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1. 发明公开

EP2726633A2 PROCESS AND APPARATUS FOR QUANTIFYING NUCLEIC ACID IN A SAMPLE 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUR QUANTIFIZIERUNG VONNUKLEINSÄURENIN EINER PROBE
公开(公告)号：EP2726633A2
公开(公告)日：2014-05-07
申请号：EP12804520.0
申请日：2012-07-02
申请人： Bioquanta Sa , Bioquanta Corp. , Assistance Publique Hôpitaux De Paris
发明人： CONTI, Marc , LORIC, Sylvain , MANIVET, Philippe , DELACOTTE, Nicolas , KEUMEUGNI KWEMO, Carlosse , SALIOU BAH, Mamadou
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6806 , C12Q1/68 , C12Q2537/125 , C12Q2545/113 , C12Q2563/173 , C12Q2522/101 , C12Q2537/161 , C12Q2545/114
摘要： In one aspect, the present invention concerns methods and kits for quantifying a target nucleic acid in a sample. In embodiments, a method comprises sequestrating the target nucleic acid by one or more interactors to form a sequestered conjugate that will be further labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In another aspect, the present invention concerns a method for quantifying a target nucleic acid in a sample by a reaction of the nucleic acids in the sample with a nucleic acid interactor or set of interactors to form a conjugate. The conjugate is then sequestered from the rest of the sample with a molecule bound to a support, to form a sequestered conjugate. The sequestered conjugate is labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In some embodiments, the target nucleic acid is cell free nucleic acids. In embodiments, the interactor binds to nucleic acids in the sample in a nonsequence specific manner.
摘要翻译：一方面，本发明涉及用于定量样品中靶核酸的方法和试剂盒。在实施方案中，一种方法包括通过一种或多种相互作用体螯合靶核酸以形成将被进一步标记以形成标记的缀合物的螯合缀合物。测量由标记的缀合物产生的信号并与靶核酸的量相关。在另一方面，本发明涉及通过样品中的核酸与核酸相互作用者或一组相互作用体的反应来定量样品中的靶核酸以形成缀合物的方法。然后将缀合物与其余的样品以分子结合到载体上形成螯合偶联物。将螯合的缀合物标记以形成标记的缀合物。测量由标记的缀合物产生的信号并与靶核酸的量相关。在一些实施方案中，靶核酸是无细胞核酸。在实施方案中，相互作用者以非序列特异性方式结合样品中的核酸。

2. 发明公开

EP2281064A1 PROCEDE DE MARQUAGE D'UN PRODUIT A L'AIDE D'UNE PLURALITE DE POLYNUCLEOTIDES, PROCEDE D'IDENTIFICATION DU MARQUAGE ET PRODUIT MARQUE 审中-公开
标题翻译：法产品标记基于多个多核苷酸，方法检测标记，并强调产品的
公开(公告)号：EP2281064A1
公开(公告)日：2011-02-09
申请号：EP09742212.5
申请日：2009-04-10
申请人： Bioquanta , Bioquanta Corp.
发明人： JACOB, Alexandre , KEUMEUGNI KWEMO, Carlosse , LORIC, Sylvain , MOUTEREAUX, Stéphane , DELACOTTE, Nicolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q1/6834 , Y10T436/143333 , C12Q2563/185 , C12Q2565/607 , C12Q2565/125 , C12Q2563/131
摘要： The present invention relates to a method for labelling a product, to a method for identifying the labelling and to a product labelled by means of the method of the invention. The labelling used in the present invention is based on single-stranded nucleic acids. The labelling method of the present invention comprises a step of addition of a plurality of single-stranded polynucleotides onto or into said product, said plurality of polynucleotides comprising: at least one target polynucleotide comprising a single-stranded polynucleotide of predetermined length and sequence, and decoy polynucleotides which have identical or different predetermined lengths and identical or different predetermined sequences, said decoy polynucleotides having a length or lengths identical to or different from and sequences different from the sequence of said, at least one, target polynucleotide, in which each of the target polynucleotide(s) and decoy polynucleotides does not hybridize with any of the other polynucleotides of said plurality of polynucleotides. The method of the invention makes it possible, for example, to label fragrances, cosmetics, hygiene products, food products, flavourings, extracts of a plant or plants, tobacco, beverages, textiles, leathers, medicaments, powders, varnishes, inks, hydrocarbons, papers, paints, and chemical products and compounds.

3. 发明公开

EP2069532A2 METHOD FOR ASSAYING NUCLEIC ACIDS BY FLUORESCENCE 有权
标题翻译：测试方法对于核酸用荧光
公开(公告)号：EP2069532A2
公开(公告)日：2009-06-17
申请号：EP07804750.3
申请日：2007-08-10
申请人： Bioquanta , Bioquanta Corp. , Assistance Publique - Hôpitaux de Paris
发明人： SACKO, Mory , DELACOTTE, Nicolas , BAH, Mamadou saliou , CONTI, Marc
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： G01N21/6428 , C12Q1/68 , C12Q1/6816 , G01J3/4406 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , C12Q2563/173 , C12Q2563/107 , C12Q2537/101 , C12Q2523/313
摘要： The invention relates to a method for determining the amount of nucleic acid present in a sample, wherein: - a fluorophore is added to the sample, - fluorescence intensities emitted by the fluorophore at at least two emission wavelengths in response to light stimulations at at least two excitation wavelengths respectively are measured, and - the amount of nucleic acid present in the sample is deduced from the measured fluorescence intensities.

4. 发明公开

EP2726633A4 PROCESS AND APPARATUS FOR QUANTIFYING NUCLEIC ACID IN A SAMPLE 有权
标题翻译：方法和设备对于核酸的在样本数量化
公开(公告)号：EP2726633A4
公开(公告)日：2015-03-04
申请号：EP12804520
申请日：2012-07-02
申请人： BIOQUANTA SA , BIOQUANTA CORP , ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS
发明人： CONTI MARC , LORIC SYLVAIN , MANIVET PHILIPPE , DELACOTTE NICOLAS , KEUMEUGNI KWEMO CARLOSSE , SALIOU BAH MAMADOU
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6806 , C12Q1/68 , C12Q2537/125 , C12Q2545/113 , C12Q2563/173 , C12Q2522/101 , C12Q2537/161 , C12Q2545/114
摘要： In one aspect, the present invention concerns methods and kits for quantifying a target nucleic acid in a sample. In embodiments, a method comprises sequestrating the target nucleic acid by one or more interactors to form a sequestered conjugate that will be further labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In another aspect, the present invention concerns a method for quantifying a target nucleic acid in a sample by a reaction of the nucleic acids in the sample with a nucleic acid interactor or set of interactors to form a conjugate. The conjugate is then sequestered from the rest of the sample with a molecule bound to a support, to form a sequestered conjugate. The sequestered conjugate is labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In some embodiments, the target nucleic acid is cell free nucleic acids. In embodiments, the interactor binds to nucleic acids in the sample in a nonsequence specific manner.

5. 发明公开

EP2497490A1 Methods for diagnosing and/or treating sterility 审中-公开
标题翻译： Verfahren zur Diagnose und / oder Behandlung vonSterilität
公开(公告)号：EP2497490A1
公开(公告)日：2012-09-12
申请号：EP11305236.9
申请日：2011-03-07
申请人： Bioquanta , Bioquanta Corp. , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人： Conti, Marc , Loric, Sylvain , Manivet, Philippe , Caradec, Josselin , Keumeugni Kwemo Carlosse , Matar, Corine , Revaud, Déborah
IPC分类号： A61K38/55 , A61P15/08 , G01N33/50
CPC分类号： C07K14/8139 , A61K38/57 , C12N5/0604 , C12N2501/734 , G01N33/50 , G01N33/689 , G01N33/6893 , G01N2333/8139 , G01N2800/367
摘要： The present invention concerns a polypeptide comprising the N-terminal fragment of a cystatin, and/or a cystatin expression inducer for use for the treatment of sterility and/or infertility, and a method of diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects, which method comprises measuring the level of at least one cystatin in a biological sample of a male subject and/or measuring the level of at least one cystatin in a biological sample of a female subject.
摘要翻译：本发明涉及包含半胱氨酸蛋白酶抑制剂的N-末端片段和/或用于治疗无菌和/或不孕症的半胱氨酸蛋白酶抑制剂表达诱导剂的多肽，以及诊断和/或预测不育和/或不孕不育的方法受试者和/或几个受试者，所述方法包括测量男性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平和/或测量女性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平。

6. 发明公开

EP1834267A2 PF4 PHARMACOPHORES AND THEIR USES 审中-公开
标题翻译： PF4药效及其用途
公开(公告)号：EP1834267A2
公开(公告)日：2007-09-19
申请号：EP05849406.3
申请日：2005-11-21
申请人： Bioquanta Corp. , UNIVERSITE RENE DESCARTES PARIS V
发明人： MANIVET, Philippe , ALEMANY, Monica , GUERIN, George, Alexandre
IPC分类号： G06F19/00
CPC分类号： C07K14/522 , A61K38/00 , G06F19/705
摘要： The invention provides a novel PF4 pharmacophore that is useful, inter alia, for identifying peptidomimetics and other compounds capable of modulating PF4 activity (e.g., as inhibitors, agonists or antagonists). Mutant PF4 polypeptide sequences are also provided that modulate PF4 activity in cells

7. 发明授权

EP2726633B1 PROCESS AND APPARATUS FOR QUANTIFYING NUCLEIC ACID IN A SAMPLE 有权
标题翻译：量化样品中核酸的方法和设备
公开(公告)号：EP2726633B1
公开(公告)日：2018-01-24
申请号：EP12804520.0
申请日：2012-07-02
申请人： BIOQUANTA SA , BIOQUANTA, CORP. , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人： CONTI, Marc , LORIC, Sylvain , MANIVET, Philippe , DELACOTTE, Nicolas , KEUMEUGNI KWEMO, Carlosse , SALIOU BAH, Mamadou
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6806 , C12Q1/68 , C12Q2537/125 , C12Q2545/113 , C12Q2563/173 , C12Q2522/101 , C12Q2537/161 , C12Q2545/114
摘要： In one aspect, the present invention concerns methods and kits for quantifying a target nucleic acid in a sample. In embodiments, a method comprises sequestrating the target nucleic acid by one or more interactors to form a sequestered conjugate that will be further labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In another aspect, the present invention concerns a method for quantifying a target nucleic acid in a sample by a reaction of the nucleic acids in the sample with a nucleic acid interactor or set of interactors to form a conjugate. The conjugate is then sequestered from the rest of the sample with a molecule bound to a support, to form a sequestered conjugate. The sequestered conjugate is labeled to form a labeled conjugate. The signal produced by the labeled conjugate is measured and correlated to the amount of the target nucleic acid. In some embodiments, the target nucleic acid is cell free nucleic acids. In embodiments, the interactor binds to nucleic acids in the sample in a nonsequence specific manner.

8. 发明公开

EP2683399A2 METHODS FOR DIAGNOSING AND/OR TREATING STERILITY 审中-公开
标题翻译： VERFAHREN ZUR DIAGNOSE UND / ODER BEHANDLUNG VONSTERILITÄT
公开(公告)号：EP2683399A2
公开(公告)日：2014-01-15
申请号：EP12707757.6
申请日：2012-03-07
申请人： Bioquanta , Bioquanta Corp. , Assistance Publique Hôpitaux De Paris
发明人： CONTI, Marc , LORIC, Sylvain , MANIVET, Philippe , CARADEC, Josselin , KEUMEUGNI KWEMO, Carlosse , MATAR, Corine , REVAUD, Déborah
IPC分类号： A61K38/57 , A61P15/08 , G01N33/50
CPC分类号： C07K14/8139 , A61K38/57 , C12N5/0604 , C12N2501/734 , G01N33/50 , G01N33/689 , G01N33/6893 , G01N2333/8139 , G01N2800/367
摘要： The present invention concerns a polypeptide comprising the N-terminal fragment of a cystatin, and/or a cystatin expression inducer for use for the treatment of sterility and/or infertility, and a method of diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects, which method comprises measuring the level of at least one cystatin in a biological sample of a male subject and/or measuring the level of at least one cystatin in a biological sample of a female subject, and optionally measuring further the level of at least one cathepsin in a biological sample of said male of female subject.
摘要翻译：本发明涉及包含半胱氨酸蛋白酶抑制剂的N-末端片段和/或用于治疗无菌和/或不孕症的半胱氨酸蛋白酶抑制剂表达诱导剂的多肽，以及诊断和/或预测不育和/或不孕不育的方法受试者和/或几个受试者，所述方法包括测量男性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平和/或测量女性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平。

9. 发明授权

EP2069532B1 METHOD FOR ASSAYING NUCLEIC ACIDS BY FLUORESCENCE 有权
标题翻译：测试方法对于核酸用荧光
公开(公告)号：EP2069532B1
公开(公告)日：2011-01-05
申请号：EP07804750.3
申请日：2007-08-10
申请人： Bioquanta , Bioquanta Corp. , Assistance Publique - Hôpitaux de Paris
发明人： SACKO, Mory , DELACOTTE, Nicolas , BAH, Mamadou saliou , CONTI, Marc
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： G01N21/6428 , C12Q1/68 , C12Q1/6816 , G01J3/4406 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , C12Q2563/173 , C12Q2563/107 , C12Q2537/101 , C12Q2523/313
摘要： The invention relates to a method for determining the amount of nucleic acid present in a sample, wherein: - a fluorophore is added to the sample, - fluorescence intensities emitted by the fluorophore at at least two emission wavelengths in response to light stimulations at at least two excitation wavelengths respectively are measured, and - the amount of nucleic acid present in the sample is deduced from the measured fluorescence intensities.

10. 发明公开

EP1834267A4 PF4 PHARMACOPHORES AND THEIR USES 审中-公开
标题翻译： PF4药效及其用途
公开(公告)号：EP1834267A4
公开(公告)日：2010-02-17
申请号：EP05849406
申请日：2005-11-21
申请人： BIOQUANTA CORP
发明人： MANIVET PHILIPPE , ALEMANY MONICA , GUERIN GEORGE ALEXANDRE
IPC分类号： A61K51/00 , A61K38/19 , C07K14/52
CPC分类号： C07K14/522 , A61K38/00 , G06F19/705

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