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1. 发明公开

EP0927060A4 INTRALUMINAL RADIATION TREATMENT SYSTEM 失效
标题翻译：腔内RAYS处理系统
公开(公告)号：EP0927060A4
公开(公告)日：2008-05-14
申请号：EP97945233
申请日：1997-09-23
申请人： BEST VASCULAR INC
发明人： MELOUL RAPHAEL F , HILLSTEAD RICHARD A , BONNOIT GEORGE K JR , TOBIAS MARTIN B
IPC分类号： A61M25/00 , A61N5/10 , A61M1/20 , A61M29/02 , A61M36/04
CPC分类号： A61N5/1002 , A61N5/1007 , A61N2005/1008
摘要： This invention is a tranfer device (12) and catheter assembly (14, 16) for the delivery of treatment elements (unnumbered) to a selected location within the intraluminal passageways of a patient as part of an intraluminal radiation system. The transfer device (12) includes a gate member (98) that permits the treatment elements to leave the transfer device (12) only if the catheter (14) is attached thereto. A pressure indicator (314) provides a visual indication of the fluid pressure within the transfer device, and provides for a release of the fluid if the pressure exceeds a predetermined pressure. The catheter (14) also includes detent (350) to secure it to the transfer device (12), and which must be manually activated to remove the catheter (14) from the transfer device (12).

2. 发明公开

EP1808196A2 Automated system for the radiation treatment of a desired area within the body of a patient 审中-公开
标题翻译：自动化系统zur Strahlungsbehandlung eines bestimmtenKörperbereichseines Patienten
公开(公告)号：EP1808196A2
公开(公告)日：2007-07-18
申请号：EP07007107.1
申请日：1999-12-22
申请人： Best Vascular, Inc.
发明人： Hughett, James D. , Webster, Robert, Michael , Armstrong, Doug, Layland , Boylston, Byron, Lee , Juett, Gregg, T. , Hillstead, Richard A. , Griffis, Jack C., III. , Lerohl, Andrew, L. , Dedashtian, Mark , Guiles, Marvin, A.
IPC分类号： A61M36/00
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： This invention is a transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device has an integral pump (66) for pressurizing, for circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge (50) is provided including a reservoir (52) from which fluid is drawn by the pump (66) and into which fluid is returned after being circulated through the fluid path. The pump (66) may be a peristaltic pump (66) and the fluid cartridge (50) may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge (70) having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge (70) may be of a radiation-blocking material, such as quartz.
摘要翻译：本发明是一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中转运装置具有用于加压的一体式泵（66），用于使流体通过由转运装置和相关的导管。提供了可拆卸的流体盒（50），其包括储存器（52），流体由泵（66）从该容器中抽出，并且在循环通过流体路径之后流体返回到该容器中。泵（66）可以是蠕动泵（66），并且流体盒（50）可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。流体拾取器的长度尺寸，使得入口总是浸没在流体中，而与传送装置的取向无关。还可以设置具有形成流体路径的一部分的内腔的可拆卸处理盒（70），并且用于处理盒（70）的储存套筒可以是诸如石英的辐射阻挡材料。

3. 发明授权

EP1169079B1 RADIATION DELIVERY CATHETER 有权
标题翻译：导管，用于将辐射
公开(公告)号：EP1169079B1
公开(公告)日：2006-06-14
申请号：EP01910405.8
申请日：2001-02-01
申请人： Best Vascular, Inc.
发明人： FARNAN, Robert, C.
IPC分类号： A61M25/00 , A61N5/10
CPC分类号： A61M25/0068 , A61M25/0071 , A61M25/008 , A61M25/0108 , A61M2025/0004 , A61M2025/0081 , A61M2025/0183 , A61N5/1002
摘要： A radiation delivery catheter (10) that is compatible with a transfer device wherein the radiation delivery catheter (10) is a component of a system designed to reduce the frequency of restenosis in coronary arteries after ballon angioplasty or other interventional procedures. The catheter is inserted into the patient using a guidewire and the distal tip (26) of the catheter (10) is guided to a treatement site in the artery for radioactive treatment.

4. 发明公开

EP2067502A1 Intraluminal radiation treatment system 失效
标题翻译：内分泌系统
公开(公告)号：EP2067502A1
公开(公告)日：2009-06-10
申请号：EP09156155.5
申请日：1997-09-23
申请人： Best Vascular, Inc.
发明人： Meloul, Raphael, F. , Hillstead, Richard, A. , Bonnoit, Georg, K., Jr. , Tobias, Martin, B.
IPC分类号： A61N5/10 , A61M29/02
CPC分类号： A61N5/1002 , A61N5/1007 , A61N2005/1008
摘要： In a transfer device having a fluid passageway therein in fluid communication with an integral fluid control valve and useable in a system for intraluminal treatment of a selected site in a body of a patient by at least one treating element advanced from the transfer device into a lumen of a catheter by means of pressurized fluid. The fluid passageway of the transfer device is in communication with a source of pressurized fluid, the improvement comprising a pressure indicator in fluid communication with the fluid passageway and interposed between the fluid passageway and the fluid control valve. The said pressure indicator includes a transparent elongated housing having a first portion of a first inside dimension and viewable by a user of the transfer device, a piston slidingly received within said housing, and sized to sealingly engage said first portion. The said piston is biased into said first portion of said housing. An inlet port in said first portion in communication with the source of pressurized fluid through the fluid passageway, whereby the relative position of said piston in said first portion of said housing provides a visual indication of the relative fluid pressure.
摘要翻译：在一种转运装置中，其中一个流体通道与一个整体的流体控制阀流体连通，并且可用于一个系统中，用于通过至少一个从转移装置进入管腔的治疗元件对患者体内的选定部位进行腔内处理的导管。传送装置的流体通道与加压流体源连通，改进包括与流体通道流体连通并插入在流体通道和流体控制阀之间的压力指示器。所述压力指示器包括透明细长壳体，其具有第一内部尺寸的第一部分，并且可由所述转移装置的使用者观看，活塞滑动地容纳在所述壳体内，并且尺寸设定成密封地接合所述第一部分。所述活塞被偏压到所述壳体的所述第一部分中。所述第一部分中的入口通过流体通道与加压流体源连通，由此所述活塞在所述壳体的所述第一部分中的相对位置提供相对流体压力的视觉指示。

5. 发明授权

EP0927060B1 INTRALUMINAL RADIATION TREATMENT SYSTEM 失效
标题翻译：腔内RAYS处理系统
公开(公告)号：EP0927060B1
公开(公告)日：2009-04-01
申请号：EP97945233.1
申请日：1997-09-23
申请人： Best Vascular, Inc.
发明人： MELOUL, Raphael, F. , HILLSTEAD, Richard, A. , BONNOIT, George, K., Jr. , TOBIAS, Martin, B.
IPC分类号： A61N5/10 , A61M29/02
CPC分类号： A61N5/1002 , A61N5/1007 , A61N2005/1008
摘要： This invention is a tranfer device (12) and catheter assembly (14, 16) for the delivery of treatment elements (unnumbered) to a selected location within the intraluminal passageways of a patient as part of an intraluminal radiation system. The transfer device (12) includes a gate member (98) that permits the treatment elements to leave the transfer device (12) only if the catheter (14) is attached thereto. A pressure indicator (314) provides a visual indication of the fluid pressure within the transfer device, and provides for a release of the fluid if the pressure exceeds a predetermined pressure. The catheter (14) also includes detent (350) to secure it to the transfer device (12), and which must be manually activated to remove the catheter (14) from the transfer device (12).

6. 发明公开

EP1019148A4 INTRALUMINAL RADIATION TREATMENT SYSTEM 有权
标题翻译： INTRA LUMINALE辐射安排
公开(公告)号：EP1019148A4
公开(公告)日：2008-05-21
申请号：EP99922801
申请日：1999-05-04
申请人： BEST VASCULAR INC
发明人： MELOUL RAPHAEL F , HILLSTEAD RICHARD A , BONNOITT GEORGE K JR , TOBIAS MARTIN B , HALPERN DAVID S , TRIP ROELOF
IPC分类号： A61M25/02 , A61N5/10 , A61M36/04
CPC分类号： A61N5/1002 , A61N5/1007 , A61N2005/1008

7. 发明公开

EP1808196A3 Automated system for the radiation treatment of a desired area within the body of a patient 审中-公开
标题翻译：用于患者的特定身体区域的放射治疗系统的自动化
公开(公告)号：EP1808196A3
公开(公告)日：2009-04-01
申请号：EP07007107.1
申请日：1999-12-22
申请人： Best Vascular, Inc.
发明人： Hughett, James D. , Webster, Robert, Michael , Armstrong, Doug, Layland , Boylston, Byron, Lee ICE Company, LLC , Juett, Gregg, T. , Hillstead, Richard A. , Griffis, Jack C., III. , Lerohl, Andrew, L. , Dedashtian, Mark , Guiles, Marvin, A.
IPC分类号： A61M36/00
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： This invention is a transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device has an integral pump (66) for pressurizing, for circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge (50) is provided including a reservoir (52) from which fluid is drawn by the pump (66) and into which fluid is returned after being circulated through the fluid path. The pump (66) may be a peristaltic pump (66) and the fluid cartridge (50) may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge (70) having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge (70) may be of a radiation-blocking material, such as quartz.

8. 发明公开

EP1429649A4 METHODS AND APPARATUS EMPLOYING IONIZING RADIATION FOR TREATMENT OF CARDIAC ARRHYTHMIA 审中-公开
标题翻译：方法和装置与电离辐射心脏治疗心律失常
公开(公告)号：EP1429649A4
公开(公告)日：2008-08-20
申请号：EP02768885
申请日：2002-09-23
申请人： BEST VASCULAR INC
发明人： BONAN RAOUL , LARSEN CHARLES E , TRIP ROELOF , SCHUMER DOUGLAS B , GRIFFIS JACK C III , LEROHL ANDREW L
IPC分类号： A61M25/00 , A61M25/01 , A61M36/04 , A61N5/10 , A61B1/00
CPC分类号： A61N5/1002 , A61B2017/003 , A61B2018/00363 , A61B2018/00559 , A61B2018/00577 , A61M25/0147 , A61M2025/0034 , A61M2025/004
摘要： Method and apparatus (20) employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus (20) may include a catheter (20) in which a radiation source (42) is advanced hydraulically after the catheter (20) is in place within the heart. Various fixation devices (72) are also disclosed for fixing the location of the catheter (20) within the heart.

9. 发明授权

EP1265673B1 AUTOMATED SYSTEM FOR RADIATION TREATMENT OF A PATIENT 有权
标题翻译：自动化系统患者的放射治疗
公开(公告)号：EP1265673B1
公开(公告)日：2007-08-08
申请号：EP01916522.4
申请日：2001-03-09
申请人： Best Vascular, Inc.
发明人： HUGHETT, J., David , CLAY, Bradford, G. , KNODEL, Bryan, David
IPC分类号： A61N5/00
CPC分类号： A61N5/1007 , A61N5/1002 , A61N2005/1008
摘要： An automated system for the radiation treatment of a desired area within the body of a patient is presented. Included in this system is a microprocessor-controlled transfer device (10) and a separate catheter (12) for intraluminal treatment of a patient with a treating element advanced from a removable cartridge (40) received in the transfer device (10).

10. 发明授权

EP1140274B1 AUTOMATED SYSTEM FOR THE RADIATION TREATMENT OF A DESIRED AREA WITHIN THE BODY OF A PATIENT 有权
标题翻译：自动化系统所要求的区域内的病人体内放射治疗
公开(公告)号：EP1140274B1
公开(公告)日：2007-05-09
申请号：EP99968900.3
申请日：1999-12-22
申请人： Best Vascular, Inc.
发明人： HUGHETT, James, D. , WEBSTER, Robert, Michael , ARMSTRONG, Doug, Layland , BOYLSTON, Byron, Lee , JUETT, Gregg, T. , HILLSTEAD, Richard, A. , GRIFFIS, Jack, C., III. , LEROHL, Andrew, L. , DEDASHTIAN, Mark , GUILES, Marvin, A.
IPC分类号： A61M36/00
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： This invention is a transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device has an integral pump (66) for pressurizing, for circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge (50) is provided including a reservoir (52) from which fluid is drawn by the pump (66) and into which fluid is returned after being circulated through the fluid path. The pump (66) may be a peristaltic pump (66) and the fluid cartridge (50) may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge (70) having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge (70) may be of a radiation-blocking material, such as quartz.

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