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1. 发明公开

EP1440077A4 SYNTHETIC HEPARIN PENTASACCHARIDES 有权
标题翻译：合成肝素PENTAAC CHARIDE
公开(公告)号：EP1440077A4
公开(公告)日：2010-06-02
申请号：EP02766941
申请日：2002-09-06
申请人： ALCHEMIA LTD
发明人： SEIFERT JOACHIM , SINGH LATIKA , RAMSDALE TRACIE ELIZABETH , WEST MICHAEL LEO , DRINNAN NICHOLAS BARRY
IPC分类号： C07H15/18 , A61K31/7028 , A61K31/7034 , A61K31/7072 , A61P7/02 , A61P9/10 , C07H3/06 , C07H7/033 , C07H11/00 , C07H15/203 , C07H15/26 , C07H23/00 , C07H3/02 , A61K31/702 , C07H3/04
CPC分类号： C07H9/00 , C07H3/06 , C07H5/04 , C07H7/033 , C07H11/00 , C07H13/04 , C07H13/08 , C07H15/10 , C07H15/18

2. 发明公开

EP1843760A4 CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS 审中-公开
标题翻译：随着整合互动合成药
公开(公告)号：EP1843760A4
公开(公告)日：2009-03-25
申请号：EP06704810
申请日：2006-02-02
申请人： ALCHEMIA LTD
发明人： MEUTERMANS WIM , WEST MICHAEL LEO , THANH LE GIANG , HALLIDAY JUDY , CLARK CHRISTOPHER
IPC分类号： A61K31/351 , A61K31/70 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/06 , A61P17/02 , A61P19/10 , A61P25/28 , A61P35/00
CPC分类号： A61K31/351 , A61K31/70

3. 发明公开

EP1549325A4 CLASSES OF COMPOUNDS THAT INTERACT WITH GPCRS 审中-公开
标题翻译：与GPCR的INTERACT相关的类
公开(公告)号：EP1549325A4
公开(公告)日：2008-10-29
申请号：EP03747740
申请日：2003-10-10
申请人： ALCHEMIA LTD
发明人： MEUTERMANS WIM , LE THANH GIANG , ABBENANTE GIOVANNI , TOMETZKI GERALD , HALLIDAY JUDY , ZEUGG JOHANNES
IPC分类号： A61K31/7008 , A61K31/7034 , A61K31/7036 , A61K31/7052 , A61K31/70
CPC分类号： A61K31/7008 , A61K31/7034 , A61K31/7036 , A61K31/7052

4. 发明公开

EP1934388A1 METHOD OF DRUG DESIGN 有权转让
标题翻译： VERFAHREN ZUR ENTWICKLUNG VON ARZNEISTOFFEN
公开(公告)号：EP1934388A1
公开(公告)日：2008-06-25
申请号：EP06790302.1
申请日：2006-10-03
申请人： Alchemia Ltd
发明人： TOMETZKI, Gerald, B. , MEUTERMANS, Wim , ZEUGG, Johannes
IPC分类号： C40B30/04 , C07H7/02 , C40B20/06 , A61K31/7052 , C07H15/00 , C40B40/12 , A61P5/02 , C07H15/04 , C40B50/08 , C07B61/00 , C07H15/12 , C40B50/14 , C07D309/10 , C07H15/18 , G01N33/53 , C07D309/14 , C07H15/26 , C07H7/00 , C07K14/655
CPC分类号： G01N33/68 , C07H3/02 , C07H15/18 , G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
摘要翻译：本发明提供了鉴定生物活性化合物的方法，包括：（a）设计式（1）化合物的第一文库以扫描分子多样性，其中文库的每种化合物具有如下定义的至少两个药用基团R 1至R 5，并且其中文库的化合物具有相同数量的药效团; （b）在一个或多个生物测定中测定化合物的第一文库; 和（c）设计第二文库，其中第二文库的每个化合物相对于第一文库含有一个或多个另外的药物亲和基团; 使得第一和第二文库的每个组分是式（1）的化合物。

5. 发明公开

EP1546167A4 COMPOUNDS THAT INTERACT WITH KINASES 审中-公开
标题翻译：与激酶INTERACT链接
公开(公告)号：EP1546167A4
公开(公告)日：2008-05-21
申请号：EP03793479
申请日：2003-09-05
申请人： ALCHEMIA LTD
发明人： MEUTERMANS WIM , SCHAFER KARL , WEST MICHAEL LEO , MULDOON CRAIG , FOLEY FIONA , BOULOC NATALIE , TOMETZKI GERALD
IPC分类号： A61K31/7056 , A61K31/7076 , A61K31/708 , A61P9/00 , A61P29/00 , C07H17/02 , C07H17/08 , A61K31/4184
CPC分类号： C07H17/02 , A61K31/7056 , A61K31/7076 , A61K31/708 , C07H17/08

6. 发明公开

EP1732573A4 BIOLOGICALLY ACTIVE COMPOUNDS WITH ANTI-ANGIOGENIC PROPERTIES 审中-公开
标题翻译：生物活性化合物的抗血管生成特性
公开(公告)号：EP1732573A4
公开(公告)日：2010-09-01
申请号：EP05729499
申请日：2005-04-07
申请人： ALCHEMIA LTD
发明人： HALLIDAY JUDY , MEUTERMANS WIM , TOMETZKI GERALD , RAMSDALE TRACIE ELIZABETH , ZUEGG JOHANNES , BECKER BERND , MULDOON CRAIG , MCKEVENEY DECLAN , PREMRAJ RAJARATNAM , CONDIE GLENN
IPC分类号： A61K31/7008 , A61K31/70 , A61P35/00
CPC分类号： A61K31/7008 , A61K31/70

7. 发明公开

EP1934388A4 METHOD OF DRUG DESIGN 有权转让
标题翻译：过程对于原料药的发展
公开(公告)号：EP1934388A4
公开(公告)日：2010-07-21
申请号：EP06790302
申请日：2006-10-03
申请人： ALCHEMIA LTD
发明人： TOMETZKI GERALD B , MEUTERMANS WIM , ZUEGG JOHANNES
IPC分类号： C40B30/04 , A61K31/7052 , A61P5/02 , C07B61/00 , C07D309/10 , C07D309/14 , C07H7/00 , C07H7/02 , C07H15/00 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/26 , C07K14/655 , C40B20/06 , C40B40/12 , C40B50/08 , C40B50/14 , G01N33/53
CPC分类号： G01N33/68 , C07H3/02 , C07H15/18 , G01N33/566 , G01N2333/726 , G01N2500/04

8. 发明授权

EP1934388B1 METHOD OF DRUG DESIGN 有权转让
标题翻译：过程对于原料药的发展
公开(公告)号：EP1934388B1
公开(公告)日：2012-12-05
申请号：EP06790302.1
申请日：2006-10-03
申请人： Alchemia Ltd
发明人： TOMETZKI, Gerald, B. , MEUTERMANS, Wim , ZUEGG, Johannes
IPC分类号： C40B30/04 , C07H7/02 , C40B20/06 , A61K31/7052 , C07H15/00 , C40B40/12 , A61P5/02 , C07H15/04 , C40B50/08 , C07B61/00 , C07H15/12 , C40B50/14 , C07D309/10 , C07H15/18 , G01N33/53 , C07D309/14 , C07H15/26 , C07H7/00 , C07K14/655
CPC分类号： G01N33/68 , C07H3/02 , C07H15/18 , G01N33/566 , G01N2333/726 , G01N2500/04

9. 发明公开

EP1501844A4 DISACCHARIDES FOR DRUG DISCOVERY 审中-公开
标题翻译：二糖的药物开发
公开(公告)号：EP1501844A4
公开(公告)日：2010-10-27
申请号：EP03714557
申请日：2003-04-24
申请人： ALCHEMIA LTD
发明人： MEUTERMANS WIM , WEST MICHAEL LEO , ADAMSON GEORGE , THANH LE GIANG , DRINNAN NICHOLAS BARRY , ABBENANTE GIOVANI , BECKER BERND , GRATHWOHL MATTHIAS , RAJARATNAM PREMRAJ , TOMETZKI GERALD
IPC分类号： C07H15/18 , C07D309/14 , C07H1/00 , C07H3/02 , C07H3/04 , C07H15/26 , C07H17/04 , C40B40/12 , C40B50/14 , C07D307/18 , C07D309/10
CPC分类号： C07H3/04 , C07H3/02 , C40B40/12 , C40B50/14

10. 发明公开

EP1487812A4 ANOMERIC DERIVATIVES OF MONOSACCHARIDES 审中-公开
标题翻译：异味单加糖
公开(公告)号：EP1487812A4
公开(公告)日：2006-07-26
申请号：EP03745223
申请日：2003-03-28
申请人： ALCHEMIA LTD
发明人： MEUTERMANS WIM , WEST MICHAEL LEO , THANH LE GIANG , ADAMSON GEORGE , SCHAFER KARL , ABBENANTE GIOVANI
IPC分类号： C07H9/04 , C07D309/14 , C07D405/12 , C07F7/18 , C07H15/12 , C07H15/18 , C07H15/20 , C07D307/20 , C07D307/22 , C07D307/24 , C07D309/08 , C07D309/10 , C07H5/04 , C07H7/02 , C07H7/04
CPC分类号： C07D405/12 , C07D309/14 , C07F7/1856 , C07H15/12
摘要： A compound of formula (I), wherein, n is 0 or 1; R6 and R7 are h ydrogen, or together form a carbonyl oxygen; R1 is selected from the group consisting of hydrogen; -N(Z)Y and -C(Z)Y wherein; When R1 is -N(Z)Y, then: Y is selected from hydrogen, or the following, where G denotes the point of connection to the nitrogen atom in N(Y)Z (i-v); Z is selected from hydrogen or X1; Q is selected from hydrogen or W; The groups W are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , The groups X1 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , When R1 is -C(Z)Y, then: Y is selected from the group consisting of two hydrogen atoms, a double bonded oxygen (=O) to form a carbonyl, and a triple bonded nitrogen to form a nitrile, Z is absent, or is selected from hydrogen or U, Wherein U is selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aminoalkyl, aminoaryl, aryloxy, alkoxy, heteroaryloxy, aminoaryl, aminoheteroaryl, thioalkyl, thioaryl or thioheteroaryl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms, . When R1 is H, at least two of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms, When R1 is N(Z)Y or C(Z)Y, at least one of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms.

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