及跨膜和卷曲螺旋结构域3（TMCO 3）在癌症中的方法和组合物
公开(公告)号：EP3270924A1
公开(公告)日：2018-01-24
申请号：EP16765711.3
申请日：2016-03-17
申请人： Baylor Research Institute
发明人： GOEL, Ajay , SHIGEYASU, Kunitoshi
IPC分类号： A61K31/495 , A61K31/4965 , A61K31/7105 , A61K39/395 , C12Q1/68 , A61P35/00
CPC分类号： C12N15/1138 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/713 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/32 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57419 , G01N2800/56
摘要： Certain embodiments provide methods and compositions related to clinical management of cancer patients based on the expression level of TMCO3. Further embodiments involve methods and compositions related to treatment of cancer patients or patients determined to have an increased TMCO3 level relative to a control or a reference level that is normal or indicating favorable prognosis.

10. 发明公开

EP3191165A1 INTRALUMINAL TUBES WITH DEPLOYABLE STRUCTURES AND RELATED METHODS 有权转让
标题翻译：具有可展开结构的腔内管及相关方法
公开(公告)号：EP3191165A1
公开(公告)日：2017-07-19
申请号：EP15840441.8
申请日：2015-09-09
申请人： Baylor Research Institute , Leeds, Steven G.
发明人： LEEDS, Steven G.
IPC分类号： A61M25/04
CPC分类号： A61J15/0003 , A61J15/0038 , A61M1/008 , A61M25/007 , A61M25/0074 , A61M25/04 , A61M2210/1053
摘要： This disclosure includes intraluminal tubes comprising: an elongated tube (e.g., having a proximal portion, a distal portion configured to be disposed inside of an internal cavity of a patient, and a sidewall defining a lumen extending from the proximal portion to the distal portion, the distal portion defining one or more openings in fluid communication with the lumen) and a plurality of deployable tines, each coupled to the tube and disposed outside the sidewall of the distal portion, where each tine is movable from a collapsed state to a deployed state in which a portion of the tine extends laterally away from the distal portion of the tube. In some of the present intraluminal tubes, the sidewall of the distal portion defines a plurality of longitudinal grooves, and each tine is disposed in a different one of the grooves when the tines are in the collapsed state.
摘要翻译：本公开内容包括管腔内管，其包括：细长管（例如，具有近侧部分，构造成布置在患者的内腔内的远侧部分和限定从近侧部分延伸到远侧部分的内腔的侧壁，所述远侧部分限定与所述内腔流体连通的一个或多个开口）以及多个可展开尖齿，每个尖端都联接到所述管并设置在所述远侧部分的所述侧壁的外侧，其中每个尖齿可从塌缩状态移动到展开状态其中叉齿的一部分横向延伸远离管的远端部分。在一些本发明的腔内管中，远侧部分的侧壁限定多个纵向凹槽，并且当尖叉处于塌缩状态时，每个尖齿设置在不同的一个凹槽中。

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