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1. 发明授权

EP2057184B1 CYCLIC ANGIOTENSIN ANALOGS 失效转让
标题翻译：骑行血管紧张素类似物
公开(公告)号：EP2057184B1
公开(公告)日：2011-02-09
申请号：EP07808529.7
申请日：2007-08-07
申请人： Applied NanoSystems B.V.
发明人： HAAS, Marijke , KLUSKENS, Leonardus, Dorothea , KUIPERS, Anneke , RINK, Rick , NELEMANS, Sieger, Adriaan , MOLL, Gert, Nikolaas
IPC分类号： C07K7/14 , A61K38/08 , A61L31/16
CPC分类号： C07K7/14 , A61L31/16 , A61L2300/25
摘要： The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(l-8) agonistic or antagonistic activity and to cyclised Ang(l-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr4 and Pro7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.

2. 发明授权

EP1397123B1 DELIVERY OF SMALL HYDROPHILIC MOLECULES PACKAGED INTO LIPID VESICLES 有权
标题翻译：包装在脂质囊泡亲水性小分子的施用
公开(公告)号：EP1397123B1
公开(公告)日：2009-12-30
申请号：EP02743969.4
申请日：2002-06-21
申请人： Applied NanoSystems B.V.
发明人： FRIESEN, Robert, Heinz, Edward , POOLMAN, Berend , FERINGA, Bernard Lucas , ENGBERTS, Jan, Bernard, Frederik, Nicolaas
IPC分类号： A61K9/127
CPC分类号： A61K9/1271
摘要： Means and methods are provided for the generation and use of delivery vehicles for small molecules. In one aspect of the invention lipid vesicles comprising proteinaceous channel and said small molecules are generated. Said proteinaceous channel and/or said lipid vesicle are formulated such that said small molecule is released in the vicinity of a target cell. Said target cell may be present in vitro or in vivo.

3. 发明公开

EP1535903A1 Modified MscL protein channel 审中-公开
标题翻译： Modifizierter MSCL-Protein-Kanal
公开(公告)号：EP1535903A1
公开(公告)日：2005-06-01
申请号：EP03078718.8
申请日：2003-11-25
申请人： Applied NanoSystems B.V.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C07C381/04 , A61K9/127 , A61K47/48 , A61P35/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04 , Y02A50/473
摘要： The invention relates to the field of drug delivery, in particular to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/ or localised release of therapeutic molecules (e.g. small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E.coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
摘要翻译：本发明涉及药物递送领域，特别涉及化学修饰用于药物递送载体中的蛋白质通道的化合物和方法，用于治疗分子的受控和/或局部释放（例如小分子，肽，蛋白质或其他大分子）。提供能够控制机械敏感通道（例如大肠杆菌的MscL通道蛋白质）或其功能等同物的通道活性的pH-和/或光响应化合物，以及这些化合物用于转化机械敏感通道蛋白进入pH和/或光响应通道。还提供了包含pH和/或光响应通道蛋白的药物递送载体。

4. 发明公开

EP1527090A1 METHOD OF BINDING A COMPOUND TO A SURFACE 有权
标题翻译：方法用于绑定连接到表面
公开(公告)号：EP1527090A1
公开(公告)日：2005-05-04
申请号：EP03733634.4
申请日：2003-06-13
申请人： Applied NanoSystems B.V.
发明人： HEKTOR, Harm, Jan , RINK, Rick , SCHOLTMEIJER, Karin , WEMER, Johannes , ROGALSKA, Ewa, Maria , WALCARIUS, Alain, Georges, Ghislain
IPC分类号： C07K14/36 , C07K14/375
CPC分类号： G01N33/54393 , C07K14/36 , C07K14/375
摘要： The present invention relates to a method of binding a compound to at least a part of a surface of an object, said method comprising the step of adsorbing a hydrophobin-like substance to said surface. The invention provides a method of providing a surface of an object with a reactive compound comprising the steps of coating at least a part of the surface of the object with a coating of a hydrophobin-like substance and contacting the compound with the coated hydrophobin-like substance to form a non-covalent bond between said hydrophobin-like substance and said compound.

5. 发明公开

EP1410028A2 IMMOBILISATION OF PROTEINS AND ELECTROACTIVE COMPOUNDS ON A SENSOR SURFACE BY MEANS OF A HYDROPHOBIN COATING 有权
标题翻译：固定化蛋白电力活性化合物在传感器表面上的USING A疏水涂层
公开(公告)号：EP1410028A2
公开(公告)日：2004-04-21
申请号：EP02743968.6
申请日：2002-06-21
申请人： Applied NanoSystems B.V.
发明人： ROGALSKA, Ewa, Maria , BILEWICZ, Renata , TAGU, Denis, Etienne, Marie, André , WALCARIUS, Alain, Georges, Ghislain , WEMER, Johannes , SCHOLTMEIJER, Karin , RINK, Rick , HEKTOR, Harm, Jan
IPC分类号： G01N33/543 , C12Q1/00
CPC分类号： G01N33/5438 , C12Q1/004 , Y10T428/24917 , Y10T428/24926 , Y10T428/31504 , Y10T428/31678
摘要： The present invention relates to a method of non-covalently binding a compound to a sensor surface, said method comprising the step of adsorbing a hydrophobin-like substance to at least a part said sensor surface (which part preferably comprises an electrode). Furthermore, the invention provides sensor provided with a surface at least a part of which is provided with a coating of a hydrophobin-like substance comprising a non-covalently bonded compound.

6. 发明公开

EP1279742A1 Method of binding a compound to a sensor surface using hydrophobin 审中-公开
标题翻译： Methode unter Verwendung von Hydrophobin，um eine Verbindung an eine Sensoroberflaeche zu binden
公开(公告)号：EP1279742A1
公开(公告)日：2003-01-29
申请号：EP01202802.3
申请日：2001-07-23
申请人： Applied NanoSystems B.V.
发明人： Rogalska, Eva Maria , Tagu, Denis Etienne Marie André , Bilewicz, Renata
IPC分类号： C12Q1/00 , G01N27/327
CPC分类号： G01N33/5438 , C12Q1/004 , Y10T428/24917 , Y10T428/24926 , Y10T428/31504 , Y10T428/31678
摘要： The present invention relates to a method of binding a compound to a sensor surface, said method comprising the step of adsorbing hydrophobin to said sensor surface. According to the invention, the compound is chosen from the group consisting of i) an electroactive compound, an ii) a compound capable of being converted into an electroactive compound, said method comprising the steps of

e) coating the electrode with a hydrophobin, and
f) contacting the compound with the hydrophobin
to form a hydrophobin coating containing said compound in a non-covalently bound form.
摘要翻译：本发明涉及一种将化合物与传感器表面结合的方法，所述方法包括将疏水蛋白吸附到所述传感器表面的步骤。根据本发明，化合物选自i）电活性化合物，ii）能够转化为电活性化合物的化合物，所述方法包括以下步骤：e）用疏水蛋白包被电极，以及 f）使化合物与疏水蛋白接触以形成含有非共价结合形式的所述化合物的疏水蛋白涂层。

7. 发明公开

EP1257571A1 METHOD OF PURIFYING A HYDROPHOBIN PRESENT IN A HYDROPHOBIN-CONTAINING SOLUTION 有权
标题翻译： PROCEDURE FOR CLEANING疏水蛋白从含疏水蛋白的溶液
公开(公告)号：EP1257571A1
公开(公告)日：2002-11-20
申请号：EP01910215.1
申请日：2001-02-02
申请人： Applied NanoSystems B.V.
发明人： DE VOCHT, Marcel, Leo , WÖSTEN, Herman, Abel, Bernard , WESSELS, Joseph, Gerard, Hubert
IPC分类号： C07K14/375 , C07K1/20
CPC分类号： C07K14/375
摘要： The invention relates to a method of purifying a hydrophobin present in a hydrophobin-containing solution. According to the invention the solution is contacted with a surface for the adsorption to that surface, and separated from a solution depleted in hydrophobin. Subsequently the surface is contacted with a solution containing a surfactant at a temperature lower than 90 °C. Desorbed hydrophobin is separated from said surface.

8. 发明授权

EP1687267B1 MODIFIED MSCL PROTEIN CHANNEL 有权
标题翻译：改进MSCL蛋白CHANNEL
公开(公告)号：EP1687267B1
公开(公告)日：2011-10-05
申请号：EP04808728.2
申请日：2004-11-25
申请人： Applied NanoSystems B.V.
发明人： KOCER, Armagan , WALKO, Martin , ROBILLARD, George, Thomas
IPC分类号： C07C381/04 , A61K9/127 , A61K47/48 , A61P35/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04 , Y02A50/473
摘要： The invention relates to the field of drug delivery, in particular to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/ or localised release of therapeutic molecules (e.g. small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E.coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.

9. 发明公开

EP2267003A1 Biologically produced cyclic affinity tags 审中-公开
标题翻译： Biologisch hergestellte cyclischeAffinitätsmarker
公开(公告)号：EP2267003A1
公开(公告)日：2010-12-29
申请号：EP09163581.3
申请日：2009-06-24
申请人： Applied NanoSystems B.V.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C07K7/50
CPC分类号： C07K7/06 , C07K1/22 , C07K5/0812 , C07K5/1016 , C07K14/4703 , C12P21/02
摘要： The invention relates to novels ways of introducing an affinity tag into a protein of interest. Provided is an enzymatic method for providing a proteinaceous substance comprising a polypeptide of interest and a cyclic affinity tag, comprising the steps of: (a) providing at least one precursor proteinaceous substance, the precursor comprising said protein of interest and at least one motif of the general formula X1-Tag-X2, wherein X1 and X2 represent amino acids whose side chains can be linked enzymatically by a covalent bond; Tag is an amino acid sequence capable of binding to a binding partner when cyclized; (b) contacting said precursor with at least one enzyme capable of forming a covalent bond between X1 and X2, thereby introducing an intramolecular ring structure comprising the Tag sequence; and (c) isolating the resulting cyclized proteinaceous substance. Also provided are proteinaceous substances obtainable thereby and the use thereof, for instance for preparing a peptide library.
摘要翻译：本发明涉及将亲和标签引入感兴趣的蛋白质的方法。本发明提供了一种用于提供包含感兴趣的多肽和环状亲和标签的蛋白质物质的酶法，其包括以下步骤：（a）提供至少一种前体蛋白质物质，所述前体蛋白质物质包含所述目的蛋白质和至少一种通式X1-Tag-X2，其中X1和X2表示其侧链可以通过共价键酶联的氨基酸; 标记是能够结合时结合配偶体的氨基酸序列; （b）使所述前体与能够在X 1和X 2之间形成共价键的至少一种酶接触，从而引入包含Tag序列的分子内环结构; 和（c）分离得到的环化蛋白质物质。还提供了可获得的蛋白质物质及其用途，例如用于制备肽文库。

10. 发明授权

EP1410028B1 IMMOBILISATION OF PROTEINS AND ELECTROACTIVE COMPOUNDS ON A SENSOR SURFACE BY MEANS OF A HYDROPHOBIN COATING 有权
标题翻译：固定化蛋白电力活性化合物在传感器表面上的USING A疏水涂层
公开(公告)号：EP1410028B1
公开(公告)日：2008-12-10
申请号：EP02743968.6
申请日：2002-06-21
申请人： Applied NanoSystems B.V.
发明人： ROGALSKA, Ewa, Maria , BILEWICZ, Renata , TAGU, Denis, Etienne, Marie, André , WALCARIUS, Alain, Georges, Ghislain , WEMER, Johannes , SCHOLTMEIJER, Karin , RINK, Rick , HEKTOR, Harm, Jan
IPC分类号： G01N33/543 , C12Q1/00
CPC分类号： G01N33/5438 , C12Q1/004 , Y10T428/24917 , Y10T428/24926 , Y10T428/31504 , Y10T428/31678
摘要： The present invention relates to a method of non-covalently binding a compound to a sensor surface, said method comprising the step of adsorbing a hydrophobin-like substance to at least a part said sensor surface (which part preferably comprises an electrode). Furthermore, the invention provides sensor provided with a surface at least a part of which is provided with a coating of a hydrophobin-like substance comprising a non-covalently bonded compound.

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