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1. 发明公开

EP2502999A3 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 审中-公开
公开(公告)号：EP2502999A3
公开(公告)日：2013-01-23
申请号：EP12161571.0
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim, Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

2. 发明公开

EP2502999A2 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 审中-公开
公开(公告)号：EP2502999A2
公开(公告)日：2012-09-26
申请号：EP12161571.0
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim, Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

3. 发明公开

EP1989308A4 METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES 失效转让
标题翻译：用于治疗和鉴定MISSGEFALTETEM SOD1方法和组合物实现的疾病
公开(公告)号：EP1989308A4
公开(公告)日：2009-12-30
申请号：EP07710682
申请日：2007-03-05
申请人： AMORFIX LIFE SCIENCES LTD , UNIV HEALTH NETWORK
发明人： CASHMAN NEIL R , CHAKRABARTTY AVIJIT , RAKHIT RISHI , OSTERMANN JOACHIM BERNHARD
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828

4. 发明公开

EP2514823A2 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 失效转让
公开(公告)号：EP2514823A2
公开(公告)日：2012-10-24
申请号：EP12161564.5
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

5. 发明公开

EP2495327A3 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 失效转让
标题翻译：方法和组合物用于治疗和检测missgefaltetem SOD 1诱导的疾病
公开(公告)号：EP2495327A3
公开(公告)日：2012-10-17
申请号：EP12161575.1
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim, Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573 , C12N9/00 , A61K31/713
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

6. 发明公开

EP1668369A4 EPITOPE PROTECTION ASSAY AND METHOD FOR DETECTING PROTEIN CONFORMATIONS 有权
标题翻译： EPITOPSCHUTZTEST和方法检测蛋白构象
公开(公告)号：EP1668369A4
公开(公告)日：2009-10-21
申请号：EP04761667
申请日：2004-08-20
申请人： AMORFIX LIFE SCIENCES LTD
发明人： CASHMAN NEIL , LEHTO MARTY
IPC分类号： G01N33/68 , G01N33/53 , G01N33/569
CPC分类号： G01N33/6896 , A61K38/00 , C07K16/18 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/626 , G01N33/58 , G01N33/581 , G01N33/68 , G01N33/6845 , G01N2333/90283 , G01N2800/28 , G01N2800/2828
摘要： The invention relates to a composition for eliciting an immune response in an animal to produce an antibody that binds selectively to an amyotrophic lateral sclerosis (ALS)-specific epitope.

7. 发明公开

EP1989308A1 METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES 失效转让
标题翻译：用于治疗和鉴定MISSGEFALTETEM SOD1方法和组合物实现的疾病
公开(公告)号：EP1989308A1
公开(公告)日：2008-11-12
申请号：EP07710682.1
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： CASHMAN, Neil R. , CHAKRABARTTY, Avijit , RAKHIT, Rishi , OSTERMANN, Joachim Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

8. 发明公开

EP1668369A1 EPITOPE PROTECTION ASSAY AND METHOD FOR DETECTING PROTEIN CONFORMATIONS 有权
标题翻译： EPITOPSCHUTZTEST和方法检测蛋白构象
公开(公告)号：EP1668369A1
公开(公告)日：2006-06-14
申请号：EP04761667.7
申请日：2004-08-20
申请人： Amorfix Life Sciences Ltd.
发明人： CASHMAN, Neil , LEHTO, Marty
IPC分类号： G01N33/68 , G01N33/53 , G01N33/569
CPC分类号： G01N33/6896 , A61K38/00 , C07K16/18 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/626 , G01N33/58 , G01N33/581 , G01N33/68 , G01N33/6845 , G01N2333/90283 , G01N2800/28 , G01N2800/2828
摘要： The invention relates to a composition for eliciting an immune response in an animal to produce an antibody that binds selectively to an amyotrophic lateral sclerosis (ALS)-specific epitope.

9. 发明公开

EP2514824A3 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 审中-公开
标题翻译：方法和组合物用于治疗和检测missgefaltetem SOD 1诱导的疾病
公开(公告)号：EP2514824A3
公开(公告)日：2013-01-23
申请号：EP12161568.6
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

10. 发明公开

EP2514823A3 Methods and compositions to treat and detect misfolded-SOD1 mediated diseases 失效转让
标题翻译：方法和组合物用于治疗和检测missgefaltetem SOD 1诱导的疾病
公开(公告)号：EP2514823A3
公开(公告)日：2013-01-23
申请号：EP12161564.5
申请日：2007-03-05
申请人： Amorfix Life Sciences Ltd. , University Health Network
发明人： Cashman, Neil , Chakrabartty, Avijit , Rakhit, Rishi , Ostermann, Joachim Bernhard
IPC分类号： C12N15/53 , A61K31/7088 , A61K38/44 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/40 , C12N5/12 , C12N9/02 , G01N33/573
CPC分类号： C07K16/40 , A01K2267/0312 , A01K2267/0318 , A61K31/7088 , A61K31/713 , A61K39/0005 , A61K39/0007 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/575 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N9/0089 , G01N33/573 , G01N33/6896 , G01N2333/90283 , G01N2800/2828
摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.
摘要翻译：本发明提供了用于在需要治疗的受试者中治疗的医学病症，疾病或由超氧化物歧化酶（SOD）的错误折叠形式介导的病症的方法。该方法可选地包括施用给所述受试者的组合物，其包含药学上可接受的载体和由式（1）至外源抗体或其片段那样的试剂选择性结合到SOD的错误折叠形式，和/或（2）的免疫原性没有引起生产的内源性抗体的选择性结合做以SOD的错误折叠形式，和/或（3）的核酸序列的编码（1）或（2）。在某些实施方案，本发明提供治疗疾病的方法：如阿尔茨海默氏病，帕金森氏病，或使用疾病特异性表位的肌萎缩侧索硬化症肌萎缩性，和组合物，包括本文的表位。因此本发明提供的抗体没有结合到单体或错误折叠SOD1，而不是在天然同源二聚体SOD1的分子表面。此外，本发明包括诊断阿尔茨海默氏病，帕金森氏病或肌萎缩性侧索硬化症中的受试者的方法。所以，本发明提供鉴定物质用于治疗阿尔茨海默氏病，帕金森氏病的治疗或预防或肌萎缩性侧索硬化和使用本发明的结合蛋白的试剂盒的方法。

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