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1. 发明公开

EP3403615A1 TRANSCATHETER VALVE PROSTHESIS FOR BLOOD VESSEL 审中-公开
公开(公告)号：EP3403615A1
公开(公告)日：2018-11-21
申请号：EP17171583.2
申请日：2017-05-17
申请人： AORTICLAB SARL
发明人： PASQUINO, Enrico , BONETTI, Francesco , OSTA, Stefano , OSTA, Franco
IPC分类号： A61F2/24 , A61F2/01
CPC分类号： A61F2/2412 , A61F2/013 , A61F2/2436 , A61F2002/011 , A61F2250/0059
摘要： A transcatheter temporary valve prosthesis for blood vessel comprising an expandable support structure (5"), a valve (7), a filter (12) and a conveyor (6); said support structure (5") forming a tubular shape when expanded, with a distal and a proximal end, said valve (7) being located at said distal end and said conveyor (6) extending within said support structure (5), from said proximal to said distal end and including a central passage that is adapted to act as an introducer for other devices.

2. 发明公开

EP3151763A1 DISPOSITIF TRANSCATHETER POUR L'ABLATION DE TISSUS CALCIFIES AU NIVEAU DES VOLETS D'UNE VALVE AORTIQUE 有权转让
标题翻译： KATHETERVORRICHTUNG ZUR ABLATION VON VERKALKTEM GEWEBE AN DEN KLAPPEN EINER AORTENKLAPPE
公开(公告)号：EP3151763A1
公开(公告)日：2017-04-12
申请号：EP15733805.4
申请日：2015-06-04
申请人： AORTICLAB SARL , Centre Hospitalier Universitaire De Saint Etienne
发明人： PAIN, Bernard , VOLA, Marco , PASQUINO, Enrico
IPC分类号： A61B17/22 , A61F2/24
CPC分类号： A61B17/320783 , A61B17/2202 , A61B17/320758 , A61B2017/22038 , A61B2017/22071 , A61B2017/22079 , A61B2017/22098 , A61B2017/320791 , A61B2090/3966 , A61F2/2496
摘要： This transcatheter device for the ablation of calcified tissue at the flaps of an aortic valve, is characterised in that it comprises a flexible body (1) acting as a catheter and having a soft and flexible end piece (2) that engages with a previously inserted wire guide (g) suitable for passing through the flaps of the valve above the part where the calcified tissue needs to be removed, said end piece (2) having at least one cutting system (3) comprising two motorised rotating cutting heads (3a) and (3b) disposed coaxially one above the other, the head (3a) located at the end of the end piece and acting first to remove the calcified tissue, has arrangements suitable for making a rough cut by grinding, while the other head (3b) has arrangements suitable for making a fine cut by grinding, said cutting system being mounted in combination with a vacuum suction means (4), said end piece (2) being provided with an adjustable guide means (5) suitable for engaging with the calcified tissue over the course of the ablation operation performed by the cutting system (3) in combination with a spiral path effect applied to the end piece.
摘要翻译：用于在主动脉瓣的瓣片处消融钙化组织的经导管装置的特征在于，其包括用作导管的柔性体（1），并且具有柔软且柔性的端部件（2），其与先前插入的所述端部件（2）具有至少一个切割系统（3），所述切割系统（3）包括两个电动旋转切割头（3a），所述切割系统（3）包括两个电动旋转切割头（3a）和（3b）彼此同轴地设置，位于端件端部并首先起作用以移除钙化组织的头部（3a）具有适于通过研磨进行粗切割的结构，而另一个头部（3b））具有适于通过研磨进行精细切割的布置，所述切割系统与真空抽吸装置（4）组合安装，所述端部件（2）设置有适于与钙化的接合的可调导向装置（5）组织ove r由切割系统（3）执行的消融操作的过程与施加到端部件的螺旋路径效应相结合。

3. 发明公开

EP3718505A1 TRANSCATHETER ANTI EMBOLIC FILTER FOR ARTERIAL AND VENOUS VESSELS 审中-公开
公开(公告)号：EP3718505A1
公开(公告)日：2020-10-07
申请号：EP19167599.0
申请日：2019-04-05
申请人： AORTICLAB SARL
发明人： BONETTI, Francesco , OSTA, Stefano , PASQUINO, Enrico , OSTA, Franco , BAI, Yi Peng , PARIGI, Giulia
IPC分类号： A61F2/01 , A61F2/95
摘要： An intra-vessel transcatheter filter device (1) designed to capture and remove emboli, thus preventing distal embolization, comprising:
• a tubular filter (2) comprising a flexible porous material and defined by a distal element and a proximal element, namely a main body (3) and a funnel (4);
i. said main body (3) having a length adapted to extend within a suitable vessel zone; said main body (3) comprising:
a) a distal end (5) that is adapted to be radially coupled with said zone and hermetically sealed to it when the device is in an active configuration, said distal end (5) being provided of selectively actionable closure means so that said distal end is designed to be open when the device is in an active configuration and closed before the device retraction,
b) a proximal end (6);

ii. said funnel (4) forming an extension of said main body (3), with the funnel base located at said proximal end (6).

• a support structure assembly (8) comprising:
i. a supporting catheter (11) extending within said main body (3),
ii. one radially expandable distal structure (9) fixed to said distal end (5),
iii. one radially expandable proximal structure (10) positioned in correspondence of said proximal end (6),

said distal structure (9) and said proximal structure (10) being fixed at least in an end to said supporting catheter (11).

4. 发明公开

EP3685772A1 DEVICE FOR THE TREATMENT OF TISSUE CALCIFICATION 审中-公开
公开(公告)号：EP3685772A1
公开(公告)日：2020-07-29
申请号：EP19153513.7
申请日：2019-01-24
申请人： AORTICLAB SARL
发明人： PASQUINO, Enrico , OSTA, Franco , BONETTI, Francesco , FERMI, Enrico , BENETTIN, Davide , OSTA, Stefano
IPC分类号： A61B17/22 , A61N7/00
摘要： Device for the treatment of tissue calcification, in particular aortic valve leaflets, characterized by the fact that it comprises a first ultrasound emission unit that is adapted to provide ultrasound waves with MHz frequencies and a second ultrasound emission unit that is adapted to provide ultrasound waves with KHz frequencies.
The invention also includes a method for the treatment of tissue calcification that is characterized by the simultaneous use of ultrasound waves with MHz frequencies and ultrasound waves with KHz frequencies.

6. 发明授权

EP3151783B1 DISPOSITIF D'INTRODUCTION TRANSCATHETER DANS LA RACINE AORTIQUE AU NIVEAU DE LA JONCTION SINO TUBULAIRE 有权转让
公开(公告)号：EP3151783B1
公开(公告)日：2019-03-27
申请号：EP15733803.9
申请日：2015-06-04
申请人： AORTICLAB SARL , Centre Hospitalier Universitaire De Saint Etienne
发明人： PAIN, Bernard , VOLA, Marco , PASQUINO, Enrico
IPC分类号： A61F2/01 , A61F2/24

7. 发明公开

EP3151783A1 DISPOSITIF D'INTRODUCTION TRANSCATHETER DANS LA RACINE AORTIQUE AU NIVEAU DE LA JONCTION SINO TUBULAIRE 有权转让
标题翻译： VORRICHTUNGFÜRDEN KATHETEREINSATZ IN DIE AORTENWURZEL AN DER SINOTUBULAREN VERBINDUNG
公开(公告)号：EP3151783A1
公开(公告)日：2017-04-12
申请号：EP15733803.9
申请日：2015-06-04
申请人： AORTICLAB SARL , Centre Hospitalier Universitaire De Saint Etienne
发明人： PAIN, Bernard , VOLA, Marco , PASQUINO, Enrico
IPC分类号： A61F2/01 , A61F2/24
CPC分类号： A61F2/013 , A61F2/2412
摘要： This device for transcatheter insertion into the aortic root at the sinotubular junction by means of a wire guide and a catheter (1) with a means for protecting the surrounding tissues
is characterised in that it comprises an assembly (E) acting as a valved embolic filter, mounted with the ability to slide in a guided manner into said catheter (1), said assembly (E) having arrangements capable of producing, in each aortic root (RA), a safety chamber carrying out a valve function and a protective function protecting against embolic accidents, said arrangements comprising a tubular body (2) secured, at one of the ends of same, to a part (2a) capable, as required, of being either deployed outside the catheter (1), or retracted into the catheter (1), said part (2a) having filtration arrangements combined with means capable of reproducing the temporary valve function corresponding to opening during the systolic phase and to closing during the diastolic phase in order to prevent any regurgitation of blood in a deployed position of said part to cover the native aortic valve with a seat secured in the aortic root at the sinuses of Valsalva without blocking the blood flow.
摘要翻译：该装置用于通过线导向器和具有用于保护周围组织的装置的导管（1）在导管（1）处经由导管插入主动脉根部的特征在于其包括用作阀瓣栓塞过滤器安装有能够以导向方式滑入所述导管（1）的能力，所述组件（E）具有能够在每个主动脉根部（RA）中产生安全室，其执行阀功能和保护功能保护所述装置包括一个管状体（2），该管状体（2）在其一个端部处固定到能够根据需要部署在导管（1）外部或缩回到导管内的部分（2a）（1），所述部分（2a）具有过滤装置，其结合了能够再现与收缩期期间的开放相对应的临时瓣膜功能的装置，并且在舒张期期间闭合以防止任何反流在所述部分的展开位置处的血液覆盖原生主动脉瓣，其中座位固定在Valsalva窦的主动脉根部，而不阻塞血流。

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