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    • 4. 发明公开
    • TRICHOLINE NASAL FORMULATION AND METHOD OF USE
    • TRICHOLINE鼻用制剂和使用方法
    • EP2964192A1
    • 2016-01-13
    • EP14730777.1
    • 2014-05-28
    • BRIU GmbH
    • VOß, ChristianeROSE, Uwe-Bernd
    • A61K9/00A61K47/08A61K31/00
    • A61K47/46A61K9/0043A61K31/205A61K47/02A61K47/08A61K47/10A61K47/36
    • A commercially-suitable tricholine nasal formulation for administration to a human as a nasal spray is disclosed. The tricholine nasal formulation includes an aqueous solution of tricholine citrate, a volatile oil and a buffer system. The disclosed tricholine nasal formulation possesses an acceptable odor and a reasonable shelf-life. The tricholine nasal formulation may be used to treat the symptoms associated with stress, anxiety, depression, malaise, or “burn out” syndrome. Optionally, a moisturizer is included in the composition to alleviate any dryness resulting from administration of the formulation to a user. A preservative may be included in the composition to produce a longer shelf-life.
    • 公开了一种用于作为鼻腔喷雾剂施用于人体的商业上适用的tricholine鼻用制剂。 毛氯灵鼻用制剂包括柠檬酸毛利灵啉的水溶液,挥发性油和任选的缓冲系统。 所公开的tricholine鼻用制剂具有可接受的气味和合理的保质期。 毛氯灵鼻用制剂可用于治疗与压力,焦虑,抑郁,不适或“烧尽”综合症有关的症状。 任选地,组合物中包含增湿剂以减轻任何干燥,如果这种干燥应该是由于将制剂给予使用者而产生的话。 防腐剂可以包含在组合物中以产生更长的储存期限。