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1. 发明公开

EP2510394A2 METHOD AND SYSTEM FOR FAST THREE-DIMENSIONAL STRUCTURED-ILLUMINATION-MICROSCOPY IMAGING 审中-公开
标题翻译：方法和系统使用结构化照明显微镜FAST三维成像
公开(公告)号：EP2510394A2
公开(公告)日：2012-10-17
申请号：EP10836720.2
申请日：2010-12-09
申请人： Applied Precision, Inc.
发明人： DOUGHERTY, William M. , QUARRE, Steven Charles
IPC分类号： G02B21/22 , G01B11/24
CPC分类号： G02B21/06 , G01N21/6458 , G02B21/16 , G02B21/24 , G02B21/367 , G02B26/105 , G02B27/145
摘要： Embodiments of the present invention are directed to providing and controlling illumination for three-dimensional structured illumination microscopy. Three phase-coherent beams, referred to as a "beam triplet," are produced with planar beamsplitters. The relative phases of the beams are controlled by piezo-coupled mirrors or other means. The beams pass through the microscope objective and interfere to produce the 3D structured illumination pattern. The spatial orientation and location of the pattern is manipulated by adjusting the relative phases of the beams.

2. 发明公开

EP2406676A2 OPTICAL-FIBER-BASED LIGHT SOURCE 无效转让
标题翻译： LICHTQUELLE AUF GLASFASERBASIS
公开(公告)号：EP2406676A2
公开(公告)日：2012-01-18
申请号：EP10751524.9
申请日：2010-03-12
申请人： Applied Precision, Inc.
发明人： SEUBERT, Ronald
IPC分类号： G02B6/42 , F21V8/00
CPC分类号： G02B6/4298 , G02B21/06
摘要： Various embodiments of the present invention are directed to optical-fiber-based light sources for use in microscopy, spectrometry, and other scientific and technical instruments, devices, and processes. Light-emitting diodes ("LEDs") and other light sources are, in various embodiments of the present invention, incorporated on or within an optical fiber or fiber-optic cable in order to produce a bright optical-fiber-based light source. By incorporating light-emitting devices on or within an optical fiber, a significantly greater photon flux can be obtained, within the optical fiber or fiber-optic cable, than can be obtained by directing light from equivalent, external light-emitting elements into the optical fiber or fiber-optic cable, and the optical-fiber-based light sources of the present invention provide desirable characteristics of the light sources embedded on or within them.
摘要翻译：本发明的各种实施方案涉及用于显微镜，光谱测定以及其它科技仪器，装置和方法的基于光纤的光源。在本发明的各种实施例中，发光二极管（“LED”）和其它光源被并入到光纤或光纤电缆之上或之内，以便产生基于光纤的光源。通过将光发射器件并入光纤内或光纤内，在光纤或光纤电缆内可以获得明显更大的光子通量，这可以通过将来自等效的外部发光元件的光引导到光学光纤或光纤电缆以及本发明的基于光纤的光源提供嵌入在其中或内部的光源的期望特性。

3. 发明公开

EP1061381A2 Method for optimizing probe card analysis and scrub mark analysis data 有权
标题翻译： DatenptimierungsverfahrenfürSondenkartenanalyse und Riebmarkanalyse
公开(公告)号：EP1061381A2
公开(公告)日：2000-12-20
申请号：EP00112260.5
申请日：2000-06-07
申请人： Applied Precision, Inc.
发明人： Strom, John
IPC分类号： G01R35/00
CPC分类号： G01R1/00 , G01R1/06794 , G01R1/07342 , G01R3/00 , G01R31/2887 , G01R31/2891 , G01R35/00
摘要： A method for quantitatively determining probe card errors relying on merging data sets from a probe card analysis machine and a scrub mark analysis machine. Minimizing error values related to the data sets provides an indication of probe card/ probe machine combination tolerance.
摘要翻译：一种用于定量地确定探针卡错误的方法，它依赖于来自探针卡分析机和擦洗标记分析机的合并数据。最小化与数据集相关的错误值提供了探针卡/探针机组合公差的指示。

4. 发明公开

EP2681608A1 LASER BEAM IRRADIANCE CONTROL SYSTEMS 审中-公开
标题翻译：控制系统激光束照射
公开(公告)号：EP2681608A1
公开(公告)日：2014-01-08
申请号：EP12752065.8
申请日：2012-01-16
申请人： Applied Precision, Inc.
发明人： COOPER, Jeremy, R. , REESE, Steven, A. , DOUGHERTY, William, M.
IPC分类号： G02B26/02 , G02B6/26
CPC分类号： G02B26/08 , G02B6/266 , G02B6/32 , G02B21/16 , G02B26/0816 , G02B26/0875 , G02B26/105 , G02B2207/113
摘要： Irradiance control systems ("ICSs") that control the irradiance of a beam of light are disclosed. ICSs include in a beam translator and a beam launch. The beam translator translates the beam substantially perpendicular to the propagating direction of the beam with a desired displacement so that the beam launch can remove a portion of the translated beam and the beam can be output with a desired irradiance. The beam launch attenuates the irradiance of the beam based on the amount by which the beam is translated. ISCs can be incorporated into fluorescent microscopy instruments to provide high-speed, fine-tune control over the irradiance of excitation beams.

5. 发明公开

EP2681533A1 SYSTEMS AND METHODS FOR ILLUMINATION PHASE CONTROL IN FLUORESCENCE MICROSCOPY 有权转让
标题翻译：系统和方法照明控制阶段在荧光显微镜中
公开(公告)号：EP2681533A1
公开(公告)日：2014-01-08
申请号：EP12752425.4
申请日：2012-02-29
申请人： Applied Precision, Inc.
发明人： COOPER, Jeremy, R.
IPC分类号： G01N21/64 , G02B26/06 , G02B26/08
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/14 , G02B21/367 , G02B26/0875 , G02B27/106 , G02B27/1093 , G02B27/144 , G02B27/58
摘要： Illumination phase controls that provide precise and fast phase control of structured illumination patterns used in structure illumination microscopy are described. A coherent light source is used to generate a beam of coherent light that is split into at least three coherent beams of light. In one aspect, an illumination phase control is composed of at least one pair of rotatable windows to apply at least one phase shift to at least one of the beams. An objective lens is to receive the beams and focus the at least three beams to form an interference pattern. The phase control can be used to change the position of the interference pattern by changing the at least one phase shift applied to the at least one beam.

6. 发明公开

EP2663856A1 SYSTEMS AND METHODS FOR CAMERA-BASED IMAGE PROCESSING IN MICROSCOPY INSTRUMENTS 审中-实审转让
标题翻译：密歇根州立大学的VERFAHRENFÜRKAMERABASIERTE BILDVERARBEITUNG
公开(公告)号：EP2663856A1
公开(公告)日：2013-11-20
申请号：EP12734384.6
申请日：2012-01-11
申请人： Applied Precision, Inc.
发明人： GOODWIN, Paul, C.
IPC分类号： G01N21/64 , G01B21/06
CPC分类号： G01N21/6458 , G01B11/002 , G01N21/6408 , G01N21/6428 , G01N2201/06113 , G01N2201/12 , G02B21/02 , G02B21/06 , G02B21/082 , G02B21/16 , G02B21/361 , G02B21/367 , G06T3/4053
摘要： Systems and methods for executing super-resolution microscopy of a specimen with most of the image processing performed in a camera of a fluorescence microscopy instrument are described. In one aspect, the camera includes one or more processors to execute machine-readable instructions that control excitation light output from a multi-channel light source, control capture of intermediate images of the specimen, and perform image processing of the intermediate images to produce a final super-resolution image of the specimen.
摘要翻译：描述了在荧光显微镜仪器的相机中执行的大部分图像处理用于执行样本的超分辨率显微镜的系统和方法。一方面，相机包括一个或多个处理器，用于执行机器可读指令，其控制从多声道光源输出的激发光，控制拍摄样本的中间图像，并执行中间图像的图像处理以产生样品的最终超分辨率图像。

7. 发明公开

EP2516994A4 SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING 有权转让
标题翻译： SYSTEM AND METHOD FOR密度图像演示随机样本
公开(公告)号：EP2516994A4
公开(公告)日：2013-07-03
申请号：EP10843458
申请日：2010-12-08
申请人： APPLIED PRECISION INC
发明人： DANUSER GAUDENZ , GOODWIN PAUL C
IPC分类号： G01N21/64 , G06K9/00 , G06T1/00
CPC分类号： G01N21/6428 , G01N21/636 , G01N21/6458 , G01N2021/6415 , G01N2021/6419 , G01N2201/126 , G02B21/365 , G02B21/367 , G06T3/4053
摘要： The present invention is directed to an imaging system (902, 1706, 2002) and method for detecting relatively weak signals, over time. The system and method use the detected signals to determine the positions of signal emitters (602,604, 606). In certain embodiments imaging fluorophore-labelled samples are used and images thereof at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy are obtained. The invention employs overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images (2102-2109) as well as the number of intermediate images needed to computationally construct high-resolution final images by summing the intermediate images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

8. 发明公开

EP2561395A2 UNIFORM LIGHT SOURCE FOR AN IMAGING INSTRUMENT 审中-公开
标题翻译：均匀光源用于图片仪
公开(公告)号：EP2561395A2
公开(公告)日：2013-02-27
申请号：EP11772726.3
申请日：2011-04-21
申请人： Applied Precision, Inc. , Curts, Kyle
发明人： DOUGHERTY, William
IPC分类号： G02B26/02
CPC分类号： G02B21/06 , G02B27/48
摘要： The approach of one embodiment of the present invention is to mechanically vibrate a length of fiber optic cable transmitting coherent laser light, so that a mechanical resonance in the optical fiber is excited. This is achieved by suspending the fiber optic cable between two points and controlling both the axial tension on the suspended fiber optic cable as well as the mechanical forcing frequency. The cyclic, high-frequency mechanical perturbations of the fiber rapidly vary the path length and internal reflection angles of one or more respective modes of the transmitted laser light. In certain embodiments, the system may be tuned to induce a standing mechanical wave in the fiber. Higher-harmonic waveforms and higher amplitudes in the resonant fiber produce excellent speckle reduction and uniform intensity distributions.

9. 发明公开

EP1061381A3 Method for optimizing probe card analysis and scrub mark analysis data 有权
标题翻译：对于探针卡分析和执行器的市场分析数据的优化方法
公开(公告)号：EP1061381A3
公开(公告)日：2001-09-26
申请号：EP00112260.5
申请日：2000-06-07
申请人： Applied Precision, Inc.
发明人： Strom, John
IPC分类号： G01R35/00 , G01R1/067
CPC分类号： G01R1/00 , G01R1/06794 , G01R1/07342 , G01R3/00 , G01R31/2887 , G01R31/2891 , G01R35/00
摘要： A method for quantitatively determining probe card errors relying on merging data sets from a probe card analysis machine and a scrub mark analysis machine. Minimizing error values related to the data sets provides an indication of probe card/ probe machine combination tolerance.

10. 发明公开

EP2516994A2 SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING 有权转让
标题翻译： SYSTEM AND METHOD FOR IMAGE专题介绍POET随机扫描
公开(公告)号：EP2516994A2
公开(公告)日：2012-10-31
申请号：EP10843458.0
申请日：2010-12-08
申请人： Applied Precision, Inc.
发明人： DANUSER, Gaudenz , GOODWIN, Paul, C.
IPC分类号： G01N21/64 , G06T1/00
CPC分类号： G01N21/6428 , G01N21/636 , G01N21/6458 , G01N2021/6415 , G01N2021/6419 , G01N2201/126 , G02B21/365 , G02B21/367 , G06T3/4053
摘要： The present invention is directed to an imaging system (902, 1706, 2002) and method for detecting relatively weak signals, over time. The system and method use the detected signals to determine the positions of signal emitters (602,604, 606). In certain embodiments imaging fluorophore-labelled samples are used and images thereof at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy are obtained. The invention employs overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images (2102-2109) as well as the number of intermediate images needed to computationally construct high-resolution final images by summing the intermediate images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

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