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1. 发明公开

EP3146094A1 OLIGONUCLEOTIDE PROBE INVERSION PROCESS FOR IN SITU SYNTHESIZED PROBE ARRAYS 有权
标题翻译：合作伙伴合作伙伴关系
公开(公告)号：EP3146094A1
公开(公告)日：2017-03-29
申请号：EP15796731.6
申请日：2015-05-22
申请人： Centrillion Technology Holdings Corporation
发明人： MCGALL, Glenn , SINGH, Vijay
IPC分类号： C40B50/18
CPC分类号： C12Q1/6837 , C12Q1/6834 , C40B50/18 , C12Q2525/307
摘要： The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3′-bound to 5′-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.
摘要翻译：本公开涉及在原位合成阵列中反转寡核苷酸探针的方法。这些方法可用于从3'-结合到5'-结合的方向逆转探针相对于底物的取向。这些方法也可用于从原位合成的阵列中减少或消除截短的探针序列的存在。

2. 发明公开

EP3133171A1 PROBE INVERSION PROCESS FOR IN SITU SYNTHESIZED PROBE ARRAYS 有权
标题翻译：合作伙伴关系
公开(公告)号：EP3133171A1
公开(公告)日：2017-02-22
申请号：EP16184815.5
申请日：2016-08-18
申请人： Centrillion Technology Holdings Corporation
发明人： ZHOU, Wei , McGALL, Glenn , SINGH, Vijay
IPC分类号： C12Q1/68 , B01J19/00 , C40B60/14
CPC分类号： C12Q1/6834 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , C40B50/18 , C40B80/00 , C12Q2565/513 , C12Q2565/514
摘要： The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3'-bound to 5'-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.
摘要翻译：本公开涉及在原位合成阵列中反转寡核苷酸探针的方法。这些方法可用于从3'-结合到5'-结合的方向逆转探针相对于底物的取向。这些方法也可用于从原位合成的阵列中减少或消除截短的探针序列的存在。

3. 发明授权

EP2984163B1 IMMUNO-MODULATORY PROGENITOR (IMP) CELL 有权
标题翻译：免疫调节剂VORLÄUFERZELLE
公开(公告)号：EP2984163B1
公开(公告)日：2017-02-01
申请号：EP15729886.0
申请日：2015-06-09
申请人： Cell Therapy Limited
发明人： REGINALD, Ajan , EVANS, Martin John , SULTAN, Sabena
IPC分类号： C12N5/071 , C12N5/078
CPC分类号： A61K35/28 , C12N5/0633 , C12N5/0634 , C12N2500/84 , C12N2500/90 , C12N2506/1353

4. 发明公开

EP3087204A1 METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTS 有权
标题翻译：方法和系统检测遗传变异
公开(公告)号：EP3087204A1
公开(公告)日：2016-11-02
申请号：EP14874157.2
申请日：2014-12-24
申请人： Guardant Health Inc.
发明人： ELTOUKHY, Helmy , TALASAZ, AmirAli
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6886 , C12Q2535/122 , C12Q2600/158 , G06F19/16
摘要： Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample. A method for determining copy number variations includes tagging double-stranded polynucleotides with duplex tags, sequencing polynucleotides from the sample and estimating total number of polynucleotides mapping to selected genetic loci. The estimate of total number of polynucleotides can involve estimating the number of double-stranded polynucleotides in the original sample for which no sequence reads are generated. This number can be generated using the number of polynucleotides for which reads for both complementary strands are detected and reads for which only one of the two complementary strands is detected.

5. 发明公开

EP3077430A1 MODIFIED SURFACES 无效转让
标题翻译： MODIFIZIERTEOBERFLÄCHE
公开(公告)号：EP3077430A1
公开(公告)日：2016-10-12
申请号：EP14868406.1
申请日：2014-12-05
申请人： Centrillion Technology Holding Corporation , Mcgall, Glenn
发明人： MCGALL, Glenn
IPC分类号： C08F220/58 , G01N33/543
CPC分类号： C12N15/1093 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C08F220/56 , C08F220/58 , C09D4/00 , C12Q1/6834 , C12Q1/686 , C12Q1/6874 , C40B50/18 , C12Q2523/101 , C12Q2527/153 , C12Q2531/113
摘要： Provided herein are methods and compositions for coating surfaces with polymers. The methods and compositions are suited for conducting biological reactions. In particular, the biological reactions can include enzymatic reactions.
摘要翻译：本文提供了用聚合物涂覆表面的方法和组合物。方法和组合物适于进行生物反应。

6. 发明公开

EP3076991A2 NUTRITIVE POLYPEPTIDES AND FORMULATIONS THEREOF, AND METHODS OF PRODUCTION AND USE THEREOF 无效
标题翻译： NUTRITIOUS多肽及其制剂及方法进行生产及其用途
公开(公告)号：EP3076991A2
公开(公告)日：2016-10-12
申请号：EP14792624.0
申请日：2014-09-25
申请人： Axcella Health Inc.
发明人： HAMILL, Michael, J. , HEARD, Kathryn , BERRY, David, A. , VON MALTZAHN, Geoffrey , SILVER, Nathaniel, W. , SAMAYOA, Phillip , RAHMAN, Shaila , KRAMARCZYK, John, F. , BOGHIGIAN, Brett, Adam , YOUNG, David, M. , BASU, Subhayu , CHEN, Ying-Ja , DOHERTY, Michael
IPC分类号： A61K38/38
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G06F19/18
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：中提供营养多肽。所以提供了包含编码多肽，重组微生物确实使所述多肽，用于表达所述多肽的载体，使用重组微生物制造的多肽的方法，组合物和式蒸发散也包括多肽，核酸以及使用所述多肽的方法的各种其他实施例中组合物和配方重刑。

7. 发明公开

EP2998026A3 COLLECTOR ARCHITECTURE LAYOUT DESIGN 有权
标题翻译：收集器架构布局设计
公开(公告)号：EP2998026A3
公开(公告)日：2016-07-13
申请号：EP15182577.5
申请日：2015-08-26
申请人： Academia Sinica
发明人： CHANG, Ying-Chih , LAI, Jr-Ming , WU, Jen-Chia
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L2200/0652 , B01L2200/0668 , B01L2300/08 , B01L2300/0809 , B01L2300/16 , B01L2400/086
摘要： The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.
摘要翻译：本公开内容提供了使用散布微结构设计来收集稀有细胞的组合物和方法。

8. 发明授权

EP2530083B1 Inhibitors of bruton's tyrosine kinase 有权转让
标题翻译：布鲁顿氏酪氨酸激酶抑制剂
公开(公告)号：EP2530083B1
公开(公告)日：2016-04-27
申请号：EP12166295.1
申请日：2006-12-28
申请人： Pharmacyclics LLC
发明人： Honingberg, Lee , Vernier, Erik , Pan, Zhengying
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： A61K31/52 , A61K9/4825 , A61K31/00 , A61K31/519 , A61K39/3955 , A61K45/06 , A61K2300/00 , C07D487/04 , C07K16/2887 , C07K2317/24
摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described arc irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

9. 发明授权

EP2307098B1 SYSTEM FOR ULTRASONIC ABLATION 有权转让
标题翻译：超声消融系统
公开(公告)号：EP2307098B1
公开(公告)日：2015-03-04
申请号：EP09798856.2
申请日：2009-07-20
申请人： Vytronus, Inc.
发明人： THAPLIYAL, Hira, V. , GALLUP, David, A. , ARENSON, James, W.
IPC分类号： A61N7/02
CPC分类号： A61B17/320068 , A61B17/2202 , A61B18/148 , A61B18/18 , A61B2017/00106 , A61B2017/22051 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/0262 , A61B2018/1807 , A61N7/022

10. 发明公开

EP2831100A1 NUTRITIVE PROTEINS AND METHODS 审中-公开
标题翻译： NERHRSTOFFPROTEINE UND VERFAHREN
公开(公告)号：EP2831100A1
公开(公告)日：2015-02-04
申请号：EP13768270.4
申请日：2013-03-15
申请人： Pronutria, Inc.
发明人： BERRY, David, Arthur , BOGHIGIAN, Brett, Adam , SILVER, Nathaniel, W. , VON MALTZAHN, Geoffrey , CHILLAKURU, Rajeev , HAMILL, Michael, J.
IPC分类号： C07K14/435 , A23J3/04 , C12N15/12 , C12N15/63 , C12N15/74
CPC分类号： C07K14/415 , A23J3/04 , A23L33/175 , A23V2002/00 , A61K38/00 , C07K14/47
摘要： Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.
摘要翻译：提供营养蛋白质。在一些实施方案中，营养蛋白质包含以下中的至少一种：a）支链氨基酸残基与营养蛋白中存在的总氨基酸残基的比例等于或大于支链氨基酸残基与总氨基酸的比例存在于乳清蛋白中的酸残基; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例等于或大于乳清蛋白中存在的亮氨酸残基与总氨基酸残基的比例; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例等于或大于乳清蛋白中存在的必需氨基酸残基与总氨基酸残基的比例。还提供了编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

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