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1. 发明授权

EP2405917B1 SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS 有权转让
标题翻译：取代的稠合嘧啶化合物
公开(公告)号：EP2405917B1
公开(公告)日：2014-04-23
申请号：EP10725293.4
申请日：2010-03-12
申请人： Advinus Therapeutics Private Limited
发明人： PALLE, Venkata , RAMDAS, Vidya , BARAWKAR, Dinesh , BASU, Sujay , KOUL, Summon , WAMAN, Yogesh , PATEL, Meena , PANMAND, Anil
IPC分类号： C07D473/06 , C07D473/18 , C07D473/30 , C07D473/40
CPC分类号： C07D473/40 , A61K31/522 , A61K31/5377 , C07D473/06 , C07D473/18 , C07D473/30

2. 发明授权

EP2195304B1 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS 有权转让
标题翻译：乙酰胺衍生物ALS葡萄糖激酶激活你的程序和医疗应用
公开(公告)号：EP2195304B1
公开(公告)日：2014-01-08
申请号：EP08838336.9
申请日：2008-10-07
申请人： Advinus Therapeutics Private Limited
发明人： BHUNIYA, Debanath , BHOSALE, Sandeep, Bhausaheb , KAPKOTI, Gobind, Sing , PALLE, Venkata, Poornapragnacharyulu , DE, Siddhartha , MOOKHTIAR, Kasim A , DESHPANDE, Anil , KANDALKAR, Sachin , NAIK, Keshav , KURHADE, Santosh , DAVE, Bhavesh , KOBAL, Balasaheb
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61P3/00 , A61P3/06 , A61P3/10
CPC分类号： C07D277/46 , C07D213/80 , C07D241/26 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04

3. 发明公开

EP2619211A2 FUSED TRICYCLIC COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONIST 有权转让
标题翻译：稠合三环化合物作为腺苷受体拮抗
公开(公告)号：EP2619211A2
公开(公告)日：2013-07-31
申请号：EP11790674.3
申请日：2011-09-22
申请人： Advinus Therapeutics Private Limited
发明人： BARAWKAR, Dinesh , BASU, Sujay , RAMDAS, Vidya , NAYKODI, Minakshi , PATEL, Meena , SHEJUL, Yogesh , THORAT, Sachin , PANMAND, Anil
IPC分类号： C07D487/14
摘要： The present disclosure relates to fused tricyclic compounds of formula (I) or its tautomers, polymorphs, stereoisomers, prodrugs, solvate or a pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by thereof as A2A adenosine receptor antagonists. [Formula should be inserted here] The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by the mediation of adenosine A2A receptor. Such conditions include, but are not limited to, Parkinsons disease, restless leg syndrome, Alzheimers disease, neurodegenerative disorder, inflammation, wound healing, dermal fibrosis, nocturnal myoclonus, cerebral ischaemia, myocardial ischemia, Huntington's disease, multiple system atrophy, corticobasal degeneration, Wilson's disease or other disorders of basal ganglia which results in dyskinesias, post traumatic stress disorder, hepatic cirrhosis, sepsis, spinal cord injury, retinopathy, hypertension, social memory impairment, depression, neuroprotection, narcolepsy or other sleep related disorders, attention deficit hyperactivity disorder, drug addiction, post traumatic stress disorder and vascular injury and the like. The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

4. 发明授权

EP2155720B1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权
标题翻译：吡咯-2-甲酰胺ALS葡萄糖激酶激活你的过程和药物应用
公开(公告)号：EP2155720B1
公开(公告)日：2013-07-17
申请号：EP08776680.4
申请日：2008-06-05
申请人： Advinus Therapeutics Private Limited
发明人： BHUNIYA, Debnath , KAPKOTI, S., Gobind , WARRIER, S., Jayakumar , KUKREJKA, Gagan , MAVINAHALLI, N., Jagadeesh , PALLE, P., Venkata , MOOKHTIAR, A., Kasim
IPC分类号： C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , A61K31/40 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14

5. 发明公开

EP2405917A2 SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS 有权转让
标题翻译：取代的稠合嘧啶化合物
公开(公告)号：EP2405917A2
公开(公告)日：2012-01-18
申请号：EP10725293.4
申请日：2010-03-12
申请人： Advinus Therapeutics Private Limited
发明人： PALLE, Venkata , RAMDAS, Vidya , BARAWKAR, Dinesh , BASU, Sujay , KOUL, Summon , WAMAN, Yogesh , PATEL, Meena , PANMAND, Anil
IPC分类号： A61K31/522
CPC分类号： C07D473/40 , A61K31/522 , A61K31/5377 , C07D473/06 , C07D473/18 , C07D473/30
摘要： The present invention discloses substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor, such as asthma, chronic obstructive pulmonary disorder, angiogenesis, pulmonary fibrosis, emphysema, allergic diseases, inflammation, reperfusion injury, myocardial ischemia, atherosclerosis, hypertension, congestive heart failure, retinopathy, diabetes mellitus, obesity, inflammatory gastrointestinal tract disorders, and/or autoimmune diseases.

6. 发明授权

EP2125735B1 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权
标题翻译： 2,2,2-三取代乙酰胺衍生物的葡萄糖激酶激活你的过程和药物应用
公开(公告)号：EP2125735B1
公开(公告)日：2012-06-27
申请号：EP08738368.3
申请日：2008-02-25
申请人： Advinus Therapeutics Private Limited
发明人： MOOKHTIAR, Kasim, A. , BHUNIYA, Debnath , DAVE, Bhavesh , KAPKOTI, Gobind, S. , BASU, Sujay , CHUGH, Anita , DE, Siddartha , PALLE, Venkata, P.
IPC分类号： C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/46 , C07D277/82 , C07D417/12 , C07D285/135 , A61K31/44 , A61K31/4168 , A61P3/10
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.

7. 发明公开

EP2195304A2 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS 有权转让
标题翻译：乙酰胺衍生物ALS葡萄糖激酶激活你的程序和医疗应用
公开(公告)号：EP2195304A2
公开(公告)日：2010-06-16
申请号：EP08838336.9
申请日：2008-10-07
申请人： Advinus Therapeutics Private Limited
发明人： BHUNIYA, Debanath , BHOSALE, Sandeep, Bhausaheb , KAPKOTI, Gobind, Sing , PALLE, Venkata, Poornapragnacharyulu , DE, Siddhartha , MOOKHTIAR, Kasim A , DESHPANDE, Anil , KANDALKAR, Sachin , NAIK, Keshav , KURHADE, Santosh , DAVE, Bhavesh , KOBAL, Balasaheb
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61P3/00 , A61P3/06 , A61P3/10
CPC分类号： C07D277/46 , C07D213/80 , C07D241/26 , C07D277/54 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Acetamide derivative compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

8. 发明公开

EP2402327A1 Acetamide compounds as glucokinase activators, their process and medicinal applications 有权转让
标题翻译：乙酰胺作为葡糖激酶活化剂，它们的方法和医疗应用
公开(公告)号：EP2402327A1
公开(公告)日：2012-01-04
申请号：EP10172616.4
申请日：2010-08-12
申请人： Advinus Therapeutics Private Limited
发明人： Deshpande, Anil , Dave, Bhavesh , Kurhade, Santosh , Kobal, Balasaheb , Naik, Keshav , Kandalkar, Sachin , Bhuniya, Debnath , Palle, Venkata Poornapragnacharyulu
IPC分类号： C07D277/54 , C07D417/12 , C07D417/14 , C07D513/04 , A61K31/426 , A61P3/00
CPC分类号： C07D309/08 , C07D231/16 , C07D277/54 , C07D309/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed.

The disclosure also provides process of preparation of these acetamide derivatives.
The disclosure also provides use of a compound of formula (I) its polymorphs, stereoisomers, pharmaceutically acceptable salt, solvate or pro-drug thereof, for the manufacture of a medicament for the activation of Glucokinase.
摘要翻译：乙酰胺衍生物，它们的立体异构体，互变异构体，前药，药学上可接受的盐，多晶型物，溶剂化物和式蒸发散其用于预防，管理，治疗，进展的控制，或疾病和/或医学病症的辅助治疗，其中葡糖激酶的活化将是有益，是游离缺失盘。本公开因此提供了制备合成乙酰胺衍生物的方法。本发明因此提供式（I）多晶型物，立体异构体，药学上可接受的盐，溶剂合物或前药的化合物在制备用于葡萄糖激酶活化的药物中的用途。

9. 发明公开

EP2125735A2 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权
标题翻译： 2,2,2-三取代乙酰胺衍生物的葡萄糖激酶激活你的过程和药物应用
公开(公告)号：EP2125735A2
公开(公告)日：2009-12-02
申请号：EP08738368.3
申请日：2008-02-25
申请人： Advinus Therapeutics Private Limited
发明人： MOOKHTIAR, Kasim, A. , BHUNIYA, Debnath , DAVE, Bhavesh , KAPKOTI, Gobind, S. , BASU, Sujay , CHUGH, Anita , DE, Siddartha , PALLE, Venkata, P. , PANMAND, Anil , PATEL, Meena
IPC分类号： C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/46 , C07D277/82 , C07D417/12 , C07D285/135 , A61K31/44 , A61K31/4168 , A61P3/10
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.

10. 发明公开

EP2155720A1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 有权
标题翻译：吡咯-2-甲酰胺ALS葡萄糖激酶激活你的过程和药物应用
公开(公告)号：EP2155720A1
公开(公告)日：2010-02-24
申请号：EP08776680.4
申请日：2008-06-05
申请人： Advinus Therapeutics Private Limited
发明人： BHUNIYA, Debnath , KAPKOTI, S., Gobind , WARRIER, S., Jayakumar , KUKREJKA, Gagan , MAVINAHALLI, N., Jagadeesh , PALLE, P., Venkata , MOOKHTIAR, A., Kasim
IPC分类号： C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , A61K31/40 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14
摘要： Pyrrole-2-carboxamide derivatives, their polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, beneficial for prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these pyrrole-2-carboxamides.

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